Prazine 25mg indications
Oral
Agitation
Adult: 100-200 mg 4 times daily.
Elderly: Initially, 25 mg, may increase to 50 mg 4 times daily, if necessary.
Oral
Nausea and vomiting
Adult: 25-50 mg every 4-6 hr. May also be given via IM inj.
Parenteral
Agitation
Adult: 50 mg IM or slow IV inj (concentrations not >25 mg/ml), repeated if necessary after 6-8 hr.
Elderly: 25 mg administered IM.
Prazine 25mg description
A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. Prazine 25mg is not approved for use in the United States.
Prazine 25mg dosage
Prazine 25mg Dosage
Applies to the following strengths: 50 mg; 25 mg; 50 mg/mL; 25 mg/mL
Usual Adult Dose for:
- Agitated State
Usual Pediatric Dose for:
- Psychosis
Additional dosage information:
- Dose Adjustments
- Dialysis
- Other Comments
Usual Adult Dose for Agitated State
IM: 50-150 mg, depending on the degree of severity.
May give additional doses in 30 minutes up to a total of 300 mg. Once control is obtained, administer orally.
Oral or IM: 10-200 mg every 4-6 hours.
Usual Pediatric Dose for Psychosis
Child > 12 years:
Oral or IM: 10-25 mg every 4-6 hours.
Dose Adjustments
In less severe disturbances, adjust dose downward.
Dialysis
Prazine 25mg is not dialyzable.
Other Comments
The total daily dose should not exceed 1000 mg.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
More about Prazine 25mg
- Prazine 25mg Side Effects
- During Pregnancy
- Drug Interactions
- 1 Review
- Drug class: phenothiazine antiemetics
Related treatment guides
- Agitated State
- Psychosis
- Schizophrenia
Prazine 25mg interactions
The concomitant administration of this product with other medication such as central nervous system depressants (including alcohol and anaesthetics) or antihypertensives, anticholinergic or dopaminergic drugs may result in accentuation of their effects, while potentiation of action may also occur with monoamine oxidase inhibitors, antidepressants and analgesics. Prazine 25mg may impair the effects of anticonvulsants. Prazine 25mg may affect the control of diabetes. Undesirable anticholinergic effects can be enhanced by anti-parkinson or other anticholinergic drugs.
The concomitant administration of this product with myelosuppressive drugs (carbamazepine, co-trimoxazole, chloramphenicol, sulphonamides, pyralizone analgesics (e.g. azapropazone), penicillamine and cytotoxics) increases the risk of toxicity.
Lithium administration will result in an increased risk of extrapyramidal effects and the possibility of neurotoxicity.
Sotalol administration will result in an increased risk of ventricular arrhythmia.
Concomitant use of Prazine 25mg with drugs known to prolong the QT interval may increase the risk of ventricular arrhythmias, including torsade de pointes. Therefore concomitant use of these products is not recommended. Examples include certain antiarrhythmics, such as those of Class 1A (such as quinidine, disopyramide and procainamide) and Class III (such as amiodarone, sotalol and dofetilide), certain antimicrobials (sparfloxacin, moxifloxacin, erythromycin IV), tricyclic antidepressants (such as amitriptyline), certain tetracyclic antidepressants (such as maprotiline), other neuroleptics (e.g. phenothiazines, pimozide, sertindole and haloperidol), certain antihistamines (such as terfenadine), cisapride, bretylium and certain antimalarials such as quinine and mefloquine. This list is not comprehensive.
Concurrent use of drugs causing electrolyte imbalance is not recommended. Diuretics, in particular those causing hypokalemia, should be avoided but, if necessary, potassium-sparing diuretics are preferred.
Prazine 25mg side effects
See also:
What are the possible side effects of Prazine 25mg?
Prazine 25mg is a member of the phenothiazine group of drugs and the side effects associated with that group have been noted. These include drowsiness, sedation, dry mouth, nasal stuffiness. Other possible anticholinergic side effects are blurred vision, tachycardia, constipation and urinary hesitancy or retention when due to enlarged prostate.
Confusional states or epileptic fits can occur. Extrapyramidal symptoms and hyperpyrexia have been reported. Neuroleptic malignant syndrome (hyperthermia, rigidity, autonomic dysfunction and altered consciousness) may occur with any neuroleptic.
Sexual function may be impaired. Agranulocytosis and transient leucopenia have rarely been reported. Allergic skin reactions and photosensitivity have also been reported.
Prazine 25mg rarely causes obstructive jaundice associated with stasis in biliary canaliculi. Prazine 25mg treatment should then be withdrawn and not given again. Transient abnormalities of liver function tests may occur without jaundice.
Some individuals may be susceptible to the drug in low dosage and show paradoxical effects of excitement, agitation or insomnia and other minor side effects. The elderly are particularly susceptible to side effects of Prazine 25mg, especially to the sedative, hypotensive and temperature regulation effects. These effects may be dose related.
Withdrawal symptoms, including nausea, vomiting, sweating, insomnia, recurrence of psychotic symptoms and involuntary movement disorders have been noted.
Phenothiazines can produce ECG changes with prolongation of QT interval and T-wave changes, ventricular arrhythmias (VF, VT (rare)), sudden unexplained death, cardiac arrest and Torsades de pointes have been reported
Cases of venous thromboembolism, including cases of pulmonary embolism and cases of deep vein thrombosis have been reported with antipsychotic drugs – Frequency unknown
Prazine 25mg contraindications
Use in patients hypersensitive to the active ingredient or other phenothiazines.
Use in patients in coma
Use in patients with bone marrow depression
Use in patients with phaeochromocytoma
Use during lactation
Do not use during pregnancy, especially during the first three months, unless there are compelling reasons.
Active ingredient matches for Prazine 25mg:
Promazine in Switzerland.
List of Prazine 25mg substitutes (brand and generic names) | Sort by popularity |
Unit description / dosage (Manufacturer) | Price, USD |
Prazine 50mg (Switzerland) | |
Proma (Philippines) | |
Proma 100 mg x 100's | $ 10.91 |
Proma 200 mg x 100's | |
Promazil | |
Promazin Belupo (Croatia (Hrvatska)) | |
Promazin Farmavita (Bosnia & Herzegowina) | |
Promazin Jelfa (Poland) | |
Promazine (Bosnia & Herzegowina, Croatia (Hrvatska), Slovenia, Switzerland) | |
Syrup; Oral; Promazine Hydrochloride 25 mg / 5 ml | |
Syrup; Oral; Promazine Hydrochloride 50 mg / 5 ml | |
Injectable; Injection; Promazine Hydrochloride 25 mg / ml | |
Injectable; Injection; Promazine Hydrochloride 50 mg / ml | |
Chlorpromazine 25 mg/ml amp | $ 8.04 |
Chlorpromazine 200 mg tablet | $ 1.05 |
Chlorpromazine Hcl 25 mg/ml | $ 0.88 |
Chlorpromazine 100 mg tablet | $ 0.39 |
Novo-Chlorpromazine 100 mg Tablet | $ 0.35 |
Chlorpromazine 10 mg tablet | $ 0.32 |
Chlorpromazine 50 mg tablet | $ 0.30 |
Novo-Chlorpromazine 50 mg Tablet | $ 0.21 |
Novo-Chlorpromazine 25 mg Tablet | $ 0.18 |
Chlorpromazine 25 mg tablet | $ 0.17 |
Promazine / amp 25 mg/1 mL x 2 mL x 10's | |
Promazine HCl (United States) | |
Promazine HCl Zoetis (United States) | |
Promazine Hydrochloride Rosemont (United Kingdom) | |
Promazine Zoetis (United States) | |
Promwill | |
Propazin | |
Propazine | |
Tablet, Film-Coated; Oral; Promazine 25 mg | |
Tablet, Film-Coated; Oral; Promazine 50 mg | |
PROPAZINE TABLET 1 strip / 10 tablets each (Prayas Pharmaceuticals) | $ 0.12 |
Propazine NA Tablet (Prayas Pharmaceuticals) | $ 0.01 |
Protactyl (Germany) | |
Prozil | |
Psychozine | |
Romtiazin | |
Sanopron | |
Sinophenin (Greece) | |
Sparine | |
Concentrate; Oral; Promazine Hydrochloride 30 mg / ml (Meda) | |
Concentrate; Oral; Promazine Hydrochloride 100 mg / ml (Meda) | |
Injectable; Injection; Promazine Hydrochloride 25 mg / ml (Meda) | |
Injectable; Injection; Promazine Hydrochloride 50 mg / ml (Meda) | |
See 82 substitutes for Prazine 25mg |
References
- PubChem. "promazine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "promazine". http://www.drugbank.ca/drugs/DB00420 (accessed September 17, 2018).
- DTP/NCI. "promazine: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Prazine 25mg are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Prazine 25mg. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology