What is Prokinin 10mg?
Prokinin 10mg is a medicine that increases the movements or contractions of the stomach and bowel. Prokinin 10mg is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.
Prokinin 10mg is to be given only by or under the immediate supervision of your doctor.
Prokinin 10mg indications
Dyspeptic symptom complex often associated with delayed gastric emptying, gastroesophageal reflux disease (GERD) or esophagitis: Epigastric sense of fullness, feeling of abdominal distention, upper abdominal pain, flatulence (gassiness), eructation (belching), and heartburn.
Short-term treatment of nausea and vomiting of various origins including functional, organic, infectious, diabetic origin, or induced by radiotherapy or medicine therapy. (It is not considered suitable for chronic nausea and vomiting, nor for the routine prophylaxis of postoperative vomiting.)
Treatment of nausea and vomiting induced by dopamine agonists ie, L-dopa and bromocriptine used in Parkinson's disease.
Prokinin 10mg may also be given as needed, together with paracetamol for the symptomatic treatment of nausea and vomiting associated with migraine.
Uses of Prokinin 10mg in details
Prokinin 10mg is used to treat vomiting or nausea caused due to indigestion, diseases or drugs. It is also used to relieve fullness of stomach, belching and heavy bloating, gas and heartburn for a longer period up to 2 weeks.
Prokinin 10mg description
Prokinin 10mg is a synthetic anticoagulant and an indanedione derivative. It prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibiting the vitamin K mediated gamma-carboxylation of precursor proteins.
Prokinin 10mg dosage
It is recommended to take oral Prokinin 10mg before meals. If taken after meals, absorption of the drug is somewhat delayed.
Adults and Adolescents >12 years and weighing ≥35 kg: Tablets: One to two 10-mg tablet 3-4 times/day, with a maximum daily dose of 8 tablets (80 mg).
Oral Suspension:
10-20 mL (of oral susp containing Prokinin 10mg 1 mg/mL) 3-4 times/day, with a maximum daily dose of 80 mL.Infants and Children: 0.25-0.5 mg/kg 3-4 times/day with a maximum daily dose of 2.4 mg/kg (but do not exceed 80 mg/day).
Tablets are unsuitable for use in children weighing <35 kg.
Oral Suspension:
0.25-0.5 mg/kg 3-4 times/day with a maximum dose of 2.4 mg/kg (not exceeding 80 mL).Prokinin 10mg interactions
The concomitant administration of Prokinin 10mg with phenothiazines, butyrophenones and rauwolfia alkaloids may induce the endocrine disturbances or extrapyramidal disorders. If necessary, monitored carefully and administered cautiously.
Should be administered cautiously in patients receiving digitalis preparations.
The concomitant administration of Prokinin 10mg with anticholinergic agents may compromise the beneficial effects of Prokinin 10mg because of depressing the promoting action of gastrointestinal motility.
Theologically, Prokinin 10mg may have an effect on the absorption of oral preparations, especially slow-releasing or enteric-coated preparations because of increasing gastric motility. But in patients stabilized with digoxin or acetaminophen, the concomitant administration of Prokinin 10mg had no effect on plasma concentration of these drugs.
It is not reported that Prokinin 10mg enhances the effect of neuroleptics.
Prokinin 10mg inhibits peripheral adverse reactions eg, dyspepsia, nausea, vomiting, induced by dopamine agonist (eg, bromocriptine, levodopa), but has no effect on central nervous system.
As the concomitant administration of Prokinin 10mg with antacids or acid secretion inhibitors lowers biologic activity of Prokinin 10mg, these drugs should not be used together.
The actions of Prokinin 10mg on gastrointestinal function may be antagonised by antimuscarinics and opioid analgesics.
Prokinin 10mg side effects
See also:
What are the possible side effects of Prokinin 10mg?
Clinical Trial Data: The safety of Prokinin 10mg was evaluated in 1221 patients with gastroparesis, dyspepsia, gastro-oesophageal reflux disorder (GERD) or other related conditions in 45 clinical trials included in the safety database. All patients were ≥15 years and received at least 1 dose of oral Prokinin 10mg (Prokinin 10mg base). Slightly fewer than one-half (553/1221) of patients were diabetic. The median total daily dose was 80 mg (range 10-160 mg), with 230 patients receiving a dose >80 mg. Median duration of exposure was 56 days (range 1-2248 days).
Adverse drug reactions (ADRs) reported by ≥1% of patients treated with oral Prokinin 10mg in these 45 clinical trials (n=1221) are the following: Psychiatric Disorders: Depression (2.5%), anxiety (1.6%), decreased libido/loss of libido (1.5%).
Nervous System Disorders: Headache (5.6%), somnolence (2.5%), akathisia (1%).
Gastrointestinal Disorders: Diarrhoea (5.2%).
Skin and Subcutaneous Tissue Disorders: Rash (2.8%), pruritus (1.7%).
Reproductive System and Breast Disorders: Breast enlargement/gynaecomastia (5.3%), breast tenderness (4.4%), galactorrhoea (3.3%), amenorrhoea (2.9%), breast pain (2.3%), irregular menstruation (2%), lactation disorder (1.6%).
General Disorders and Administration Site Conditions: Asthenia (1.9%).
ADRs that occurred in <1% of Prokinin 10mg-treated patients in the 45 clinical trials (n=1221) are the following: Immune System Disorders: Hypersensitivity (0.2%).
Skin and Subcutaneous Disorders: Urticaria (0.7%).
Reproductive System and Breast Disorders: Breast discharge (0.8%), breast swelling (0.5%).
Dry mouth has been reported with over-the-counter use of Prokinin 10mg.
Post-Marketing: In addition to the adverse effects reported during clinical studies and previously mentioned, the following adverse drug reactions provided the frequencies according to the following convention: Very common (≥1/10), common (≥1/100 and <1/10); uncommon (≥1/1000 and <1/100); rare (≥1/10,000 and <1/1000); very rare (<1/10,000, including isolated reports).
The following ADRs are presented by frequency category based on spontaneous reporting rates: Immune System Disorders: Very Rare: Anaphylactic reactions (including anaphylactic shock).
Psychiatric Disorders: Very Rare: Agitation, nervousness.
Nervous System Disorders: Very Rare: Extrapyramidal disorder, convulsion.
Cardiac Disorders: Very Rare: Sudden cardiac death*, serious ventricular arrhythmias*.
Skin and Subcutaneous Tissue Disorders: Very Rare: Angioedema.
Renal and Urinary Disorders: Very Rare: Urinary retention.
Investigations: Very Rare: Abnormal liver function test; increased blood prolactin.
Note: *Based on epidemiology data (as follows).
As the hypophysis is outside the blood-brain barrier, Prokinin 10mg may cause an increase in prolactin levels. In rare cases, this hyperprolactinaemia may lead to neuro-endocrinological side effects eg, galactorrhoea, gynaecomastia and amenorrhoea.
Extrapyramidal disorder occurs primarily in neonates and infants.
Other central nervous system-related effects of convulsion and agitation are also reported primarily in infants and children.
An increase in the risk of serious ventricular arrhythmias and sudden cardiac death has been reported in some epidemiology studies. Due to the limitations of these data, risk factors and the exact frequency of these adverse reactions could not be defined.
Prokinin 10mg contraindications
Hypersensitivity to Prokinin 10mg or any ingredient of Prokinin 10mg.
If patients are taking oral ketoconazole, fluconazole, voriconazole, erythromycin, clarithromycin, telithromycin, amiodarone, selective serotonin reuptake inhibitors, HIV protease inhibitors, calcium antagonists which can increase plasma concentrations of Prokinin 10mg, leading to a prolonged QTc interval. These medicines can increase plasma concentrations of Prokinin 10mg leading to a prolonged QTc interval. Patients with long QT syndrome develop a very fast heart rhythm disturbance leading to a sudden loss of consciousness.
Gastrointestinal hemorrhage (bleeding), obstruction, perforation or conditions where gastrointestinal stimulation or movements may be dangerous.
Prolactin-releasing pituitary tumor (prolactinoma).
Active ingredient matches for Prokinin 10mg:
Domperidone in Oman.
List of Prokinin 10mg substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Prokinin 5mg/5ml (Oman) | |
| PROMODON | |
| PROMODON Liquid / 5mg per 5ml / 30ml units (Makers Labs) | $ 0.25 |
| PROMODON Dispersible Tablet / 10mg / 10 units (Makers Labs) | $ 0.23 |
| PROMODON 5MG SUSPENSION 1 bottle / 30 ML suspension each (Makers Laboratories Ltd) | $ 0.25 |
| Promodon 5mg Suspension (Makers Laboratories Ltd) | $ 0.25 |
| Prospep (Indonesia) | |
| Protix (Bangladesh) | |
| Pyme Pelium (Vietnam) | |
| Pyme Pelium 10 mg x 10 Blister x 10 Tablet | |
| Pymepelium (Vietnam) | |
| Q Vert D | |
| Q Vert D 20+15 Tablet (Pegasus Pharmaco India Pvt.Ltd) | $ 0.05 |
| Qualidom (Hong Kong) | |
| Qualidom 10 mg x 1, 000's (Quality) | $ 180.00 |
| Qualidom 10 mg/5 mL x 3, 600 mL (Quality) | $ 250.00 |
| Quorab D | |
| Quorab D 20+10 Tablet (Quixotic Pharma (P) Ltd.) | $ 0.06 |
| Qupraz DM | |
| Qupraz DM 40+10 Tablet (Quest Pharmaceuticals) | $ 0.07 |
| R Cid Plus | |
| R Cid Plus 20+30 Capsule (Abbott Healthcare Pvt Ltd (AHPL)) | $ 0.06 |
| R Inzod | |
| R Inzod 20+10 Tablet (Insyte Health Care) | $ 0.07 |
| RABEVERA | |
| RABEVERA TABLET 1 strip / 10 tablets each (Mcastro Pharma) | $ 0.43 |
| Rabugen (Hong Kong, Malaysia, Myanmar) | |
| Rabugen 10 mg x 50 x 10's (Unison) | |
| Rabugen 10 mg x 1, 000's (Unison) | |
| Rabugen Suspension (Malaysia) | |
| Rabugen Suspension 5 mg/5 mL x 30 mL | |
| Rabugen 胃健益 (Hongkong) | |
| Rabugen-M (Hong Kong, Thailand) | |
| Rabugen-M 10 mg x 50 x 10's (Unison) | |
| Rabugen-M 5 mg/5 mL x 30 mL (Unison) | |
| Rabugen-M tab 10 mg 50 x 10's (Unison) | |
| RAN-Domperidone (Canada) | |
| Tablet; Oral; Domperidone Maleate 10 mg | |
| Ran-domperidone tablet 10 mg (Ranbaxy Pharmaceuticals Canada Inc. (Canada)) | |
| RANYDOM | |
| RANYDOM DROPS 1 packet / 30 ML drop each (Leeford Healthcare Ltd) | $ 0.18 |
| Ranydom NA Drop (Leeford Healthcare Ltd) | $ 0.18 |
| ratio-Domperidone (Canada) | |
| Tablet; Oral; Domperidone Maleate 10 mg | |
| Ratio-domperidone tablet 10 mg (Teva Canada Limited (Canada)) | |
| Regit (Indonesia) | |
| Regit 10 mg x 5 x 10's (Landson) | $ 14.32 |
| Regit 5 mg/5 mL x 60 mL x 1's (Landson) | $ 3.25 |
| Regit 5 mg/1 mL x 10 mL x 1's (Landson) | $ 3.39 |
| Remotil (Portugal) | |
| Restol (Bangladesh, Chile, Japan) | |
| Capsule; Oral; Domperidone 10 mg (Laboratorios chile) | |
| Suppositories; Rectal; Domperidone 30 mg (Laboratorios chile) | |
| Suspension; Oral; Domperidone 50 mg / 5 ml (Laboratorios chile) | |
| Ridon (Bangladesh, Greece) | |
| Ridon 1mg TAB / 10 (East West) | $ 0.15 |
| Ridon 2mg TAB / 10 (East West) | $ 0.23 |
| Ridon 4mg TAB / 10 (East West) | $ 0.36 |
| 1 mg x 10's (East West) | $ 0.15 |
| 2 mg x 10's (East West) | $ 0.23 |
See 2682 substitutes for Prokinin 10mg | |
References
- PubChem. "domperidone". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "domperidone". http://www.drugbank.ca/drugs/DB01184 (accessed September 17, 2018).
- DTP/NCI. "domperidone: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Prokinin 10mg are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Prokinin 10mg. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yet4 consumers reported time for results
To what extent do I have to use Prokinin 10mg before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Prokinin 10mg. To get the time effectiveness of using Prokinin 10mg drug by other patients, please click here.
| Users | % | ||
|---|---|---|---|
| 1 day | 2 | 50.0% | |
| 1 month | 1 | 25.0% | |
| > 3 month | 1 | 25.0% | |
9 consumers reported age
| Users | % | ||
|---|---|---|---|
| 30-45 | 5 | 55.6% | |
| 46-60 | 3 | 33.3% | |
| 6-15 | 1 | 11.1% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
