Reviparin Sodium indications
Subcutaneous
Prophylaxis of venous thromboembolism during moderate-risk surgical procedures
Adult: 1750 anti-Xa IU, given 2 hr prior to surgery. Continue once daily dosing until patient is fully mobile.
Prophylaxis of venous thromboembolism during high-risk surgical procedures Adult: 4200 anti-Xa IU, given 12 hr before surgery. Continue once daily dosing until patient is fully mobile and for at least 14 days. Thromboembolic disorders Adult: Initiate treatment upon confirmation of diagnosis. 35-45 kg: 3500 anti-Xa IU; 46-60 kg: 4200 anti-Xa IU and >60 kg: 6300 anti-Xa IU. Doses to be given bid with an oral anticoagulant. Usual treatment duration with reviparin: 5-7 days. Reviparin Sodium, a highly sulfated glycosaminoglycan is widely used as an injectable anticoagulant. It has the highest negative charge density of any known biological molecule. Reviparin Sodium acts as an anticoagulant, preventing the formation of clots and extension of existing clots within the blood. While heparin does not break down clots that have already formed, it allows the body's natural clot lysis mechanisms to work normally to break down clots that have already formed. Reviparin Sodium binds to and accelerates the activity of antithrombin III. By activating antithrombin III, heparin preferentially potentiates the inhibition of coagulation factors Xa and IIa. Factor Xa catalyzes the conversion of prothrombin to thrombin, so heparin s inhibition of this process results in decreased thrombin and ultimately the prevention of fibrin clot formation. Subcutaneous Prophylaxis of venous thromboembolism during moderate-risk surgical procedures Adult: 1750 anti-Xa IU, given 2 hr prior to surgery. Continue once daily dosing until patient is fully mobile. Prophylaxis of venous thromboembolism during high-risk surgical procedures Adult: 4200 anti-Xa IU, given 12 hr before surgery. Continue once daily dosing until patient is fully mobile and for at least 14 days. Thromboembolic disorders Adult: Initiate treatment upon confirmation of diagnosis. 35-45 kg: 3500 anti-Xa IU; 46-60 kg: 4200 anti-Xa IU and >60 kg: 6300 anti-Xa IU. Doses to be given bid with an oral anticoagulant. Usual treatment duration with reviparin: 5-7 days. Drug Interactions: Oral anticoagulants: Reviparin Sodium sodium may prolong the one-stage prothrombin time. Therefore, when heparin sodium is given with dicumarol or warfarin sodium, a period of at least 5 hours after the last intravenous dose or 24 hours after the last subcutaneous dose should elapse before blood is drawn if a valid prothrombin time is to be obtained. Platelet inhibitors: Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. The anticoagulant effect of heparin is enhanced by concurrent treatment with antithrombin III (human) in patients with hereditary antithrombin III deficiency. Thus in order to avoid bleeding, reduced dosage of heparin is recommended during treatment with antithrombin III (human). b. Drugs Decreasing Reviparin Sodium Effect Digitalis, tetracyclines, nicotine, or antihistamines may partially counteract the anticoagulant action of heparin sodium. Reviparin Sodium Sodium Injection should not be mixed with doxorubicin, droperidol, ciprofloxacin, or mitoxantrone, since it has been reported that these drugs are incompatible with heparin and a precipitate may form. Drug/ Laboratory Tests Interactions Hyperaminotransferasemia: Significant elevations of aminotransferase (SGOT [S-AST] and SGPT [S-ALT]) levels have occurred in a high percentage of patients (and healthy subjects) who have received heparin sodium. Since aminotransferase determinations are important in the differential diagnosis of myocardial infarction, liver disease and pulmonary emboli, rises that might be caused by drugs (heparin sodium) should be interpreted with caution. Vomiting, constipation, epistaxis, conjunctivitis, asthma, rhinitis. Bleeding from skin, mucosa, GI tract, wounds and genital tract; thrombosis; thromboembolism; consumption coagulopathy; Inj site necrosis; melena; petechiae; purpura; allergic features like pruritus, urticaria; nausea, headache, fever, body pain, dyspnoea and hypotension; transient alopoecia, hyperkalaemia, hypoaldosteronism; metabolic acidosis; priapism. Potentially Fatal: Severe thrombocytopaenia with severe thromboembolic disorders and haemorrhage. Reviparin Sodium sodium should not be used in patients: Reviparin Sodium Information checked by Dr. Sachin Kumar, MD PharmacologyReviparin Sodium description
Reviparin Sodium dosage
Reviparin Sodium interactions
a. Drugs Enhancing Reviparin Sodium Effect
Reviparin Sodium side effects
Reviparin Sodium contraindications
Active ingredient matches for Reviparin Sodium:
List of Reviparin Sodium substitutes (brand and generic names)
Sort by popularity Unit description / dosage (Manufacturer) Price, USD Clivarin (Bosnia & Herzegowina, Bulgaria, Croatia (Hrvatska), Czech Republic, Germany, Greece, Hungary, Luxembourg, Poland, Portugal, Romania, Serbia, Slovakia, Slovenia) Injectable; Injection; Reviparin Sodium 1432 IU AXa (Abbott) Injectable; Injection; Reviparin Sodium 3436 IU AXa (Abbott) Injectable; Injection; Reviparin Sodium 5153 IU Axa (Abbott) Clivarin 5726 I.E./ml (Germany) Clivarina (Italy) Injectable; Injection; Reviparin Sodium 1432 IU AXa (Schwarz) Injectable; Injection; Reviparin Sodium 3436 IU AXa (Schwarz) Injectable; Injection; Reviparin Sodium 5153 IU Axa (Schwarz) Clivarine (India, Japan, Lithuania) Injectable; Injection; Reviparin Sodium 1432 IU AXa (Abbott India Ltd.) Injectable; Injection; Reviparin Sodium 3436 IU AXa (Abbott India Ltd.) Injectable; Injection; Reviparin Sodium 5153 IU Axa (Abbott India Ltd.) CLIVARINE Prefilled Syringe / 3436 I.U.. / 1 units (Abbott India Ltd.) $ 4.22
CLIVARINE Prefilled Syringe / 1432 I.U.. / 1 units (Abbott India Ltd.) $ 2.71 CLIVARINE Prefilled Syringe / 3436 I.U. / 1 units (Abbott India Ltd.) $ 4.22 Clivarine 1432anti-Xa iu PFS / 0.25ml (Abbott India Ltd.) $ 3.36 Clivarine 3436anti-Xa iu PFS / 0.6ml (Abbott India Ltd.) $ 5.12 1432 anti-Xa iu x 0.25ml (Abbott India Ltd.) $ 3.36 3436 anti-Xa iu x 0.6ml (Abbott India Ltd.) $ 5.12 Clivarine Prefilled Syringe 0.6 ml Injection (Abbott India Ltd.) $ 4.70 Clivarine Prefilled Syringe 0.25 ml Injection (Abbott India Ltd.) $ 3.36 CLIVARINE 3436IU INJECTION 1 vial / 1 ML injection each (Abbott India Ltd.) $ 6.13 CLIVARINE inj 1432 AXa iu x 0.25ml (Abbott India Ltd.) $ 3.36 CLIVARINE inj 3436 AXa iu x 0.6ml (Abbott India Ltd.) $ 5.12 Clivarine 3436IU Injection (Abbott India Ltd.) $ 6.13 Clivarine MDV Clivarine MDV 6 ml Injection (Abbott India Ltd.) $ 5.92 Clivarine-MDV (India) Clivarine-MDV 34356anti-Xa iu VIAL / 6ml (Abbott) $ 35.54 34356 anti-Xa iu x 6ml (Abbott) $ 35.54 CLIVARINE-MDV inj 34356 AXa iu x 6ml (Abbott) $ 35.54 Clivarodi (Germany) Lowmorin (Japan) References
Reviews
The results of a survey conducted on ndrugs.com for Reviparin Sodium are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Reviparin Sodium. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners. User reports
Consumer reported useful
No survey data has been collected yet
Consumer reported price estimates
No survey data has been collected yet
Consumer reported time for results
No survey data has been collected yet
Consumer reported age
No survey data has been collected yet
Consumer reviews
There are no reviews yet. Be the first to write one!
