Rheumaton Uses

• Rheumaton indications
• Uses of Rheumaton in details
• Rheumaton description
• Rheumaton dosage
• Rheumaton interactions
• Rheumaton side effects
• Rheumaton contraindications

What is Rheumaton?

Rheumaton (Rheumaton) is a nonsteroidal anti-inflammatory drug (NSAID). Rheumaton works by reducing hormones that cause inflammation and pain in the body.

Rheumaton is used to relieve the symptoms of rheumatoid arthritis or osteoarthritis.

Rheumaton may also be used for purposes not listed in this medication guide.

Rheumaton indications

Carefully consider the potential benefits and risks of Rheumaton (Rheumaton) and other treatment options before deciding to use Rheumaton (Rheumaton). Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.

Rheumaton (Rheumaton) is indicated for relief of signs and symptoms of osteoarthritis and rheumatoid arthritis.

How should I use Rheumaton?

Use Rheumaton as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Rheumaton comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Rheumaton refilled.
• Take Rheumaton by mouth. It may be taken with food if it upsets your stomach. This may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor if you have persistent stomach upset.
• Take Rheumaton with a full glass of water (8 oz/240 mL) as directed by your doctor.
• If you miss a dose of Rheumaton and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Rheumaton.

Uses of Rheumaton in details

Rheumaton is used to reduce pain, swelling, and joint stiffness from arthritis. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID).

If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to treat gout attacks.

How to use Rheumaton

Read the Medication Guide provided by your pharmacist before you start using Rheumaton and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually once or twice daily with a full glass of water (8 ounces or 240 milliliters). Do not lie down for at least 10 minutes after taking this drug. To prevent stomach upset, take it with food, milk, or an antacid.

Dosage is based on your medical condition and response to treatment. To minimize side effect risks (such as stomach bleeding), use this medication at the lowest effective dose for the shortest possible length of time. Do not increase your dose or take it more often than prescribed. For chronic conditions such as arthritis, continue taking it as directed by your doctor. Discuss the risks and benefits with your doctor or pharmacist.

In certain conditions (such as arthritis), it may take up to 2 weeks when this drug is taken regularly before you notice the full benefits.

If you are taking this drug on an "as needed" basis (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Tell your doctor if your condition worsens.

Rheumaton description

Rheumaton is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid family (which includes diclofenac). Marketed under the brand name Rheumaton, it has been shown to have a slightly lower risk of gastrointestinal side effects than most other non-selective NSAIDs.

Rheumaton dosage

Carefully consider the potential benefits and risks of Rheumaton (Rheumaton) and other treatment options before deciding to use Rheumaton (Rheumaton). Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.

After observing the response to initial therapy with Rheumaton (Rheumaton), the dose and frequency should be adjusted to suit an individual patient's needs.

Osteoarthritis and Rheumatoid Arthritis: The recommended starting dose is 1,000 mg taken as a single dose with or without food. Some patients may obtain more symptomatic relief from 1,500 mg to 2,000 mg per day. Rheumaton (Rheumaton) can be given in either a single or twice-daily dose. Dosages greater than 2,000 mg per day have not been studied. The lowest effective dose should be used for chronic treatment. Patients weighing under 50 kg may be less likely to require dosages beyond 1,000 mg; therefore, after observing the response to initial therapy, the dose should be adjusted to meet individual patients' requirements.

How supplied

Tablets: Oval-shaped, film-coated: 500 mg-white, imprinted with the product name Rheumaton (Rheumaton) and 500, in bottles of 100, and in Single-Unit Packages of 100 (intended for institutional use only). 750 mg-beige, imprinted with the product name Rheumaton (Rheumaton) and 750, in bottles of 100, and in Single-Unit Packages of 100 (intended for institutional use only).

Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) in well-closed container; dispense in light-resistant container.

500 mg 100's: NDC 0029-4851-20

500 mg SUP 100's: NDC 0029-4851-21

750 mg 100's: NDC 0029-4852-20

GlaxoSmithKline

Research Triangle Park, NC 27709

©2005, GlaxoSmithKline. All rights reserved.

FDA rev date: 1/24/2006

Rheumaton interactions

See also:
What other drugs will affect Rheumaton?

ACE-inhibitors: Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors.

Aspirin: When Rheumaton (Rheumaton) is administered with aspirin, its protein binding is reduced, although the clearance of free Rheumaton (Rheumaton) is not altered. The clinical significance of this interaction is not known; however, as with other NSAIDs, concomitant administration of Rheumaton and aspirin is not generally recommended because of the potential of increased adverse effects.

Diuretics: Clinical studies, as well as post marketing observations, have shown that Rheumaton (Rheumaton) can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with NSAIDs, the patient should be observed closely for signs of renal failure, as well as to assure diuretic efficacy.

Lithium: NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance. The mean minimum lithium concentration increased 15% and the renal clearance was decreased by approximately 20%. These effects have been attributed to inhibition of renal prostaglandin synthesis by the NSAID. Thus, when NSAIDs and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.

Methotrexate: NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices. This may indicate that they could enhance the toxicity of methotrexate. Caution should be used when NSAIDs are administered concomitantly with methotrexate.

Warfarin: The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.

In vitro studies have shown that, because of its affinity for protein, 6MNA may displace other protein-bound drugs from their binding site. Caution should be exercised when administering Rheumaton (Rheumaton) with warfarin since interactions have been seen with other NSAIDs.

Concomitant administration of an aluminum-containing antacid had no significant effect on the bioavailability of 6MNA. When administered with food or milk, there is more rapid absorption; however, the total amount of 6MNA in the plasma is unchanged.

Rheumaton side effects

See also:
What are the possible side effects of Rheumaton?

Applies to Rheumaton: oral tablet

Warning

Oral route (Tablet)

NSAIDs cause an increased risk of serious or fatal cardiovascular thrombotic events, myocardial infarction, and stroke. Rheumaton is contraindicated in the setting of CABG surgery. NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events.

Along with its needed effects, Rheumaton (the active ingredient contained in Rheumaton) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking Rheumaton:

More Common

• Headache
• itching skin
• nausea
• rash
• stomach pain
• swelling

Less Common

• Burning feeling in chest or stomach
• indigestion
• stomach upset
• swelling or inflammation of the mouth
• tenderness in stomach area
• vomiting

Rare

• Bleeding gums
• blistering, peeling, loosening of skin
• bloody or black, tarry stools
• bloody or cloudy urine
• burning upper abdominal pain
• changes in vision
• chest pain
• chills
• clay-colored stools
• constipation
• cough
• dark-colored urine
• diarrhea
• difficult or labored breathing
• difficulty swallowing
• dizziness
• dry cough
• dry mouth
• fast heartbeat
• fever
• fluid-filled skin blisters
• general feeling of tiredness or weakness
• greatly decreased frequency of urination or amount of urine
• high blood pressure
• hives or welts
• increased sensitivity of skin to sunlight
• increased thirst
• joint pain, stiffness, or swelling
• large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs
• light-colored stools
• loss of appetite
• muscle pain
• pain in lower back or side
• pinpoint red spots on skin
• puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
• rapid breathing
• red irritated eyes
• red skin lesions, often with a purple center
• redness or other discoloration of skin
• severe or continuing stomach pain
• severe sunburn
• shortness of breath
• skin thinness
• sore throat
• sores, ulcers, or white spots in mouth or on lips
• stomach bloating, burning, or cramping
• swelling of face, fingers, feet or lower legs
• tightness in chest
• unpleasant breath odor
• unusual bleeding or bruising
• unusual tiredness or weakness
• vaginal bleeding
• vomiting of blood or material that looks like coffee grounds
• weight gain or loss
• wheezing
• yellow eyes or skin

Symptoms of Overdose

• Agitation
• blurred vision
• coma
• confusion
• depression
• hostility
• irregular, fast or slow, or shallow breathing
• irritability
• muscle twitching
• nervousness
• pain or discomfort in chest, upper stomach, or throat
• pale or blue lips, fingernails, or skin
• pounding in the ears
• seizures
• severe stomach pain
• slow heartbeat
• stupor
• unusual drowsiness, dullness, or feeling of sluggishness

Some side effects of Rheumaton may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

• Acid or sour stomach
• belching
• bloated full feeling
• continuing ringing or buzzing or other unexplained noise in ears
• excess air or gas in stomach or intestines
• hearing loss
• indigestion
• mild diarrhea
• passing gas

Less Common

• Increased sweating
• sleepiness or unusual drowsiness
• sleeplessness
• trouble sleeping
• unable to sleep

Rare

• Anxiety
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• feeling of constant movement of self or surroundings
• general feeling of discomfort or illness
• increased appetite
• lack or loss of strength
• lightheadedness
• sensation of spinning
• shakiness in legs, arms, hands, feet
• trembling or shaking of hands or feet

Rheumaton contraindications

See also:
What is the most important information I should know about Rheumaton?

This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use Rheumaton. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

This medicine can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking Rheumaton. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to Rheumaton (such as ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen.

Do not drink alcohol while taking Rheumaton. Alcohol can increase the risk of stomach bleeding caused by Rheumaton.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Rheumaton can make your skin more sensitive to sunlight and sunburn may result.

Active ingredient matches for Rheumaton:

Nabumetone in Egypt.

Test for rheumatoid factor in serum or synovial fluid in United States.

List of Rheumaton substitutes (brand and generic names)	Sort by popularity
Unit description / dosage (Manufacturer)	Price, USD
Relafen Handok (South Korea)
Relif (Spain)
RELIF Capsule/ Tablet / 5mg - 500mg - 60mg / 10 units (Sun)	$ 0.27
Relif Cetirizine 5 mg, Pseudoephedrine 60 mg, Paracetamol 500 mg. TAB / 10 (Sun)	$ 0.27
10's (Sun)	$ 0.27
RELIF DROP 1 packet / 5 ML drop each (Sun)	$ 0.73
RELIF tab 10's (Sun)	$ 0.27
Relif Drop (Sun)	$ 0.73
Relifen (Japan, South Africa)
Relifex (Bahrain, Costa Rica, Czech Republic, Denmark, Dominican Republic, El Salvador, Estonia, Finland, Germany, Guatemala, Guyana, Honduras, Hungary, Iceland, Iran, Ireland, Israel, Italy, Kuwait, Latvia, Lithuania, Luxembourg, Mexico, Nicaragua, Norway, Oman, Panama, Philippines, Poland, Qatar, Sweden, Taiwan, Thailand, Turkey, United Arab Emirates, United Kingdom)
Suspension; Oral; Nabumetone 500 mg / 5 ml (Meda (Czeck Republic, Denmark, Finland, Germany, Greece, Hungary, Ireland, Italy, Norway, Sweden, United Kingdom), GSK (Israel, Mexico, Poland, Thailand, Turkey), SmithKline Beecham (Philippines))
Tablet; Oral; Nabumetone 500 mg (Meda (Czeck Republic, Denmark, Finland, Germany, Greece, Hungary, Ireland, Italy, Norway, Sweden, United Kingdom), GSK (Israel, Mexico, Poland, Thailand, Turkey), SmithKline Beecham (Philippines))
Relifex 500 mg x 20's (Meda (Czeck Republic, Denmark, Finland, Germany, Greece, Hungary, Ireland, Italy, Norway, Sweden, United Kingdom), GSK (Israel, Mexico, Poland, Thailand, Turkey), SmithKline Beecham (Philippines))
Relifex 500 mg x 100's (Meda (Czeck Republic, Denmark, Finland, Germany, Greece, Hungary, Ireland, Italy, Norway, Sweden, United Kingdom), GSK (Israel, Mexico, Poland, Thailand, Turkey), SmithKline Beecham (Philippines))	$ 40.00
Relifex 500 mg (Germany, Hungary)
Relifex Dispersible
Tablet; Oral; Nabumetone 500 mg
Relifex Suspension (United Kingdom)
Relifex Tablets (United Kingdom)
Religer (Ireland)
Relisan (South Africa)
Relitone (South Africa)
Rheumetone (Thailand)
Rheumetone 500 mg x 10 x 10's (Charoon Bhesaj)
Rheumetone tab 500 mg 10 x 10's (Charoon Bhesaj)
Rhoxal-Nabumetone
Tablet; Oral; Nabumetone 500 mg
Rodanol (Poland, Slovenia)
Rodanol S (Hungary, Czech Republic, Poland)
Sandoz Nabumetone
Tablet; Oral; Nabumetone 500 mg
Sandoz Nabumetone tablet 500 mg (Sandoz Canada Incorporated (Canada))
Segratone (Vietnam)
Segratone 500 mg x 5 Blister x 10 Tablet
Si Rui Ke (China)
Synmeton (Myanmar)
Tanleeg (Taiwan)
Tanleeg 500 mg x 100's, 1000's
Test for Rheumatoid Factor in Serum or Synovial Fluid
Teva-Nabumetone (Canada)
Teva-nabumetone tablet 500 mg (Teva Canada Limited (Canada))
Teva-nabumetone tablet 750 mg (Teva Canada Limited (Canada))
Tong Shu Tong (China)
Tonlex (Taiwan)
Tonlex 500 mg
Tonlex 750 mg
Tontec (Taiwan)
Tontec 500 mg x 100's
Tontec 500 mg x 1000's
Unimeton (South Korea)
Unimetone
Yifangtong (China)
See 220 substitutes for Rheumaton

References

1. DailyMed. "NABUMETONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubChem. "nabumetone". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
3. DrugBank. "nabumetone". http://www.drugbank.ca/drugs/DB00461 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Rheumaton are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Rheumaton. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology