What is Scanaflam?
Scanaflam is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and other symptoms of arthritis of the joints (eg, osteoarthritis), such as inflammation, swelling, stiffness, and joint pain. However, Scanaflam does not cure osteoarthritis and will help you only as long as you continue to use it.
Scanaflam topical 3% gel is also used to treat actinic keratosis, a skin problem that may become cancerous if not treated. The exact way that topical Scanaflam helps this condition is unknown.
Scanaflam topical solution is used to treat pain and swelling caused by osteoarthritis of the knees.
Scanaflam topical patch is used to treat acute pain caused by minor strains, sprains, and contusions (bruises).
Scanaflam is available only with your doctor's prescription.
Scanaflam indications
Intramuscular
Renal colic
Adult: As Scanaflam Na: 75 mg, may repeat once after 30 min if needed. Max: 150 mg/day. Max period: 2 days.
Intramuscular
Bursitis, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis, Sprains, Strains, Tendinitis, Acute gout, Dysmenorrhoea
Adult: As Scanaflam Na: 75 mg once daily, injected into the gluteal muscle, may increase to 75 mg bid in severe conditions. Max period: 2 days.
Intravenous
Postoperative pain
Adult: As Scanaflam Na: 75 mg infusion in glucose 5% or NaCl 0.9% (previously buffered w/ Na bicarbonate) given over 30-120 min or as bolus inj, may repeat after 4-6 hr if necessary. Max period: 2 days.
Intravenous
Prophylaxis of postoperative pain
Adult: As Scanaflam Na: Initially, 25-50 mg infusion given after surgery over 15-60 min followed by 5 mg/hr. Alternatively, initial dose may be given as bolus inj over 5-60 sec followed by additional inj, may repeat after 4-6 hr if necessary. Max: 150 mg/day. Max period: 2 days.
Ophthalmic
Postoperative ocular inflammation
Adult: As Scanaflam Na (0.1% soln): Instill into the appropriate eye 4 times daily starting 24 hr after surgery for up to 28 days.
Ophthalmic
Inflammation and discomfort after strabismus surgery
Adult: As Scanaflam Na (0.1% soln): Instill 1 drop 4 times daily for the 1st wk; then tid in the 2nd wk, bid in the 3rd wk, and as required for the 4th wk.
Ophthalmic
Pain and discomfort after radial keratotomy
Adult: As Scanaflam Na (0.1% soln): Instill 1 drop before surgery followed by 1 drop immediately after surgery, and then 1 drop 4 times daily for up to 2 days.
Ophthalmic
Pain after accidental trauma
Adult: As Scanaflam Na (0.1% soln): Instill 1 drop 4 times daily for up to 2 days.
Ophthalmic
Control of inflammation after argon laser trabeculoplasty
Adult: As Scanaflam Na (0.1% soln): Instill 1 drop 4 times during the 2 hr before procedure followed by 1 drop 4 times daily, up to 7 days after procedure.
Ophthalmic
Prophylaxis of intra-operative miosis
Adult: As Scanaflam Na (0.1% soln): Instill into appropriate eye 4 times w/in 2 hr before surgery.
Ophthalmic
Post-photorefractive keratectomy pain
Adult: As Scanaflam Na (0.1% soln): Instill into the affected eye twice, an hr before surgery, then 1 drop twice at 5-min intervals immediately after surgery, then every 2-5 hr while awake for up to 24 hr.
Ophthalmic
Seasonal allergic conjunctivitis
Adult: As Scanaflam Na (0.1% soln): Instill 1 drop before surgery followed by 1 drop immediately after surgery, and then 1 drop 4 times daily for up to 2 days.
Oral
Bursitis, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis, Sprains, Strains, Tendinitis, Acute gout, Dysmenorrhoea
Adult: As Scanaflam Na: 75-150 mg/day in divided doses. Max: 150 mg/day.
Oral
Migraine
Adult: As Scanaflam K: Initially, 50 mg taken at the 1st sign of an attack, an additional dose of 50 mg may be taken after 2 hr if symptoms persist. If needed, further doses of 50 mg may be taken 4-6 hrly. Max: 200 mg/day.
Rectal
Acute gout, Bursitis, Dysmenorrhoea, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis, Sprains, Strains, Tendinitis
Adult: As Scanaflam Na: 100 mg once daily.
Topical/Cutaneous
Actinic keratoses
Adult: As Scanaflam Na (3% gel): Apply bid for 60-90 days.
Topical/Cutaneous
Osteoarthritis
Adult: As Scanaflam Na (1.6% soln): Apply in small amounts (20 or 40 drops) onto affected area 4 times daily. As Na: (1% gel): Apply to the affected area 4 times daily. Max: 32 g/day over the affected area.
Topical/Cutaneous
Local symptomatic relief of pain and inflammation
Adult: As Scanaflam Na (1% gel): Apply onto affected area 3 or 4 times daily.
Transdermal
Acute pain
Adult: Sprains, strains, contusions: 1 patch bid.
How should I use Scanaflam?
Use Scanaflam solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Scanaflam solution comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Scanaflam solution refilled.
- Do not apply Scanaflam solution to infected skin; open wounds; or red, swollen, or peeling skin.
- Wash your hands immediately before and after using Scanaflam solution.
- Wash the affected area and dry completely before using Scanaflam solution.
- To apply Scanaflam solution, dispense 10 drops at a time onto the knee or into your hand. Spread Scanaflam solution evenly around the front, back, and sides of the knee. Repeat until you have used the whole dose.
- Be sure that you cover your entire knee with your dose of Scanaflam solution. Do not use more than the recommended amount.
- Do not apply sunscreens, cosmetics, insect repellants, other topical medicines, or any other substance to the treated area until it is completely dry.
- Do not put on clothes over the treated area until it is completely dry.
- Do not wrap, bandage, or apply heat to the treated area.
- Let the treated skin dry before touching it or letting it touch anyone else's skin.
- Do not shower, bathe, or wash the treated area for at least 30 minutes after you use Scanaflam solution.
- If you miss a dose of Scanaflam solution, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Scanaflam solution.
Uses of Scanaflam in details
Scanaflam is used to relieve pain from various conditions. This form of Scanaflam is used to treat migraine headaches. Scanaflam is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever.
OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.
This medication may also be used to treat gout attacks.
How to use Scanaflam
Read the Medication Guide provided by your pharmacist before you start taking Scanaflam and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth as directed by your doctor. Empty the contents of one packet into a cup containing 1 to 2 ounces (30 to 60 milliliters) of water. Mix well and drink all of it right away. Do not mix with any liquid other than water. If stomach upset occurs while taking this medication, take it with food, milk, or an antacid. However, if you take this medication with a meal high in fat, it may not work as well.
There are different brands and forms of this medication available. Because different forms do not have the same effects at equal strengths, do not switch forms of Scanaflam unless your doctor tells you to.
To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose. Do not increase your dose or take it more often than prescribed.
Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.
Tell your doctor if your condition persists or worsens.
Scanaflam description
The active substance is sodium-[o[(2,6-dichlorophenyl)-amino]-phenyl]-acetate (= Scanaflam sodium).
Each enteric tablet contains 25 mg or 50 mg of Scanaflam sodium.
One prolonged-release tablet contains 100 mg of Scanaflam sodium.
Excipients/Inactive Ingredients: Gastro-Resistant Tablet: Core for 25 mg and 50 mg: Cellulose microcrystalline; lactose monohydrate; magnesium stearate; maize starch; povidone; silica, colloidal anhydrous; sodium starch glycolate (type A).
Coating for 25 mg and 50 mg: Hypromellose; iron oxide yellow (E172); macrogoglycerol hydroxystearate; methacrylic acid-ethyl acrylate copolymer; macrogol 8000; talc; titanium dioxide (E171); simeticone; alpha-octadecyl-omega-hydroxy-polyglykolether; sorbic acid.
Coating for 50 mg: Iron oxide red (E172).
SR Tablet: Tablet Core: Cetyl alcohol; magnesium stearate; povidone; silica; colloidal anhydrous; sucrose.
Tablet Coating: Hypromellose; iron oxide red (E172); macrogol 8000; polysorbate 80; sucrose; talc; titanium dioxide (E171). Printing Ink: Carbon black, shellac, ammonium hydroxide, simethicone.
Injection: Each ampoule also contains the following excipients: Mannitol, sodium metabisulfite (E223), benzyl alcohol, propylene glycol, water for injection, sodium hydroxide.
Scanaflam dosage
General Dosing Instructions
Carefully consider the potential benefits and risks of Scanaflam and other treatment options before deciding to use Scanaflam. Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.
The effectiveness of Scanaflam when taken with food has not been studied in clinical studies. Taking Scanaflam with food may cause a reduction in effectiveness compared to taking Scanaflam on an empty stomach.
Acute Pain
For management of mild to moderate acute pain, the dosage is 18 mg or 35 mg orally three times daily.
Osteoarthritis Pain
For management of osteoarthritis pain, the dosage is 35 mg orally three times daily.
Dosage Adjustments in Patients with Hepatic Impairment
Patients with hepatic disease may require reduced doses of Scanaflam compared to patients with normal hepatic function. As with other Scanaflam products, start treatment at the lowest dose. If efficacy is not achieved with the lowest dose, discontinue use.
Non-Interchangeability with Other Formulations of Scanaflam
Scanaflam capsules are not interchangeable with other formulations of oral Scanaflam even if the milligram strength is the same. Scanaflam capsules contain Scanaflam free acid whereas other Scanaflam products contain a salt of Scanaflam, i.e., Scanaflam or sodium. A 35 mg dose of Scanaflam is approximately equal to 37.6 mg of sodium Scanaflam or 39.5 mg of potassium Scanaflam. Therefore, do not substitute similar dosing strengths of other Scanaflam products without taking this into consideration.
Scanaflam interactions
See also:
What other drugs will affect Scanaflam?
Aspirin: Concomitant administration of Scanaflam and aspirin is not recommended because Scanaflam is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations, peak plasma levels and AUC values.
Anticoagulants: While studies have not shown Scanaflam to interact with anticoagulants of the warfarin type, caution should be exercised, nonetheless, since interactions have been seen with other NSAIDs. Because prostaglandins play an important role in hemostasis and NSAIDs affect platelet function as well, concurrent therapy with all NSAIDs, including Scanaflam and warfarin, requires close monitoring of patients to be certain that no change in their anticoagulant dosage is required.
Digoxin, Methotrexate, Cyclosporine: Scanaflam, like other NSAIDs, may affect renal prostaglandins and increase the toxicity of certain drugs. Ingestion of Scanaflam may increase serum concentrations of digoxin and methotrexate and increase cyclosporine's nephrotoxicity. Patients who begin taking Scanaflam or who increase their Scanaflam dose or any other NSAID while taking digoxin, methotrexate or cyclosporine may develop toxicity characteristics for these drugs. They should be observed closely, particularly if renal function is impaired. In the case of digoxin, serum levels should be monitored.
Lithium: Scanaflam decreases lithium renal clearance and increases lithium plasma levels. In patients taking Scanaflam and lithium concomitantly, lithium toxicity may develop.
Oral Hypoglycemics:
Scanaflam does not alter glucose metabolism in normal subjects nor does it alter the effects of oral hypoglycemic agents. There are rare reports, however, from marketing experiences, of changes in effects of insulin or oral hypoglycemic agents in the presence of Scanaflam that necessitated changes in the doses of such agents. Both hypo- and hyperglycemic effects have been reported. A direct causal relationship has not been established, but physicians should consider the possibility that Scanaflam may alter a diabetic patient's response to insulin or oral hypoglycemic agents.Diuretics: Scanaflam and other NSAIDs can inhibit the activity of diuretics. Concomitant treatment with potassium-sparing diuretics may be associated with increased serum potassium levels.
Other Drugs: In small groups of patients (7-10/interaction study), the concomitant administration of azathioprine, gold, chloroquine, D-penicillamine, prednisolone, doxycycline or digitoxin did not significantly affect the peak levels and AUC values of Scanaflam. Phenobarbital toxicity has been reported to have occurred in a patient on chronic phenobarbital treatment following the initiation of Scanaflam therapy.
Scanaflam side effects
See also:
What are the possible side effects of Scanaflam?
There have been cases reported of Scanaflam being associated with the development of symptoms resembling the syndrome of inappropriate antidiuretic hormone secretion in elderly women. A patient who had been taking Scanaflam for several years and had increasingly complained of dry, gritty eyes noticed that eye irritation disappeared within 3 days when Scanaflam had to be discontinued because of GI effects.
The most frequent adverse effects reported in patients given Scanaflam are GI in nature. Typical reactions include epigastric pain, nausea, vomiting and diarrhoea. Rarely, peptic ulcer and GI bleeding have occurred. Scanaflam has also been implicated as the causative agent in colonic ulceration, small bowel perforation and pseudomembranous colitis.
Renal papillary necrosis and nephritic syndrome have been reported in patients taking Scanaflam. Elevations of serum aminotransferase activity and clinical hepatitis, including fetal fulminant hepatitis have occurred in patients taking Scanaflam. Self-limiting skin reaction eg, rash or pruritus may occur in patients given Scanaflam.
Aspirin-sensitive asthmatic patients have developed reactions (rhinorrhoea, tightness of chest, wheezing, dyspnoea) when challenged with Scanaflam in doses of 10-25 mg and the CMS in the UK have received a report of 1 aspirin-sensitive patient who died from acute asthma 4 hrs after a single 25-mg dose of Scanaflam.
Scanaflam contraindications
See also:
What is the most important information I should know about Scanaflam?
Hypersensitivity to Scanaflam sodium or to any of the excipients of Scanaflam.
Active gastric or intestinal ulcer, bleeding or perforation.
Last trimester of pregnancy.
Hepatic, renal and severe cardiac failure.
Patients in whom attacks of asthma, urticaria or acute rhinitis are precipitated by acetylsalicylic acid and/or other drugs with prostaglandin-synthetase inhibitory activity.
Treatment of peri-operative pain in setting of coronary artery bypass graft (CABG) surgery.
The use of high dose Scanaflam (150 mg/day) for >4 weeks is contraindicated in patients with established cardiovascular disease (congestive heart failure, established ischemic heart disease, peripheral arterial disease) or uncontrolled hypertension.
Established Cardiovascular Disease or Significant Cardiovascular Risk Factors: The use of high dose Scanaflam (150mg/day) for >4 weeks is contraindicated in patients with established cardiovascular disease (congestive heart failure, established ischemic heart disease, peripheral arterial disease) or uncontrolled hypertension. If Scanaflam treatment is needed, patients with established cardiovascular disease, uncontrolled hypertension or significant cardiovascular risk factors (eg, hypertension, hyperlipidaemia, diabetes mellitus and smoking) should be treated only after careful consideration and at doses ≤100 mg daily if the treatment is for >4 weeks. As the cardiovascular risks of Scanaflam may increase with dose and duration of exposure, Scanaflam should always be prescribed at the lowest effective daily dose and for the shortest duration possible.
Renal Impairment: Scanaflam is contraindicated in patients with renal failure. No specific studies have been carried out in patients with renal impairment, therefore, no specific dose adjustment recommendations can be made. Caution is advised when administering Scanaflam to patients with mild to moderate renal impairment.
Hepatic Impairment: Scanaflam is contraindicated in patients with hepatic failure. No specific studies have been carried out in patients with hepatic impairment, therefore, no specific dose adjustment recommendations can be made. Caution is advised when administering Scanaflam to patients with mild to moderate hepatic impairment.
Active ingredient matches for Scanaflam:
Diclofenac in Indonesia.
Diclofenac K in Indonesia.
Diclofenac potassium in Indonesia.
List of Scanaflam substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Scalpep D | |
| Scalpep D 10+50 Tablet (Scala Pharmaceuticals) | $ 0.06 |
| Scanaflam-25/Scanaflam-50 (Indonesia) | |
| Scanaflam-25/Scanaflam-50 25 mg x 5 x 10's | $ 5.58 |
| Scanaflam-25/Scanaflam-50 50 mg x 5 x 10's | $ 8.53 |
| Scantaren (Indonesia) | |
| Scantaren 50 mg x 10 x 8's (Tempo scan pacific) | $ 7.94 |
| Scantaren 1 % x 20 g x 1's (Tempo scan pacific) | $ 1.86 |
| SD-15 (India) | |
| SD-15 Diclofenac 75 mg, Serratiopeptidase 15 mg. CAP / 10 (Serum Institute) | $ 0.77 |
| 10's (Serum Institute) | $ 0.77 |
| SD-15 cap 10's (Serum Institute) | $ 0.97 |
| SDP | |
| SDP 50+10 Tablet (Accurate Pharmaceuticals) | $ 0.05 |
| Seap D | |
| Seap D 10+50 Tablet (Artel Laboratories) | $ 0.06 |
| SEAP D TABLET 1 strip / 10 tablets each (Artel Laboratories) | $ 0.62 |
| Seap D Tablet (Artel Laboratories) | $ 0.06 |
| Seazen | |
| Seazen 10+50 Tablet (Seamac India Pharmaceuticals (P) Ltd.) | $ 0.07 |
| Sefnac (Thailand) | |
| Sefnac 50 mg x 50 x 10's (Unison) | |
| Sefnac EC tab 50 mg 50 x 10's (Unison) | |
| Selectofen (Mexico) | |
| Gel; Topical; Diclofenac Sodium 1% (Diba) | |
| Injectable; Injection; Diclofenac Sodium 25 mg / ml (Diba) | |
| Tablet, Enteric Coated; Oral; Diclofenac Sodium 50 mg (Diba) | |
| Tablets, Enteric Coated; Oral; Diclofenac Sodium 50 mg (Diba) | |
| Selectofen L.P. | |
| Tablet, Extended Release; Oral; Diclofenac Sodium 100 mg | |
| Tablets, Extended Release; Oral; Diclofenac Sodium 100 mg | |
| Semdays | |
| Semdays 50+10 Tablet (Semsun Pharma Pvt. Ltd.) | $ 0.06 |
| Senak | |
| Senak 50+10 Tablet (Egis Healthcare) | $ 0.05 |
| Senic (India) | |
| Senic Diclofenac potassium 50 mg, Serratiopeptidase 10 mg. TAB / 100 (Mint) | |
| 100's (Mint) | |
| SENIC tab 10's (Mint) | |
| Senter D | |
| Senter D 10+50 Tablet (Pharmatech Healthcare) | $ 0.07 |
| Senter-D (India) | |
| Senter-D Serratiopeptidase 10 mg, Diclofenac potassium 50 mg TAB / 10 (Pharma-Tech) | $ 0.66 |
| 10's (Pharma-Tech) | $ 0.66 |
| SENTER-D tab 10's (Pharma-Tech) | $ 0.66 |
| Sepre D | |
| Sepre D 50+10 Tablet (Raikar Pharmaceuticals Pvt. Ltd.) | $ 0.05 |
| Septidase-D (India) | |
| Septidase-D Diclofenac potassium 50 mg, Serratiopeptidase 15 mg, zinc, cobalt, manganese. EC-TAB / 10 (MMC) | $ 0.65 |
| 10's (MMC) | $ 0.65 |
| SEPTIDASE-D enteric-coated tab 10's (MMC) | $ 0.65 |
| Ser D | |
| Ser D 50+10 Tablet (Shilar Pharmaceuticals) | $ 0.03 |
| SER D 10MG/50MG TABLET 1 strip / 10 tablets each (Shilar Pharmaceuticals) | $ 0.76 |
| Ser D 10 mg/50 mg Tablet (Shilar Pharmaceuticals) | $ 0.08 |
| Sera D | |
| Sera D 50+10 Tablet (Ruth Biotech (P)) | $ 0.07 |
| SERA D 50MG/10MG TABLET 1 strip / 10 tablets each (Ruth Biotech (P)) | $ 0.80 |
| Sera D 50 mg/10 mg Tablet (Ruth Biotech (P)) | $ 0.08 |
| Sera K | |
| Sera K 50+10 Tablet (Adips Laboratories Ltd.) | $ 0.07 |
| Seradic Gel (India) | |
| Seradic Gel Diclofenac diethylamine 1.16 %w/w, linolenic acid 3 % w/w, methyl salicylate 10 % w/w, menthol 5 % w/w, benzylalcohol 1 % w/w. GEL / 30g (Obsurge Biotech Limited) | $ 0.60 |
See 8266 substitutes for Scanaflam | |
References
- DailyMed. "DICLOFENAC EPOLAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "diclofenac". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "diclofenac". http://www.drugbank.ca/drugs/DB00586 (accessed September 17, 2018).
Reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
