Consists of diclofenac potassium, serratiopeptidase
What is Diclofenac potassium (Serose-D)?
Treating migraine headache.
Diclofenac potassium (Serose-D) potassium powder packets is an NSAID. Exactly how it works is not known. It may work by blocking certain substances in the body that are linked to inflammation. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.
Diclofenac potassium (Serose-D) indications
Carefully consider the potential benefits and risks of Diclofenac potassium (Serose-D) Potassium tablets and other treatment options before deciding to use Diclofenac potassium (Serose-D) Potassium tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
Diclofenac potassium (Serose-D) Potassium tablets are indicated:
- •
- For treatment of primary dysmenorrhea
- •
- For relief of mild to moderate pain
- •
- For relief of the signs and symptoms of osteoarthritis
- •
- For relief of the signs and symptoms of rheumatoid arthritis
How should I use Diclofenac potassium (Serose-D)?
Use Diclofenac potassium (Serose-D) potassium powder packets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Diclofenac potassium (Serose-D) potassium powder packets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Diclofenac potassium (Serose-D) potassium powder packets refilled.
- Do not open a packet of Diclofenac potassium (Serose-D) potassium powder packets until you are ready to take a dose.
- To use Diclofenac potassium (Serose-D) potassium powder packets, mix the contents of 1 packet with 2 to 4 tablespoons (30 to 60 mL) water. Do not use a liquid other than water. Mix well and drink right away. Do not store the mixed medicine for future use.
- Diclofenac potassium (Serose-D) potassium powder packets may be taken with food if it upsets your stomach. Taking it with food may make it less effective. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.
- Only 1 dose of Diclofenac potassium (Serose-D) potassium powder packets is required. If you miss your dose of Diclofenac potassium (Serose-D) potassium powder packets and you still have a migraine, take it as soon as you remember.
Ask your health care provider any questions you may have about how to use Diclofenac potassium (Serose-D) potassium powder packets.
Uses of Diclofenac potassium (Serose-D) in details
Use: Labeled Indications
Ankylosing spondylitis (delayed-release tablets only): Acute or long-term use in the relief of signs and symptoms of ankylosing spondylitis.
Dysmenorrhea (immediate-release tablets only): Treatment of primary dysmenorrhea.
Migraine (powder for oral solution only): Acute treatment of migraine attacks with or without aura in adults.
Osteoarthritis (immediate-release, extended-release, and delayed-release tablets; capsules [Zorvolex]; and suppositories [Canadian product] only): Relief of signs and symptoms of osteoarthritis.
Pain
Capsules/immediate-release tablets only: Relief of mild to moderate acute pain.
Injection only: Management of mild to moderate pain and moderate to severe pain (alone or in combination with opioid analgesics) in adults.
Rheumatoid arthritis (immediate-release, extended-release, and delayed-release tablets; and suppositories [Canadian product] only): Relief of signs and symptoms of rheumatoid arthritis.
Off Label Uses
Gout, treatment (acute flares)
Data from a limited number of trials support the efficacy of Diclofenac potassium (Serose-D) in the treatment of acute gout flares.
Based on the 2012 American College of Rheumatology guidelines for management of gout, nonsteroidal anti-inflammatory drugs are effective and recommended agents in the treatment of acute gout flares.
Diclofenac potassium (Serose-D) description
Diclofenac potassium (Serose-D) tablet also contains the following excipients: Core: Magnesium stearate, povidone, anhydrous colloidal silica, sodium starch glycollate, maize starch, calcium phosphate.
Sugar Coating: Microcrystalline cellulose, polyethylene glycol 8000, red iron oxide (E172) and titanium dioxide (E171) (dispersed Anstead), povidone, talc, sucrose.
Polish: Polyethylene glycol 8000, sucrose.
Imprint: Brown printing ink for 25 mg and white for 50 mg.
Diclofenac potassium (Serose-D) potassium is potassium-[0-[(2,6-dichlorophenyl)-amino]-phenyl]-acetate.
In Diclofenac potassium (Serose-D), the sodium ion of Diclofenac potassium (Serose-D) sodium (Voltaren) has been replaced by a potassium ion.
Diclofenac potassium (Serose-D) dosage
Carefully consider the potential benefits and risks of Diclofenac potassium (Serose-D) Potassium immediate-release tablets and other treatment options before deciding to use Diclofenac potassium (Serose-D) Potassium tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
After observing the response to initial therapy with Diclofenac potassium (Serose-D) Potassium tablets, the dose and frequency should be adjusted to suit an individual patient’s needs.
For treatment of pain or primary dysmenorrhea the recommended dosage is 50 mg three times a day. With experience, physicians may find that in some patients an initial dose of 100 mg of Diclofenac potassium (Serose-D) Potassium tablets, followed by 50 mg doses, will provide better relief.
For the relief of osteoarthritis the recommended dosage is 100 to 150 mg/day in divided doses, 50 mg twice a day, or three times a day.
For the relief of rheumatoid arthritis the recommended dosage is 150 to 200 mg/day in divided doses, 50 mg three times a day or four times a day.
Different formulations of Diclofenac potassium (Serose-D) [Voltaren® (Diclofenac potassium (Serose-D) sodium enteric-coated tablets); Voltaren®-XR (Diclofenac potassium (Serose-D) sodium extended-release tablets); Diclofenac potassium (Serose-D) Potassium tablets] are not necessarily bioequivalent even if the milligram strength is the same.
Diclofenac potassium (Serose-D) interactions
See also:
What other drugs will affect Diclofenac potassium (Serose-D)?
Not to be given IV to patients who are receiving other NSAIDs or anticoagulants including low dose heparin. Renal function may be worsened when used with ciclosporin or triamterene. Altered absorption when given with sucralfate, colestyramine or colestipol. Ophthalmic application of Diclofenac potassium (Serose-D) may reduce the efficacy of ophthalmic acetylcholine and carbachol. Increased risk of GI ulceration and bleeding when used with corticosteroids, aspirin or anticoagulants.
Potentially Fatal: Increases blood levels of digoxin, lithium and methotrexate. Potentiate potassium-sparing diuretics.
Food Interaction
Slow absorption of enteric-coated tab when given with food.
Diclofenac potassium (Serose-D) side effects
See also:
What are the possible side effects of Diclofenac potassium (Serose-D)?
The following serious adverse reactions are discussed elsewhere in the labeling:
- Cardiovascular thrombotic events
- Gastrointestinal effects
- Hepatic effects
- Hypertension
- Congestive Heart Failure and Edema
- Renal Effects
- Anaphylactoid Reactions
- Serious Skin Reactions
The most common adverse reactions reported with Diclofenac potassium (Serose-D) Potassium for
Oral Solution are nausea and dizziness.
The most common adverse events resulting in discontinuation of patients following Diclofenac potassium (Serose-D) Potassium for
Oral Solution dosing in controlled clinical trials were urticaria (0.2%) and flushing (0.2%).
Clinical Studies Experience With Diclofenac potassium (Serose-D) Potassium for
Oral Solution
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.
The safety of a single dose of Diclofenac potassium (Serose-D) Potassium for
Oral Solution was evaluated in 2 placebo-controlled trials with a total of 634 migraine patients treated with Diclofenac potassium (Serose-D) Potassium for
Oral Solution for a single migraine headache. Following treatment with Diclofenac potassium (Serose-D) potassium (either Diclofenac potassium (Serose-D) Potassium for
Oral Solution or Diclofenac potassium (Serose-D) potassium immediate-release tablets [as a control]), 5 subjects (0.8%) withdrew from the studies; following placebo exposure, 1 subject (0.2%) withdrew. No withdrawals were due to a serious reaction.
The most common adverse reactions (i.e., that occurred in 1% or more of Diclofenac potassium (Serose-D) Potassium for
Oral Solution -treated patients) and more frequent with Diclofenac potassium (Serose-D) Potassium for
Oral Solution than with placebo were nausea and dizziness.
| Table 1: Treatment-Related Adverse Reactions With Incidence >1% and Greater Than Placebo in Studies 1 and 2 Combined | ||
| Disorder Event | Diclofenac potassium (Serose-D) POTASSIUM FOR ORAL SOLUTION N=634 | Placebo N=646 |
| Gastrointestinal Nausea | 3% | 2% |
| Nervous System Dizziness | 1% | 0.5% |
Adverse Reactions Reported With Diclofenac potassium (Serose-D) and Other NSAIDs
In patients taking Diclofenac potassium (Serose-D) or other NSAIDs, the most frequently reported adverse reactions occurring in approximately 1% to 10% of patients are: GI reactions (including abdominal pain, constipation, diarrhea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea, GI ulcers [gastric/duodenal], and vomiting), abnormal renal function, anemia, dizziness, edema, elevated liver enzymes, headaches, increased bleeding time, pruritus, rashes, and tinnitus.
Additional adverse reactions reported in patients taking NSAIDs include occasionally:
Body as a Whole: Fever, infection, sepsis
Cardiovascular System: Congestive heart failure, hypertension, tachycardia, syncope
Digestive System: Dry mouth, esophagitis, gastric/peptic ulcers, gastritis, gastrointestinal bleeding, glossitis, hematemesis, hepatitis, jaundice
Hemic and Lymphatic System: Ecchymosis, eosinophilia, leukopenia, melena, purpura, rectal bleeding, stomatitis, thrombocytopenia
Metabolic and Nutritional: Weight changes
Nervous System: Anxiety, asthenia, confusion, depression, dream abnormalities, drowsiness, insomnia, malaise, nervousness, paresthesia, somnolence, tremors, vertigo
Respiratory System: Asthma, dyspnea
Skin and Appendages: Alopecia, photosensitivity, sweating increased
Special Senses: Blurred vision
Urogenital System: Cystitis, dysuria, hematuria, interstitial nephritis, oliguria/polyuria, proteinuria, renal failure
Other adverse reactions in patients taking NSAIDs, which occur rarely, are:
Body as a Whole: Anaphylactic reactions, appetite changes, death
Cardiovascular System: Arrhythmia, hypotension, myocardial infarction, palpitations, vasculitis
Digestive System: Colitis, eructation, liver failure, pancreatitis
Hemic and Lymphatic System: Agranulocytosis, hemolytic anemia, aplastic anemia, lymphadenopathy, pancytopenia
Metabolic and Nutritional: Hyperglycemia
Nervous System: Convulsions, coma, hallucinations, meningitis
Respiratory System: Respiratory depression, pneumonia
Skin and Appendages: Angioedema, toxic epidermal necrolysis, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, urticaria
Special Senses: Conjunctivitis, hearing impairment
Diclofenac potassium (Serose-D) contraindications
See also:
What is the most important information I should know about Diclofenac potassium (Serose-D)?
Diclofenac potassium (Serose-D) Potassium for
Oral Solution is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to Diclofenac potassium (Serose-D).
Diclofenac potassium (Serose-D) Potassium for
Oral Solution is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients.
Diclofenac potassium (Serose-D) Potassium for
Oral Solution is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
Serratiopeptidase (Serose-D) indications
Post-trauma or post-op inflammation. Relief of inflammation due to sinusitis, congestive breast, cystitis, epididymitis, alveolar abscess, parodontitis. Difficulty in expectoration of sputum in resp tract disease & after anesth.
Uses of Serratiopeptidase (Serose-D) in details
Serratiopeptidase (Serose-D) is used in treatment of conditions associated with pain and inflammation associated with muscles, bones and joints, pulsating headaches, often on one side of the head (migraine), inflammation of the air cavities around nose (sinusitis), inflammation of larynx (laryngitis), sore throat, ear infections, swelling after surgery, inflammation of a vein caused by a blood clot (thrombophlebitis), diseases that cause inflammation and sores (ulcer) in the lining of the gut (Ulcerative colitis and Crohn’s disease).
Serratiopeptidase (Serose-D) description
Serrapeptase is a proteolytic enzyme isolated from the micro-organism Serratia E15. This enzyme is naturally processed commercially today through fermentation and was discovered in the silkworm intestine. This immunologically active enzyme is completely bound to the alpha 2 macroglobulin in biological fluids. Serrapeptase digests non-living tissue, blood clots, cysts, and arterial plaque and inflammation in all forms.
Serratiopeptidase (Serose-D) dosage
1 tab tid or as reqd.
Serratiopeptidase (Serose-D) interactions
Anticoagulants.
Serratiopeptidase (Serose-D) side effects
Abnormal blood cell, Blisters on skin, Diarrhoea, Shortness of breath, Nausea, Skin redness, Vomiting, Running nose, Liver damage
Active ingredient matches for Serose-D:
Diclofenac potassium/serratiopeptidase in India.
Serrapeptase/Serratiopeptidase
| Unit description / dosage (Manufacturer) | Price, USD |
| 10's | $ 0.59 |
| Serose-D Serratiopeptidase 10 mg, diclofenac potassium 50 mg. TAB / 10 | $ 0.59 |
| SEROSE-D tab 10's (Haledew) | $ 0.59 |
List of Serose-D substitutes (brand and generic names): | |
| Seros-D (India) | |
| SEROS-D tab 10's (DWD) | |
| Serous-D (India) | |
| Serous-D Diclofenac potassium 50 mg, Serratiopeptidase 10 mg. TAB / 10 (Zenon) | $ 0.68 |
| 10's (Zenon) | $ 0.68 |
| SEROUS-D tab 10's (Zenon) | $ 0.68 |
| SERPIK-D (India) | |
| SERPIK-D cap 10's (Aarpik) | $ 0.62 |
| Serra-D (India) | |
| Serra-D Diclofenac potassium 50 mg, Serratiopeptidase 10 mg. TAB / 10 (Kamron) | $ 0.73 |
| 10's (Kamron) | $ 0.73 |
| SERRA-D tab 10's (Kamron) | $ 0.73 |
| SERRALEX-DP (India) | |
| 100's (Lexus) | |
| Serralex-DP Diclofenac potassium 50 mg, Serratiopeptidase 10 mg. TAB / 100 (Lexus) | |
| SERRALEX-DP tab 10's (Lexus) | |
| Serralex-DP Diclofenac potassium 50 mg, Serratiopeptidase 10 mg. TAB / 100 (Lexus) | |
| Serran-D (India) | |
| Serran-D Serratiopeptidase 10 mg, diclofenac potassium 50 mg. TAB / 10 (Acto) | $ 0.72 |
| SERRAN-D tab 10's (Acto) | $ 0.72 |
| SERRANAC-K (India) | |
| SERRANAC-K tab 10's (Mediwin) | $ 0.60 |
| Serrapeptase/Serratiopeptidase | |
| Serras-D (India) | |
| Serras-D Serratiopeptidase 10 mg, Diclofenac potassium 50 mg. TAB / 100 (Shreshtha) | $ 5.18 |
| 100's (Shreshtha) | $ 5.18 |
| SERRAS-D tab 10's (Shreshtha) | $ 0.52 |
| Serrinova (India) | |
| Serrinova Diclofenac potassium 50 mg, Serratiopeptidase 10 mg. TAB / 10 (Daffohils) | |
| 10's (Daffohils) | |
| SERRINOVA tab 10's (Daffohils) | |
| Serrint-D (India) | |
| Serrint-D Diclofenac potassium 50 mg, Serratiopeptidase 10 mg. TAB / 10 (Intag) | |
| 10's (Intag) | |
| SERRINT-D tab 10's (Intag) | |
| Serrodase-D (India) | |
| Serrodase-D Serratiopeptidase 10mg, Diclofenac sodium 50 mg. TAB / 10 (Sienna) | $ 0.58 |
| 10's (Sienna) | $ 0.58 |
| SERRODASE-D tab 10's (Sienna) | $ 0.58 |
| SERROF-D (India) | |
| SERROF-D tab 10's (Iscon) | $ 0.72 |
| Serto-D (India) | |
| 100's (Kamakshi) | $ 7.23 |
| Serto-D Diclofenac potassium 50 mg, serratiopeptidase 10 mg. TAB / 100 (Kamakshi) | $ 7.23 |
| SERTO-D tab 10's (Kamakshi) | $ 0.72 |
| Sestra (India) | |
| Sestra 10mg TAB / 10x10 (Mestra) | $ 3.86 |
| SESTRA tab 10 mg x 10's (Mestra) | $ 0.39 |
| SESTRA-60 (India) | |
| SESTRA-60 tab 10's (Mestra) | $ 0.54 |
| Sfinac (Greece) | |
| Shi Xiang (China) | |
| Shoren (Taiwan) | |
| Shoren 25 mg | |
| Shoren 50 mg | |
| Shoren 12.5 mg | |
| Si Fu Xin (China) | |
| Sider-K (India) | |
| Sider-K Diclofenac potassium 50 mg, Serratiopeptidase 15 mg. TAB / 100 (Biomax) | $ 7.11 |
See 7929 substitutes for Serose-D | |
References
- DailyMed. "DICLOFENAC EPOLAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "Serrapeptase". https://pubchem.ncbi.nlm.nih.gov/sub... (accessed September 17, 2018).
- PubChem. "diclofenac". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Serose-D are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Serose-D. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
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Information checked by Dr. Sachin Kumar, MD Pharmacology
