Solvium Uses

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What is Solvium?

Solvium is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, and helps to relieve symptoms of arthritis (osteoarthritis, rheumatoid arthritis, or juvenile arthritis), such as inflammation, swelling, stiffness, and joint pain. Solvium does not cure arthritis and will help you only as long as you continue to take it.

In addition, Solvium can be used to treat fever, menstrual cramps, and other conditions as determined by your doctor.

Solvium is available both over-the-counter (OTC) and with your doctor's prescription.

Solvium indications

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Carefully consider the potential benefits and risks of Solvium

Oral Suspension and other treatment options before deciding to use Solvium. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.

In Pediatric Patients, Solvium

Oral Suspension is indicated:

In Adults, Solvium

Oral Suspension is indicated:

Since there have been no controlled trials to demonstrate whether there is any beneficial effect or harmful interaction with the use of Solvium in conjunction with aspirin, the combination cannot be recommended.

How should I use Solvium?

Use Solvium capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about the proper use of Solvium capsules.

Uses of Solvium in details

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Use: Labeled Indications

Oral: Inflammatory diseases and rheumatoid disorders, mild to moderate pain, fever, dysmenorrhea, osteoarthritis

Solvium injection (Caldolor): Management of mild to moderate pain and management of moderate to severe pain as an adjunct to opioid analgesics in adults and children 6 months and older; reduction of fever in adults and children 6 months and older.

Solvium lysine injection (NeoProfen): Patent ductus arteriosus (PDA): To close a clinically significant PDA in premature infants weighing between 500-1500 g who are no more than 32 weeks of gestational age when usual medical management (eg, diuretics, fluid restriction, respiratory support) is ineffective.

OTC labeling: Reduction of fever; management of pain due to headache, migraine, sore throat, arthritis, physical or athletic overexertion (eg, sprains/strains), menstrual pain, dental pain, minor muscle/bone/joint pain, backache, pain due to the common cold and flu

Off Label Uses

Gout, acute flares

Clinical experience suggests the utility of Solvium as an alternative option for acute gout flares.

Based on the 2012 American College of Rheumatology guidelines for management of gout, NSAIDs are effective and recommended agents in the treatment of acute gout flares.

Pericarditis

Data from double-blind, placebo-controlled, multicenter trials indicate that colchicine in combination with aspirin or Solvium significantly reduces the incidence of symptoms at 72 hours and the risk of recurrence in acute and recurrent pericarditis. Based on Brazilian Society of Cardiology guidelines for the management of myocarditis and pericarditis and European Society of Cardiology (ESC) guidelines for the management of pericardial diseases, nonsteroidal anti-inflammatory drugs (NSAIDs) (typically, aspirin or Solvium) in combination with colchicine are recommended as first-line treatment to manage pain and resolve inflammation in idiopathic and viral acute and recurrent pericarditis.

Solvium description

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Solvium is a member of the propionic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). It is a racemic mixture of [+]S- and [-]R-enantiomers.

The chemical name for Solvium is (±)-2-(4-isobutylphenyl) propionic acid. It has a molecular weight of 206.28 and a molecular formula of C13H18O2.

Solvium is a colorless, crystalline stable solid, with a melting point of 75-77°C. It is relatively insoluble in water but readily soluble in most organic solvents. Solvium has a pKa of 4.43±0.03 and an n-octanol/water partition coefficient of 11.7 at pH 7.4.

Solvium has shown analgesic, anti-inflammatory and antipyretic activity in both animal and human studies. These properties provide symptomatic relief of inflammation and pain.

Solvium dosage

2.1 Recommended Dose

A course of therapy is three doses of Solvium Lysine administered intravenously (administration via an umbilical arterial line has not been evaluated). An initial dose of 10 mg per kilogram is followed by two doses of 5 mg per kilogram each, after 24 and 48 hours. All doses should be based on birth weight. If anuria or marked oliguria (urinary output <0.6 mL/kg/hr) is evident at the scheduled time of the second or third dose of Solvium Lysine, no additional dosage should be given until laboratory studies indicate that renal function has returned to normal. If the ductus arteriosus closes or is significantly reduced in size after completion of the first course of Solvium Lysine, no further doses are necessary. If during continued medical management the ductus arteriosus fails to close or reopens, then a second course of Solvium Lysine, alternative pharmacological therapy, or surgery may be necessary.

2.2 Directions for Use

For intravenous administration only.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. Do not use Solvium Lysine if particulate matter is observed.

After the first withdrawal from the vial, any solution remaining must be discarded because Solvium Lysine contains no preservative.

For administration, Solvium Lysine should be diluted to an appropriate volume with dextrose or saline. Solvium Lysine should be prepared for infusion and administered within 30 minutes of preparation and infused continuously over a period of 15 minutes. The drug should be administered via the IV port that is nearest the insertion site. After the first withdrawal from the vial, any solution remaining must be discarded because Solvium Lysine contains no preservative.

Since Solvium Lysine is potentially irritating to tissues, it should be administered carefully to avoid extravasation.

Solvium Lysine should not be simultaneously administered in the same intravenous line with Total

Parenteral Nutrition (TPN). If necessary, TPN should be interrupted for a 15-minute period prior to and after drug administration. Line patency should be maintained by using dextrose or saline.

Solvium interactions

See also:
What other drugs will affect Solvium?

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Coumarin-Type Anticoagulants: Several short-term controlled studies failed to wshow that Solvium significantly affected prothrombin times or a variety of other clotting factors when administered to individuals on coumarin-type anticoagulants. However, because bleeding has been reported when Solvium and other nonsteroidal anti-inflammatory agents have been administered to patients on coumarin-type anticoagulants, the physician should be cautious when administering Solvium to patients on anticoagulants.

Aspirin: Animal studies wshow that aspirin given with nonsteroidal anti-inflammatory agents, including Solvium, yields a net decrease in anti-inflammatory activity with lowered blood levels of the non-aspirin drug. Single dose bioavailability studies in normal volunteers have failed to wshow an effect of aspirin on Solvium blood levels. Correlative clinical studies have not been performed.

Methotrexate: Apo-Solvium, as well as other nonsteroidal anti-inflammatory drugs, probably reduces the tubular secretion of methotrexate based on in vitro studies in rabbit kidney slices. This may indicate that Solvium could enhance the toxicity of methotrexate. Caution should be used if Solvium is administered concomitantly with methotrexate.

H-2 Antagonists: In studies with human volunteers, co-administration of cimetidine or ranitidine with Solvium had no substantive effect on Solvium serum concentrations.

Furosemide: Clinical studies, as well as random observations, have shown that Solvium can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with Solvium, the patient should be observed closely for signs of renal failure, as well as to assure diuretic efficacy.

Lithium: Apo-Solvium produced an elevation of plasma lithium levels and a reduction in renal lithium clearance in a study of eleven normal volunteers. The mean minimum lithium concentration increased 15% and the renal clearance of lithium was decreased by 19% during this period of concomitant drug administration.

This effect has been attributed to inhibition of renal prostaglandin synthesis by Solvium. Thus, when Solvium and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity. (Read circulars for lithium preparation before use of such concurrent therapy).

Solvium side effects

See also:
What are the possible side effects of Solvium?

6.1 Clinical Trials Experience

The most frequently reported adverse events with Solvium Lysine were as shown in Table 1.

6.2 Renal Function

Compared to placebo, there was a small decrease in urinary output in the Solvium group on days 2-6 of life, with a compensatory increase in urine output on day 9. In other studies, adverse events classified as renal insufficiency including oliguria, elevated BUN, elevated creatinine, or renal failure were reported in Solvium treated infants.

6.3 Additional Adverse Events

The adverse events reported in the multicenter study and of unknown association include tachycardia, cardiac failure, abdominal distension, gastroesophageal reflux, gastritis, ileus, inguinal hernia, injection site reactions, cholestasis, various infections, feeding problems, convulsions, jaundice, hypotension, and various laboratory abnormalities including neutropenia, thrombocytopenia, and hyperglycemia.

6.4 Post-marketing Experience

The following adverse reactions have been identified from spontaneous post-marketing reports or published literature: gastrointestinal perforation, necrotizing enterocolitis, and pulmonary hypertension. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency, or establish a causal relationship to drug exposure.

Solvium contraindications

See also:
What is the most important information I should know about Solvium?

This medicine may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term. Do not use Solvium just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Get emergency medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

This medicine may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking Solvium, especially in older adults.

Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Do not take more of this medication than is recommended. An overdose of Solvium can cause damage to your stomach or intestines. Use only the smallest amount of Solvium needed to get relief from your pain, swelling, or fever.



Active ingredient matches for Solvium:

Ibuprofen in Portugal, Spain.


List of Solvium substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
SOSFever Fort 400 mg x 1 Blister x 10 Tablet
SOSFever Fort 400 mg x 3 Blister x 10 Tablet
SOSFever Fort 400 mg x 10 Blister x 10 Tablet
SOSFever 200 mg x 1 Blister x 10 Tablet
SOSFever 200 mg x 3 Blister x 10 Tablet
SOSFever 200 mg x 10 Blister x 10 Tablet
SOSFever 400 mg x 1 Blister x 10 Tablet
SOSFever 400 mg x 3 Blister x 10 Tablet
SOSFever 400 mg x 10 Blister x 10 Tablet
Sotstop 2 g/100 mL x 1 Bottle 100 mL
Capsule; Oral; Ibuprofen
Capsules; Oral; Ibuprofen
Capsule; Oral; Ibuprofen
Capsules; Oral; Ibuprofen
Capsule; Oral; Ibuprofen
Capsules; Oral; Ibuprofen
Tablet; Oral; Ibuprofen Arginine 200 mg (Zambon)
Spedifen 400 mg x 4 x 6's (Zambon)
Spedifen 400 mg x 12's (Zambon)
Spedifen 400 mg x 30's (Zambon)$ 16.74
Spedifen 600 mg x 20's (Zambon)$ 13.64
Powder; Oral; Ibuprofen Arginine 400 mg (Zambon)
Tablets, Film-Coated; Oral; Ibuprofen Arginine 400 mg (Zambon)
Tablets; Oral; Ibuprofen Arginine 200 mg (Zambon)
Spedifen 400 400 mg x 30's$ 15.71

References

  1. DailyMed. "IBUPROFEN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "ibuprofen". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "ibuprofen". http://www.drugbank.ca/drugs/DB01050 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Solvium are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Solvium. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

1 consumer reported useful

Was the Solvium drug useful in terms of decreasing the symptom or the disease?
According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users%
Useful1
100.0%


Consumer reported price estimates

No survey data has been collected yet


1 consumer reported time for results

To what extent do I have to use Solvium before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 3 month and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Solvium. To get the time effectiveness of using Solvium drug by other patients, please click here.
Users%
3 month1
100.0%


Consumer reported age

No survey data has been collected yet


Consumer reviews


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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