Consists of testosterone enantate, testosterone propionate
What is Testosterone enantate?
Testosterone enantate injection is used for the treatment of men whose bodies do not make enough natural Testosterone enantate, a condition called hypogonadism. Testosterone enantate is a male hormone responsible for the growth and development of the male sex organs and maintenance of secondary sex characteristics.
Testosterone enantate injection is also used in women with breast cancer that has spread to other parts of the body (metastatic).
Testosterone enantate injection is also used to stimulate delayed puberty in male teenagers.
Testosterone enantate is to be given only by or under the direct supervision of your doctor. The Aveed® brand is only available under a restricted distribution program called the Aveed® REMS program.
Testosterone enantate indications
in men
Replacement therapy in primary hypogonadism and hypogonadotropic hypogonadism,in women
Ablation of ovaries in metastatic breast cancer
How should I use Testosterone enantate?
Use Testosterone enantate as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Testosterone enantate comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Testosterone enantate refilled.
- Prime this product before the first use. To prime it, depress the pump 3 times and wash any product that is dispensed down the sink.
- Depress the pump once to fill the applicator cup. Holding the applicator upright, wipe Testosterone enantate steadily up and down onto clean, dry skin in the armpit. If Testosterone enantate drips or runs, it can be wiped back up with the applicator cup. Do NOT apply Testosterone enantate to other parts of your body (eg, scrotum, penis, stomach, shoulders, upper arms). Do NOT apply it over open sores, wounds, or irritated skin.
- Do NOT use your fingers or hand to rub the medicine into the skin.
- You may need to alternate between armpits when applying Testosterone enantate. Be sure you understand how to apply Testosterone enantate. Contact your doctor or pharmacist if you have questions or concerns about how to apply Testosterone enantate.
- Wash your hands with soap and water immediately after using Testosterone enantate.
- Allow Testosterone enantate to dry completely before dressing.
- After Testosterone enantate has dried, cover the application site (eg, with a shirt) to prevent others from coming into contact with Testosterone enantate. If direct skin-to-skin contact with another person is expected, wash the application site well with soap and water to remove the medicine.
- After using Testosterone enantate, rinse the applicator with room temperature water and pat it dry with a tissue. Replace the applicator and cap on the bottle for storage.
- Do NOT get Testosterone enantate in your eyes. If you do, rinse thoroughly with water. If eye irritation persists, contact your doctor.
- Apply Testosterone enantate at the same time every morning after showering or bathing, unless your doctor tells you otherwise.
- If you are also using an antiperspirant or deodorant (stick or roll-on), apply it at least 2 minutes before you apply Testosterone enantate.
- For best results, wait 2 hours after applying Testosterone enantate before you wash the application site or swim.
- If you miss a dose of Testosterone enantate, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Testosterone enantate.
Uses of Testosterone enantate in details
Testosterone enantate is a male hormone primarily used to treat deficiency or absence of naturally produced hormone Testosterone enantate in men (hypogonadal disorders). The conditions include,
- Testicular diseases (primary hypogonadism) - diseases or conditions of testes, the organ that produces Testosterone enantate affecting secretion of Testosterone enantate.
- Pituitary diseases (secondary hypogonadism) - diseases or conditions of pituitary gland or hypothalamus that produce hormones (gonadotropins) which stimulate release of Testosterone enantate.
Testosterone enantate description
Testosterone enantate is a steroid sex hormone found in both men and women. In men, Testosterone enantate is produced primarily by the Leydig (interstitial) cells of the testes when stimulated by luteinizing hormone (LH). It functions to stimulate spermatogenesis, promote physical and functional maturation of spermatozoa, maintain accessory organs of the male reproductive tract, support development of secondary sexual characteristics, stimulate growth and metabolism throughout the body and influence brain development by stimulating sexual behaviors and sexual drive. In women, Testosterone enantate is produced by the ovaries (25%), adrenals (25%) and via peripheral conversion from androstenedione (50%). Testerone in women functions to maintain libido and general wellbeing. Testosterone enantate exerts a negative feedback mechanism on pituitary release of LH and follicle-stimulating hormone (FSH). Testosterone enantate may be further converted to dihydrotestosterone or estradiol depending on the tissue.
Testosterone enantate dosage
Testosterone enantate (Testosterone enantate (transdermal)) TTS
One system is applied at about the same time each day. The adhesive side of the Testosterone enantate (Testosterone enantate (transdermal)) TTS system should be placed on a clean, dry area of skin on the arm, back or upper buttocks immediately upon removal from the protective pouch. DO NOT APPLY TO THE SCROTUM. The area selected should not be oily, damaged, or irritated. The system should be pressed firmly in place with the palm of the hand for about 10 seconds, making sure there is good contact, especially around the edges. In the event that a system should fall off, the same system may be reapplied. If the system comes off after it has been worn for more than 12 hours and it cannot be reapplied, a new system may be applied at the next routine application time. In either case, the daily treatment schedule should be continued. The Testosterone enantate (Testosterone enantate (transdermal)) TTS system should be worn approximately 24 hours and then replaced. To ensure proper dosing, serum Testosterone enantate concentration may be measured 2-4 hours after an application of Testosterone enantate (Testosterone enantate (transdermal)) TTS. If the serum Testosterone enantate concentrations are low, the dosing regimen may be increased to 2 systems. Because of variability in analytical values among diagnostic laboratories, all Testosterone enantate measurements should be performed at the same laboratory.
Testosterone enantate (Testosterone enantate (transdermal)) and Testosterone enantate (Testosterone enantate (transdermal)) WITH ADHESIVE
Patients should start therapy with a 6 mg/d system of either Testosterone enantate (Testosterone enantate (transdermal)) or Testosterone enantate (Testosterone enantate (transdermal)) WITH ADHESIVE applied daily; if the scrotal area cannot accommodate a 6 mg/d system, a 4 mg/d Testosterone enantate (Testosterone enantate (transdermal)) system should be used. One Testosterone enantate (Testosterone enantate (transdermal)) or Testosterone enantate (Testosterone enantate (transdermal)) WITH ADHESIVE system should be placed on clean, dry, scrotal skin. Scrotal hair should be dry-shaved for optimal skin contact. Chemical depilatories should not be used. Testosterone enantate (Testosterone enantate (transdermal)) or Testosterone enantate (Testosterone enantate (transdermal)) WITH ADHESIVE should be worn 22-24 hours.
After 3-4 weeks of daily system use, blood should be drawn 2-4 hours after system application for determination of serum total Testosterone enantate. Because of variability in analytical values among diagnostic laboratories, this laboratory work and later analyses for assessing the effect of the Testosterone enantate (Testosterone enantate (transdermal)) and Testosterone enantate (Testosterone enantate (transdermal)) WITH ADHESIVE therapy should be performed at the same laboratory.
If patients have not achieved desired results by the end of 6-8 weeks of treatment with any of the Testosterone enantate (Testosterone enantate (transdermal)) products, another form of Testosterone enantate replacement therapy should be considered.
How supplied
Testosterone enantate (Testosterone enantate (transdermal)) TTS, Testosterone enantate (Testosterone enantate (transdermal)), and Testosterone enantate (Testosterone enantate (transdermal)) WITH ADHESIVE Testosterone enantate transdermal systems contain a Schedule III controlled substance as defined by the Anabolic Steroids Control Act.
Testosterone enantate (Testosterone enantate (transdermal)) TTS
Testosterone enantate (Testosterone enantate (transdermal)) TTS systems are supplied as individually pouched systems, 30 per carton. Testosterone enantate (Testosterone enantate (transdermal)) TTS 5 mg/d (Testosterone enantate Transdermal System) -- each 60 cm2 system contains 328 mg Testosterone enantate USP for nominal dose of 5 mg/day
Carton of 30 Testosterone enantate (Testosterone enantate (transdermal)) TTS 5 mg/d systemsNDC 17314-4717-3
Testosterone enantate (Testosterone enantate (transdermal)) and Testosterone enantate (Testosterone enantate (transdermal)) WITH ADHESIVE
Testosterone enantate (Testosterone enantate (transdermal)) and Testosterone enantate (Testosterone enantate (transdermal)) WITH ADHESIVE systems are supplied as individually pouched systems, 30 per carton.
Testosterone enantate (Testosterone enantate (transdermal)) 4 mg/d (Testosterone enantate Transdermal System) -- each 40 cm2 system contains 10 mg Testosterone enantate USP for nominal delivery of 4 mg for one day.
Carton of 30 Testosterone enantate (Testosterone enantate (transdermal)) 4 mg/d systems. NDC 17314-4608-3
Testosterone enantate (Testosterone enantate (transdermal)) and Testosterone enantate (Testosterone enantate (transdermal)) WITH ADHESIVE
6 mg/d (Testosterone enantate Transdermal System) -- each 60 cm2 system contains 15 mg Testosterone enantate USP for nominal delivery of 6 mg for one day.
Carton of 30 Testosterone enantate (Testosterone enantate (transdermal)) 6 mg/d systems. NDC 17314-4609-3
Carton of 30 Testosterone enantate (Testosterone enantate (transdermal)) WITH ADHESIVE 6 mg/d systemsNDC 17314-2836-3
Storage
Testosterone enantate (Testosterone enantate (transdermal)) TTS
Store at controlled room temperature below 25oC (77oF).
Testosterone enantate (Testosterone enantate (transdermal)) and Testosterone enantate (Testosterone enantate (transdermal)) WITH ADHESIVE
Store at room temperature 15-30oC (59-86oF).
Disposal
Testosterone enantate (Testosterone enantate (transdermal)) products should be discarded in household trash in a manner that prevents accidental application or ingestion by children or pets.
Caution: Federal law prohibits dispensing without prescription.
REFERENCE
1. Matsumoto AM, Sandblom RE, Schoene RB et al. Testosterone enantate replacement in hypogonadal men: Effects on obstructive sleep apnoea, respiratory drives, and sleep. Clin Endocrinol (1985) 22: 713-721.
2. Schneider BK, Pickett CK, Zwillich CW et al. Influence of Testosterone enantate on breathing during sleep. J Appl Physiol (1986) 61: 618-623.
3. Matsumoto AM. Hormonal therapy of male hypogonadism. Endocrinol Metab Clin North Am. (1994) 23: 857-875.
4. Bardin CW, Swerdloff RS, Santen RJ. Androgens: Risks and benefits. J Clin Endocinol Metab (1991) 73: 4-7.
5. Nieschlag E, Wang CCL. Guidelines for the use of androgens in men. Geneva: World Health Organization (1992); 1-16.
6. Walle T, Walle UK, Mathur RS et al. Propranolol metabolism in normal subjects: Association with sex steroid hormones. Curr Pharmacol Ther (1994) 56:127-132.
7. Physicians Generic Rx: The Complete Drug Reference. (1996); II-1972
Testosterone enantate interactions
See also:
What other drugs will affect Testosterone enantate?
Enhance activities of ciclosporine, antidiabetics, thyroxine, anticoagulants. Long term use of Testosterone enantate may cause resistance to effects of neuromuscular blockers. Enhance fluid retention from corticosteroids.
Testosterone enantate side effects
See also:
What are the possible side effects of Testosterone enantate?
Fluid and electrolyte retention; increased vascularity of the skin; hypercalcaemia, impaired glucose tolerance; increased bone growth and skeletal weight; increase LDL cholesterol; increase haematocrit and fibrinolytic activity; headache, depression and GI bleeding. Males: spermatogenesis suppression, priapism, gynaecomastia, prostatic hyperplasia and accelerate growth of malignant prostate neoplasms. Females: suppression of lactation, ovarian activity and menstruation; virilization, clitoris hypertrophy, increased libido, oily skin, acne, hirsutism, male pattern baldness. Children: Closure of the epiphyses and stop linear growth in early puberty, symptoms of virilisation. Precocious sexual development, increased frequency of erection in boys, and clitoral enlargement in girls. IM: urticaria, inflammation at Inj site, postinjection induration, furunculosis. Transdermal: local irritation. Buccal: Gum irritation, bitter taste, gum pain, tenderness.
Potentially Fatal: Peliosis hepatis, liver toxicity, malignant neoplasm.
Testosterone enantate contraindications
See also:
What is the most important information I should know about Testosterone enantate?
Hypersensitivity to product; serious cardiac, hepatic, or renal disease; men with carcinoma of breast or prostate; women who are or may become pregnant; Testosterone enantate gel and buccal system are contraindicated in women.
What is Testosterone propionate?
Testosterone propionate injection is used for the treatment of men whose bodies do not make enough natural Testosterone propionate, a condition called hypogonadism. Testosterone propionate is a male hormone responsible for the growth and development of the male sex organs and maintenance of secondary sex characteristics.
Testosterone propionate injection is also used in women with breast cancer that has spread to other parts of the body (metastatic).
Testosterone propionate injection is also used to stimulate delayed puberty in male teenagers.
Testosterone propionate is to be given only by or under the direct supervision of your doctor. The Aveed® brand is only available under a restricted distribution program called the Aveed® REMS program.
Testosterone propionate indications
Testosterone propionate propionate is an anabolic steroid and a short ester form of Testosterone propionate that becomes active in the body. It is often used for muscle mass building.
How should I use Testosterone propionate?
Use Testosterone propionate as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Testosterone propionate comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Testosterone propionate refilled.
- Prime this product before the first use. To prime it, depress the pump 3 times and wash any product that is dispensed down the sink.
- Depress the pump once to fill the applicator cup. Holding the applicator upright, wipe Testosterone propionate steadily up and down onto clean, dry skin in the armpit. If Testosterone propionate drips or runs, it can be wiped back up with the applicator cup. Do NOT apply Testosterone propionate to other parts of your body (eg, scrotum, penis, stomach, shoulders, upper arms). Do NOT apply it over open sores, wounds, or irritated skin.
- Do NOT use your fingers or hand to rub the medicine into the skin.
- You may need to alternate between armpits when applying Testosterone propionate. Be sure you understand how to apply Testosterone propionate. Contact your doctor or pharmacist if you have questions or concerns about how to apply Testosterone propionate.
- Wash your hands with soap and water immediately after using Testosterone propionate.
- Allow Testosterone propionate to dry completely before dressing.
- After Testosterone propionate has dried, cover the application site (eg, with a shirt) to prevent others from coming into contact with Testosterone propionate. If direct skin-to-skin contact with another person is expected, wash the application site well with soap and water to remove the medicine.
- After using Testosterone propionate, rinse the applicator with room temperature water and pat it dry with a tissue. Replace the applicator and cap on the bottle for storage.
- Do NOT get Testosterone propionate in your eyes. If you do, rinse thoroughly with water. If eye irritation persists, contact your doctor.
- Apply Testosterone propionate at the same time every morning after showering or bathing, unless your doctor tells you otherwise.
- If you are also using an antiperspirant or deodorant (stick or roll-on), apply it at least 2 minutes before you apply Testosterone propionate.
- For best results, wait 2 hours after applying Testosterone propionate before you wash the application site or swim.
- If you miss a dose of Testosterone propionate, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Testosterone propionate.
Uses of Testosterone propionate in details
Testosterone propionate is a male hormone primarily used to treat deficiency or absence of naturally produced hormone Testosterone propionate in men (hypogonadal disorders). The conditions include,
- Testicular diseases (primary hypogonadism) - diseases or conditions of testes, the organ that produces Testosterone propionate affecting secretion of Testosterone propionate.
- Pituitary diseases (secondary hypogonadism) - diseases or conditions of pituitary gland or hypothalamus that produce hormones (gonadotropins) which stimulate release of Testosterone propionate.
Testosterone propionate description
An ester of Testosterone propionate with a propionate substitution at the 17-beta position. [PubChem]
Testosterone propionate dosage
Testosterone propionate (Testosterone propionate (transdermal)) TTS
One system is applied at about the same time each day. The adhesive side of the Testosterone propionate (Testosterone propionate (transdermal)) TTS system should be placed on a clean, dry area of skin on the arm, back or upper buttocks immediately upon removal from the protective pouch. DO NOT APPLY TO THE SCROTUM. The area selected should not be oily, damaged, or irritated. The system should be pressed firmly in place with the palm of the hand for about 10 seconds, making sure there is good contact, especially around the edges. In the event that a system should fall off, the same system may be reapplied. If the system comes off after it has been worn for more than 12 hours and it cannot be reapplied, a new system may be applied at the next routine application time. In either case, the daily treatment schedule should be continued. The Testosterone propionate (Testosterone propionate (transdermal)) TTS system should be worn approximately 24 hours and then replaced. To ensure proper dosing, serum Testosterone propionate concentration may be measured 2-4 hours after an application of Testosterone propionate (Testosterone propionate (transdermal)) TTS. If the serum Testosterone propionate concentrations are low, the dosing regimen may be increased to 2 systems. Because of variability in analytical values among diagnostic laboratories, all Testosterone propionate measurements should be performed at the same laboratory.
Testosterone propionate (Testosterone propionate (transdermal)) and Testosterone propionate (Testosterone propionate (transdermal)) WITH ADHESIVE
Patients should start therapy with a 6 mg/d system of either Testosterone propionate (Testosterone propionate (transdermal)) or Testosterone propionate (Testosterone propionate (transdermal)) WITH ADHESIVE applied daily; if the scrotal area cannot accommodate a 6 mg/d system, a 4 mg/d Testosterone propionate (Testosterone propionate (transdermal)) system should be used. One Testosterone propionate (Testosterone propionate (transdermal)) or Testosterone propionate (Testosterone propionate (transdermal)) WITH ADHESIVE system should be placed on clean, dry, scrotal skin. Scrotal hair should be dry-shaved for optimal skin contact. Chemical depilatories should not be used. Testosterone propionate (Testosterone propionate (transdermal)) or Testosterone propionate (Testosterone propionate (transdermal)) WITH ADHESIVE should be worn 22-24 hours.
After 3-4 weeks of daily system use, blood should be drawn 2-4 hours after system application for determination of serum total Testosterone propionate. Because of variability in analytical values among diagnostic laboratories, this laboratory work and later analyses for assessing the effect of the Testosterone propionate (Testosterone propionate (transdermal)) and Testosterone propionate (Testosterone propionate (transdermal)) WITH ADHESIVE therapy should be performed at the same laboratory.
If patients have not achieved desired results by the end of 6-8 weeks of treatment with any of the Testosterone propionate (Testosterone propionate (transdermal)) products, another form of Testosterone propionate replacement therapy should be considered.
How supplied
Testosterone propionate (Testosterone propionate (transdermal)) TTS, Testosterone propionate (Testosterone propionate (transdermal)), and Testosterone propionate (Testosterone propionate (transdermal)) WITH ADHESIVE Testosterone propionate transdermal systems contain a Schedule III controlled substance as defined by the Anabolic Steroids Control Act.
Testosterone propionate (Testosterone propionate (transdermal)) TTS
Testosterone propionate (Testosterone propionate (transdermal)) TTS systems are supplied as individually pouched systems, 30 per carton. Testosterone propionate (Testosterone propionate (transdermal)) TTS 5 mg/d (Testosterone propionate Transdermal System) -- each 60 cm2 system contains 328 mg Testosterone propionate USP for nominal dose of 5 mg/day
Carton of 30 Testosterone propionate (Testosterone propionate (transdermal)) TTS 5 mg/d systemsNDC 17314-4717-3
Testosterone propionate (Testosterone propionate (transdermal)) and Testosterone propionate (Testosterone propionate (transdermal)) WITH ADHESIVE
Testosterone propionate (Testosterone propionate (transdermal)) and Testosterone propionate (Testosterone propionate (transdermal)) WITH ADHESIVE systems are supplied as individually pouched systems, 30 per carton.
Testosterone propionate (Testosterone propionate (transdermal)) 4 mg/d (Testosterone propionate Transdermal System) -- each 40 cm2 system contains 10 mg Testosterone propionate USP for nominal delivery of 4 mg for one day.
Carton of 30 Testosterone propionate (Testosterone propionate (transdermal)) 4 mg/d systems. NDC 17314-4608-3
Testosterone propionate (Testosterone propionate (transdermal)) and Testosterone propionate (Testosterone propionate (transdermal)) WITH ADHESIVE
6 mg/d (Testosterone propionate Transdermal System) -- each 60 cm2 system contains 15 mg Testosterone propionate USP for nominal delivery of 6 mg for one day.
Carton of 30 Testosterone propionate (Testosterone propionate (transdermal)) 6 mg/d systems. NDC 17314-4609-3
Carton of 30 Testosterone propionate (Testosterone propionate (transdermal)) WITH ADHESIVE 6 mg/d systemsNDC 17314-2836-3
Storage
Testosterone propionate (Testosterone propionate (transdermal)) TTS
Store at controlled room temperature below 25oC (77oF).
Testosterone propionate (Testosterone propionate (transdermal)) and Testosterone propionate (Testosterone propionate (transdermal)) WITH ADHESIVE
Store at room temperature 15-30oC (59-86oF).
Disposal
Testosterone propionate (Testosterone propionate (transdermal)) products should be discarded in household trash in a manner that prevents accidental application or ingestion by children or pets.
Caution: Federal law prohibits dispensing without prescription.
REFERENCE
1. Matsumoto AM, Sandblom RE, Schoene RB et al. Testosterone propionate replacement in hypogonadal men: Effects on obstructive sleep apnoea, respiratory drives, and sleep. Clin Endocrinol (1985) 22: 713-721.
2. Schneider BK, Pickett CK, Zwillich CW et al. Influence of Testosterone propionate on breathing during sleep. J Appl Physiol (1986) 61: 618-623.
3. Matsumoto AM. Hormonal therapy of male hypogonadism. Endocrinol Metab Clin North Am. (1994) 23: 857-875.
4. Bardin CW, Swerdloff RS, Santen RJ. Androgens: Risks and benefits. J Clin Endocinol Metab (1991) 73: 4-7.
5. Nieschlag E, Wang CCL. Guidelines for the use of androgens in men. Geneva: World Health Organization (1992); 1-16.
6. Walle T, Walle UK, Mathur RS et al. Propranolol metabolism in normal subjects: Association with sex steroid hormones. Curr Pharmacol Ther (1994) 56:127-132.
7. Physicians Generic Rx: The Complete Drug Reference. (1996); II-1972
Testosterone propionate interactions
See also:
What other drugs will affect Testosterone propionate?
Drug Interactions
Anticoagulants: C-17 substituted derivatives of Testosterone propionate, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants. Patients receiving oral anticoagulant therapy require close monitoring, especially when androgens are started or stopped.
Oxyphenbutazone: Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.
Insulin: In diabetic patients, the metabolic effects of androgens may decrease blood glucose and therefore, insulin requirements.
Propranolol: In a published pharmacokinetic study of an injectable Testosterone propionate product, administration of Testosterone propionate cypionate led to an increased clearance of propranolol in the majority of men tested.6
Corticosteroids: The concurrent administration of Testosterone propionate with ACTH or corticosteroids may enhance edema formation; thus these drugs should be administered cautiously, particularly in patients with cardiac or hepatic disease.7
Drug/Laboratory Test Interactions
Androgens may decrease levels of thyroxin-binding globulin, resulting in decreased total T. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.
The Testosterone propionate (Testosterone propionate (transdermal)) products contain a Schedule III controlled substance as defined by the Anabolic Steroids Control Act.
Testosterone propionate (Testosterone propionate (transdermal)) TTS is designed for application to arm, back or upper buttocks skin.
Testosterone propionate (Testosterone propionate (transdermal)) and Testosterone propionate (Testosterone propionate (transdermal)) WITH ADHESIVE are designed for application to scrotal skin only. Because scrotal skin is at least five times more permeable to Testosterone propionate than other skin sites, Testosterone propionate (Testosterone propionate (transdermal)) or Testosterone propionate (Testosterone propionate (transdermal)) WITH ADHESIVE will not produce adequate serum Testosterone propionate concentrations if applied to non-scrotal skin.
Ingestion of Testosterone propionate, or the contents of any of the Testosterone propionate (Testosterone propionate (transdermal)) products will not result in clinically significant serum Testosterone propionate concentrations due to extensive first-pass metabolism. In addition, an intramuscular injection of Testosterone propionate from any of the Testosterone propionate (Testosterone propionate (transdermal)) products will not produce adequate serum Testosterone propionate levels due to its short half-life (about 10 minutes).
Testosterone propionate side effects
See also:
What are the possible side effects of Testosterone propionate?
Adverse events are reported in this section by product. Adverse events reported during use of a given product may occur in patients who are treated with any Testosterone propionate (Testosterone propionate (transdermal)) product.
Adverse Events with Testosterone propionate (Testosterone propionate (transdermal)) TTS
In clinical studies of 457 participants (116 hypogonadal males and 341 healthy adult males) treated for up to 6 weeks with Testosterone propionate (Testosterone propionate (transdermal)) TTS, the most commonly reported adverse events were application site reactions of transient itching (12%) and moderate or severe erythema (3%).
Adverse events reported by less than 1% of Testosterone propionate (Testosterone propionate (transdermal)) TTS users in clinical trials that were of probable or unknown relationship to drug were:
Topical Reactions
Of 457 study participants, 3 men (1%) discontinued prematurely because of application site reactions.
There were no clinically significant differences in skin tolerability in younger (<65 years old) and older (³ 65 years old) subjects.
A contact sensitization rate of 0.5% for Testosterone propionate (Testosterone propionate (transdermal)) TTS was observed in a 6-week study of 233 normal male volunteers.
In one study with 14 days of daily use, 42% of patients reported 3 or more detachments of their Testosterone propionate (Testosterone propionate (transdermal)) TTS; of these detachments, 33% occurred during exercise.
Adverse Events with Testosterone propionate (Testosterone propionate (transdermal))
In clinical studies of 104 patients treated with Testosterone propionate (Testosterone propionate (transdermal)), the most common adverse effects reported were local effects. In US clinical trials, most of the 72 patients filling out a daily questionnaire reported scrotal itching, discomfort, or irritation at some time during therapy. Of all the daily questionnaire responses, 7% reported itching, 4% discomfort, and 2% irritation. All topical reactions decreased with duration of use.
The following adverse effects (greater than 1%) were reported in association with Testosterone propionate (Testosterone propionate (transdermal)) therapy in 104 patients using the product for up to three years. These effects are listed in decreasing frequency of occurrence with the percentages of patients reporting the effect in parentheses: Gynecomastia (5%), acne (4%), prostatitis/urinary tract infection (4%), breast tenderness (3%), stroke (2%). For this same patient population, the following adverse effects were reported by 1% of users: memory loss, pupillary dilation, abnormal liver enzymes, scrotal cellulitis, deep vein phlebitis, benign prostatic hyperplasia, rectal mucosal lesion over prostate, hematuria/bladder cancer, papilloma on scrotum, and congestive heart failure.
Adverse Events with Testosterone propionate (Testosterone propionate (transdermal)) WITH ADHESIVE
In a pharmacokinetic study in 50 normal men, skin assessment scores following a single 24-hour application of Testosterone propionate (Testosterone propionate (transdermal)) WITH ADHESIVE to scrotal skin were similar to those for Testosterone propionate (Testosterone propionate (transdermal)). Other adverse events reported during the study were headache (6%), dizziness (6%), back pain, pain, nausea, and pustular rash (1% each).
General Adverse Events with Androgen Replacement Therapy
Skin and Appendages: Hirsutism, male pattern baldness, seborrhea, and acne.
Endocrine and Urogenital: Gynecomastia and excessive frequency and duration of penile erections. Oligospermia may occur at high doses.
Fluid and Electrolyte Disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.
Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests. Rare instances of hepatocellular neoplasms and peliosis hepatis have occurred.
Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.
Nervous System: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.
Metabolic: Increased serum cholesterol.
Miscellaneous: Rarely, anaphylactoid reactions.
DRUG ABUSE AND DEPENDENCE
The Testosterone propionate (Testosterone propionate (transdermal)) products contain a Schedule III controlled substance as defined by the Anabolic Steroids Control Act.
Testosterone propionate (Testosterone propionate (transdermal)) TTS is designed for application to arm, back or upper buttocks skin.
Testosterone propionate (Testosterone propionate (transdermal)) and Testosterone propionate (Testosterone propionate (transdermal)) WITH ADHESIVE are designed for application to scrotal skin only. Because scrotal skin is at least five times more permeable to Testosterone propionate than other skin sites, Testosterone propionate (Testosterone propionate (transdermal)) or Testosterone propionate (Testosterone propionate (transdermal)) WITH ADHESIVE will not produce adequate serum Testosterone propionate concentrations if applied to non-scrotal skin.
Ingestion of Testosterone propionate, or the contents of any of the Testosterone propionate (Testosterone propionate (transdermal)) products will not result in clinically significant serum Testosterone propionate concentrations due to extensive first-pass metabolism. In addition, an intramuscular injection of Testosterone propionate from any of the Testosterone propionate (Testosterone propionate (transdermal)) products will not produce adequate serum Testosterone propionate levels due to its short half-life (about 10 minutes).
Testosterone propionate contraindications
See also:
What is the most important information I should know about Testosterone propionate?
-
Testosterone propionate 1% is contraindicated in men with carcinoma of the breast or known or suspected carcinoma of the prostate.
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Testosterone propionate 1% is contraindicated in women who are or may become pregnant, or who are breastfeeding. Testosterone propionate 1% may cause fetal harm when administered to a pregnant woman. Testosterone propionate 1% may cause serious adverse reactions in nursing infants. Exposure of a female fetus or nursing infant to androgens may result in varying degrees of virilization. Pregnant women or those who may become pregnant need to be aware of the potential for transfer of Testosterone propionate from men treated with Testosterone propionate 1%. If a pregnant woman is exposed to Testosterone propionate 1%, she should be apprised of the potential hazard to the fetus.
Active ingredient matches for Testosterone enantate/testosterone propionate:
Testosterone enantate/testosterone propionate
References
- DailyMed. "TESTOSTERONE PROPIONATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "TESTOSTERONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "testosterone". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Testosterone enantate/testosterone propionate are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Testosterone enantate/testosterone propionate. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
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Information checked by Dr. Sachin Kumar, MD Pharmacology