Tetrafol PLUS Uses

• Tetrafol PLUS indications
• Uses of Tetrafol PLUS in details
• Tetrafol PLUS description
• Tetrafol PLUS dosage
• Tetrafol PLUS side effects

What is Tetrafol PLUS?

Tetrafol PLUS is a form of vitamin B12. Vitamin B12 is important for the brain and nerves, and for the production of red blood cells.

Tetrafol PLUS is used to treat vitamin B12 deficiency. Tetrafol PLUS is sometimes used in people with pernicious anemia, diabetes, and other conditions.

Tetrafol PLUS may also be used for purposes not listed in this medication guide.

Tetrafol PLUS indications

Tab: Treatment of peripheral neuropathies. Inj: Megaloblastic anemia due to vit B₁₂ deficiency, peripheral neuropathies.

Uses of Tetrafol PLUS in details

Tetrafol PLUS is an active form of vitamin B12, which is used to treat anemia as well as nerve damage with numbness, tingling, pain in various neurological disorders.

Tetrafol PLUS description

Each ampoule also contains D-mannitol 50 mg as an additive. pH 5.3-7.3. Osmotic Pressure (to physiological saline): Approximately 1.

Mecobalamin is α-(5,6-dimethylbenzimidazolyl)-Co-methyl-cobamide.

Molecular Formula: C₆₃H₉₁CoN₁₃O₁₄P.

Molecular Weight: 1344.4.

Mecobalamin occurs as a dark red, odorless and almost tasteless crystal or crystalline powder. It is sparingly soluble in water, methanol and ethanol and practically insoluble in acetone, ether and chloroform. Mecobalamin is hygroscopic and decomposes upon exposure to light.

Tetrafol PLUS dosage

Tablet: Adults: Usual Daily Dose: 3 tabs, equivalent to a total of 1500 mcg of mecobalamin, administered orally in 3 divided doses. The dose should be adjusted according to age of patient and severity of symptoms.

Injection: Peripheral Neuropathies: The usual adult dosage is 1 amp, equivalent to 500 mcg of mecobalamin administered IM or IV 3 times a week. The dosage should be adjusted according to age of patient and severity of symptoms.

Megaloblastic Anemia: The usual adult dosage is 1 amp, equivalent to 500 mcg of mecobalamin administered IM or IV 3 times a week. After approximately 2 months of medication, the dose should be reduced to a single administration of 1 amp at 1- to 3-month intervals for maintenance therapy.

What other drugs will affect Tetrafol PLUS?

Tell your doctor about all your other medicines, especially:

• chloramphenicol;

• oral diabetes medicine that contains metformin; or

• medicines that reduce stomach acid, such as cimetidine, omeprazole, lansoprazole, Nexium, Prevacid, Prilosec, Zantac, and others.

This list is not complete. Other drugs may affect Tetrafol PLUS, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

See also:

Drug Interactions (in more detail)

Tetrafol PLUS side effects

See also:
What are the possible side effects of Tetrafol PLUS?

Tablet: Gastrointestinal: Symptoms eg, anorexia, nausea or diarrhea may occur infrequently.

Dermatological: Skin rash may occur rarely.

Others: Prolonged use of larger doses of Tetrafol PLUS is not recommended for patients whose occupation requires handling of mercury or its compounds.

Injection: Hypersensitivity: Use of Tetrafol PLUS should be discontinued if symptoms of hypersensitivity eg, eruptions, occur.

Others: Pain and induration may infrequently occur at the site of IM injection and headache, sweating or hot sensation may rarely occur.

What is the most important information I should know about Tetrafol PLUS?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Active ingredient matches for Tetrafol PLUS:

Methylcobalamin

Levomefolate calcium/mecobalamin/pyridoxal 5-phosphate in India.

References

1. PubChem. "methylcobalamin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
2. DrugBank. "methylcobalamin". http://www.drugbank.ca/drugs/DB03614 (accessed September 17, 2018).
3. MeSH. "MeSH Tree: MeSH (Medical Subject Headings) is the NLM controlled vocabulary thesaurus used for indexing articles for PubMed.". http://www.nlm.nih.gov/mesh/meshhome... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology