Tetrafol PLUS Uses

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What is Tetrafol PLUS?

Tetrafol PLUS is a form of vitamin B12. Vitamin B12 is important for the brain and nerves, and for the production of red blood cells.

Tetrafol PLUS is used to treat vitamin B12 deficiency. Tetrafol PLUS is sometimes used in people with pernicious anemia, diabetes, and other conditions.

Tetrafol PLUS may also be used for purposes not listed in this medication guide.

Tetrafol PLUS indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Tab: Treatment of peripheral neuropathies. Inj: Megaloblastic anemia due to vit B12 deficiency, peripheral neuropathies.

Uses of Tetrafol PLUS in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Tetrafol PLUS is an active form of vitamin B12, which is used to treat anemia as well as nerve damage with numbness, tingling, pain in various neurological disorders.

Tetrafol PLUS description

Each ampoule also contains D-mannitol 50 mg as an additive. pH 5.3-7.3. Osmotic Pressure (to physiological saline): Approximately 1.

Mecobalamin is α-(5,6-dimethylbenzimidazolyl)-Co-methyl-cobamide.

Molecular Formula: C63H91CoN13O14P.

Molecular Weight: 1344.4.

Mecobalamin occurs as a dark red, odorless and almost tasteless crystal or crystalline powder. It is sparingly soluble in water, methanol and ethanol and practically insoluble in acetone, ether and chloroform. Mecobalamin is hygroscopic and decomposes upon exposure to light.

Tetrafol PLUS dosage

Tablet: Adults: Usual Daily Dose: 3 tabs, equivalent to a total of 1500 mcg of mecobalamin, administered orally in 3 divided doses. The dose should be adjusted according to age of patient and severity of symptoms.

Injection: Peripheral Neuropathies: The usual adult dosage is 1 amp, equivalent to 500 mcg of mecobalamin administered IM or IV 3 times a week. The dosage should be adjusted according to age of patient and severity of symptoms.

Megaloblastic Anemia: The usual adult dosage is 1 amp, equivalent to 500 mcg of mecobalamin administered IM or IV 3 times a week. After approximately 2 months of medication, the dose should be reduced to a single administration of 1 amp at 1- to 3-month intervals for maintenance therapy.

What other drugs will affect Tetrafol PLUS?

Tell your doctor about all your other medicines, especially:

  • chloramphenicol;

  • oral diabetes medicine that contains metformin; or

  • medicines that reduce stomach acid, such as cimetidine, omeprazole, lansoprazole, Nexium, Prevacid, Prilosec, Zantac, and others.

This list is not complete. Other drugs may affect Tetrafol PLUS, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Drug Interactions (in more detail)

Tetrafol PLUS side effects

See also:
What are the possible side effects of Tetrafol PLUS?


Tablet: Gastrointestinal: Symptoms eg, anorexia, nausea or diarrhea may occur infrequently.

Dermatological: Skin rash may occur rarely.

Others: Prolonged use of larger doses of Tetrafol PLUS is not recommended for patients whose occupation requires handling of mercury or its compounds.

Injection: Hypersensitivity: Use of Tetrafol PLUS should be discontinued if symptoms of hypersensitivity eg, eruptions, occur.

Others: Pain and induration may infrequently occur at the site of IM injection and headache, sweating or hot sensation may rarely occur.

What is the most important information I should know about Tetrafol PLUS?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Active ingredient matches for Tetrafol PLUS:


Levomefolate calcium/mecobalamin/pyridoxal 5-phosphate in India.

Unit description / dosage (Manufacturer)Price, USD
TETRAFOL PLUS film-coated tab 10's (Sun)$ 1.90

List of Tetrafol PLUS substitutes (brand and generic names):

Templer M 300mg/500mcg Capsule (D.R.John & Lab)$ 0.19
Theracobal 1500 mcg Tablet (Parex Phamaceuticals Pvt. Ltd.)$ 0.13
Theracobal 500 mcg Tablet (Parex Phamaceuticals Pvt. Ltd.)$ 0.08
Theracobal Inj 500 mcg Injection (Parex Phamaceuticals Pvt. Ltd.)$ 0.40
Tonerve 1000 mcg Injection (Ethix Health Care)$ 0.14
Tonerve TD 1500 mcg Capsule (Ethix Health Care)$ 0.06
Trico GB 300 mg+500 mcg Capsule (Forgo Pharmaceuticals (P) Ltd.)$ 0.17
Tricobal OD Capsule (Surien Pharmaceuticals (Geno Pharmacreuticals Ltd))$ 0.16
Uhemzy 500 mcg Injection (Jpee Drugs)$ 0.30
ULINERV-OD tab 1500 mcg x 10's (Unique Life Sciences)
Uninerv OD 1500 mcg+100 mg Capsule (Unilite Medicare Pvt Ltd)$ 0.17
Uniron OD 1500 mcg Welcure Drugs Tablet (Welcure Drugs & Pharma Ltd)$ 0.06
Uniron OD 1500 mcg Tablet (Welcure Drugs & Pharma Ltd)$ 0.10
V Nerve 75 mg+750 mcg Capsule (Vatican Life Sciences Pvt Ltd)$ 0.17
Vancobal 500 mcg Tablet (Evans Pharma (P) Ltd.)$ 0.06
Veical Forte 1500 mcg Tablet (Vertex India Healthcare)$ 0.11
Viminta Forte Capsule (Molekule (India) Pvt. Ltd.)$ 0.22
VITACOMF-OD tab 1500 mcg x 10's (Signova)$ 0.95
Vitcobin P 150 mg+500 mcg Capsule (Vista (FDC Limited))$ 0.23
Vitcobin P 75 mg+500 mcg Capsule (Vista (FDC Limited))$ 0.12
VITCOBIN P 500 MCG/75 MG TABLET SR 1 strip / 10 tablet srs each (Vista (FDC Limited))$ 1.57
Void OD 1500 mcg Tablet (D.R. Johns Labs)$ 0.20
Void OD 500 mcg Tablet (D.R. Johns Labs)$ 0.08
Wegalin Forte 150 mg+750 mcg Capsule (Ronyd Healthcare (P) Ltd)$ 0.25
WEGALIN FORTE 750MCG/150MG CAPSULE 1 strip / 10 capsules each (Ronyd Healthcare (P) Ltd)$ 2.84
Wincoba PG 75 mg+750 mcg Capsule (Paradigm Healthcare)$ 0.19
Zacobal OD 1500 mcg Tablet (Trumac Healthcare)$ 0.17
Zenerv M 75 mg+750 mcg Capsule (Eris (Enzo Biopharma))$ 0.14
ZENERV M 750 MCG/75 MG CAPSULE 1 strip / 10 capsules each (Eris (Enzo Biopharma))$ 1.69
Zenerv M 750 mcg/75 mg Capsule (Eris (Enzo Biopharma))$ 0.18
ZINTRA M INJECTION 1 vial / 2 ML injection each (Ravenbhel Pharmaceuticals Pvt Ltd)$ 0.52
500 mcg x 1ml (Zota Healthcare Pvt. Ltd.)$ 0.25
Zonuron 500 mcg AMP / 1ml (Zota Healthcare Pvt. Ltd.)$ 0.25
Zonuron 500 mcg Injection (Zota Healthcare Pvt. Ltd.)$ 0.25
Zonuron 500 mcg+3 mg+1.5 mg Tablet (Zota Healthcare Pvt. Ltd.)$ 0.08
ZONURON inj 0.5 mg x 1ml (Zota Healthcare Pvt. Ltd.)$ 0.25
Zonuron 500 mcg AMP / 1ml (Zota Healthcare Pvt. Ltd.)$ 0.25
ZONURON PLUS 1.5MG INJECTION 1 vial / 2 ML injection each (Zota Health care Ltd)$ 0.70
Zonuron Plus 500mcg Injection (Zota Health care Ltd)$ 0.35


  1. PubChem. "methylcobalamin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "methylcobalamin". http://www.drugbank.ca/drugs/DB03614 (accessed September 17, 2018).
  3. MeSH. "MeSH Tree: MeSH (Medical Subject Headings) is the NLM controlled vocabulary thesaurus used for indexing articles for PubMed.". http://www.nlm.nih.gov/mesh/meshhome... (accessed September 17, 2018).


The results of a survey conducted on ndrugs.com for Tetrafol PLUS are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Tetrafol PLUS. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet

3 consumers reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by ndrugs.com website users about whether the Tetrafol PLUS drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.

6 consumers reported time for results

To what extent do I have to use Tetrafol PLUS before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 1 week and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Tetrafol PLUS. To get the time effectiveness of using Tetrafol PLUS drug by other patients, please click here.
1 week2
5 days1
1 month1
1 day1
> 3 month1

20 consumers reported age

> 604
< 11

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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