Trofosfamide indications
Oral
Malignant disease
Adult: Initially, 300-400 mg/day.
Maintenance: 50-150 mg/day.
Trofosfamide dosage
Oral
Malignant disease
Adult: Initially, 300-400 mg/day.
Maintenance: 50-150 mg/day.
Trofosfamide interactions
Doxorubicin and other cardiotoxic drugs may enhance cardiotoxicity. Increased risk of bone marrow suppression with allopurinol. Increased risk of renal impairment with amphotericin B, cisplatin. Possible increase in INR with warfarin.
Trofosfamide side effects
Myelosuppression; thrombocytopenia, anaemia; nausea, vomiting, mucositis; alopecia; hyperpigmenation. Disturbances of carbohydrate metabolism; gonadal suppression; interstitial pulmonary fibrosis; cardiotoxicity (high doses).
Potentially Fatal: Haemorrhagic cystitis (after high dose or prolonged use).
Trofosfamide contraindications
Pregnancy, lactation; acute infection, bone-marrow aplasia, drug or radiation-induced urothelial toxicity.
Active ingredient matches for Trofosfamide:
Trofosfamide
List of Trofosfamide substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Genoxal Trofosfamida (Spain) | |
| Ixoten (Germany) | |
References
- PubChem. "Trofosfamide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Trofosfamide". http://www.drugbank.ca/drugs/DB12902 (accessed September 17, 2018).
- DTP/NCI. "Trofosfamide: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Trofosfamide are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Trofosfamide. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
