Vectrine indications
Relieving symptoms of sinus congestion, runny nose, sneezing, cough, and throat and airway irritation due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.
Bromhist-PDX Syrup is an antihistamine, decongestant, cough suppressant, and expectorant combination. It works by constricting blood vessels and reducing swelling in the nasal passages, loosening mucus and lung secrtions in the chest, and making coughs more productive. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing while the cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough.
Uses of Vectrine in details
Vectrine is used to treat short and severe episodes of worsening of chronic bronchitis (an inflammation of the airways that carry air to lungs). It may also be used as an expectorant to expel mucus.
Vectrine description
Vectrine 300 mg Capsule: Each capsule contains 300 mg Vectrine.
Vectrine 175 mg/5 mL Powder for Suspension: Each 5 mL of reconstituted suspension contains 175 mg Vectrine.
Vectrine dosage
Adults: 300 mg Capsule: One capsule twice daily.
175 mg/5 mL Powder for Suspension: 8.5 mL (300 mg) twice daily.
No dose adjustment is required in treatment of adult relapses of COPD, or in geriatric patients.
Paediatric Use: As a general rule, 10 mg/kg/day in two administrations at 12 hours intervals.
175 mg/5 mL Powder for Suspension: The recommended dosage regimen is: See Table.
Directions for Reconstitution: To make 60 mL reconstituted suspension, loosen the powder by shaking and slowly add 42 mL of water, then replace cap and shake well.
To make 100 mL reconstituted suspension, loosen the powder by shaking and slowly add 70 mL of water, then replace cap and shake well.
Always shake well before use. The reconstituted suspension can be stored in a refrigerator for a maximum of 10 days.
Vectrine interactions
No harmful interaction has been observed with other drugs, often used in treatment of respiratory infections and COPD, like theophylline, bronchodilating compounds (corticoid treatment), erythromycin, amoxicillin or co-trimoxazole.
Vectrine increases amoxicillin concentration in the respiratory tract.
The simultaneous administration of an anti-cough treatment is irrational and could induce the accumulation of liquefied excreatum in the bronchial tree with an increase of risk of superinfection or bronchospasm.
Vectrine side effects
Administration of Vectrine could occasionally cause gastro-intestinal side-effect, like gastric burning, nausea and rarely diarrhea.
In few cases, at the beginning of treatment, ageusia or dysgeusia have been observed.
Hypersensitivity reactions (skin rash, urticaria, unexpected hyperpyrexia) are rare.
The following adverse reaction rates are based on the use of Vectrine in treated population (1520 patients) during phase III clinical trials: 1 to 3%: Gastralgia, nausea, headache.
0.5 to 1%: Constipation, diarrhea, mouth dryness, vertigo, general malaise.
The observed adverse reactions are not different, from a qualitative point of view, from those observed under placebo.
Vectrine contraindications
Hypersensitivity to active substance or to any of the excipients or to free SH-group containing products.
Hepatic disorders and abnormalities (e.g. increase of serum alkaline phosphatase, transaminases, etc.).
Renal insufficiency (creatinine clearance <25 mL/min).
Homocystinuria (the active substance is partially metabolised to homocysteine and there are no data concerning administration of Vectrine in case of congenital errors of the metabolism of amino acids, especially in those patients obliged to follow a methionine-free dietary regimen).
Phenylketonuria (only for powder for suspension due to the presence of aspartame in this presentation).
Active ingredient matches for Vectrine:
Erdosteine in France, Indonesia, Vietnam.
| Unit description / dosage (Manufacturer) | Price, USD |
| Capsule; Oral; Erdosteine 300 mg | |
| Vectrine 300 mg x 2 Blister x 10 Tablet | |
| Vectrine 175 mg/5 mL x 1 Bottle boät ñeå pha 60 mL xiroâ | |
| Vectrine 300 mg x 20's | $ 8.68 |
| Vectrine 175 mg/5 mL x 60 mL x 1's | $ 3.58 |
List of Vectrine substitutes (brand and generic names): | |
| Erstant (South Korea) | |
| Ertusin (Indonesia) | |
| Esteclin (Mexico) | |
| Capsule; Oral; Erdosteine (Syntex) | |
| Suspension; Oral; Erdosteine (Syntex) | |
| Tablet; Oral; Erdosteine (Syntex) | |
| Esteclin Distab | |
| Tablet, Dispersible; Oral; Erdosteine | |
| Ethiros (Indonesia) | |
| Evosten (Turkey) | |
| Flusten (Brazil) | |
| Fudostin (Indonesia) | |
| He Tan (China) | |
| Ilvico (Ireland) | |
| Ilvico 20's (Merck) | |
| Lactrin (Indonesia) | |
| Lu Chang (China) | |
| Macdrio (Vietnam) | |
| Macdrio 150 mg x 2 Blister x 10 Tablet | |
| Macdrio 300 mg x 2 Blister x 10 Tablet | |
| Medistein (Indonesia) | |
| Medisteine (Indonesia) | |
| Milid (Portugal) | |
| Mucodox 300mg (Luxembourg) | |
| Mucofor (Switzerland) | |
| Capsule; Oral; Erdosteine 300 mg (Vifor) | |
| Mucofor 300mg (Switzerland) | |
| Mucotec (Bahrain, Egypt, Iraq, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Saudi Arabia, Sudan, Syria, United Arab Emirates, Yemen) | |
| Mucotein (Indonesia) | |
| Mucotein 300 mg x 2 x 10's (Combiphar) | $ 8.18 |
| Mucotein 175 mg/5 mL x 60 mL x 1's (Combiphar) | $ 2.65 |
| Mucothera (Luxembourg) | |
| Muctrien (Indonesia) | |
| Recustein (Indonesia) | |
| Recustein 300 mg x 2 x 10's (Landson) | $ 7.37 |
| Recustein 175 mg/5 mL x 60 mL x 1's (Landson) | |
| SP Edonal (Vietnam) | |
| Tantong (China) | |
| Theovix (Greece) | |
| Tusselin (Greece) | |
| Vestein (Indonesia) | |
| Vestein 300 mg x 2 x 10's | $ 8.68 |
| Vestein 175 mg/5 mL x 60 ml x 1's | $ 3.53 |
| Vostrin (Indonesia) | |
| Vostrin 175 mg x 60 mL x 1's (Novell Pharma) | $ 3.16 |
| Zertin (Philippines) | |
| Zertin 300 mg x 20's (GlaxoSmithKline) | $ 8.24 |
| Zertin 35 mL (GlaxoSmithKline) | $ 2.40 |
| Zertin 60 mL (GlaxoSmithKline) | $ 3.42 |
| Zertin 100 mL (GlaxoSmithKline) | $ 4.74 |
| Zertin cap 300 mg 20's (GlaxoSmithKline) | $ 8.74 |
See 93 substitutes for Vectrine | |
References
- PubChem. "Erdosteine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Erdosteine". http://www.drugbank.ca/drugs/DB05057 (accessed September 17, 2018).
- MeSH. "Expectorants". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Vectrine are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Vectrine. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
