What is Volsaid Retard 75mg & 100mg tablets?
Volsaid Retard 75mg & 100mg tablets is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and other symptoms of arthritis of the joints (eg, osteoarthritis), such as inflammation, swelling, stiffness, and joint pain. However, Volsaid Retard 75mg & 100mg tablets does not cure osteoarthritis and will help you only as long as you continue to use it.
Volsaid Retard 75mg & 100mg tablets topical 3% gel is also used to treat actinic keratosis, a skin problem that may become cancerous if not treated. The exact way that topical Volsaid Retard 75mg & 100mg tablets helps this condition is unknown.
Volsaid Retard 75mg & 100mg tablets topical solution is used to treat pain and swelling caused by osteoarthritis of the knees.
Volsaid Retard 75mg & 100mg tablets topical patch is used to treat acute pain caused by minor strains, sprains, and contusions (bruises).
Volsaid Retard 75mg & 100mg tablets is available only with your doctor's prescription.
Volsaid Retard 75mg & 100mg tablets indications
Carefully consider the potential benefits and risks of Volsaid Retard 75mg & 100mg tablets delayed-release tablets and other treatment options before deciding to use Volsaid Retard 75mg & 100mg tablets delayed-release tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
Volsaid Retard 75mg & 100mg tablets delayed-release tablets are indicated:
- •
- For relief of the signs and symptoms of osteoarthritis
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- For relief of the signs and symptoms of rheumatoid arthritis
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- For acute or long-term use in the relief of signs and symptoms of ankylosing spondylitis
How should I use Volsaid Retard 75mg & 100mg tablets?
Use Volsaid Retard 75mg & 100mg tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Volsaid Retard 75mg & 100mg tablets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Volsaid Retard 75mg & 100mg tablets refilled.
- Do not apply Volsaid Retard 75mg & 100mg tablets to infected skin; open wounds; or red, swollen, or peeling skin.
- Wash your hands immediately before and after using Volsaid Retard 75mg & 100mg tablets.
- Wash the affected area and dry completely before using Volsaid Retard 75mg & 100mg tablets.
- To apply Volsaid Retard 75mg & 100mg tablets, dispense 10 drops at a time onto the knee or into your hand. Spread Volsaid Retard 75mg & 100mg tablets evenly around the front, back, and sides of the knee. Repeat until you have used the whole dose.
- Be sure that you cover your entire knee with your dose of Volsaid Retard 75mg & 100mg tablets. Do not use more than the recommended amount.
- Do not apply sunscreens, cosmetics, insect repellants, other topical medicines, or any other substance to the treated area until it is completely dry.
- Do not put on clothes over the treated area until it is completely dry.
- Do not wrap, bandage, or apply heat to the treated area.
- Let the treated skin dry before touching it or letting it touch anyone else's skin.
- Do not shower, bathe, or wash the treated area for at least 30 minutes after you use Volsaid Retard 75mg & 100mg tablets.
- If you miss a dose of Volsaid Retard 75mg & 100mg tablets, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Volsaid Retard 75mg & 100mg tablets.
Uses of Volsaid Retard 75mg & 100mg tablets in details
Use: Labeled Indications
Ankylosing spondylitis (delayed-release tablets only): Acute or long-term use in the relief of signs and symptoms of ankylosing spondylitis.
Dysmenorrhea (immediate-release tablets only): Treatment of primary dysmenorrhea.
Migraine (powder for oral solution only): Acute treatment of migraine attacks with or without aura in adults.
Osteoarthritis (immediate-release, extended-release, and delayed-release tablets; capsules [Zorvolex]; and suppositories [Canadian product] only): Relief of signs and symptoms of osteoarthritis.
Pain
Capsules/immediate-release tablets only: Relief of mild to moderate acute pain.
Injection only: Management of mild to moderate pain and moderate to severe pain (alone or in combination with opioid analgesics) in adults.
Rheumatoid arthritis (immediate-release, extended-release, and delayed-release tablets; and suppositories [Canadian product] only): Relief of signs and symptoms of rheumatoid arthritis.
Off Label Uses
Gout, treatment (acute flares)
Data from a limited number of trials support the efficacy of Volsaid Retard 75mg & 100mg tablets in the treatment of acute gout flares.
Based on the 2012 American College of Rheumatology guidelines for management of gout, nonsteroidal anti-inflammatory drugs are effective and recommended agents in the treatment of acute gout flares.
Volsaid Retard 75mg & 100mg tablets description
A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
Volsaid Retard 75mg & 100mg tablets dosage
Carefully consider the potential benefits and risks of Volsaid Retard 75mg & 100mg tablets extended-release tablets, and other treatment options before deciding to use Volsaid Retard 75mg & 100mg tablets extended-release tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
After observing the response to initial therapy with Volsaid Retard 75mg & 100mg tablets extended-release tablets the dose and frequency should be adjusted to suit an individual patient’s needs.
For the relief of osteoarthritis, the recommended dosage is 100 mg daily.
For the relief of rheumatoid arthritis, the recommended dosage is 100 mg daily. In the rare patient where Volsaid Retard 75mg & 100mg tablets extended-release tablets 100 mg/day is unsatisfactory, the dose may be increased to 100 mg twice a day if the benefits outweigh the clinical risks of increased side effects.
Different formulations of Volsaid Retard 75mg & 100mg tablets (Volsaid Retard 75mg & 100mg tablets enteric-coated tablets; Volsaid Retard 75mg & 100mg tablets extended-release tablets; Volsaid Retard 75mg & 100mg tablets potassium immediate-release tablets) are not necessarily bioequivalent even if the milligram strength is the same.
Volsaid Retard 75mg & 100mg tablets interactions
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What other drugs will affect Volsaid Retard 75mg & 100mg tablets?
Aspirin: Concomitant administration of Volsaid Retard 75mg & 100mg tablets and aspirin is not recommended because Volsaid Retard 75mg & 100mg tablets is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations, peak plasma levels, and AUC values.
Anticoagulants: While studies have not shown Volsaid Retard 75mg & 100mg tablets to interact with anticoagulants of the warfarin type, caution should be exercised, nonetheless, since interactions have been seen with other NSAIDs. Because prostaglandins play an important role in hemostasis, and NSAIDs affect platelet function as well, concurrent therapy with all NSAIDs, including Volsaid Retard 75mg & 100mg tablets, and warfarin requires close monitoring of patients to be certain that no change in their anticoagulant dosage is required.
Digoxin, Methotrexate, Cyclosporine: Volsaid Retard 75mg & 100mg tablets, like other NSAIDs, may affect renal prostaglandins and increase the toxicity of certain drugs. Ingestion of Volsaid Retard 75mg & 100mg tablets may increase serum concentrations of digoxin and methotrexate and increase cyclosporineís nephrotoxicity. Patients who begin taking Volsaid Retard 75mg & 100mg tablets or who increase their Volsaid Retard 75mg & 100mg tablets dose or any other NSAID while taking digoxin, methotrexate, or cyclosporine may develop toxicity characteristics for these drugs. They should be observed closely, particularly if renal function is impaired. In the case of digoxin, serum levels should be monitored.
Lithium: Volsaid Retard 75mg & 100mg tablets decreases lithium renal clearance and increases lithium plasma levels. In patients taking Volsaid Retard 75mg & 100mg tablets and lithium concomitantly, lithium toxicity may develop.
Oral Hypoglycemics:
Volsaid Retard 75mg & 100mg tablets does not alter glucose metabolism in normal subjects nor does it alter the effects of oral hypoglycemic agents. There are rare reports, however, from marketing experiences, of changes in effects of insulin or oral hypoglycemic agents in the presence of Volsaid Retard 75mg & 100mg tablets that necessitated changes in the doses of such agents. Both hypo- and hyperglycemic effects have been reported. A direct causal relationship has not been established, but physicians should consider the possibility that Volsaid Retard 75mg & 100mg tablets may alter a diabetic patientís response to insulin or oral hypoglycemic agents.
Diuretics: Volsaid Retard 75mg & 100mg tablets and other NSAIDs can inhibit the activity of diuretics. Concomitant treatment with potassium-sparing diuretics may be associated with increased serum potassium levels.
Other Drugs: In small groups of patients (7-10/interaction study), the concomitant administration of azathioprine, gold, chloroquine, D-penicillamine, prednisolone, doxycycline, or digitoxin did not significantly affect the peak levels and AUC values of Volsaid Retard 75mg & 100mg tablets. Phenobarbital toxicity has been reported to have occurred in a patient on chronic phenobarbital treatment following the initiation of Volsaid Retard 75mg & 100mg tablets therapy.
Protein Binding
In vitro, Volsaid Retard 75mg & 100mg tablets interferes minimally or not at all with the protein binding of salicylic acid (20% decrease in binding), tolbutamide, prednisolone (10% decrease in binding), or warfarin. Benzylpenicillin, ampicillin, oxacillin, chlortetracycline, doxycycline, cephalothin, erythromycin, and sulfamethoxazole have no influence in vitro on the protein binding of Volsaid Retard 75mg & 100mg tablets in human serum.
Drug/Laboratory Test Interactions
Effect on Blood Coagulation: Volsaid Retard 75mg & 100mg tablets increases platelet aggregation time but does not affect bleeding time, plasma thrombin clotting time, plasma fibrinogen, or factors V and VII to XII. Statistically significant changes in prothrombin and partial thromboplastin times have been reported in normal volunteers. The mean changes were observed to be less than 1 second in both instances, however, and are unlikely to be clinically important. Volsaid Retard 75mg & 100mg tablets is a prostaglandin synthetase inhibitor, however, and all drugs that inhibit prostaglandin synthesis interfere with platelet function to some degree; therefore, patients who may be adversely affected by such an action should be carefully observed.
Volsaid Retard 75mg & 100mg tablets side effects
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What are the possible side effects of Volsaid Retard 75mg & 100mg tablets?
Ocular
Transient burning and stinging were reported in approximately 15% of patients across studies with the use of Volsaid Retard 75mg & 100mg tablets ophthalmic solution, 0.1%. In cataract surgery studies, keratitis was reported in up to 28% of patients using Volsaid Retard 75mg & 100mg tablets ophthalmic solution, 0.1%, although in many of these cases keratitis was initially noted prior to the initiation of treatment. Elevated intraocular pressure following cataract surgery was reported in approximately 15% of patients undergoing cataract surgery. Lacrimation complaints were reported in approximately 30% of case studies undergoing incisional refractive surgery. The following adverse reactions were reported in approximately 10% or less of the patients: abnormal vision, acute elevated IOP, blurred vision, conjunctivitis, corneal deposits, corneal edema, corneal opacity, corneal lesions, discharge, eyelid swelling, eye pain, injection (redness), iritis, irritation, itching, lacrimation disorder, and ocular allergy.
Systemic
The following adverse reactions were reported in 3% or less of the patients: abdominal pain, asthenia, chills, dizziness, facial edema, fever, headache, insomnia, nausea, pain, rhinitis, viral infection and vomiting.
Clinical Practice
The following reactions have been identified during postmarketing use of topical Volsaid Retard 75mg & 100mg tablets ophthalmic solution, 0.1% in clinical practice. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. The reactions, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to topical Volsaid Retard 75mg & 100mg tablets ophthalmic solution, 0.1%, or a combination of these factors, include corneal erosion, corneal infiltrates, corneal perforation, corneal thinning, corneal ulceration and epithelilal breakdown.
TO REPORT SUSPECTED ADVERSE REACTIONS, contact Altaire Pharmaceuticals, Inc., at 1-800-258-2471 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Volsaid Retard 75mg & 100mg tablets contraindications
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What is the most important information I should know about Volsaid Retard 75mg & 100mg tablets?
Volsaid Retard 75mg & 100mg tablets in all formulations, Cataflam, Voltaren, and Voltaren-XR, is contraindicated in patients with known hypersensitivity to Volsaid Retard 75mg & 100mg tablets and Volsaid Retard 75mg & 100mg tablets-containing products. Volsaid Retard 75mg & 100mg tablets should not be given to patients who have experienced asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to Volsaid Retard 75mg & 100mg tablets have been reported in such patients.
Active ingredient matches for Volsaid Retard 75mg & 100mg tablets:
Diclofenac sodium in United Kingdom.
List of Volsaid Retard 75mg & 100mg tablets substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| VOLFLAM - SR | |
| VOLFLAM - SR Modified Release Capsule/ Tablet / 100mg / 10 units (Psychotropics India) | $ 0.16 |
| Volta 100 | |
| Volta 25 | |
| Volta 50 | |
| Volta 75 | |
| Voltagesic | |
| Voltalina 0.1% | |
| Voltamed 0.1% | |
| Voltamed 100 | |
| Voltamed 12.5 | |
| Voltamed 25 | |
| Voltamed 50 | |
| Voltaraze 1% | |
| Voltaraze 100 | |
| Voltaraze 12.5 | |
| Voltaraze 25 | |
| Voltaraze 50 | |
| Voltaraze 75 | |
| Voltarazesr 100 | |
| Voltaren 100 | |
| Voltaren children | |
| Voltarenac 50 | |
| Voltarile 100 | |
| Voltarile 12.5 | |
| Voltarile 25 | |
| Voltarile 50 | |
| Voltarile 75 | |
| Voltarile Emulgel 1% | |
| Voltarilesr 100 | |
| Voltarino 25 | |
| Voltarino 50 | |
| Voparan | |
| Voparan 75 mg Injection (Swiss Pharma Pvt. Ltd.) | $ 0.04 |
| Vosun Gel | |
| Vosun Gel 30 gm Ointment (Sungrace Pharma Pvt. Ltd.) | $ 0.51 |
| Vovenec | |
| Vovenec 50 mg Tablet (Psyco Remedies.) | $ 0.01 |
| VOVERAN - D | |
| VOVERAN - D Capsule/ Tablet / 50mg / 10 units (Novartis) | $ 0.33 |
| VOVERAN TPM (India) | |
| VOVERAN TPM topical gel 1 % w/w x 30g (Novartis Pharma) | $ 1.16 |
| Vovin | |
| Vovin 50 mg Tablet (Mediwin Pharmaceuticals) | $ 0.01 |
| Vovin F | |
| Vovin F 50+20 Tablet (Mediwin Pharmaceuticals) | $ 0.02 |
| Wisnac R | |
| Wisnac R 100+20 Capsule (Wisdom Pharma Pvt. Ltd) | $ 0.05 |
| Wisnac S | |
| Wisnac S 50+10 Tablet (Wisdom Pharma Pvt. Ltd) | $ 0.05 |
See 919 substitutes for Volsaid Retard 75mg & 100mg tablets | |
References
- DailyMed. "DICLOFENAC EPOLAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "diclofenac". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "diclofenac". http://www.drugbank.ca/drugs/DB00586 (accessed September 17, 2018).
Reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
