What is Zalastin?
Zalastin nasal spray is used to help relieve symptoms (eg, stuffy or runny nose, itching, sneezing) of seasonal (short-term) or perennial (year-round) allergic rhinitis (hay fever), and vasomotor rhinitis.
Zalastin is an antihistamine. It works by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes.
Zalastin is available only with your doctor's prescription.
Zalastin indications
Zalastin hydrochloride nasal solution (nasal spray) is indicated for the treatment of the symptoms of seasonal allergic rhinitis in adults and pediatric patients 5 years and older, and for the treatment of the symptoms of vasomotor rhinitis in adults and adolescent patients 12 years and older.
How should I use Zalastin?
Use Zalastin spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Zalastin spray. Talk to your pharmacist if you have questions about this information.
- Zalastin spray is for the nose only. Do not get it in your eyes or mouth. If you get Zalastin spray in your eyes, rinse with cool tap water at once.
- Prime the spray pump before the first use of a new bottle. Remove the blue dust cover over the tip of the bottle and the blue safety clip. To prime the pump, point the spray pump away from you and others. Spray rapidly and firmly several times until a fine mist appears (6 sprays or less).
- Gently blow your nose to clear your nostrils.
- Keep your head tilted downward. Place the spray tip ¼ to ½ inch into the nostril. Hold bottle upright, allowing spray tip to aim toward the back of the nose. Close the other nostril with one finger.
- Spray rapidly and firmly once and sniff gently at the same time. Repeat in the other nostril as directed.
- Breathe in gently. Do not tilt your head back after using Zalastin spray. This will help you to avoid the bitter taste that may be caused by Zalastin spray.
- After using Zalastin spray, wipe the spray tip with a clean tissue or cloth. Keep the dust cover and safety clip on the bottle when it is not in use.
- If 3 or more days have passed since the last use of this bottle, reprime the pump with 2 sprays or until a fine mist appears.
- If the nozzle becomes clogged, do NOT clean it by using a pointed object. Remove the spray pump from the bottle. Soak it in warm water, squirting it several times while under water. Dry the spray pump completely. Attach the spray pump to the bottle and reprime.
- Throw away any medicine that is left in the bottle after you have used 200 sprays. You may no longer receive the correct amount of medicine with each spray.
- If you miss a dose of Zalastin spray, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Zalastin spray.
Uses of Zalastin in details
Zalastin is an antihistamine (antiallergic) medication used for the treatment of hay fever, and allergy symptoms including runny nose, sneezing, and itchy nose and eye allergies (allergic conjunctivitis).
Zalastin description
Zalastin, a phthalazine derivative, is an antihistamine and mast cell stabilizer available as a nasal spray for hay fever and as eye drops for allergic conjunctivitis. Zalastin is also available as a combination product of Zalastin hydrochloride and fluticasone propionate called Dymista™. Dymista™ is indicated in patient over 12 years old for symptomatic relief of seasonal allergic rhinitis.
Zalastin dosage
Seasonal Allergic Rhinitis
The recommended dosage of Zalastin hydrochloride nasal solution (nasal spray) in adults and adolescent patients 12 years and older with seasonal allergic rhinitis is one or two sprays per nostril twice daily. The recommended dosage of Zalastin hydrochloride nasal solution (nasal spray) in pediatric patients 5 years to 11 years of age is one spray per nostril twice daily.
Vasomotor Rhinitis
The recommended dosage of Zalastin hydrochloride nasal solution (nasal spray) in adults and adolescent patients 12 years and older with vasomotor rhinitis is two sprays per nostril twice daily.
Important Administration Instructions
Administer Zalastin hydrochloride nasal solution (nasal spray) by the intranasal route only.
Priming: Prime Zalastin hydrochloride nasal solution (nasal spray) before initial use by releasing 4 sprays or until a fine mist appears. When Zalastin hydrochloride nasal solution (nasal spray) has not been used for 3 or more days, reprime with 2 sprays or until a fine mist appears. Avoid spraying Zalastin hydrochloride nasal solution (nasal spray) into the eyes.
Zalastin interactions
Additive effects with CNS depressants and ethanol.
Zalastin side effects
See also:
What are the possible side effects of Zalastin?
Use of Zalastin hydrochloride nasal solution (nasal spray) has been associated with somnolence.
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect rates observed in practice.
Seasonal Allergic Rhinitis
Zalastin Hydrochloride Nasal Solution (Nasal Spray) Two Sprays Per Nostril Twice Daily
Adverse experience information for Zalastin hydrochloride nasal solution (nasal spray) is derived from six placebo- and active-controlled, 2-day to 8-week clinical trials which included 391 patients, 12 years of age and older, with seasonal allergic rhinitis who received Zalastin hydrochloride nasal solution (nasal spray) at a dose of 2 sprays per nostril twice daily. In placebo-controlled efficacy trials, the incidence of discontinuation due to adverse reactions in patients receiving Zalastin hydrochloride nasal solution (nasal spray) and vehicle placebo was 2.2% and 2.8%, respectively.
Table 1 contains adverse reactions that were reported with frequencies ≥2% in the Zalastin hydrochloride nasal solution (nasal spray) 2 sprays per nostril twice daily treatment group and more frequently than placebo.
| Zalastin Hydrochloride Nasal Solution (Nasal Spray) N = 391 | Vehicle Placebo N = 353 | |
|---|---|---|
| Bitter Taste | 77 (19.7%) | 2 (0.6%) |
| Headache | 58 (14.8%) | 45 (12.7%) |
| Somnolence | 45 (11.5%) | 19 (5.4%) |
| Nasal Burning | 16 (4.1%) | 6 (1.7%) |
| Pharyngitis | 15 (3.8%) | 10 (2.8%) |
| Paroxysmal Sneezing | 12 (3.1%) | 4 (1.1%) |
| Dry Mouth | 11 (2.8%) | 6 (1.7%) |
| Nausea | 11 (2.8%) | 4 (1.1%) |
| Rhinitis | 9 (2.3%) | 5 (1.4%) |
| Fatigue | 9 (2.3%) | 5 (1.4%) |
| Dizziness | 8 (2.0%) | 5 (1.4%) |
| Epistaxis | 8 (2.0%) | 5 (1.4%) |
| Weight Increase | 8 (2.0%) | 0 (0.0%) |
Zalastin Hydrochloride Nasal Solution (Nasal Spray) One Spray Per Nostril Twice Daily
Adverse experience information for Zalastin hydrochloride nasal solution (nasal spray) at a dose of one spray per nostril twice daily is derived from two placebo-controlled 2-week clinical studies which included 276 patients 12 years of age and older with seasonal allergic rhinitis. The incidence of discontinuation due to adverse reactions in patients receiving Zalastin hydrochloride nasal solution (nasal spray) and vehicle placebo was 0.0% and 0.8%, respectively. Bitter taste was reported in 8.3% of patients compared to none in the placebo group. Somnolence was reported in 0.4% of patients compared to none in the placebo group.
A total of 176 patients 5 to 11 years of age were exposed to Zalastin hydrochloride nasal solution (nasal spray) at a dose of 1 spray each nostril twice daily in 3 placebo-controlled studies. In these studies, adverse reactions that occurred more frequently in patients treated with Zalastin hydrochloride nasal solution (nasal spray) than with placebo, and that were not represented in the adult adverse reactions table above include rhinitis/cold symptoms (17.0% vs. 9.5%), cough (11.4% vs. 8.3%), conjunctivitis (5.1% vs. 1.8%), and asthma (4.5% vs. 4.1%).
Adverse Reactions <2% in Zalastin Hydrochloride Nasal Solution (Nasal Spray) One or Two Sprays Per Nostril Twice Daily
The following reactions were observed infrequently (<2% and exceeding placebo incidence) in patients who received Zalastin hydrochloride nasal solution (nasal spray) dosed at 1 or 2 sprays per nostril twice daily in U.S. clinical trials.
Cardiovascular: flushing, hypertension, tachycardia.
Dermatological: contact dermatitis, eczema, hair and follicle infection, furunculosis, skin laceration.
Digestive: constipation, gastroenteritis, glossitis, ulcerative stomatitis, vomiting, increased SGPT, aphthous stomatitis, diarrhea, toothache.
Metabolic and Nutritional: increased appetite.
Musculoskeletal: myalgia, temporomandibular dislocation, rheumatoid arthritis.
Neurological: hyperkinesia, hypoesthesia, vertigo.
Psychological: anxiety, depersonalization, depression, nervousness, sleep disorder, thinking abnormal.
Respiratory: bronchospasm, coughing, throat burning, laryngitis, bronchitis, dry throat, nocturnal dyspnea, nasopharyngitis, nasal congestion, pharyngolaryngeal pain, sinusitis, nasal dryness, paranasal sinus hypersecretion, post nasal drip.
Special Senses: conjunctivitis, eye abnormality, eye pain, watery eyes, taste loss.
Urogenital: albuminuria, amenorrhea, breast pain, hematuria, increased urinary frequency.
Whole Body: allergic reaction, back pain, herpes simplex, viral infection, malaise, pain in extremities, abdominal pain, pyrexia.
Vasomotor Rhinitis
Adverse experience information for Zalastin hydrochloride nasal solution (nasal spray) is derived from two placebo-controlled clinical studies which included 216 patients 12 years and older with vasomotor rhinitis who received Zalastin hydrochloride nasal solution (nasal spray) at a dose of 2 sprays per nostril twice daily for up to 28 days. The incidence of discontinuation due to adverse reactions in patients receiving Zalastin hydrochloride nasal solution (nasal spray) and vehicle placebo was 2.8% and 2.9%, respectively.
The following adverse reactions were reported with frequencies ≥ 2% in the Zalastin hydrochloride nasal solution (nasal spray) treatment group and more frequently than placebo.
| Zalastin Hydrochloride Nasal Solution (Nasal Spray) N = 216 | Vehicle Placebo N = 210 | |
|---|---|---|
| Bitter Taste | 42 (19.4%) | 5 (2.4%) |
| Headache | 17 (7.9%) | 16 (7.6%) |
| Dysesthesia | 17 (7.9%) | 7 (3.3%) |
| Rhinitis | 12 (5.6%) | 5 (2.4%) |
| Epistaxis | 7 (3.2%) | 5 (2.4%) |
| Sinusitis | 7 (3.2%) | 4 (1.9%) |
| Somnolence | 7 (3.2%) | 2 (1.0%) |
Reactions observed infrequently (<2% and exceeding placebo incidence) in patients who received Zalastin hydrochloride nasal solution (nasal spray) (2 sprays/nostril twice daily) in U.S. clinical trials in vasomotor rhinitis were similar to those observed in U.S. clinical trials in seasonal allergic rhinitis.
In controlled trials involving nasal and oral Zalastin hydrochloride formulations, there were infrequent occurrences of hepatic transaminase elevations.
Postmarketing Experience
During the post approval use of Zalastin hydrochloride nasal solution (nasal spray), the following adverse reactions have been identified. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Adverse reactions reported include: anaphylaxis, application site irritation, atrial fibrillation, chest pain, confusion, dyspnea, facial edema, involuntary muscle contractions, nasal sores, palpitations, paresthesia, parosmia, pruritus, rash, disturbance or loss of sense of smell and/or taste, tolerance, urinary retention, vision abnormal and xerophthalmia.
Zalastin contraindications
See also:
What is the most important information I should know about Zalastin?
Hypersensitivity.
Active ingredient matches for Zalastin:
Azelastine in Egypt.
List of Zalastin substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| OCULAST (India) | |
| Oculast 0.05% w/v Eye Drops / 5ml (Centaur Pharmaceuticals Pvt.Ltd.) | $ 0.61 |
| Oculast Eye 5 ml Drop (Centaur Pharmaceuticals Pvt.Ltd.) | $ 0.11 |
| OCULAST 0.05% EYE DROP 1 packet / 5 ML eye drop each (Centaur Pharmaceuticals Pvt.Ltd.) | $ 0.71 |
| OCULAST 0.05% EYE DROP 1 packet / 15 ML eye drop each (Centaur Pharmaceuticals Pvt.Ltd.) | $ 0.65 |
| OCULAST eye drops 0.05 % w/v x 5ml (Centaur Pharmaceuticals Pvt.Ltd.) | $ 0.61 |
| Oculast 0.05% w/v Eye Drops / 5ml (Centaur Pharmaceuticals Pvt.Ltd.) | $ 0.61 |
| Oculastin (Netherlands, Portugal) | |
| Drops; Ophthalmic; Azelastine Hydrochloride (Meda) | |
| Opthazel (Peru) | |
| Optihist AZ | |
| Optihist AZ Eye 5 ml Drop (Entod Pharmaceuticals Ltd) | $ 0.14 |
| OPTIHIST AZ EYE DROP 1 packet / 5 ML eye drop each (Entod Pharmaceuticals Ltd) | $ 0.78 |
| Optihist AZ 0.50% Eye Drop (Entod Pharmaceuticals Ltd) | $ 0.78 |
| Optihist AZ NA Eye Drop (Entod Pharmaceuticals Ltd) | $ 0.78 |
| OPTIHIST AZ (ENTOD) | |
| OPTIHIST AZ / ENTOD 0.50% EYE DROP 1 packet / 5 ML eye drop each (Entod Pharmaceuticals Ltd) | $ 0.78 |
| Optilast (Israel, South Africa, United Kingdom) | |
| Solution; Ophthalmic; Azelastine Hydrochloride 0.05% (Asta medica) | |
| Otrivin Azelastine (Netherlands) | |
| Otrivin Heuschnupfen (Switzerland) | |
| Spray, Metered-Dose; Nasal; Azelastine Hydrochloride 0.14 mg / dose | |
| Otrivin Neusallergie Azelastine (Netherlands) | |
| Otrivin Rhume des Foins (Switzerland) | |
| Otrivine Anti-Allergie (Belgium) | |
| Proallergodil (France) | |
| Prorhinite (France) | |
| Solution; Nasal; Azelastine Hydrochloride 0.1% (Novartis sante) | |
| Raspjine (Japan) | |
| Rhinolast (Ireland, Israel, South Africa, United Kingdom) | |
| Spray; Nasal; Azelastine Hydrochloride 0.1% (Viatris) | |
| Rhinolast Allergy (United Kingdom) | |
| Rinalin (Belize, Costa Rica, Dominican Republic, El Salvador, Guatemala, Honduras, Nicaragua, Panama) | |
| Rinazina Antiallergica (Italy) | |
| Rinelaz (Sweden) | |
| Rino-Lastin (Brazil) | |
| Sarnase (India) | |
| Sarnase Fluticasone 50 mcg, azelastine140 mcg. N-SPY / 15ml (Ranbaxy) | $ 2.19 |
| SARNASE 50 MCG/140 MCG NASAL SPRAY 1 packet / 15 ML nasal spray each (Ranbaxy) | $ 2.19 |
| SARNASE nasal spray 15ml (Ranbaxy) | $ 2.19 |
| Sarnase 50 mcg/140 mcg Nasal Spray (Ranbaxy) | $ 2.19 |
| Snizex (Bangladesh) | |
| Sophistina (Colombia) | |
| Tebarat (Spain) | |
| Vividrin akut Azelastin (Germany) | |
| Solution; Ophthalmic; Azelastine Hydrochloride (Mann) | |
| Vividrin Azelastin (Germany) | |
| Xanaes (Argentina) | |
| Xin Bai Ke (China) | |
| Zelanex (Bangladesh) | |
| Zelass-M (Turkey) | |
See 222 substitutes for Zalastin | |
References
- PubChem. "azelastine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "azelastine". http://www.drugbank.ca/drugs/DB00972 (accessed September 17, 2018).
- MeSH. "Anti-Allergic Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Zalastin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Zalastin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
