What is Zylofen?
Zylofen is a type of asthma medication which, when taken every day and used along with other antiasthma medications, may reduce the frequency, severity, and duration of asthma symptoms or attacks in children. It may also lead to a reduction in daily requirements of other antiasthma medications. Zylofen is not effective for the prevention or treatment of acute asthma attacks. Zylofen works by inhibiting certain substances in the body that are known to cause inflammation and symptoms of asthma.
Zylofen is available only with your doctor's prescription.
Zylofen indications
Long term prevention of :
Bronchial asthma(all forms, including Mixed)
Allergic bronchitis
Asthmatic symptoms associated with hay fever.
It may take several weeks before the full therapeutic effect of Zylofen is achieved. Prevention and treatment of:
Multisystemic allergies
Allergic rhinitis
Allergic dermatoses Zylofen is not effective in aborting established attacks of asthma. ymptomatic treatment of seasonal allergic conjunctivitis
How should I use Zylofen?
Use Zylofen drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- To use Zylofen drops in the eye, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eyelid for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
- To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.
- Zylofen drops is only for the eye. Do not get it in your nose or mouth.
- Do not wear contact lenses if your eye is red.
- Do not use Zylofen drops to treat irritation caused by contact lenses.
- Remove contact lenses before you use Zylofen drops; soft contact lenses may be placed back in the eyes 10 minutes after use of Zylofen drops if your eyes are not red.
- If you miss a dose of Zylofen drops, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Zylofen drops.
Uses of Zylofen in details
This medication is used to prevent and treat itching of the eyes caused by allergies (allergic/seasonal conjunctivitis). Zylofen is an antihistamine for the eye that treats allergic symptoms by blocking a certain natural substance (histamine). It is also a mast cell stabilizer that prevents allergic reactions by reducing the release of natural substances that cause an allergic reaction.
How to use Zylofen ophthalmic
If you are using the over-the-counter product, read all directions on the product package before using this medication. If your doctor has prescribed this medication, use it exactly as directed.
Apply 1 drop to the affected eye(s), usually twice a day (every 8 to 12 hours) or as directed by the package instructions or your doctor.
Dosage is based on your medical condition and response to treatment.
To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.
Ask your doctor if you can wear contact lenses while you are being treated with this medication. If your doctor says you may continue wearing them, remove them before using the eye drops, and wait at least 10 minutes after each dose before putting in your lenses. Do not use this medication to treat irritation from contact lens wear. Consult your doctor about the use of contact lenses when the eyes are red or irritated.
Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and apply 1 drop in the lower eyelid. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye.
Do not rinse the dropper. Replace the dropper cap after each use, and keep the bottle tightly closed.
If you are using another kind of eye medication (drops or ointment), wait at least 5 minutes before applying it. Apply eye drops before eye ointments to allow the eye drops to enter the eye.
If your doctor has prescribed this medication, use it regularly in order to get the most benefit from it. To help you remember, use it at the same times each day. Continue to use this medication as prescribed until pollen season is over or you are no longer exposed to the allergic substance, even when allergic symptoms disappear or improve.
If your condition persists or worsens, if you develop new symptoms, or if you think you have a serious medical problem, seek immediate medical attention. If you are treating yourself with nonprescription Zylofen, consult your doctor if your itching worsens or lasts more than 72 hours. You may need a different medication.
Zylofen description
A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Zylofen inhibits the 3&
Zylofen dosage
Zylofen Dosage
Generic name: Zylofen fumarate
Dosage form: Ophthalmic Solution, 0.025%
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
The recommended dose is one drop in the affected eye(s) twice daily, every 8 to 12 hours.
More about Zylofen (Zylofen ophthalmic)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Support Group
- Pricing & Coupons
- En Espanol
- 3 Reviews - Add your own review/rating
Consumer resources
- Zylofen drops
- Zylofen
- Zylofen (Advanced Reading)
- Other brands: Zylofen, Zyrtec Itchy Eye Drops, Claritin Eye
Professional resources
- Zylofen (AHFS Monograph)
- Zylofen (FDA)
Related treatment guides
- Conjunctivitis, Allergic
Zylofen interactions
See also:
What other drugs will affect Zylofen?
Zylofen interacts with a wide variety of drugs. The interaction may be pharmacodynamic, i.e., alterations in the therapeutic response to theophylline or another drug or occurrence of adverse effects without a change in serum theophylline concentration. More frequently, however, the interaction is pharmacokinetic, i.e., the rate of theophylline clearance is altered by another drug resulting in increased or decreased serum theophylline concentrations. Zylofen only rarely alters the pharmacokinetics of other drugs.
The drugs listed in TABLES 2A and 2B have the potential to produce clinically significant pharmacodynamic or pharmacokinetic interactions with theophylline. The information in the "Effect" column of TABLES 2A and 2B assumes that the interacting drug is being added to a steady-state theophylline regimen. If theophylline is being initiated in a patient who is already taking a drug that inhibits theophylline clearance (e.g., cimetidine, erythromycin), the dose of theophylline required to achieve a therapeutic serum theophylline concentration will be smaller. Conversely, if theophylline is being initiated in a patient who is already taking a drug that enhances theophylline clearance (e.g., rifampin), the dose of theophylline required to achieve a therapeutic serum theophylline concentration will be larger. Discontinuation of a concomitant drug that increases theophylline clearance will result in accumulation of theophylline to potentially toxic levels, unless the theophylline dose is appropriately reduced. Discontinuation of a concomitant drug that inhibits theophylline clearance will result in decreased serum theophylline concentrations, unless the theophylline dose is appropriately increased.
The listing of drugs in TABLES 2A and 2B is current as of April 3, 1995. New interactions are continuously being reported for theophylline, especially with new chemical entities. The clinician should not assume that a drug does not interact with theophylline if it is not listed in TABLES 2A and 2B.Before addition of a newly available drug in a patient receiving theophylline, the package insert of the new drug and/or the medical literature should be consulted to determine if an interaction between the new drug and theophylline has been reported.
TABLE 2A - Clinically significant drug interactions with theophylline*
| Drug | Type of Interaction | Effect** |
| Adenosine | Zylofen blocks adenosine receptors. | Higher doses of adenosine may be required to achieve desired effect. |
| Alcohol | A single large dose of alcohol (3 ml/kg of whiskey) decreases theophylline clearance for up to 24 hours. | 30% increase |
| Allopurinol | Decreases theophylline clearance at allopurinol doses ³600 mg/day. | 25% increase |
| Aminoglutethimide | Increases theophylline clearance by induction of microsomal enzyme activity. | 25% decrease |
| Carbamazepine | Similar to aminoglutethimide. | 30% decrease |
| Cimetidine | Decreases theophylline clearance by inhibiting cytochrome P450 1A2. | 70% increase |
| Ciprofloxacin | Similar to cimetidine. | 40% increase |
| Clarithromycin | Similar to erythromycin. | 25% increase |
| Diazepam | Benzodiazepines increase CNS concentrations of adenosine, a potent CNS depressant, while theophylline blocks adenosine receptors. | Larger diazepam doses may be required to produce desired level of sedation. |
| Discontinuation of theophylline without reduction of diazepam dose may result in respiratory depression. | ||
| Disulfiram | Decreases theophylline clearance by inhibiting hydroxylation and demethylation. | 50% increase |
| Enoxacin | Similar to cimetidine. | 300% increase |
| Ephedrine | Synergistic CNS effects | Increased frequency of nausea, nervousness, and insomnia. |
| Erythromycin | Erythromycin metabolite decreases theophylline clearance by inhibiting cytochrome P450 3A3. | 35% increase. |
| Erythromycin steady-state serum concentrations decreased by a similar amount. | ||
| Estrogen | Estrogen containing oral contraceptives decrease theophylline clearance in a dose-dependent fashion. The effect of progesterone on theophylline clearance is unknown. | 30% increase |
| Flurazepam | Similar to diazepam. | Similar to diazepam. |
| Fluvoxamine | Similar to cimetidine myocardium to catecholamines, theophylline increases release of endogenous catecholamines. | Similar to cimetidine ventricular arrhythmias. |
| Interferon, human recombinant alpha-A | Decreases theophylline clearance. | 100% increase |
| Isoproterenol (IV) | Increases theophylline clearance. | 20% decrease |
| Ketamine | Pharmacologic | May lower theophylline seizure threshold. |
| Lithium | Zylofen increases renal lithium clearance. | Lithium dose required to achieve a therapeutic serum concentration increased an average of 60%. |
| Lorazepam | Similar to diazepam. | Similar to diazepam. |
TABLE 2B - Clinically significant drug interactions with theophylline*
| Drug | Type of Interaction | Effect** | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Methotrexate (MTX) | Decreases theophylline clearance. | 20% increase after low dose MTX, higher dose MTX may have a greater effect. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Mexiletine | Similar to disulfiram. | 80% increase | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Midazolam | Similar to diazepam. | Similar to diazepam. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Moricizine | Increases theophylline clearance. | 25% decrease | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pancuronium | Zylofen may antagonize non-depolarizing neuromuscular blocking effects; possibly due to phosphodiesterase inhibition. | Larger dose of pancuronium may be required to achieve neuromuscular blockade. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pentoxifylline | Decreases theophylline clearance. | 30% increase | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Phenobarbital (PB) | Similar to aminoglutethimide. | 25% decrease after two weeks of concurrent PB. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Phenytoin | Phenytoin increases theophylline clearance by increasing microsomal enzyme activity. Zylofen decreases phenytoin absorption. | Serum theophylline and phenytoin concentrations decrease about 40%. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Propafenone | Decreases theophylline clearance and pharmacologic interaction. | 40% increase. Beta-2 blocking effect may decrease efficacy of theophylline. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Propranolol | Similar to cimetidine and pharmacologic interaction. | 100% increase. Beta-2 blocking effect may decrease efficacy of theophylline. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Rifampin | Increases theophylline clearance by increasing cytochrome P450 1A2 and 3A3 activity. | 20-40% decrease | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sulfinpyrazone | Increases theophylline clearance by increasing demethylation and hydroxylation. | 20% decrease | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Decreases renal clearance of theophylline. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tacrine | Similar to cimetidine, also increases renal clearance of theophylline. | 90% increase | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Thiabendazole | Decreases theophylline clearance. | 190% increase | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ticlopidine | Decreases theophylline clearance. | 60% increase | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Troleandomycin | Similar to erythromycin. | 33-100% increase depending on troleandomycin dose. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Verapamil | Similar to disulfiram. | 20% increase | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| * Refer to
DRUG INTERACTIONSfor further information regarding table.Zylofen side effectsSee also: Applies to Zylofen ophthalmic: oral syrup, oral tablet Other dosage forms:
As well as its needed effects, Zylofen ophthalmic (the active ingredient contained in Zylofen) may cause unwanted side effects that require medical attention. Severity: ModerateIf any of the following side effects occur while taking Zylofen ophthalmic, check with your doctor or nurse as soon as possible: Less common:
If any of the following symptoms of overdose occur while taking Zylofen ophthalmic, get emergency help immediately:
Minor Side EffectsSome Zylofen ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them: More common:
Zylofen contraindicationsSee also: Do not use this medication if you are allergic to Zylofen, or if you have an untreated eye infection. Zylofen ophthalmic should not be used to treat eye irritation caused by wearing contact lenses. Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended. If you wear contact lenses, remove them before applying Zylofen ophthalmic. This medication may contain a preservative (benzalkonium chloride) that may cause discoloration of contact lenses. Wait at least 10 minutes after using in the eye drops before putting contact lenses into your eyes. Do not allow the medicine dropper tip to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye. Active ingredient matches for Zylofen:Ketotifen in Egypt.
References
ReviewsThe results of a survey conducted on ndrugs.com for Zylofen are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Zylofen. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reportsConsumer reported usefulNo survey data has been collected yetConsumer reported price estimatesNo survey data has been collected yetConsumer reported time for resultsNo survey data has been collected yetConsumer reported ageNo survey data has been collected yetConsumer reviews
Information checked by Dr. Sachin Kumar, MD Pharmacology More about ZylofenClinician Information
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
