What is Bexon 500?
Bexon 500 is used to treat bacterial infections in different areas of the body. The extended-release tablets are used to treat women with vaginal infections (bacterial vaginosis).
Bexon 500 belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, Bexon 500 will not work for colds, flu, or other virus infections.
Bexon 500 is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Bexon 500 is used in certain patients with the following medical conditions:
- Clostridium difficile diarrhea or colitis (antibiotic-associated colitis).
- Crohn's disease (inflammatory bowel disease).
- Gastritis or stomach ulcers due to Helicobacter pylori.
- Giardiasis (parasite infection in the intestines).
Bexon 500 indications
Symptomatic Trichomoniasis. Bexon 500 Capsules USP 375 mg are indicated for the treatment of T. vaginalis infection in females and males when the presence of the trichomonad has been confirmed by appropriate laboratory procedures (wet smears and/or cultures).
Asymptomatic Trichomoniasis. Bexon 500 Capsules USP 375 mg are indicated in the treatment of asymptomatic T. vaginalis infection in females when the organism is associated with endocervicitis, cervicitis, or cervical erosion. Since there is evidence that presence of the trichomonad can interfere with accurate assessment of abnormal cytological smears, additional smears should be performed after eradication of the parasite.
Treatment of Asymptomatic Sexual Partners. T. vaginalis infection is a venereal disease. Therefore, asymptomatic sexual partners of treated patients should be treated simultaneously if the organism has been found to be present, in order to prevent reinfection of the partner. The decision as to whether to treat an asymptomatic male partner who has a negative culture or one for whom no culture has been attempted is an individual one. In making this decision, it should be noted that there is evidence that a woman may become reinfected if her sexual partner is not treated. Also, since there can be considerable difficulty in isolating the organism from the asymptomatic male carrier, negative smears and cultures cannot be relied upon in this regard. In any event, the sexual partner should be treated with Bexon 500 in cases of reinfection.
Amebiasis. Bexon 500 Capsules USP 375 mg are indicated in the treatment of acute intestinal amebiasis (amebic dysentery) and amebic liver abscess.
In amebic liver abscess, Bexon 500 Capsules USP 375 mg therapy does not obviate the need for aspiration or drainage of pus.
Anaerobic Bacterial Infections. Bexon 500 Capsules USP 375 mg are indicated in the treatment of serious infections caused by susceptible anaerobic bacteria. Indicated surgical procedures should be performed in conjunction with Bexon 500 therapy. In a mixed aerobic and anaerobic infection, antimicrobials appropriate for the treatment of the aerobic infection should be used in addition to Bexon 500 Capsules USP 375 mg.
INTRA-ABDOMINAL INFECTIONS, including peritonitis, intra-abdominal abscess, and liver abscess, caused by Bacteroides species including the B. fragilis group (B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus), Clostridium species, Eubacterium species, Peptococcus species, or Peptostreptococcus species.
SKIN AND SKIN STRUCTURE INFECTIONS caused by Bacteroides species including the B. fragilis group, Clostridium species, Peptococcus species, Peptostreptococcus species, or Fusobacterium species.
GYNECOLOGIC INFECTIONS, including endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection, caused by Bacteroides species including the B. fragilis group, Clostridium species, Peptococcus species, Peptostreptococcus species, or Fusobacterium species.
BACTERIAL SEPTICEMIA caused by Bacteroides species including the B. fragilis group or Clostridium species.
BONE AND JOINT INFECTIONS (as adjunctive therapy) caused by Bacteroides species including the B. fragilis group.
CENTRAL NERVOUS SYSTEM (CNS) INFECTIONS, including meningitis and brain abscess, caused by Bacteroides species including the B. fragilis group.
LOWER RESPIRATORY TRACT INFECTIONS, including pneumonia, empyema, and lung abscess, caused by Bacteroides species including the B. fragilis group.
ENDOCARDITIS caused by Bacteroides species including the B. fragilis group.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Bexon 500 Capsules USP 375 mg and other antibacterial drugs, Bexon 500 Capsules USP 375 mg should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
How should I use Bexon 500?
Use Bexon 500 cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Wash and completely dry the affected area. Be sure the area is completely dry before applying Bexon 500 cream.
- Apply a thin layer of Bexon 500 cream to the affected area. Gently rub the medicine in until it is evenly distributed.
- Wash your hands immediately after using Bexon 500 cream.
- You may apply cosmetics after you use Bexon 500 cream. If you are using the lotion, wait 5 minutes after you use Bexon 500 cream before you apply cosmetics so that the lotion has time to dry.
- Use Bexon 500 cream on a regular schedule to get the most benefit from it. Using it at the same time(s) each day will help you remember to use it.
- Continue to use Bexon 500 cream even if your condition improves, unless a doctor tells you otherwise. Do not miss any doses.
- If you miss a dose of Bexon 500 cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Bexon 500 cream.
Uses of Bexon 500 in details
Bexon 500 is an antibiotic that is used to treat a wide variety of infections. It works by stopping the growth of certain bacteria and parasites.
This antibiotic treats only certain bacterial and parasitic infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.
Bexon 500 may also be used with other medications to treat certain stomach/intestinal ulcers caused by a bacteria (H. pylori).
How to use Bexon 500
Take this medication by mouth as directed by your doctor. To prevent stomach upset, take this medication with food or a full glass of water or milk. The dosage is based on your medical condition and response to treatment.
Antibiotics work best when the amount of medicine in your body is kept at a constant level. Take this drug at evenly spaced intervals.
Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.
Tell your doctor if your condition lasts or gets worse.
Bexon 500 description
Each 100 mL contains Metronidazole USP 500 mg, sodium chloride USP 0.72% w/v, water for injection USP as needed.
Bexon 500 injection, USP is a parenteral dosage form of the synthetic antibacterial agent 1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole. The empirical formula is C6H9N3O3 and the molecular weight is 171.15.
Bexon 500 injection, USP in 100 mL is a sterile, nonpyrogenic, iso-osmotic, buffered solution of 500 mg Bexon 500, USP, 790 mg sodium chloride, USP, 47.6 mg dried dibasic sodium phosphate, USP and 22.9 mg anhydrous citric acid, USP. Bexon 500 injection, USP has an osmolarity of 310 mOsmol/L (calc) and a pH of 5.5 (4.5 to 7).
Bexon 500 dosage
Bexon 500 ER Dosage
Generic name: Bexon 500 750mg
Dosage form: tablet, film coated, extended release
See also:
- Bexon 500 tablet, film coated
- Bexon 500 375 Capsules capsule
- Bexon 500 Injection injection, solution
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Bacterial Vaginosis
750 mg once daily by mouth for seven consecutive days.
Bexon 500 ER 750 mg tablets should be taken under fasting conditions, at least one hour before or two hours after meals. The optimum extended-release characteristics of Bexon 500 ER 750 mg are obtained when the drug is taken under fasting conditions.
Bexon 500 ER tablets should not be split, chewed, or crushed.
Dosage Adjustments
Patients Undergoing Hemodialysis
Hemodialysis removes significant amounts of Bexon 500 and its metabolites from systemic circulation. The clearance of Bexon 500 will depend on the type of dialysis membrane used, the duration of the dialysis session, and other factors. If the administration of Bexon 500 cannot be separated from a hemodialysis session, supplementation of Bexon 500 dosage following the hemodialysis session should be considered, depending on the patient's clinical situation.
More about Bexon 500 ER (Bexon 500)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- En Espanol
- 6 Reviews - Add your own review/rating
- Generic Availability
Consumer resources
- Bexon 500 ER extended-release tablets
- Bexon 500 ER
- Bexon 500 ER (Advanced Reading)
- Other brands: Metro
Professional resources
- Bexon 500 ER (FDA)
- Bexon 500 Hydrochloride (AHFS Monograph)
Other formulations
- Bexon 500
- Bexon 500 IV
- Bexon 500 375
Related treatment guides
- Bacterial Vaginitis
- Balantidium coli
- Dientamoeba fragilis
- Nongonococcal Urethritis
- STD Prophylaxis
Bexon 500 interactions
See also:
What other drugs will affect Bexon 500?
Simultaneous administration of Zol with:
Bexon 500 side effects
See also:
What are the possible side effects of Bexon 500?
In a controlled clinical trial, safety data from 141 patients who used Bexon 500 Lotion
Topical Lotion (n=71), or the lotion vehicle (n=70), twice daily and experienced a local cutaneous adverse event which may or may not have been related to the treatments include: local allergic reaction, Bexon 500
Topical Lotion 2 (3%), lotion vehicle 0; contact dermatitis, Bexon 500 Lotion
Topical Lotion 2 (3%), lotion vehicle 1 (1%); pruritus, Bexon 500 Lotion
Topical Lotion 1 (1%), lotion vehicle 0; skin discomfort (burning and stinging), Bexon 500 Lotion
Topical Lotion 1 (1%), lotion vehicle 2 (3%); erythema, Bexon 500 Lotion
Topical Lotion 4 (6%), lotion vehicle 0; dry skin, Bexon 500 Lotion
Topical Lotion 0, lotion vehicle 1 (1%); and worsening of rosacea, Bexon 500 Lotion
Topical Lotion 1 (1%), lotion vehicle 7 (10%).
The following additional adverse experiences have been reported with the topical use of Bexon 500: skin irritation, transient redness, metallic taste, tingling or numbness of extremities, and nausea.
Bexon 500 contraindications
See also:
What is the most important information I should know about Bexon 500?
Hypersensitivity
Bexon 500 Capsules 375 mg are contraindicated in patients with a prior history of hypersensitivity to Bexon 500 or other nitroimidazole derivatives.
In patients with trichomoniasis, Bexon 500 Capsules 375 mg are contraindicated during the first trimester of pregnancy.
Psychotic Reaction with Disulfiram
Use of oral Bexon 500 is associated with psychotic reactions in alcoholic patients who were using disulfiram concurrently. Do not administer Bexon 500 to patients who have taken disulfiram within the last two weeks.
Interaction with Alcohol
Use of oral Bexon 500 is associated with a disulfiram-like reaction to alcohol, including abdominal cramps, nausea, vomiting, headaches, and flushing. Discontinue consumption of alcohol or products containing propylene glycol during and for at least three days after therapy with Bexon 500.
Active ingredient matches for Bexon 500:
Metronidazole in Argentina.
List of Bexon 500 substitutes (brand and generic names) | Sort by popularity |
Unit description / dosage (Manufacturer) | Price, USD |
Bexon Tablets | |
Tablets; Oral; Metronidazole | |
Biatron (Indonesia) | |
Biatron 500 (Indonesia) | |
Biatron 500 500 mg x 5 x 10's | $ 8.46 |
Bio-Metronidazole (South Africa) | |
Biomona (Mexico) | |
Biotazol (Mexico) | |
Biozyl (Bangladesh) | |
Boie Metronidazole (Philippines) | |
Boie Metronidazole 500 mg x 100's | $ 8.89 |
C Dial | |
C Dial 30 ml Suspension (Corona Laboratories) | $ 0.05 |
Camezol (Ghana, Kenya, Latvia, Malawi, Nigeria, Sudan, Tanzania, Uganda, Zambia) | |
Canderm (Brazil) | |
Canderme | |
Cariodent ZOL (Paraguay) | |
Carvezole (Philippines) | |
Cezyl-N | |
Cezyl-N 30 ml Suspension (Ceza Formulations Pvt.Ltd) | $ 0.05 |
Chemagyl (Bangladesh) | |
Chomozin (Taiwan) | |
Chomozin 250 mg | |
Chozine (Taiwan) | |
Chozine 250 mg | |
Ciniflox-M | |
Ciniflox-M 30 ml Syrup (Hinglaj Laboratories of India) | $ 0.05 |
Cipfun M | |
Cipfun M 30 ml Suspension (Moraceae Pharmaceuticals (P) Ltd.) | $ 0.07 |
Ciptrogil (Russian Federation) | |
Cironite M | |
Cironite M 50 ml Suspension (Ciron Drugs & Pharmaceuticals Pvt Ltd) | $ 0.03 |
Claraze (Pakistan) | |
Clinazole (South Africa) | |
Clogel (Taiwan) | |
Clogel 7.5 mg/1 g x 1 g (Oyster Labs Limited) | |
Clogel 7.5 mg/1 g x 10 g (Oyster Labs Limited) | |
Clogel 7.5 mg/1 g x 12 g (Oyster Labs Limited) | |
Clogel 7.5 mg/1 g x 15 g (Oyster Labs Limited) | |
Clogel 7.5 mg/1 g x 20 g (Oyster Labs Limited) | |
Clogel 7.5 mg/1 g x 30 g (Oyster Labs Limited) | |
Clogel Mouth/Throat 100 ml Mouth Wash/Gargle (Oyster Labs Limited) | $ 0.47 |
Clogel Mouth/Throat 50 gm Tooth Paste (Oyster Labs Limited) | $ 0.45 |
CLOGEL CREAM 1 tube / 20 GM cream each (Oyster Labs Limited) | $ 0.69 |
Clogel Cream (Oyster Labs Limited) | $ 0.69 |
Clovizole (Philippines) | |
Clovizole 500 mg/100 mL x 100 mL | $ 4.22 |
Collazole (France) | |
Sponge; Dental; Metronidazole 4.5 mg | |
Colpocin T (Greece, Malta, Serbia) | |
Colpocin-T (Bosnia & Herzegowina, Georgia, Greece, Malta, Serbia) | |
Colpofilin (Argentina) | |
Combizol F | |
Combizol F 30 ml Syrup (Navil Laboratories) | $ 0.08 |
Combizol F Syrup (Navil Laboratories) | $ 0.57 |
COMPEBA (India) | |
COMPEBA Capsule/ Tablet / 200mg / 10 units (Indian Drugs & Pharmaceuticals Ltd.) | $ 0.05 |
See 2352 substitutes for Bexon 500 |
References
- DailyMed. "BISMUTH SUBCITRATE POTASSIUM; METRONIDAZOLE; TETRACYCLINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "metronidazole". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "metronidazole". http://www.drugbank.ca/drugs/DB00916 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Bexon 500 are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Bexon 500. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology