What is Chloro-S?
Chloro-S belongs to the family of medicines called antibiotics. Chloro-S ophthalmic preparations are used to treat infections of the eye. Chloro-S may be given alone or with other medicines that are taken by mouth for eye infections.
Chloro-S is available only with your doctor's prescription.
Chloro-S indications
Chloro-S should be used only in those serious infections for which less potentially dangerous drugs are ineffective or contraindicated. Bacteriological studies should be performed to determine the causative organisms and their sensitivity to Chloro-S.
Chloro-S, 1% (Chloro-S Ophthalmic Ointment, USP) is indicated for the treatment of surface ocular infections involving the conjunctiva and/or cornea caused by Chloro-S-susceptible organisms.
The particular antiinfective drug in this product is active against the following common bacterial eye pathogens:
Staphylococcus aureus
Streptococcus, including Streptococcus pneumoniae
Escherichia coli
Haemophilus influenzae
Klebsiella/Enterobacter species
Moraxella lucunata
(Morax-Axenfeld bacillus)
Neisseria species
This product does not provide adequate coverage against:
Pseudomonas aeruginosa
Serratia marcescens
How should I use Chloro-S?
Use Chloro-S as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Chloro-S is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Chloro-S at home, carefully follow the injection procedures taught to you by your health care provider.
- If Chloro-S contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
- To clear up your infection completely, continue using Chloro-S for the full course of treatment even if you feel better in a few days.
- Keep this product, as well as syringes and needles, out of the reach of children. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
- If you miss a dose of Chloro-S, use it as soon as possible. Then use your doses at evenly spaced times as directed by your doctor. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Chloro-S.
Uses of Chloro-S in details
Use: Labeled Indications
Serious infections: Treatment of serious infections, including cystic fibrosis exacerbations, bacterial meningitis, and bacteremia, caused by Chlamydiaceae, Haemophilus influenzae, Rickettsia, Salmonella spp. (acute infections), and other organisms when other less toxic agents are ineffective or contraindicated.
Guideline recommendations: Chloro-S may be considered for use as an alternative agent to doxycycline in the treatment of tickborne rickettsial diseases (eg, Rocky Mountain spotted fever [RMSF]); however, epidemiologic studies suggest that Chloro-S-treated patients with RMSF are at a higher risk of death compared to tetracycline-treated patients. In addition, Chloro-S is not effective in the treatment of human ehrlichiosis or anaplasmosis, therefore, use with caution in the empiric treatment of tickborne rickettsial diseases (CDC [Biggs 2016]).
Chloro-S description
Each 100 g contains Chloramphenicol 1 g.
Chloro-S dosage
Chloro-S Dosage
Generic name: Chloro-S
Dosage form: ophthalmic ointment
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
A small amount of ointment placed in the lower conjunctival sac every three hours, or more frequently if deemed advisable by the prescribing physician. Administration should be continued day and night the first 48 hours, after which the interval between applications may be increased. Treatment should be continued for at least 48 hours after the eye appears normal.
More about Chloromycetin Ophthalmic (Chloro-S ophthalmic)
- Side Effects
- Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
- 0 Reviews · Be the first to review/rate this drug
Consumer resources
- Other brands: Ocu-Chlor, Chloroptic, AK-Chlor
Professional resources
- Chloro-S (FDA)
Other formulations
- Chloromycetin
- Chloromycetin Sodium Succinate
Chloro-S interactions
Alcohol (Ethyl): Chloro-S (Systemic) may enhance the adverse/toxic effect of Alcohol (Ethyl). Monitor therapy
Barbiturates: Chloro-S (Systemic) may decrease the metabolism of Barbiturates. Barbiturates may increase the metabolism of Chloro-S (Systemic). Monitor therapy
BCG (Intravesical): Antibiotics may diminish the therapeutic effect of BCG (Intravesical). Avoid combination
BCG (Intravesical): Myelosuppressive Agents may diminish the therapeutic effect of BCG (Intravesical). Avoid combination
BCG Vaccine (Immunization): Antibiotics may diminish the therapeutic effect of BCG Vaccine (Immunization). Monitor therapy
Carbocisteine: Chloro-S (Systemic) may enhance the adverse/toxic effect of Carbocisteine. Specifically, Chloro-S may enhance adverse effects of alcohol that is present in liquid formulations of carbocisteine-containing products. Monitor therapy
CefTAZidime: Chloro-S (Systemic) may diminish the therapeutic effect of CefTAZidime. Management: Consider using a different combination of antimicrobials, especially if bactericidal activity is desired. If these agents are combined, monitor for reduced antimicrobial effectiveness and/or therapeutic failure. Consider therapy modification
Chloro-S (Ophthalmic): May enhance the adverse/toxic effect of Myelosuppressive Agents. Monitor therapy
Cholera Vaccine: Antibiotics may diminish the therapeutic effect of Cholera Vaccine. Management: Avoid cholera vaccine in patients receiving systemic antibiotics, and within 14 days following the use of oral or parenteral antibiotics. Avoid combination
Cladribine: May enhance the myelosuppressive effect of Myelosuppressive Agents. Avoid combination
CloZAPine: Myelosuppressive Agents may enhance the adverse/toxic effect of CloZAPine. Specifically, the risk for neutropenia may be increased. Monitor therapy
CycloSPORINE (Systemic): Chloro-S (Systemic) may increase the serum concentration of CycloSPORINE (Systemic). Management: Cyclosporine dose reductions will likely be required with initiation of concurrent Chloro-S. Monitor cyclosporine concentrations and response closely following initiation and/or discontinuation of Chloro-S. Consider therapy modification
Deferiprone: Myelosuppressive Agents may enhance the neutropenic effect of Deferiprone. Management: Avoid the concomitant use of deferiprone and myelosuppressive agents whenever possible. If this combination cannot be avoided, monitor the absolute neutrophil count more closely. Consider therapy modification
Dipyrone: May enhance the adverse/toxic effect of Myelosuppressive Agents. Specifically, the risk for agranulocytosis and pancytopenia may be increased Avoid combination
Fosphenytoin: May decrease the serum concentration of Chloro-S (Systemic). Fosphenytoin may increase the serum concentration of Chloro-S (Systemic). Chloro-S (Systemic) may increase the serum concentration of Fosphenytoin. Monitor therapy
Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol. Monitor therapy
Mesalamine: May enhance the myelosuppressive effect of Myelosuppressive Agents. Monitor therapy
Phenytoin: May decrease the serum concentration of Chloro-S (Systemic). Phenytoin may increase the serum concentration of Chloro-S (Systemic). Chloro-S (Systemic) may increase the serum concentration of Phenytoin. Monitor therapy
Promazine: May enhance the myelosuppressive effect of Myelosuppressive Agents. Monitor therapy
RifAMPin: May increase the metabolism of Chloro-S (Systemic). Monitor therapy
Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Consider therapy modification
Sulfonylureas: Chloro-S (Systemic) may decrease the metabolism of Sulfonylureas. Monitor therapy
Tacrolimus (Systemic): Chloro-S (Systemic) may increase the serum concentration of Tacrolimus (Systemic). Management: Tacrolimus dose reductions will likely be required with initiation of concurrent Chloro-S. Monitor tacrolimus concentrations and response closely following initiation and/or discontinuation of Chloro-S. Consider therapy modification
Typhoid Vaccine: Antibiotics may diminish the therapeutic effect of Typhoid Vaccine. Only the live attenuated Ty21a strain is affected. Management: Vaccination with live attenuated typhoid vaccine (Ty21a) should be avoided in patients being treated with systemic antibacterial agents. Use of this vaccine should be postponed until at least 3 days after cessation of antibacterial agents. Consider therapy modification
Vitamin B12: Chloro-S (Systemic) may diminish the therapeutic effect of Vitamin B12. Monitor therapy
Vitamin K Antagonists (eg, warfarin): Chloro-S (Systemic) may enhance the anticoagulant effect of Vitamin K Antagonists. Chloro-S (Systemic) may increase the serum concentration of Vitamin K Antagonists. Monitor therapy
Voriconazole: Chloro-S (Systemic) may increase the serum concentration of Voriconazole. Monitor therapy
Chloro-S side effects
See also:
What are the possible side effects of Chloro-S?
Applies to Chloro-S: capsule, powder for solution, suspension
In addition to its needed effects, some unwanted effects may be caused by Chloro-S (the active ingredient contained in Chloro-S). In the event that any of these side effects do occur, they may require medical attention.
Stop taking Chloro-S and get emergency help immediately if any of the following effects occur:
Rare - in babies only
- Bloated stomach
- drowsiness
- gray skin color
- low body temperature
- uneven breathing
- unresponsiveness
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Chloro-S:
Less common:
- Pale skin
- sore throat and fever
- unusual bleeding or bruising
- unusual tiredness or weakness (the above side effects may also occur up to weeks or months after you Stop taking Chloro-S)
- Confusion, delirium, or headache
- eye pain, blurred vision, or loss of vision
- numbness, tingling, burning pain, or weakness in the hands or feet
- skin rash, fever, or difficulty in breathing
Minor Side Effects
Some of the side effects that can occur with Chloro-S may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
Less common:
- Diarrhea
- nausea or vomiting
Chloro-S contraindications
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What is the most important information I should know about Chloro-S?
Chloro-S Lotion is contraindicated for premature neonates because their skin may be more permeable than full term infants and their liver enzymes may not be sufficiently developed. It is also contraindicated for patients with Norwegian (crusted) scabies due to possible increased absorption. It is also contraindicated for patients with known seizure disorders and for individuals with a known sensitivity to the product or any of its components.
Active ingredient matches for Chloro-S:
Chloramphenicol in Philippines.
Chloramphenicol or chloramphenicol palmitate in Philippines.
| Unit description / dosage (Manufacturer) | Price, USD |
| Chloro-S 500 mg x 100's | $ 18.60 |
| Chloro-S 125 mg/5 mL x 60 mL | $ 1.29 |
| Chloro-S cap 500 mg 100's (Medic+Aid) | $ 18.60 |
| Chloro-S oral susp 125 mg/5 mL 60 mL x 1's (Medic+Aid) | $ 1.29 |
List of Chloro-S substitutes (brand and generic names): | |
| Chloro-25 Vetag | |
| Chloro-Sleecol (Germany) | |
| Chloro-V (Philippines) | |
| Chloro-V 5 mg/1 mL x 5 mL (Vista Pharma) | |
| Chloro-V ear drops 5 mg/mL 5 mL x 1's (Vista Pharma) | |
| Chlorocaire (Philippines) | |
| Chlorocaire 125 mg/5 mL x 60 mL | |
| Chlorocap | |
| Chlorocap 500 mg Capsule (Pharma Synth Formulations Ltd.) | $ 0.04 |
| Chlorocap 250 mg Capsule (Pharma Synth Formulations Ltd.) | $ 0.02 |
| CHLOROCAP 500MG CAPSULE 1 strip / 10 capsules each (Pharma Synth Formulations Ltd.) | $ 0.70 |
| Chlorocap 500mg Capsule (Pharma Synth Formulations Ltd.) | $ 0.07 |
| Chlorocaps | |
| CHLOROCEPT | |
| CHLOROCEPT 250MG TABLET 1 strip / 10 tablets each (Concept Pharmaceuticals Ltd) | $ 0.12 |
| CHLOROCEPT SUSPENSION 1 bottle / 60 ML suspension each (Concept Pharmaceuticals Ltd) | $ 0.25 |
| CHLOROCEPT TABLET 1 packet / 250 tablets each (Concept Pharmaceuticals Ltd) | $ 2.45 |
| Chlorocept NA Suspension (Concept Pharmaceuticals Ltd) | $ 0.25 |
| Chlorocept 250mg Tablet (Concept Pharmaceuticals Ltd) | $ 0.01 |
| Chlorocid (Ethiopia) | |
| Chlorocid S | |
| Chlorocide | |
| Chlorocidin C | |
| Chlorocidin C Tetran | |
| CHLOROCIN (India) | |
| CHLOROCIN Capsule/ Tablet / 250mg / 10 units (Jagsonpal Pharmaceuticals Ltd) | $ 0.24 |
| CHLOROCIN Liquid / 125mg per 5ml / 60ml units (Jagsonpal Pharmaceuticals Ltd) | $ 0.28 |
| CHLOROCIN Capsule/ Tablet / 250mg / 100 units (Jagsonpal Pharmaceuticals Ltd) | $ 1.20 |
| CHLOROCIN Liquid / 125mg per 5ml / 450ml units (Jagsonpal Pharmaceuticals Ltd) | $ 1.20 |
| CHLOROCIN Capsule/ Tablet / 500mg / 10 units (Jagsonpal Pharmaceuticals Ltd) | $ 0.43 |
| Chlorocin 250mg CAP / 10 (Jagsonpal Pharmaceuticals Ltd) | $ 0.24 |
| Chlorocin 250mg CAP / 100 (Jagsonpal Pharmaceuticals Ltd) | $ 1.20 |
| Chlorocin 500mg CAP / 10 (Jagsonpal Pharmaceuticals Ltd) | |
| Chlorocin 125mg x 5mL SUSP / 450ml (Jagsonpal Pharmaceuticals Ltd) | $ 1.20 |
| Chlorocin 125mg x 5mL SUSP / 60ml (Jagsonpal Pharmaceuticals Ltd) | $ 0.28 |
| 250 mg x 10's (Jagsonpal Pharmaceuticals Ltd) | $ 0.24 |
| 250 mg x 100's (Jagsonpal Pharmaceuticals Ltd) | $ 1.20 |
| 500 mg x 10's (Jagsonpal Pharmaceuticals Ltd) | |
| 125 mg x 5 mL x 450ml (Jagsonpal Pharmaceuticals Ltd) | $ 1.20 |
| 125 mg x 5 mL x 60ml (Jagsonpal Pharmaceuticals Ltd) | $ 0.28 |
| Chlorocin 250 mg Capsule (Jagsonpal Pharmaceuticals Ltd) | $ 0.02 |
| Chlorocin 60 ml Suspension (Jagsonpal Pharmaceuticals Ltd) | $ 0.02 |
| CHLOROCIN 125 MG SUSPENSION 1 bottle / 450 ML suspension each (Jagsonpal Pharmaceuticals Ltd) | $ 1.54 |
| CHLOROCIN 125 MG SYRUP 1 bottle / 60 ML syrup each (Jagsonpal Pharmaceuticals Ltd) | $ 0.31 |
| CHLOROCIN 250 MG CAPSULE 1 packet / 100 capsules each (Jagsonpal Pharmaceuticals Ltd) | $ 2.86 |
| CHLOROCIN 250 MG CAPSULE 1 strip / 10 capsules each (Jagsonpal Pharmaceuticals Ltd) | $ 0.26 |
| CHLOROCIN 500 MG CAPSULE 1 strip / 10 capsules each (Jagsonpal Pharmaceuticals Ltd) | $ 0.80 |
See 1905 substitutes for Chloro-S | |
References
- DailyMed. "CHLORAMPHENICOL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "chloramphenicol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "chloramphenicol". http://www.drugbank.ca/drugs/DB00446 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Chloro-S are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Chloro-S. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
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Information checked by Dr. Sachin Kumar, MD Pharmacology
