• Clobex Shampoo indications
• Uses of Clobex Shampoo in details
• Clobex Shampoo description
• Clobex Shampoo dosage
• Clobex Shampoo interactions
• Clobex Shampoo side effects
• Clobex Shampoo contraindications

What is Clobex Shampoo?

Clobex Shampoo lotion is a prescription corticosteroid medicine used on the skin (topical) for the relief of swelling (inflammation) and itching caused by certain skin conditions in people 18 years of age and older.

Clobex Shampoo lotion should not be used for the treatment of acne vulgaris, rosacea or red, dry itchy skin (dermatitis) around the mouth.

Clobex Shampoo lotion is not recommended in children under 18 years of age.

Important: Clobex Shampoo lotion is for use on the skin only. Do not get the lotion near or in your eyes, mouth or vagina.

Clobex Shampoo indications

Indication

Clobex Shampoo® Spray, 0.05% is a super-high potent topical corticosteroid formulation indicated for the treatment of moderate to severe plaque psoriasis affecting up to 20% body surface area (BSA) in patients 18 years of age or older. The total dosage should not exceed 50 g (59 mL or 2 fl. oz.) per week. Do not use more than 26 sprays per application or 52 sprays per day. Treatment should be limited to 4 consecutive weeks.

Patients should be instructed to use Clobex Shampoo® Spray, 0.05% for the minimum amount of time necessary to achieve the desired results see [Dosage and Administration (2)].

Use in patients under 18 years of age is not recommended because safety has not been established and because numerically high rates of HPA axis suppression were seen with other clobetasol propionate topical formulations.

Limitations of Use

Clobex Shampoo® Spray, 0.05% should not be used on the face, axillae, or groin. Clobex Shampoo® Spray, 0.05% should not be used if there is atrophy at the treatment site. Clobex Shampoo® Spray, 0.05% should not be used in the treatment of rosacea or perioral dermatitis.

How should I use Clobex Shampoo?

Use Clobex Shampoo as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Wash your hands before using Clobex Shampoo. If your fingers are warm, rinse them in cold water and dry before you apply Clobex Shampoo.
• Use the smallest amount of medicine necessary to cover the affected area.
• Turn the can upside down and squirt a small amount of foam (up to the size of a golf ball or about 1½ capfuls) into the cap of the can, onto a clean saucer, or onto another cool, clean surface. You may also squirt it directly onto the affected area. Do not squirt the medicine directly into the hand because it will start to melt immediately upon touching warm skin.
• If you are applying Clobex Shampoo to the scalp, move the hair away from the affected area and gently rub the medicine into the affected area until the foam disappears. Repeat until the entire affected area of the scalp is treated.
• If you are applying Clobex Shampoo to other areas, gently rub the medicine into the skin until it disappears.
• Throw away any unused medicine that has been squirted out of the can.
• Wash your hands immediately after using Clobex Shampoo, unless your hands are a part of the treated area.
• Do not use Clobex Shampoo on your face, groin, or underarms unless your doctor tells you otherwise.
• Do not use Clobex Shampoo over large areas of the body without first checking with your doctor.
• Do not bandage or wrap the affected area unless directed to do so by your doctor.
• If the can seems warm or the foam seems runny, rinse the can with cool water.
• If you miss a dose of Clobex Shampoo, apply it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Clobex Shampoo.

Uses of Clobex Shampoo in details

Clobex Shampoo is used to treat itching, redness, dryness, inflammation, and discomfort of various scalp and skin conditions, including immune-mediated skin disease with red scaly patches (psoriasis).

Clobex Shampoo description

Clobex Shampoo scalp application also contains the following excipients: Carbomer, isopropyl alcohol, sodium hydroxide and purified water.

Clobex Shampoo cream also contains the following excipients: Glyceryl monostearate, cetostearyl alcohol, chlorocresol, sodium citrate, monohydrated citric acid, purified water, Arlacel 165, beeswax substitute 6621 and propylene glycol.

Clobex Shampoo ointment also contains the following excipients: Propylene glycol, white soft paraffin and sorbitan sesquioleate.

Clobex Shampoo dosage

Clobex Shampoo Dosage

Generic name: clobetasol propionate 0.5mg in 1g

Dosage form: cream, ointment

See also:

• Clobex Shampoo Cream cream
• Clobex Shampoo E Cream cream
• Clobex Shampoo Gel topical gel

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Apply a thin layer of Clobex Shampoo® Cream or Ointment to the affected skin areas twice daily and rub in gently and completely.

Clobex Shampoo® Cream and Ointment are super-high potency topical corti-costeroids; therefore, treatment should be limited to 2 consecutive weeks and amounts greater than 50 g/week should not be used.

As with other highly active corticosteroids, therapy should be discontinued when control has been achieved. If no improvement is seen within 2 weeks, reassessment of diagnosis may be necessary.

Clobex Shampoo® Cream and Ointment should not be used with occlusive dressings.

Geriatric Use: In studies where geriatric patients (65 years of age or older, see PRECAUTIONS) have been treated with Clobex Shampoo® Cream or Ointment, safety did not differ from that in younger patients; therefore, no dosage adjustment is recommended.

More about Clobex Shampoo (Clobex Shampoo)

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Consumer resources

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Clobex Shampoo interactions

See also:
What other drugs will affect Clobex Shampoo?

Aldesleukin: Corticosteroids may diminish the antineoplastic effect of Aldesleukin. Avoid combination

Corticorelin: Corticosteroids may diminish the therapeutic effect of Corticorelin. Specifically, the plasma ACTH response to corticorelin may be blunted by recent or current corticosteroid therapy. Monitor therapy

Deferasirox: Corticosteroids may enhance the adverse/toxic effect of Deferasirox. Specifically, the risk for GI ulceration/irritation or GI bleeding may be increased. Monitor therapy

Hyaluronidase: Corticosteroids may diminish the therapeutic effect of Hyaluronidase. Management: Patients receiving corticosteroids (particularly at larger doses) may not experience the desired clinical response to standard doses of hyaluronidase. Larger doses of hyaluronidase may be required. Consider therapy modification

Ritodrine: Corticosteroids may enhance the adverse/toxic effect of Ritodrine. Monitor therapy

Clobex Shampoo side effects

See also:
What are the possible side effects of Clobex Shampoo?

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug, and may not reflect the rates observed in practice.

Clobex Shampoo Cream was evaluated in two randomized, multicenter, prospective, vehicle-controlled clinical trials in subjects with moderate to severe plaque psoriasis. Subjects applied Clobex Shampoo Cream or vehicle cream twice daily for 14 days. A total of 354 subjects applied Clobex Shampoo Cream and 178 subjects applied vehicle.

The adverse reaction that occurred in at least 1% of subjects treated with Clobex Shampoo Cream and at a higher incidence than in subjects treated with vehicle cream was application site discoloration (2% versus 1%).

Less common local adverse events occurring in < 1% of subjects treated with Clobex Shampoo Cream were application site atrophy, telangiectasia and rash.

Postmarketing Experience

The following adverse reactions have been identified during post-approval use of clobetasol propionate: striae, irritation, dryness, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, hypertrichosis, and miliaria. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Clobex Shampoo contraindications

See also:
What is the most important information I should know about Clobex Shampoo?

Hypersensitivity to clobetasol propionate or to any of the excipients of Clobex Shampoo.

Scalp Application: Infections of the scalp.

Cream/Ointment: Primary skin lesions caused by infection with fungi or bacteria; primary cutaneous viral infections (eg, herpes simplex, chickenpox); rosacea; acne vulgaris; pruritus without inflammation; perianal and genital pruritus; perioral dermatitis.

Use in children: Clobex Shampoo is contraindicated in children <1 year.

Children are more likely to develop local and systemic side effects of topical corticosteroids and in general, require shorter courses and less potent agents than adults.

Care should be taken when using Clobex Shampoo to ensure the amount applied is the minimum that provides therapeutic benefit.

Active ingredient matches for Clobex Shampoo:

Clobetasol topical

05g in 100mL/Clobetasol propionate 0

References

1. PubChem. "clobetasol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
2. DrugBank. "Clobetasol". http://www.drugbank.ca/drugs/DB11750 (accessed September 17, 2018).
3. MeSH. "Glucocorticoids". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology