Digene Tab Tablet Uses

• Digene Tab Tablet indications
• Uses of Digene Tab Tablet in details
• Digene Tab Tablet dosage
• Digene Tab Tablet interactions
• Digene Tab Tablet side effects
• Digene Tab Tablet contraindications

What is Digene Tab Tablet?

Digene Tab Tablet is used as a dietary supplement for individuals who are deficient in Digene Tab Tablet. Although a balanced diet usually supplies all the Digene Tab Tablet a person needs, Digene Tab Tablet supplements may be needed by patients who have lost Digene Tab Tablet because of illness or treatment with certain medicines.

Lack of Digene Tab Tablet may lead to irritability, muscle weakness, and irregular heartbeat.

Injectable Digene Tab Tablet is given only by or under the supervision of a health care professional. Some oral Digene Tab Tablet preparations are available only with a prescription. Others are available without a prescription.

Digene Tab Tablet indications

peptic ulcer, gastritis, dyspepsia

How should I use Digene Tab Tablet?

Use Digene Tab Tablet as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Digene Tab Tablet by mouth with food.
• If you miss a dose of Digene Tab Tablet and are using it regularly, take it as soon as possible. If it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Digene Tab Tablet.

Uses of Digene Tab Tablet in details

This medication is a mineral supplement used to prevent and treat low amounts of Digene Tab Tablet in the blood. Digene Tab Tablet is very important for the normal functioning of cells, nerves, muscles, bones, and the heart. Usually, a well-balanced diet provides normal blood levels of Digene Tab Tablet. However, certain situations cause your body to lose Digene Tab Tablet faster than you can replace it from your diet. These situations include treatment with "water pills" (diuretics such as furosemide, hydrochlorothiazide), a poor diet, alcoholism, or other medical conditions (e.g., severe diarrhea/vomiting, stomach/intestinal absorption problems, poorly controlled diabetes).

How to use Digene Tab Tablet (oxide/AA chelate)

Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

It is best to take Digene Tab Tablet supplements with a meal to reduce stomach upset and diarrhea unless otherwise directed by the product instructions or your doctor.

Take each dose with a full glass (8 ounces or 240 milliliters) of water unless your doctor directs you otherwise. Swallow extended-release capsules and delayed-release/enteric coated tablets or capsules whole. Do not crush or chew extended-release or delayed-release/enteric coated capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

If you are using a liquid product, use a medication measuring device to carefully measure the dose. Do not use a household spoon because you may not get the correct dose. If you are using a suspension, shake the bottle well before each dose.

Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time(s) each day. Dosage is based on your medical condition and response to treatment. Do not increase your dose or take it more often than directed on the product package or by your doctor. Too much Digene Tab Tablet in the blood can cause serious side effects.

Tell your doctor if symptoms of low Digene Tab Tablet blood levels (e.g., muscle cramps, tiredness, irritability, depression) persist or worsen. If you think you may have a serious medical problem, seek immediate medical attention.

Digene Tab Tablet dosage

Usual Adult Dose for Hypomagnesemia

500 to 1000 mg Digene Tab Tablet gluconate (27 to 54 mg elemental Digene Tab Tablet) orally 3 times a day.

Usual Adult Dose for Dietary Supplement

500 to 1000 mg Digene Tab Tablet gluconate (27 to 54 mg elemental Digene Tab Tablet) orally once a day.

Usual Pediatric Dose for Hypomagnesemia

10 to 20 mg/kg of elemental Digene Tab Tablet per dose orally 4 times a day. Use Digene Tab Tablet gluconate oral liquid preparations for more accurate measurement of dose.

Renal Dose Adjustments

Do not use without physician supervision in patients with renal impairment due to increased risk of hypermagnesemia. The use of Digene Tab Tablet salts are generally contraindicated in patients with severe renal dysfunction.

Liver Dose Adjustments

Data not available

Dose Adjustments

May increase by 500 to 1,000 mg/day (27 to 54 mg elemental Digene Tab Tablet) in order to achieve a normal serum Digene Tab Tablet level. Daily doses > 1,000 mg (54 mg elemental Digene Tab Tablet) should be given in 2 to 3 divided doses.

Precautions

Because Digene Tab Tablet is primarily eliminated by the kidney, there is significant risk of hypermagnesemia in patients with renal dysfunction.

Dialysis

Data not available; however, use of Digene Tab Tablet salts is generally contraindicated in renal failure.

Other Comments

Digene Tab Tablet supplements are often used with "low normal" serum Digene Tab Tablet levels in patients predisposed to hypomagnesemia (e.g., patients on diuretics).

Digene Tab Tablet interactions

See also:
What other drugs will affect Digene Tab Tablet?

Alfacalcidol: May increase the serum concentration of Digene Tab Tablet Salts. Consider therapy modification

Alpha-Lipoic Acid: Digene Tab Tablet Salts may decrease the absorption of Alpha-Lipoic Acid. Alpha-Lipoic Acid may decrease the absorption of Digene Tab Tablet Salts. Consider therapy modification

Baloxavir Marboxil: Polyvalent Cation Containing Products may decrease the serum concentration of Baloxavir Marboxil. Avoid combination

Bictegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Bictegravir. Management: Administer bictegravir under fasting conditions at least 2 hours before or 6 hours after polyvalent cation containing products. Coadministration of bictegravir with or 2 hours after most polyvalent cation products is not recommended. Consider therapy modification

Bisphosphonate Derivatives: Polyvalent Cation Containing Products may decrease the serum concentration of Bisphosphonate Derivatives. Management: Avoid administration of oral medications containing polyvalent cations within: 2 hours before or after tiludronate/clodronate/etidronate; 60 minutes after oral ibandronate; or 30 minutes after alendronate/risedronate. Exceptions: Pamidronate; Zoledronic Acid. Consider therapy modification

Calcitriol (Systemic): May increase the serum concentration of Digene Tab Tablet Salts. Management: Consider using a non-Digene Tab Tablet-containing antacid or phosphate-binding product in patients also receiving calcitriol. If Digene Tab Tablet-containing products must be used with calcitriol, serum Digene Tab Tablet concentrations should be monitored closely. Consider therapy modification

Calcium Channel Blockers: May enhance the adverse/toxic effect of Digene Tab Tablet Salts. Digene Tab Tablet Salts may enhance the hypotensive effect of Calcium Channel Blockers. Monitor therapy

Deferiprone: Polyvalent Cation Containing Products may decrease the serum concentration of Deferiprone. Management: Separate administration of deferiprone and oral medications or supplements that contain polyvalent cations by at least 4 hours. Consider therapy modification

Dolutegravir: Digene Tab Tablet Salts may decrease the serum concentration of Dolutegravir. Management: Administer dolutegravir at least 2 hours before or 6 hours after oral Digene Tab Tablet salts. Administer the dolutegravir/rilpivirine combination product at least 4 hours before or 6 hours after oral Digene Tab Tablet salts. Consider therapy modification

Doxercalciferol: May enhance the hypermagnesemic effect of Digene Tab Tablet Salts. Management: Consider using a non-Digene Tab Tablet-containing antacid or phosphate-binding product in patients also receiving doxercalciferol. If Digene Tab Tablet-containing products must be used with doxercalciferol, serum Digene Tab Tablet concentrations should be monitored closely. Consider therapy modification

Eltrombopag: Polyvalent Cation Containing Products may decrease the serum concentration of Eltrombopag. Management: Administer eltrombopag at least 2 hours before or 4 hours after oral administration of any polyvalent cation containing product. Consider therapy modification

Elvitegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Elvitegravir. Management: Administer elvitegravir 2 hours before or 6 hours after the administration of polyvalent cation containing products. Consider therapy modification

Gabapentin: Digene Tab Tablet Salts may enhance the CNS depressant effect of Gabapentin. Specifically, high dose intravenous/epidural Digene Tab Tablet sulfate may enhance the CNS depressant effects of gabapentin. Digene Tab Tablet Salts may decrease the serum concentration of Gabapentin. Management: Administer gabapentin at least 2 hours after use of a Digene Tab Tablet-containing antacid. Monitor patients closely for evidence of reduced response to gabapentin therapy. Monitor for CNS depression if high dose IV/epidural Digene Tab Tablet sulfate is used. Consider therapy modification

Levothyroxine: Digene Tab Tablet Salts may decrease the serum concentration of Levothyroxine. Management: Separate administration of oral levothyroxine and oral Digene Tab Tablet salts by at least 4 hours. Consider therapy modification

Multivitamins/Fluoride (with ADE): Digene Tab Tablet Salts may decrease the serum concentration of Multivitamins/Fluoride (with ADE). Specifically, Digene Tab Tablet salts may decrease fluoride absorption. Management: To avoid this potential interaction separate the administration of Digene Tab Tablet salts from administration of a fluoride-containing product by at least 1 hour. Consider therapy modification

Mycophenolate: Digene Tab Tablet Salts may decrease the serum concentration of Mycophenolate. Management: Separate doses of mycophenolate and oral Digene Tab Tablet salts. Monitor for reduced effects of mycophenolate if taken concomitant with oral Digene Tab Tablet salts. Consider therapy modification

Neuromuscular-Blocking Agents: Digene Tab Tablet Salts may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. Monitor therapy

PenicillAMINE: Polyvalent Cation Containing Products may decrease the serum concentration of PenicillAMINE. Management: Separate the administration of penicillamine and oral polyvalent cation containing products by at least 1 hour. Consider therapy modification

Phosphate Supplements: Digene Tab Tablet Salts may decrease the serum concentration of Phosphate Supplements. Management: Administer oral phosphate supplements as far apart from the administration of an oral Digene Tab Tablet salt as possible to minimize the significance of this interaction. Exceptions: Sodium Glycerophosphate Pentahydrate. Consider therapy modification

Quinolones: Digene Tab Tablet Salts may decrease the serum concentration of Quinolones. Management: Administer oral quinolones several hours before (4 h for moxi/pe/spar-, 2 h for others) or after (8 h for moxi-, 6 h for cipro/dela-, 4 h for lome/pe-, 3 h for gemi-, and 2 h for levo-, nor-, or ofloxacin or nalidixic acid) oral Digene Tab Tablet salts. Exceptions: LevoFLOXacin (Oral Inhalation). Consider therapy modification

Raltegravir: Digene Tab Tablet Salts may decrease the serum concentration of Raltegravir. Management: Avoid the use of oral / enteral Digene Tab Tablet salts with raltegravir. No dose separation schedule has been established that adequately reduces the magnitude of interaction. Avoid combination

Tetracyclines: Digene Tab Tablet Salts may decrease the absorption of Tetracyclines. Only applicable to oral preparations of each agent. Management: Avoid coadministration of oral Digene Tab Tablet salts and oral tetracyclines. If coadministration cannot be avoided, administer oral Digene Tab Tablet at least 2 hours before, or 4 hours after, oral tetracyclines. Monitor for decreased tetracycline therapeutic effects. Exceptions: Eravacycline. Consider therapy modification

Trientine: Polyvalent Cation Containing Products may decrease the serum concentration of Trientine. Management: Avoid concomitant administration of trientine and oral products that contain polyvalent cations. If oral iron supplements are required, separate the administration by 2 hours. If other oral polyvalent cations are needed, separate administration by 1 hour. Consider therapy modification

Digene Tab Tablet side effects

See also:
What are the possible side effects of Digene Tab Tablet?

Diarrhoea and bowel discomfort, due to the release of carbon dioxide caused by both Digene Tab Tablet carbonate and sodium bicarbonate.

Excessive administration of Digene Tab Tablet leads to the development of hypermagnesaemia, especially in renal insufficiency. Symptoms of hypermagnesaemia may include flushing of the skin, thirst, hypotension due to peripheral vasodilation, drowsiness, confusion, loss of tendon reflexes due to neuromuscular blockade, muscle weakness, respiratory depression, cardiac arrhythmias, coma, and cardiac arrest. Digene Tab Tablet carbonate and Digene Tab Tablet trisilicate may interfere with the absorption of other medicines when taken concomitantly. Administration of sodium bicarbonate by mouth can cause stomach cramps and flatulence.

Excessive administration of sodium bicarbonate may lead to metabolic alkalosis, especially in patients with impaired renal function. Symptoms may include shortness of breath, muscle weakness (associated with potassium depletion), and mental disturbances such as restlessness, convulsions, and coma. Muscle hypertonicity, twitching, and tetany may develop especially in hypocalcaemic patients due to increased protein binding and renal reabsorption of calcium. Excessive doses may also lead to sodium overloading and hyperosmolality. Sodium excess may result in hypernatraemia, a rise in extracellular concentration or in too much sodium and water in the body without change in extracellular concentration.

Retention of sodium leads to the accumulation of extracellular fluid (oedema) which may affect the cerebral, pulmonary or peripheral circulations.

Digene Tab Tablet contraindications

See also:
What is the most important information I should know about Digene Tab Tablet?

Sensitivity to any of the ingredients; patients with renal impairment and acute dehydration.

Active ingredient matches for Digene Tab Tablet:

Magnesium Hydroxide (Milk of Magnesia)

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Information checked by Dr. Sachin Kumar, MD Pharmacology