Grilinctus- BM Uses

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• Grilinctus- BM indications
• Uses of Grilinctus- BM in details
• Grilinctus- BM description
• Grilinctus- BM dosage
• Grilinctus- BM interactions
• Grilinctus- BM side effects
• Grilinctus- BM contraindications

What is Grilinctus- BM?

Grilinctus- BM injection is used to prevent bronchospasm in patients 12 years of age and older with asthma, bronchitis, emphysema, and other lung diseases.

Grilinctus- BM belongs to the family of medicines known as bronchodilators. Bronchodilators are medicines that relax the muscles in the bronchial tubes (air passages) of the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.

Grilinctus- BM is available only with your doctor's prescription.

Grilinctus- BM indications

Oral

Acute bronchospasm

Adult: Initially, 2.5 mg or 3 mg tid, up to 5 mg tid as necessary. As modified-release tab: 5 mg or 7.5 mg bid.

Child: <12 yr Initially, 0.05 mg/kg/dose tid, increase gradually as required. Max: 5 mg/day; 12-15 yr 2.5 mg tid; >15 yr Same as adult dose.

Inhalation

Acute bronchospasm

Adult: As metered-dose powd inhaler: 250-500 mcg as required. Max: 2,000 mcg daily.

Parenteral

Severe bronchospasm

Adult: 250-500 mcg up to 4 times daily by SC, IM or IV inj, or by IV infusion as a soln containing 3-5 mcg/mL at a rate of 0.5-1 mL/min.

Child: 2-15 yr 0.01 mg/kg. Max: 0.3 mg/dose.

Reconstitution: Add 10 mL of Grilinctus- BM soln for inj to 40 mL of dextrose 5% if using a syringe pump or to 490 mL of dextrose 5% if syringe pump is not available.

Intravenous

Uncomplicated premature labour

Adult: To arrest labour between 22-37 wk of gestation: Initially, 5 mcg/min, w/ increments of 2.5 mcg/min at 20 min intervals until contractions stop. Max: 20 mcg/min. Continue for 1 hr after contractions have ceased, then decrease by 2.5 mcg/min every 20 min to lowest dose that maintains suppression. Max duration: 48 hr.

Reconstitution: Add 10 mL of Grilinctus- BM soln for inj to 40 mL of dextrose 5% if using a syringe pump or to 490 mL of dextrose 5% if syringe pump is not available.

Inhalation

Severe bronchospasm

Adult: As 1% nebuliser soln: 2.5-10 mg 2-4 times daily.

Child: <25 kg: 2-5 mg 2-4 times daily; ≥25 kg: 5 mg 2-4 times daily.

How should I use Grilinctus- BM?

Use Grilinctus- BM as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Grilinctus- BM is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Grilinctus- BM at home, a health care provider will teach you how to use it. Be sure you understand how to use Grilinctus- BM. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
• Do not use Grilinctus- BM if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
• If you miss a dose of Grilinctus- BM and are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Grilinctus- BM.

Uses of Grilinctus- BM in details

Use: Labeled Indications

Asthma/Bronchospasm: Prevention and reversal of bronchospasm in patients ≥12 years of age with asthma and reversible bronchospasm associated with bronchitis and emphysema

Off Label Uses

Extravasation management, sympathomimetic vasoconstrictors

Data from a limited number of patients suggests that Grilinctus- BM may be beneficial for the management of extravasation of sympathomimetic vasoconstrictors.

Grilinctus- BM description

Grilinctus- BM turbuhaler is a breath-activated, multiple-dose powder inhaler free from propellant, lubricant, preservative, carrier substances or other additives.

Grilinctus- BM injection also contains the following inactive ingredients: Sodium chloride, HCl (for pH adjustment) and water for injections.

Grilinctus- BM sulphate is 2-(tert-butylamino)-1-(3,5-dihydroxyphenyl)ethanol sulphate.

Grilinctus- BM dosage

Tablet: Adults: Usual Dose: 1-2 tablets. Children 12-15 years: 1 tablet. All doses to be taken 2-3 times daily.

To be administered at approximately 6-hr intervals. In most patients, the optimum single dose is 2 tablets. In patients unusually sensitive to sympathomimetic amines, initiate treatment with 1 tablet 3 times a day. If adequate bronchodilation is not obtained, the dose may be increased to 2 tablets.

Syrup: Adults and Children >15 years: 10-15 mL (2-3 tsp). Children 7-15 years: 5-10 mL (1-2 tsp); 3-7 years: 2.5-5 mL (½-1 tsp); <3 years: Not recommended. All doses to be taken 3 times a day.

Nebulizing Solution: Grilinctus- BM nebulizing solution is used with dilution.

Inhale 1 mL of solution containing Grilinctus- BM sulfate 2.5 mg every 6 hrs (or 4 times in 24-hr period).

If the entire dose is not inhaled at 1 occasion, the solution is stable for 24 hrs in the reservoir of the nebulizer.

Note: The patient's inhalation technique should be checked regularly and the optimal dose of Grilinctus- BM should be adjusted for each nebulizer. If the effect of the inhalation is reduced, the patient should seek medical care.

Nonselective blocking agents may partly or totally inhibit the effect of β-stimulants.

Directions for Use: 1. Pipette 1 mL of Grilinctus- BM nebulizing solution from the bottle by using a calibrated medicine dropper provided in the pack, equivalent to Grilinctus- BM sulfate 2.5 mg.

2. Drop the solution into an electric nebulizer and dilute it with normal saline solution 2 mL and start inhalation.

3. Repeat the same procedure every 6 hrs or 4 times in 24-hr period.

Grilinctus- BM interactions

See also:
What other drugs will affect Grilinctus- BM?

Drug Interactions

The concomitant use of Grilinctus- BM with other sympathomimetic agents is not recommended, since the combined effect on the cardiovascular system may be deleterious to the patient

Monoamine Oxidase Inhibitors or Tricyclic Antidepressants: Grilinctus- BM should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents, since the action of Grilinctus- BM on the vascular system may be potentiated

Beta-Blockers Beta-adrenergic receptor blocking agents not only block the pulmonary effect of beta-agonists, such as Grilinctus- BM, but may produce severe bronchospasm in asthmatic patients. Therefore, patients with asthma should not normally be treated with beta-blockers. However, under certain circumstances, e.g., as prophylaxis after myocardial infarction, there may be no acceptable alternatives to the use of beta-adrenergic blocking agents in patients with asthma. In this setting, cardioselective beta-blockers could be considered, although they should be administered with caution

Diuretics The ECG changes and/or hypokalemia that may result from the administration of nonpotassium-sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. Although the clinical significance of these effects is not known, caution is advised in the coadministration of beta-agonists with nonpotassium-sparing diuretics.

Grilinctus- BM side effects

See also:
What are the possible side effects of Grilinctus- BM?

Applies to Grilinctus- BM: oral elixir, oral tablet

Other dosage forms:

• subcutaneous solution

In addition to its needed effects, some unwanted effects may be caused by Grilinctus- BM (the active ingredient contained in Grilinctus- BM). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Grilinctus- BM:

More common:

• Shakiness in the legs, arms, hands, or feet
• trembling or shaking of the hands or feet

• Extra heartbeat
• feeling faint, dizzy, or lightheadedness
• feeling of warmth or heat
• flushing or redness of the skin, especially on the face and neck
• headache
• sweating

• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• excessive muscle tone
• muscle stiffness
• muscle tension or tightness

If any of the following symptoms of overdose occur while taking Grilinctus- BM, get emergency help immediately:

Symptoms of overdose:

• Arm, back, or jaw pain
• blurred vision
• chest pain or discomfort
• chest tightness or heaviness
• confusion
• convulsions
• decreased urine
• dizziness
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• dry mouth
• fainting
• fast, pounding, or irregular heartbeat or pulse
• general feeling of discomfort or illness
• increased thirst
• loss of appetite
• mood changes
• muscle pain or cramps
• nausea or vomiting
• nervousness
• numbness or tingling in the hands, feet, or lips
• pounding in the ears
• seizures
• shortness of breath
• sleeplessness
• slow or fast heartbeat
• trouble sleeping
• unable to sleep
• unusual tiredness or weakness

Minor Side Effects

Some of the side effects that can occur with Grilinctus- BM may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

• Sleepiness or unusual drowsiness

• Anxiety
• lack or loss of strength

• Fever
• rash
• redness, soreness, or itching skin
• seeing, hearing, or feeling things that are not there
• sores, welting, or blisters

Grilinctus- BM contraindications

See also:
What is the most important information I should know about Grilinctus- BM?

1.

Prolonged Tocolysis

Grilinctus- BM sulfate has not been approved for and should not be used for prolonged tocolysis (beyond 48-72 hours). In particular, Grilinctus- BM sulfate should not be used for maintenance tocolysis in the outpatient or home setting.

2.

Hypersensitivity

Grilinctus- BM sulfate injection is contraindicated in patients known to be hypersensitive to sympathomimetic amines or any component of this drug product.

Active ingredient matches for Grilinctus- BM:

Terbutaline

References

1. DailyMed. "TERBUTALINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubChem. "terbutaline". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
3. DrugBank. "terbutaline". http://www.drugbank.ca/drugs/DB00871 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology