What is Hidralazina Clorhidrato?
Hidralazina Clorhidrato is used to treat high blood pressure (hypertension). It is also used to control high blood pressure in a mother during pregnancy (pre-eclampsia or eclampsia) or in emergency situations when blood pressure is extremely high (hypertensive crisis).
High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure can increase the risk of heart attacks and strokes.
Hidralazina Clorhidrato works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload.
Hidralazina Clorhidrato is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not specifically included in product labeling, Hidralazina Clorhidrato is used in certain patients with the following medical condition:
- Congestive heart failure.
Hidralazina Clorhidrato indications
Oral
Hypertension
Adult: 40-50 mg daily in divided doses, increased according to response. Max: 200 mg/day.
Renal impairment: Reduce dose or prolong dosage interval.
Hepatic impairment: Reduce dose or prolong dosage interval.
Intravenous
Hypertensive crisis
Adult: 5-10 mg via slow IV inj, repeated if necessary after 20-30 min. Alternatively, as continuous IV, initial dose is 200-300 mcg/min.
Maintenance: 50-150 mcg/min.
How should I use Hidralazina Clorhidrato?
Use Hidralazina Clorhidrato injection as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Hidralazina Clorhidrato injection is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Hidralazina Clorhidrato injection at home, a health care provider will teach you how to use it. Be sure you understand how to use Hidralazina Clorhidrato injection. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Hidralazina Clorhidrato injection if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Hidralazina Clorhidrato injection, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Hidralazina Clorhidrato injection.
Uses of Hidralazina Clorhidrato in details
Use: Labeled Indications
Hypertension: Management of moderate to severe hypertension. Note: Not recommended for the initial treatment of hypertension (ACC/AHA [Whelton 2017])
Off Label Uses
Heart failure with reduced ejection fraction
Data from a randomized, double-blind trial comparing enalapril and Hidralazina Clorhidrato plus isosorbide dinitrate in patients with chronic heart failure with reduced ejection fraction (HFrEF) support the use of Hidralazina Clorhidrato (in combination with isosorbide dinitrate) in patients with intolerance to angiotensin-converting enzyme (ACE) inhibitor therapy.
Hidralazina Clorhidrato description
A direct-acting vasodilator that is used as an antihypertensive agent. [PubChem]
Hidralazina Clorhidrato dosage
Hidralazina Clorhidrato Dosage
Generic name: Hidralazina Clorhidrato hydrochloride
Dosage form: Tablets
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Initiate therapy in gradually increasing dosages; adjust according to individual response. Start with 10 mg four times daily for the first 2-4 days, increase to 25 mg four times daily for the balance of the first week. For the second and subsequent weeks, increase dosage to 50 mg four times daily. For maintenance, adjust dosage to the lowest effective levels.
The incidence of toxic reactions, particularly the L.E. cell syndrome, is high in the group of patients receiving large doses of Hidralazina Clorhidrato.
In a few resistant patients, up to 300 mg of Hidralazina Clorhidrato daily may be required for a significant antihypertensive effect. In such cases, a lower dosage of Hidralazina Clorhidrato combined with a thiazide and/or reserpine or a beta blocker may be considered. However, when combining therapy, individual titration is essential to ensure the lowest possible therapeutic dose of each drug.
More about Hidralazina Clorhidrato (Hidralazina Clorhidrato)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- En Espanol
- 0 Reviews - Add your own review/rating
Consumer resources
- Hidralazina Clorhidrato
- Hidralazina Clorhidrato (Advanced Reading)
- Hidralazina Clorhidrato Injection (Advanced Reading)
Professional resources
- Hidralazina Clorhidrato (FDA)
- Hidralazina Clorhidrato Hydrochloride (AHFS Monograph)
Related treatment guides
- Heart Failure
- High Blood Pressure
- Hypertensive Emergency
Hidralazina Clorhidrato interactions
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What other drugs will affect Hidralazina Clorhidrato?
MAO inhibitors should be used with caution in patients receiving Hidralazina Clorhidrato.
When other potent parenteral antihypertensive drugs, such as diazoxide, are used in combination with Hidralazina Clorhidrato, patients should be continuously observed for several hours for any excessive fall in blood pressure. Profound hypotensive episodes may occur when diazoxide injection and Hidralazina Clorhidrato (Hidralazina Clorhidrato) are used concomitantly.
Hidralazina Clorhidrato side effects
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What are the possible side effects of Hidralazina Clorhidrato?
Applies to Hidralazina Clorhidrato: oral tablet
Other dosage forms:
- injection solution
In addition to its needed effects, some unwanted effects may be caused by Hidralazina Clorhidrato (the active ingredient contained in Hidralazina Clorhidrato). In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Hidralazina Clorhidrato:
More common:
- Arm, back, or jaw pain
- chest pain or discomfort
- chest tightness or heaviness
- fast, pounding, or irregular heartbeat or pulse
- nausea
- shortness of breath
- sweating
- Black, tarry stools
- blindness or vision changes
- blisters on the skin
- blurred vision
- burning of the face or mouth
- burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings
- chills
- clumsiness or unsteadiness
- confusion
- cough
- difficult or labored breathing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fever and sore throat
- general feeling of discomfort or illness or weakness
- joint pain
- lower back or side pain
- muscle pain
- numbness, tingling, pain, or weakness in the hands or feet
- painful or difficult urination
- pale skin
- shakiness in the legs, arms, hands, or feet
- skin rash or itching
- swelling of the feet or lower legs
- swollen, painful, or tender lymph glands in the neck, armpit, or groin
- tightness in the chest
- trembling or shaking of the hands or feet
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
- unusual tiredness or weakness
- weakness in hands or feet
- Dark urine
- light-colored stools
- upper right abdominal or stomach pain
- yellow eyes and skin
If any of the following symptoms of overdose occur while taking Hidralazina Clorhidrato, get emergency help immediately:
Symptoms of overdose:
- Feeling of warmth
- headache
- redness of the face, neck, arms, and occasionally, upper chest
Minor Side Effects
Some of the side effects that can occur with Hidralazina Clorhidrato may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
More common:
- Diarrhea
- loss of appetite
- weight loss
- Constipation
- difficulty with moving
- dizziness
- feeling anxious or depressed
- muscle cramps, pain, or stiffness
- pain in the joints
- rash, hives, welts, or itching
- stuffy nose
- watery eyes
Hidralazina Clorhidrato contraindications
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What is the most important information I should know about Hidralazina Clorhidrato?
You should not use this medication if you are allergic to Hidralazina Clorhidrato, or if you have coronary artery disease, or rheumatic heart disease affecting the mitral valve.
Before taking Hidralazina Clorhidrato, tell your doctor if you have kidney disease, lupus, angina pectoris (chest pain), or if you have ever had a stroke.
While taking Hidralazina Clorhidrato, avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Call your doctor at once if you have a serious side effect such as fast or pounding heartbeats, swelling, numbness or tingling, dark-colored urine, joint pain or swelling with fever, chest pain, weakness or tired feeling, and urinating less than usual or not at all.
To be sure this medication is helping your condition and is not causing harmful effects, your blood pressure will need to be checked often. You may also need occasional blood tests. Do not miss any scheduled appointments.
Keep using Hidralazina Clorhidrato as directed, even if you feel well. High blood pressure often has no symptoms, so you may not know when your blood pressure is high. You may need to use blood pressure medication for the rest of your life.
Active ingredient matches for Hidralazina Clorhidrato:
Hydralazine in Chile, Colombia.
List of Hidralazina Clorhidrato substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Hidralazina Synthesis (Colombia) | |
| Hipoftalin | |
| HYDRALAZE | |
| HYDRALAZE 25 MG TABLET 1 strip / 10 tablets each (Dahlia Pharmaceutical Pvt Ltd) | $ 1.15 |
| Hydralaze 25mg Tablet (Dahlia Pharmaceutical Pvt Ltd) | $ 0.11 |
| Hydralazine (Australia, Bahrain, Canada, Ireland, Japan, Malta, New Zealand, Oman, Philippines, Taiwan, Thailand, United Kingdom) | |
| Tablet; Oral; Hydralazine Hydrochloride 25 mg | |
| Tablet; Oral; Hydralazine Hydrochloride 50 mg | |
| Tablet; Oral; Hydralazine Hydrochloride 10 mg | |
| Tablet; Oral; Hydralazine Hydrochloride 100 mg | |
| Injectable; Injection; Hydralazine Hydrochloride 20 mg / ml | |
| Hydralazine 20 mg/ml vial | $ 18.00 |
| Hydralazine 100 mg tablet | $ 1.65 |
| Hydralazine-HCTZ 50-50 mg capsule | $ 1.20 |
| HydrALAZINE HCl 100 mg tablet | $ 1.05 |
| Hydralazine-HCTZ 25-25 mg capsule | $ 0.81 |
| Hydralazine-HCTZ 100-50 mg capsule | $ 0.75 |
| HydrALAZINE HCl 50 mg tablet | $ 0.67 |
| Apresoline 50 mg tablet | $ 0.65 |
| HydrALAZINE HCl 25 mg tablet | $ 0.53 |
| HydrALAZINE HCl 10 mg tablet | $ 0.47 |
| Hydralazine 50 mg tablet | $ 0.44 |
| Hydralazine 25 mg tablet | $ 0.35 |
| Apo-Hydralazine 50 mg Tablet | $ 0.29 |
| Novo-Hylazin 50 mg Tablet | $ 0.29 |
| Apo-Hydralazine 25 mg Tablet | $ 0.24 |
| Hydralazine 10 mg tablet | $ 0.22 |
| Apo-Hydralazine 10 mg Tablet | $ 0.11 |
| Novo-Hylazin 10 mg Tablet | $ 0.11 |
| Hydralazine tablet 10 mg (Aa Pharma Inc (Canada)) | |
| Hydralazine tablet 25 mg (Aa Pharma Inc (Canada)) | |
| Hydralazine tablet 50 mg (Aa Pharma Inc (Canada)) | |
| Hydralazine tablet 25 mg/1 (Cardinal Health (US)) | |
| Hydralazine tablet 50 mg/1 (Cardinal Health (US)) | |
| Hydralazine Actavis (United Kingdom) | |
| Hydralazine CBS (New Zealand) | |
| HYDRALAZINE HCL 25MG TAB | |
| Hydralazine HCl CF (Netherlands) | |
| Hydralazine Hydrochloride Hetero (United States) | |
| Hydralazine Injection | |
| Hydralazine T.O. (Thailand) | |
| Hydrapres (Argentina, Spain) | |
| Hydrapress (Japan) | |
| Hylazine (Taiwan) | |
| Hylazine 25 mg (Unijules Life Sciences) | |
See 174 substitutes for Hidralazina Clorhidrato | |
References
- PubChem. "hydralazine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "hydralazine". http://www.drugbank.ca/drugs/DB01275 (accessed September 17, 2018).
- DTP/NCI. "hydralazine: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Hidralazina Clorhidrato are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Hidralazina Clorhidrato. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
