What is Kafosed?
Kafosed is a cough suppressant. It affects the signals in the brain that trigger cough reflex.
Kafosed is used to treat a cough.
Kafosed will not treat a cough that is caused by smoking, asthma, or emphysema.
Kafosed may also be used for purposes not listed in this medication guide.
Kafosed indications
used to treat symptoms caused by the common cold, flu, allergies, hay fever, or other breathing illnesses (e.g., sinusitis, bronchitis). Kafosed is a cough suppressant that affects a certain part of the brain (cough center), reducing the urge to cough. Decongestants help relieve stuffy nose symptoms. Antihistamines relieve watery eyes, itchy eyes/nose/throat, runny nose, and sneezing.
How should I use Kafosed?
Use Kafosed orally disintegrating strips as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Kafosed orally disintegrating strips by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Do not remove the strip from the pouch until you are ready to take Kafosed orally disintegrating strips. Be sure that your hands are dry when you touch the strip.
- Remove the strip from the pouch and place it onto the tongue. The strip dissolves quickly and can be swallowed with saliva. It may be taken with or without water.
- Use the strip right away after you open the pouch. Do not store it for future use.
- If you miss a dose of Kafosed orally disintegrating strips and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Kafosed orally disintegrating strips.
Uses of Kafosed in details
This medication is used for temporary relief of coughs without phlegm that are caused by certain infections of the air passages (e.g., sinusitis, common cold). This product should not usually be used for an ongoing cough from smoking or long-term breathing problems (e.g., chronic bronchitis, emphysema) unless directed by your doctor. This product contains Dextromethorphan. It is a cough suppressant that works by decreasing the feeling of needing to cough.
Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Ask your doctor or pharmacist for more details about using your product safely.
These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients. Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).
How to use Kafosed
Take this medication by mouth, usually every 4 to 12 hours as needed or as directed by your doctor. If stomach upset occurs, take with food or milk. Use a medication-measuring device to measure your dose of liquid medication. Do not use a household spoon because you may not get the correct dose. If you are taking a suspension, shake the product well before measuring out your dose.
Dosage is based on the product you are taking and your age, medical condition, and response to treatment. If you are using this medication for self-treatment (without a prescription from your doctor), follow the specific dosing instructions on the packaging to find the correct dose for your age.
If your doctor directs you to take this medication daily, take it regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.
Improper use of this medication (abuse) may result in serious harm (e.g., brain damage, seizure, death). Do not increase your dose, take it more frequently, or use it for a longer time than prescribed. Properly stop the medication when so directed.
Tell your doctor if your symptoms persist or worsen after more than 1 week or if you also have fever, chills, headache, or rash. These may be signs of a more serious condition.
Kafosed description
The d-isomer of the codeine analog of levorphanol. Kafosed shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.
Kafosed dosage
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Capsule,
Oral, as hydrobromide:
Robafen Cough: 15 mg [contains brilliant blue fcf (fd&c blue #1), fd&c red #40]
Robitussin Lingering CoughGels: 15 mg [contains brilliant blue fcf (fd&c blue #1), fd&c red #40, polyethylene glycol, propylene glycol]
Gel,
Oral, as hydrobromide:
ElixSure Cough: 7.5 mg/5 mL (120 mL) [alcohol free; contains carbomer 934p, propylene glycol, propylparaben; cherry bubblegum flavor]
Liquid,
Oral, as hydrobromide:
Buckleys Cough: 12.5 mg/5 mL (118 mL) [alcohol free, sugar free; contains butylparaben, menthol, propylparaben, saccharin sodium]
Little Colds Cough Formula: 7.5 mg/mL (30 mL) [alcohol free, dye free, saccharin free; contains sodium benzoate; grape flavor]
PediaCare Childrens Long-Act: 7.5 mg/5 mL (118 mL) [contains brilliant blue fcf (fd&c blue #1), saccharin sodium, sodium benzoate]
Robitussin Lingering LA Cough: 15 mg/5 mL (118 mL [DSC]) [contains alcohol, usp, fd&c red #40, menthol, saccharin sodium, sodium benzoate]
Kafosed: 10 mg/5 mL (480 mL [DSC], 3780 mL [DSC]) [alcohol free, dye free, fructose free, sodium free, sorbitol free, sugar free]
Triaminic Long Acting Cough: 7.5 mg/5 mL (118 mL) [alcohol free, dye free, pseudoephedrine free; contains benzoic acid, propylene glycol]
Lozenge, Mouth/Throat, as hydrobromide:
Hold: 5 mg (10 ea)
Hold: 5 mg (10 ea) [cherry flavor]
Trocal Cough Suppressant: 7.5 mg (1 ea [DSC])
Strip,
Oral, as hydrobromide:
Triaminic Long Acting Cough: 7.5 mg (14 ea, 16 ea) [contains alcohol, usp, fd&c red #40; cherry flavor]
Triaminic Long Acting Cough: 7.5 mg (14 ea) [contains alcohol, usp, fd&c red #40, isopropyl alcohol]
Suspension Extended Release,
Oral:
Cough DM: Kafosed polistirex [equivalent to Kafosed hydrobromide 30 mg/5 mL] (89 mL) [alcohol free; contains fd&c yellow #10 aluminum lake, methylparaben, polysorbate 80, propylparaben, sodium metabisulfite; orange flavor]
Delsym: Kafosed polistirex [equivalent to Kafosed hydrobromide 30 mg/5 mL] (89 mL, 148 mL) [alcohol free; contains brilliant blue fcf (fd&c blue #1), disodium edta, methylparaben, polyethylene glycol, polysorbate 80, propylene glycol, propylparaben; grape flavor]
Delsym: Kafosed polistirex [equivalent to Kafosed hydrobromide 30 mg/5 mL] (89 mL, 148 mL) [alcohol free; contains edetate disodium, fd&c yellow #6 (sunset yellow), methylparaben, polyethylene glycol, polysorbate 80, propylene glycol, propylparaben; orange flavor]
Delsym Cough Childrens: Kafosed polistirex [equivalent to Kafosed hydrobromide 30 mg/5 mL] (89 mL, 148 mL) [alcohol free; contains brilliant blue fcf (fd&c blue #1), edetate disodium, methylparaben, polyethylene glycol, polysorbate 80, propylene glycol, propylparaben, soybean oil; grape flavor]
Delsym Cough Childrens: Kafosed polistirex [equivalent to Kafosed hydrobromide 30 mg/5 mL] (89 mL, 148 mL) [alcohol free; contains edetate disodium, fd&c yellow #6 (sunset yellow), methylparaben, polyethylene glycol, polysorbate 80, propylene glycol, propylparaben, soybean oil; orange flavor]
GoodSense Cough DM: Kafosed polistirex [equivalent to Kafosed hydrobromide 30 mg/5 mL] (148 mL) [alcohol free, gluten free; contains fd&c yellow #10 aluminum lake, methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
GoodSense Cough DM Childrens: Kafosed polistirex [equivalent to Kafosed hydrobromide 30 mg/5 mL] (89 mL, 148 mL) [alcohol free, gluten free; contains fd&c yellow #10 aluminum lake, methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
Robitussin 12 Hour Cough: Kafosed polistirex [equivalent to Kafosed hydrobromide 30 mg/5 mL] (89 mL) [alcohol free; contains brilliant blue fcf (fd&c blue #1), methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
Robitussin 12 Hour Cough: Kafosed polistirex [equivalent to Kafosed hydrobromide 30 mg/5 mL] (89 mL) [alcohol free; contains fd&c yellow #10 (quinoline yellow), methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
Robitussin 12 Hour Cough
Child: Kafosed polistirex [equivalent to Kafosed hydrobromide 30 mg/5 mL] (89 mL) [alcohol free; contains brilliant blue fcf (fd&c blue #1), methylparaben, polysorbate 80, propylparaben, sodium metabisulfite]
Generic: Kafosed polistirex [equivalent to Kafosed hydrobromide 30 mg/5 mL] (89 mL)
Syrup,
Oral, as hydrobromide:
Creomulsion
Adult: 20 mg/15 mL (118 mL [DSC])
Creomulsion for Children: 5 mg/5 mL (118 mL [DSC]) [cherry flavor]
Robitussin Childrens Cough LA: 7.5 mg/5 mL (118 mL) [alcohol free; contains fd&c red #40, propylene glycol, saccharin sodium, sodium benzoate; fruit punch flavor]
Silphen DM Cough: 10 mg/5 mL (118 mL) [contains alcohol, usp; strawberry flavor]
Triaminic Long Acting Cough: 7.5 mg/5 mL (118 mL [DSC]) [alcohol free, dye free; contains benzoic acid, edetate disodium, propylene glycol]
Dosing: Adult
Cough suppressant:
Oral: 10 to 20 mg every 4 hours
or 20 to 30 mg every 6 to 8 hours; extended release: 60 mg twice daily; maximum: 120 mg/24 hours
Dosing: Geriatric
Refer to adult dosing.
Dosing: Pediatric
Note: Safety and efficacy for the use of cough and cold products in infants and young children limited; the AAP warns against the use of these products for respiratory illnesses in infants and young children (AAP 2018; FDA 2017).
Cough suppressant:
Oral:
Oral syrup (immediate release):
Children 2 to <6 years: 5 mg every 4 hours as needed; do not exceed 6 doses in 24 hours.
Children 6 to <12 years: 10 mg every 4 hours as needed; do not exceed 6 doses in 24 hours.
Children ≥12 years and Adolescents: 20 mg every 4 hours as needed; do not exceed 6 doses in 24 hours.
Long-acting liquid: Children ≥12 years and Adolescents: 30 mg every 6 to 8 hours as needed; do not exceed 4 doses in 24 hours.
Oral capsule: Children ≥12 years and Adolescents: 30 mg every 6 to 8 hours as needed; do not exceed 4 doses in 24 hours.
Extended-release suspension (Kafosed polistirex):
Children 4 to <6 years: 15 mg every 12 hours as needed; do not exceed 30 mg in 24 hours.
Children 6 to <12 years: 30 mg every 12 hours as needed; do not exceed 60 mg in 24 hours.
Children ≥12 years and Adolescents: 60 mg every 12 hours as needed; do not exceed 120 mg in 24 hours.
Kafosed interactions
See also:
What other drugs will affect Kafosed?
MAO inhibitors (including furazolidone, procarbazine, selegiline) when administered simultaneous with Kafosed may cause adrenergic crisis, collapse, coma, dizziness, agitation, increased blood pressure, hyperpyrexia, intracranial hemorrhage, lethargy, nausea, cramps, tremor. In combination with tricyclic antidepressants (amitriptyline, etc.) Kafosed Lafayette Pharmaceutical Laboratory may appeal serotonin syndrome and possible subsequent death. Amiodarone, fluoxetine, quinidine, inhibiting system cytochrome P450, may increase the drug concentration in the blood. Tobacco smoke can lead to increased secretion of glands in the background of inhibition of cough reflex. Some inhibitors of CYP450 (such as quinidine) increase and extended effects of this medicine.
Kafosed side effects
See also:
What are the possible side effects of Kafosed?
Applies to Kafosed: oral capsule, oral capsule liquid filled, oral elixir, oral liquid, oral lozenge/troche, oral solution, oral suspension, oral suspension extended release, oral syrup, oral tablet
In addition to its needed effects, some unwanted effects may be caused by Kafosed (the active ingredient contained in Kafosed Adult Formula). In the event that any of these side effects do occur, they may require medical attention.
Severity: Moderate
If any of the following side effects occur while taking Kafosed, check with your doctor or nurse as soon as possible:
Symptoms of overdose:
- Blurred vision
- confusion
- difficulty in urination
- drowsiness or dizziness
- nausea or vomiting (severe)
- shakiness and unsteady walk
- slowed breathing
- unusual excitement, nervousness, restlessness, or irritability (severe)
Minor Side Effects
Some of the side effects that can occur with Kafosed may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
Less common or rare:
- Confusion
- constipation
- dizziness (mild)
- drowsiness (mild)
- headache
- nausea or vomiting
- stomach pain
Kafosed contraindications
See also:
What is the most important information I should know about Kafosed?
Do not use Kafosed if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take Kafosed before the MAO inhibitor has cleared from your body.
Do not use any other over-the-counter cough, cold, or allergy medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains Dextromethorphan.
Active ingredient matches for Kafosed:
Dextromethorphan in Bahrain, Oman.
List of Kafosed substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| K.B. Dextro (Thailand) | |
| K.B. Dextro 15 mg x 1, 000's | |
| Kafosed 15mg/ml (Oman) | |
| Kaumatuss (Italy) | |
| Kazu Soln (Taiwan) | |
| Kazu Soln 3 mg/1 mL x 1 mL | |
| Kazu Soln 3 mg/1 mL x 60 mL | |
| Ke Le Er (China) | |
| Ke Li Ting (China) | |
| KeDi (China) | |
| Kening (China) | |
| Kidcof | |
| Kidcof 60 ml Syrup (Ceza Formulations Pvt.Ltd) | $ 0.02 |
| Kidkof DM | |
| Kidkof DM 60 ml Syrup (Oyster Labs Limited) | $ 0.03 |
| Kimipect 15 | |
| Ko Ko Sou (Taiwan) | |
| Ko Ko Sou 1 gal | |
| Kofarest Lozenges (India) | |
| Kofarest Lozenges Dextromethorphan hydrobromide5 mg, Cetylpyridinium chloride1.3 mg, Menthol 5.2 mg. LOZ / 10 (Centaur) | $ 0.30 |
| 10's (Centaur) | $ 0.30 |
| KOFAREST LOZENGES loz 10's (Centaur) | $ 0.30 |
| Kofarest-Dx (India) | |
| Kofarest-Dx Dextromethorphan hydrobromide10 mg, Chlorpheniraminemaleate 2 mg, Menthol 1.5 mg/5mL. SYR / 60ml (Centaur (Shashvatam)) | $ 0.42 |
| 60ml (Centaur (Shashvatam)) | $ 0.42 |
| KOFAREST-DX syr 60ml (Centaur (Shashvatam)) | $ 0.42 |
| Kofban (India) | |
| Kofban Dextromethorphan 15 mg, Phenylephrine 5 mg, Chlorpheniramine maleate 2 mg, Menthol 0.5 mg. SYR / 100ml (Auspi Medicaments) | $ 0.58 |
| 100ml (Auspi Medicaments) | $ 0.58 |
| Kofban 100 ml Syrup (Auspi Medicaments) | $ 0.03 |
| KOFBAN syr 100ml (Auspi Medicaments) | $ 0.58 |
| Kofend-D (India) | |
| Kofend-D - SYR / 100ml | $ 0.30 |
| 100ml | $ 0.30 |
| Koffex (Canada) | |
| Koffex DM (Canada) | |
| Syrup; Oral; Dextromethorphan Hydrobromide 3 mg / ml (Rougier) | |
| Koffex DM syrup 15 mg (Rougier) | |
| Koffex DM Children | |
| Liquid; Oral; Dextromethorphan Hydrobromide 7.5 mg / 5 ml | |
| Koffex DM Children liquid 7.5 mg (Technilab Pharma Inc. (Canada)) | |
| Koffex DM pour Enfants | |
| Syrup; Oral; Dextromethorphan Hydrobromide 7.5 mg / 5 ml | |
| Koffex DM sucrose free | |
| Syrup; Oral; Dextromethorphan Hydrobromide 3 mg / ml | |
| Kofrid Tab (India) | |
| Kofrid Tab Dextromethorphan hydrobromide10 mg, Cetirizinedihydrochloride 5 mg. TAB / 10 (Meridian) | $ 0.28 |
| 10's (Meridian) | $ 0.28 |
| KOFRID TAB tab 10's (Meridian) | $ 0.28 |
| Kofryl P | |
| Kofryl P 100 ml Syrup (Bactolac Formulations Pvt. Ltd.) | $ 0.02 |
| Kofsooth (India) | |
| Kofsooth Dextromethorphan 10 mg, Phenylephrine hydrochloride 5mg, Chlorphenamine maleate 2mg. SYR / 100ml (Amray) | $ 0.59 |
| KOFSOOTH syr 100ml (Amray) | $ 0.59 |
| Koftame (India) | |
| Koftame Chlorpheniramine maleate 2 mg, Dextromethorphan hydrobromide10 mg, Phenylephrinehydrochloride 5 mg/5 mL. SYR / 120ml (ICPA Health Products Ltd.) | $ 0.43 |
| 120ml (ICPA Health Products Ltd.) | $ 0.43 |
| Koftame 60 ml Syrup (ICPA Health Products Ltd.) | $ 0.02 |
| Koftame 120 ml Syrup (ICPA Health Products Ltd.) | $ 0.01 |
See 1851 substitutes for Kafosed | |
References
- DailyMed. "DEXTROMETHORPHAN HYDROBROMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "dextromethorphan". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "dextromethorphan". http://www.drugbank.ca/drugs/DB00514 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Kafosed are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Kafosed. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yet1 consumer reported price estimates
Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?The below mentioned numbers have been reported by ndrugs.com website users about whether the Kafosed drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
| Users | % | ||
|---|---|---|---|
| Not expensive | 1 | 100.0% | |
4 consumers reported time for results
To what extent do I have to use Kafosed before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 2 days and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Kafosed. To get the time effectiveness of using Kafosed drug by other patients, please click here.
| Users | % | ||
|---|---|---|---|
| 2 days | 1 | 25.0% | |
| 2 weeks | 1 | 25.0% | |
| 1 month | 1 | 25.0% | |
| 3 days | 1 | 25.0% | |
45 consumers reported age
| Users | % | ||
|---|---|---|---|
| 30-45 | 22 | 48.9% | |
| 16-29 | 8 | 17.8% | |
| 1-5 | 6 | 13.3% | |
| 6-15 | 5 | 11.1% | |
| 46-60 | 2 | 4.4% | |
| < 1 | 2 | 4.4% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
