What is Kloderma?
Kloderma topical is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. The solution are used for scalp problems, the foam is used for mild to moderate plaque psoriasis, the cream, lotion, and spray are used for moderate to severe plaque psoriasis, and the foam and shampoo are used for moderate to severe scalp psoriasis. Kloderma is a corticosteroid (cortisone-like medicine or steroid).
Kloderma is available only with your doctor's prescription.
Kloderma indications
Indication
Kloderma Spray, 0.05% is a super-high potent topical corticosteroid formulation indicated for the treatment of moderate to severe plaque psoriasis affecting up to 20% body surface area (BSA) in patients 18 years of age or older. The total dosage should not exceed 50 g (59 mL or 2 fl. oz.) per week. Do not use more than 26 sprays per application or 52 sprays per day. Treatment should be limited to 4 consecutive weeks. Patients should be instructed to use Kloderma Spray, 0.05% for the minimum amount of time necessary to achieve the desired results. Use in patients under 18 years of age is not recommended because safety has not been established and because numerically high rates of HPA axis suppression were seen with other Kloderma topical formulations.
Limitations of Use
Kloderma Spray, 0.05% should not be used on the face, axillae, or groin. Kloderma Spray, 0.05% should not be used if there is atrophy at the treatment site. Kloderma Spray, 0.05% should not be used in the treatment of rosacea or perioral dermatitis.
How should I use Kloderma?
Use Kloderma emollient foam as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Wash your hands before using Kloderma emollient foam. If your fingers are warm, rinse them in cold water and dry before you apply Kloderma emollient foam.
- Use the smallest amount of medicine necessary to cover the affected area.
- Shake well before each use.
- Turn the can upside down and squirt a small amount of foam (up to the size of a golf ball) into the cap of the can, onto a clean saucer, or onto another cool, clean surface. You may also squirt it directly onto the affected area. Do not squirt the medicine directly into the hand because it will start to melt immediately upon touching warm skin.
- Gently rub the medicine into the affected area until it disappears.
- Throw away any unused medicine that has been squirted out of the can.
- Wash your hands immediately after using Kloderma emollient foam, unless your hands are a part of the treated area.
- Do not use Kloderma emollient foam on your face, groin, or underarms unless your doctor tells you otherwise.
- Do not use Kloderma emollient foam over large areas of the body without first checking with your doctor.
- Do not bandage or wrap the affected area unless directed to do so by your doctor.
- If you miss a dose of Kloderma emollient foam, apply it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Kloderma emollient foam.
Uses of Kloderma in details
Kloderma is used to treat itching, redness, dryness, swelling, and discomfort of various scalp and skin conditions, including immune-mediated skin disease with red scaly patches (psoriasis).
Kloderma description
Kloderma is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Kloderma diminishes gastric acid and pepsin secretion. Kloderma also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ganglionic parasympathetic inhibitor. It has not been shown to be effective in contributing to the healing of peptic ulcer, decreasing the rate of recurrence, or preventing complications.
Kloderma dosage
Kloderma Dosage
Generic name: Kloderma 0.5mg in 1g
Dosage form: aerosol foam
See also:
- Kloderma-E aerosol, foam
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Kloderma-E Foam is not for oral, ophthalmic, or intravaginal use.
Apply a thin layer of Kloderma-E Foam to the affected area(s) twice daily, morning and evening for up to 2 consecutive weeks; therapy should be discontinued when control has been achieved. The maximum weekly dose should not exceed 50 g or an amount greater than 21 capfuls per week. For proper dispensing of foam, shake the can, hold it upside down, and depress the actuator. Dispense a small amount of foam (about a capful) and gently massage the medication into the affected areas (excluding the face, groin, and axillae) until the foam is absorbed. Avoid contact with the eyes.
More about Kloderma (Kloderma topical)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Espanol
- 8 Reviews - Add your own review/rating
- Generic Availability
Consumer resources
- Kloderma foam
- Kloderma
- Kloderma (Advanced Reading)
- Other brands: Temovate, Clobex, Dermovate, Clobevate, More (6) »
Professional resources
- Kloderma (FDA)
- Kloderma (AHFS Monograph)
Other formulations
- Kloderma-E
- Kloderma/Kloderma-E Kit
Related treatment guides
- Lichen Planus
- Atopic Dermatitis
- Dermatitis
- Dermatological Disorders
- Eczema
- More (2) »
Kloderma interactions
See also:
What other drugs will affect Kloderma?
ACE inhibitors
May result in severely elevated serum potassium levels.
Alcohol, barbiturates, narcotics
Orthostatic hypotension may be potentiated.
Angiotensin II receptor antagonists (eg, candesartan, losartan, telmisartan)
Risk of hyperkalemia, especially in patients with renal impairment or type 2 diabetes, may be increased.
Corticosteroids
Increased risk of electrolyte depletion, particularly hypokalemia.
Digitalis glycosides
May decrease digoxin clearance, resulting in increased serum digoxin levels and toxicity; may attenuate inotropic action of digoxin.
Diuretics
Risk of dilutional hyponatremia may be increased.
Mitotane
May decrease therapeutic response to mitotane.
Salicylates
May result in decreased diuretic effect.
Lithium
Lithium clearance may be reduced, increasing the risk of toxicity.
Nondepolarizing muscle relaxants (eg, tubocurarine)
Increased responsiveness to muscle relaxant effect may occur.
NSAIDs (eg, indomethacin)
Risk of severe hyperkalemia may be increased.
Potassium preparations
May severely increase serum potassium levels, possibly resulting in cardiac arrhythmias or cardiac arrest. Do not take with potassium preparations.
Pressor amines (eg, norepinephrine)
Vascular responsiveness to norepinephrine may be decreased. Use with caution in patients receiving regional or general anesthesia.
Kloderma side effects
See also:
What are the possible side effects of Kloderma?
In a controlled pharmacokinetic study, 5 of 13 subjects experienced reversible suppression of the adrenals at any time during the 14 days of Kloderma (Kloderma) Foam therapy to at least 20% of the body surface area. Of the 13 subjects studied, 1 of 9 with psoriasis were suppressed after 14 days and all 4 of the subjects with atopic dermatitis had abnormal cortisol levels indicative of adrenal suppression at some time after starting therapy with Kloderma (Kloderma) Foam.
Table 3: Subjects with reversible HPA axis suppression at any time during treatment
| Dermatosis | Kloderma Foam |
| Psoriasis | 1 of 9 |
| Atopic Dermatitis* | 4 of 4 |
| *Kloderma Foam is not indicated for non-scalp atopic dermatitis, as the safety and efficacy of Kloderma Foam in non-scalp atopic dermatitis has not been established. Use in children under 12 years of age is not recommended. |
Systemic absorption of topical corticosteroids has produced reversible adrenal suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients.
In a controlled clinical trial (188 subjects) with Kloderma (Kloderma) Foam in subjects with psoriasis of the scalp, there were no localized scalp adverse reactions reported in the Kloderma (Kloderma) Foam treated subjects. In two controlled clinical trials (360 subjects) with Kloderma (Kloderma) Foam in subjects with psoriasis of non-scalp regions, localized adverse events that occurred in the Kloderma (Kloderma) Foam treated subjects included application site burning (10%), application site dryness ( < 1%), and other application site reactions (4%).
In larger controlled trials with other Kloderma formulations, the most frequently reported local adverse reactions have included burning, stinging, irritation, pruritus, erythema, folliculitis, cracking and fissuring of the skin, numbness of the fingers, skin atrophy, and telangiectasia (all less than 2%).
The following additional local adverse reactions have been reported with topical corticosteroids, but they may occur more frequently with the use of occlusive dressings and higher potency corticosteroids such as Kloderma (Kloderma) Foam. These reactions are listed in an approximate decreasing order of occurrence: dryness, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, striae, and miliaria.
Kloderma contraindications
See also:
What is the most important information I should know about Kloderma?
Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts or for longer than recommended.
Topical steroid medicine can be absorbed through the skin, which may cause steroid side effects throughout the body.
Do not cover treated skin areas with a bandage or other covering unless your doctor has told you to. If you are treating the diaper area of a baby, do not use plastic pants or tight-fitting diapers. Covering the skin that is treated with Kloderma topical can increase the amount of medicine your skin absorbs, which may lead to unwanted side effects. Follow your doctor's instructions.
Do not use this medication on a child without medical advice. Children are more likely to absorb large amounts of a topical steroid through the skin. Steroid absorption in children may cause unwanted side effects, or a delay in growth with long-term use. Talk with your doctor if you think your child is not growing at a normal rate while using this medication over a long treatment period.
Contact your doctor if your condition does not improve within 2 weeks of using this medicine, or if you develop signs of a bacterial, fungal, or viral skin infection.
Active ingredient matches for Kloderma:
Clobetasol in Indonesia.
Clobetasol propionate in Indonesia.
| Unit description / dosage (Manufacturer) | Price, USD |
| Kloderma 0.05 % x 5 g x 1's | $ 1.86 |
| Kloderma 0.05 % x 10 g x 1's | $ 2.71 |
List of Kloderma substitutes (brand and generic names): | |
| Klobecort (Thailand) | |
| Klobecort 0.05 % x 500 g | $ 28.82 |
| Klomadex (Argentina) | |
| Klonat (Indonesia) | |
| KLORYL (India) | |
| KLORYL Cream/ Gel/ Ointment / 0.05/ % / 15gm units (Unimarck Healthcare Ltd) | $ 0.39 |
| 0.05 % w/w x 15g (Unimarck Healthcare Ltd) | $ 0.48 |
| Kloryl 0.05% CRM / 15g (Unimarck Healthcare Ltd) | $ 0.39 |
| Kloryl Skin 15 gm Cream (Unimarck Healthcare Ltd) | $ 0.48 |
| Kloryl 0.05% w/w CRM / 15g (Unimarck Healthcare Ltd) | $ 0.48 |
| KLORYL 0.05% CREAM 1 tube / 15 GM cream each (Unimarck Healthcare Ltd) | $ 0.46 |
| KLORYL cream 0.05 % w/w x 15g (Unimarck Healthcare Ltd) | $ 0.48 |
| Kloryl 0.05% w/w CRM / 15g (Unimarck Healthcare Ltd) | $ 0.48 |
| Kloryl 0.05% Cream (Unimarck Healthcare Ltd) | $ 0.46 |
| Kloryl G | |
| Kloryl G Skin 10 gm Cream (Unimarck Healthcare Ltd) | $ 0.17 |
| KLORYL G CREAM 1 tube / 10 GM cream each (Unimarck Healthcare Ltd) | $ 0.17 |
| Kloryl G Cream (Unimarck Healthcare Ltd) | $ 0.17 |
| Kloryl M | |
| Kloryl M Skin 15 gm Cream (Unimarck Healthcare Ltd) | $ 0.48 |
| KLORYL M CREAM 1 tube / 15 GM cream each (Unimarck Healthcare Ltd) | $ 0.48 |
| Kloryl M Cream (Unimarck Healthcare Ltd) | $ 0.48 |
| Kloryl S | |
| Kloryl S Skin 20 gm Cream (Unimarck Healthcare Ltd) | $ 0.72 |
| KLORYL S CREAM 1 tube / 20 GM cream each (Unimarck Healthcare Ltd) | $ 0.72 |
| Kloryl S Cream (Unimarck Healthcare Ltd) | $ 0.72 |
| Kloryl-G (India) | |
| Kloryl-G Clobetasol Propionate0.05%w/w, Gentamicin Sulphate0.1% w/w CRM / 10g (Unimarck) | $ 0.17 |
| 10g (Unimarck) | $ 0.17 |
| KLORYL-G cream 10g (Unimarck) | $ 0.17 |
| Kloryl-M (India) | |
| Kloryl-M Clobetasol Propionate0.05%w/w, Miconazole Nitrate2% w/w CRM / 15g (Unimarck) | $ 0.48 |
| 15g (Unimarck) | $ 0.48 |
| KLORYL-M cream 15g (Unimarck) | $ 0.48 |
| Kloryl-S (India) | |
| Kloryl-S Clobetasol Propionate0.05%w/w, Salicyclic Acid 6%w/w CRM / 15g (Unimarck) | $ 0.72 |
| 20g (Unimarck) | $ 0.72 |
| KLORYL-S oint 20g (Unimarck) | $ 0.72 |
| Klosoft | |
| Klosoft 0.05% CREAM / 15gm (Sandoz Pvt.Ltd) | $ 0.27 |
| Klosoft Skin 15 gm Cream (Sandoz Pvt.Ltd) | $ 0.27 |
| KLOSOFT 0.05% CREAM 1 tube / 15 GM cream each (Sandoz Pvt.Ltd) | $ 0.27 |
| Klosoft 0.05% Cream (Sandoz Pvt.Ltd) | $ 0.27 |
| Klosol | |
| Klosol Skin 30 ml Lotion (Mefro Dermacare) | $ 0.94 |
| KLOSOL LOTION 1 bottle / 30 ML lotion each (Mefro Dermacare) | $ 0.97 |
| Klosol Lotion (Mefro Dermacare) | $ 0.97 |
| Kobeta (Taiwan) | |
| Kobeta 0.5 mg/1 g x 5 g | |
| Kobeta 0.5 mg/1 g x 10 g | |
| Kobeta 0.5 mg/1 g x 20 g | |
| Koniderm (Chile) | |
| Kotason (Taiwan) | |
| Kotason 0.5 mg/1 g x 1 g | |
See 1790 substitutes for Kloderma | |
References
- DailyMed. "CLOBETASOL PROPIONATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "clobetasol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- PubChem. "CLOBETASOL PROPIONATE". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Kloderma are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Kloderma. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
No survey data has been collected yet1 consumer reported age
| Users | % | ||
|---|---|---|---|
| 30-45 | 1 | 100.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
