• Librelease indications
• Uses of Librelease in details
• Librelease description
• Librelease dosage
• Librelease interactions
• Librelease side effects
• Librelease contraindications

What is Librelease?

Librelease is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Librelease affects chemicals in the brain that may become unbalanced and cause anxiety.

Librelease is used to treat anxiety disorders or alcohol withdrawal.

Librelease may also be used for other purposes not listed in this medication guide.

Librelease indications

Librelease Hydrochloride Capsule is indicated for the management of anxiety disorders or for the short term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.

The effectiveness of Librelease Hydrochloride Capsule in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient.

How should I use Librelease?

Use Librelease injection as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Librelease injection is usually administered as an injection at your doctor's office, hospital, or clinic.
• If you are using Librelease injection at home, carefully follow the injection procedures taught to you by your health care provider.
• If the medicine contains particles or is discolored, or if the vial/container is cracked or damaged in any way, do not use it.
• Try to stay in bed for 3 hours after taking Librelease injection.
• Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when full.
• If you miss a dose of Librelease injection and you are using it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Librelease injection.

Uses of Librelease in details

Librelease is used to treat anxiety and acute alcohol withdrawal. It is also used to relieve fear and anxiety before surgery. This medication belongs to a class of drugs called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. It works by enhancing the effects of a certain natural chemical in the body (GABA).

How to use Librelease

Take this medication by mouth as directed by your doctor. The dosage is based on your age, medical condition, and response to treatment.

Use this medication exactly as prescribed. Do not increase your dose, take it more frequently or use it for a longer period of time than prescribed because this drug can be habit-forming. Also, if used for an extended period of time, do not suddenly stop using this drug without your doctor's approval. Some conditions may become worse when the drug is abruptly stopped. Your dose may need to be gradually decreased to avoid side effects such as seizures.

When used for an extended period, this medication may not work as well and may require different dosing. Talk with your doctor if this medication stops working well.

Librelease description

A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Librelease has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Librelease is a controlled substance in the U.S.

Librelease dosage

Librelease Dosage

Applies to the following strength(s): 5 mg; 10 mg; 25 mg; 100 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

• Anxiety
• Light Sedation
• Alcohol Withdrawal

Usual Geriatric Dose for:

• Anxiety

Usual Pediatric Dose for:

• Anxiety

Additional dosage information:

• Renal Dose Adjustments
• Liver Dose Adjustments
• Precautions
• Dialysis
• Other Comments

Usual Adult Dose for Anxiety

Mild to moderate anxiety: 5 or 10 mg orally, 3 or 4 times per day

Severe anxiety: 20 or 25 mg orally, 3 or 4 times per day

Use: Relief of mild, moderate, and severe anxiety disorders

Usual Adult Dose for Light Sedation

On days preceding surgery, 5 to 10 mg orally, 3 or 4 times per day

Use: Relief of preoperative apprehension and anxiety

Usual Adult Dose for Alcohol Withdrawal

50 to 100 mg orally, followed by repeated doses as needed until agitation is controlled

Maximum dose: 300 mg orally per day

Use: Relief of withdrawal symptoms of acute alcoholism

Usual Geriatric Dose for Anxiety

Elderly or debilitated patients:

5 mg orally, 2 to 4 times per day

Use: Relief of mild, moderate, and severe anxiety disorders

Usual Pediatric Dose for Anxiety

6 years or older:

5 mg orally, 2 to 4 times per day; this may be increased to 10 mg orally, 2 to 3 times per day

Use: Relief of mild, moderate, and severe anxiety disorders

Renal Dose Adjustments

Renal impairment: Use with caution

Liver Dose Adjustments

Hepatic impairment: Use with caution

Precautions

Safety and efficacy have not been established in patients younger than 6 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule IV

Dialysis

Data not available

Other Comments

Storage requirements:

-Protect from light

Monitoring:

-Psychiatric: Patients with a history of alcohol or drug abuse, or patients with a marked personality disorder should be monitored frequently.

Patient advice:

-Patients should be cautioned against performing activities requiring complete mental alertness, such as operating machinery or driving a motor vehicle.

More about Librelease

• Side Effects
• During Pregnancy
• Dosage Information
• Drug Images
• Drug Interactions
• Support Group
• En Espanol
• 110 Reviews - Add your own review/rating

Consumer resources

• Librelease
• Librelease injection
• Librelease hydrochloride (Advanced Reading)

• Other brands: Librium

Professional resources

• Librelease (AHFS Monograph)
• More (4) »

Related treatment guides

• Alcohol Withdrawal
• Opiate Withdrawal
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• Burning Mouth Syndrome
• Light Sedation
• More (2) »

Librelease interactions

See also:
What other drugs will affect Librelease?

When this drug applied simultaneously with:

- antipsychotic drugs (neuroleptics), antidepressants, sedatives, hypnotics, anesthetics, analgesics, ethanol enhanced the inhibitory effect on central nervous system, especially when administered parenterally.

- concomitant use of antacids can delay but not reduce the absorption of Librelease.

- hormonal contraceptives increases the effectiveness of Librelease.

- with muscle relaxants may enhance the action of muscle relaxants, with levodopa - may suppress antiparkinsonian action.

- theophylline at low doses perverts sedative effect of Librelease.

- phenobarbital and phenytoin may accelerate the metabolism of Librelease. In rare cases this medication inhibits the metabolism and enhances the action of phenytoin.

- may increase the toxicity of cyclophosphamide.

- cimetidine, omeprazole, disulfiram may increase the intensity and duration of action of this medicine.

Librelease side effects

See also:
What are the possible side effects of Librelease?

Applies to Librelease: oral capsule, oral tablet

As well as its needed effects, Librelease (the active ingredient contained in Librelease) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking Librelease, check with your doctor immediately:

Rare

• Fainting
• mood or mental changes
• shakiness and unsteady walk
• unsteadiness, trembling, or other problems with muscle control or coordination

Incidence not known:

• Abdominal and muscle cramps
• chills
• clay-colored stools
• convulsions
• cough or hoarseness
• dark urine
• difficulty in speaking
• dizziness
• drooling
• fever with or without chills
• general feeling of tiredness or weakness
• headache
• itching
• light-colored stools
• loss of appetite
• loss of balance control
• lower back or side pain
• muscle trembling, jerking, or stiffness
• nausea and vomiting
• painful or difficult urination
• pale skin
• rash
• restlessness
• shakiness in the legs, arms, hands, or feet
• shuffling walk
• sleeplessness
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• stiffness of the limbs
• stomach pain
• sweating
• swelling
• trouble sleeping
• twisting movements of the body
• unable to sleep
• uncontrolled movements, especially of the face, neck, and back
• unpleasant breath odor
• unusual bruising or bleeding
• unusual tiredness or weakness
• vomiting of blood
• yellow eyes or skin

If any of the following symptoms of overdose occur while taking Librelease, get emergency help immediately:

Symptoms of overdose:

• Change in consciousness
• lack of coordination
• loss of consciousness
• sleepiness or unusual drowsiness

Minor Side Effects

Some Librelease side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known:

• Decreased interest in sexual intercourse
• difficulty having a bowel movement (stool)
• inability to have or keep an erection
• increased in sexual ability, desire, drive, or performance
• increased interest in sexual intercourse
• loss in sexual ability, desire, drive, or performance
• menstrual changes
• skin blisters

Librelease contraindications

See also:
What is the most important information I should know about Librelease?

this medicine is contraindicated in the presence of glaucoma (since the anticholinergic component may produce some degree of mydriasis) and in patients with prostatic hypertrophy and benign bladder neck obstruction. It is contraindicated in patients with known hypersensitivity to Librelease hydrochloride and/or clidinium bromide.

Active ingredient matches for Librelease:

Chlordiazepoxide

Unit description / dosage (Manufacturer)	Price, USD
Capsule, Extended Release; Oral; Chlordiazepoxide 30 mg
Capsules, Extended Release; Oral; Chlordiazepoxide 30 mg
List of Librelease substitutes (brand and generic names):
LIBREL
LIBREL 10MG TABLET 1 strip / 10 tablets each (Synokem Pharmaceuticals Ltd)	$ 0.72
Librinin
Libritabs
Tablet; Oral; Chlordiazepoxide 10 mg
Tablet; Oral; Chlordiazepoxide 25 mg
Tablet; Oral; Chlordiazepoxide 5 mg
Tablets; Oral; Chlordiazepoxide 10 mg
Tablets; Oral; Chlordiazepoxide 25 mg
Tablets; Oral; Chlordiazepoxide 5 mg
Librium Injection
Librosym (India)
Librosym Chlordiazepoxide 10 mg, Trifluoperazine 1 mg. TAB / 100 (Symbiosis)	$ 1.81
100's (Symbiosis)	$ 1.81
Librosym Chlordiazepoxide 10 mg, trifluoperazine 1 mg. TAB / 10 (Symbiosis)	$ 0.18
LIBROSYM tab 10's (Symbiosis)	$ 0.18
Librotop (India)
Librotop Chlordiazepoxide 10 mg, Trifluoperazine hydrochloride1 mg. FC-TAB / 20x10 (Ultramark)	$ 3.29
20x10 (Ultramark)	$ 3.29
Librotop Chlordiazepoxide 10 mg, trifluoperazine hydrochloride1 mg. FC-TAB / 20 (Ultramark)	$ 0.33
LIBROTOP film-coated tab 20's (Ultramark)	$ 0.33
Libuiu (Taiwan)
Libulin (Taiwan)
Livarium (Taiwan)
Livarium 10 mg
Liwaix (Taiwan)
Liwaix 5 mg
Lomon (Taiwan)
Lomon 10 mg
Lumrin (Taiwan)
Lumrin 10 mg
Lygen
Capsule; Oral; Chlordiazepoxide Hydrochloride 10 mg
Capsule; Oral; Chlordiazepoxide Hydrochloride 25 mg
Capsule; Oral; Chlordiazepoxide Hydrochloride 5 mg
Capsules; Oral; Chlordiazepoxide Hydrochloride 10 mg
Capsules; Oral; Chlordiazepoxide Hydrochloride 25 mg
Capsules; Oral; Chlordiazepoxide Hydrochloride 5 mg
Med-Zepoxide (Thailand)
Medilium (Thailand)
Capsule; Oral; Chlordiazepoxide Hydrochloride 10 mg (Medifive)
Capsule; Oral; Chlordiazepoxide Hydrochloride 5 mg (Medifive)
Capsules; Oral; Chlordiazepoxide Hydrochloride 10 mg (Medifive)
Capsules; Oral; Chlordiazepoxide Hydrochloride 5 mg (Medifive)
Mesural
Methaminodiazepoxide
Meva-C (India)
Meva-C Mebeverine hydrochloride 135mg, Chlordiazepoxide 5 mg. CAP / 10 (Zydus (Alidac))	$ 0.85
10's (Zydus (Alidac))	$ 0.85
MEVA-C 135 MG/5 MG CAPSULE 1 strip / 10 capsules each (Zydus (Alidac))	$ 1.47
MEVA-C 135 MG/5 MG CAPSULE 1 strip / 2 capsules each (Zydus (Alidac))	$ 1.21
MEVA-C cap 10's (Zydus (Alidac))	$ 0.85
Mildmen
See 525 substitutes for Librelease

References

1. DailyMed. "AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubChem. "chlordiazepoxide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
3. DrugBank. "chlordiazepoxide". http://www.drugbank.ca/drugs/DB00475 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Librelease are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Librelease. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology