What is Lox -2%?
Lox -2% topical jelly or ointment is used on different parts of the body to cause numbness or loss of feeling for patients having certain medical procedures. It is also used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, minor cuts, or scratches.
Lox -2% viscous topical solution is also used to treat sore mouth or throat and also reduce gagging during the taking of X-ray pictures and dental impressions.
Lox -2% skin patch is used to relieve pain caused by shingles (postherpetic neuralgia).
Lox -2% belongs to the family of medicines called local anesthetics. Lox -2% prevents pain by blocking the signals at the nerve endings in the skin. Lox -2% does not cause unconsciousness as general anesthetics do when used for surgery.
Lox -2% is available only with your doctor's prescription.
Lox -2% indications
Lox -2% (Lox -2% HCl) Injections are indicated for production of local or regioinal anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks, when the accepted procedures for these techniques as described in standard textbooks are observed.
How should I use Lox -2%?
Use Lox -2% aerosol as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Wash your hands well before and after using Lox -2% aerosol.
- Shake well before each use.
- If you are using Lox -2% aerosol on your face, spray it into your hand. Gently apply. Do not spray Lox -2% aerosol directly onto your face.
- For other areas, hold the medicine 4 to 6 inches from the skin and spray onto the affected area. Allow the medicine to slowly dry.
- Do not use large amounts of Lox -2% aerosol, especially over blistered or raw areas of your skin.
- Do not bandage or wrap the affected area, unless directed otherwise by your doctor.
- If you miss a dose of Lox -2% aerosol, use it as soon as you remember. Continue to use it as directed by your doctor or on the package label.
Ask your health care provider any questions you may have about how to use Lox -2% aerosol.
Uses of Lox -2% in details
How to use Lox -2% topical
Lox -2% description
Each gram contains Lidocaine 50 mg equivalent to Lox -2% 700 mg per 10 cm x 14 cm medicated plaster.
It also contains the following excipients: Self-Adhesive Layer: Glycerol, liquid sorbitol (crystallizing), carmellose sodium, propylene glycol (E1520), urea, heavy kaolin, tartaric acid, gelatin, polyvinyl alcohol, aluminum glycinate, disodium edetate, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), polyacrylic acid, sodium polyacrylate, purified water.
Backing Fabric and Release Liner: Polyethylene terephthalate (PET).
Lox -2% dosage
Lox -2% Dosage
Generic name: Lox -2%
Dosage form: Transoral Delivery System
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
When the Lox -2%® system is used concomitantly with other products containing Lox -2%, the total dose contributed by all formulations must be kept in mind.
Isolate the procedure area with cotton rolls and use suction as appropriate. Dry the tissue with air or gauze. Remove the Lox -2%® system from its packaging and peel off the clear protective liner. Immediately apply the Lox -2%® system using firm pressure. Allow the patch to remain in place until the desired anesthetic effect is produced but not for longer than 15 minutes. Experience in children is inadequate to recommend a pediatric dose at this time.
More about Lox -2% (Lox -2%)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
- 0 Reviews - Add your own review/rating
Consumer resources
- Other brands: Nervocaine, UAD Caine, Truxacaine, Lox -2% HCl, More (4) »
Professional resources
- Lox -2% (FDA)
- Lox -2% Hydrochloride (Local) (AHFS Monograph)
Related treatment guides
- Anesthesia
- Arrhythmia
- Burning Mouth Syndrome
- Ventricular Fibrillation
- Ventricular Tachycardia
Lox -2% interactions
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What other drugs will affect Lox -2%?
Beta-blockers increase the risk of bradycardia and hypotension. Norepinephrine and beta-blockers by reducing hepatic blood flow decrease (increased toxicity), isadrine and glucagon - increase the clearance of Lox -2%. Cimetidine increases the plasma concentration of Lox -2% Haffkine Bio-Pharmaceutical Corporation (displaces from its association with proteins and slows inactivation in the liver). Barbiturates causing induction of microsomal enzymes stimulate the degradation of Lox -2% and reduce its activity. Anticonvulsants (hydantoin derivatives) accelerate the biotransformation in the liver (decreased concentration in the blood), for IV injections it may increases cardiodepressive action of Lox -2%. Antiarrhythmics (amiodarone, verapamil, quinidine, aymalin) potentiate cardiac depression. Combination with novocainamide may cause CNS excitement and hallucinations. Lox -2% Haffkine Bio-Pharmaceutical Corporation strengthens the inhibitory effect of anesthesia (hexobarbital, thiopental sodium), hypnotics and sedatives on the respiratory center, weakens the cardiac effects of digitoxin, enhances muscle relaxation caused by drugs curare like (possible paralysis of respiratory muscles). MAO inhibitors prolong local anesthesia.
Lox -2% side effects
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What are the possible side effects of Lox -2%?
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.
The safety of Lox -2%™ has been evaluated in 10 clinical trials, five in adults and five in pediatric patients.
The five adult clinical trials consisted of a randomized, double-blind, parallel-arm, sham-placebo controlled Phase 3 trial that enrolled 693 patients, two randomized, double-blind, crossover design, sham-placebo controlled Phase 1 trials that enrolled 455 patients, and two open-label studies that enrolled 44 patients. A total of 742 adults received an active treatment with an active treatment that delivered a 0.5 mg dose of Lox -2%, while 775 received placebo.
The five pediatric clinical trials consisted of five randomized, double-blind, parallel-arm, sham-placebo controlled trials in which 1761 patients, ages 3 to 18, received either Lox -2%™ or a sham placebo device. A total of 906 pediatric patients received active treatment, while 855 received placebo.
Application Site Reaction
The application site was specifically assessed for four categories of skin site reaction (erythema, edema, pruritus, and petechiae).
In adults, erythema occurred in 67.3% of Lox -2%™-treated patients, and in 25.0% of placebo-treated patients. Petechiae occurred in 46.4% of Lox -2%™-treated patients, and in 7.0% of placebo-treated patients. Edema occurred in 4.3% of Lox -2%™-treated patients, and in 0.8% of placebo-treated patients. Pruritus occurred in 9.4% of Lox -2%™-treated patients and in 6.2% of placebo-treated patients.
In pediatric patients, erythema occurred in 53% of Lox -2%-treated patients, and in 27% of placebo-treated patients. Petechiae occurred in 44% of Lox -2%-treated patients, and in 5% of placebo-treated patients. Edema occurred in 8% of Lox -2%-treated patients, and in 3% of placebo-treated patients. Pruritus occurred in 1% of patients in both treatment groups.
Adverse Reactions
Amongst the 742 adult patients receiving active treatment and 775 adult patients receiving sham placebo treatment in the 5 adult studies, the percentage of adult patients with any adverse reactions was 3.9% in the active-treated patients and 4.9% in the sham placebo treated patients.
Most adverse reactions were application-site related (i.e., hypoaesthesia (0% active, 0.5% sham placebo), burning (0.54% active, 0.4% sham placebo), and venipuncture site hemorrhage (0.4% active, 1.7% sham placebo)).
The most common systemic adverse reaction was dizziness, which occurred in 0.9% of active-treated adult patients and in 0.7% of sham placebo treated adult patients. No other systemic adverse events occurred in more than two patients in either treatment group.
Amongst the 906 pediatric patients receiving active treatment and 855 pediatric patients receiving sham placebo treatment, the percentage of pediatric patients with any adverse reactions was approximately 9% in each treatment group.
Most adverse reactions were application-site related (i.e., bruising, burning, pain, contusion, hemorrhage), occurring in 4% of pediatric patients in each treatment group.
The most common systemic adverse reactions were nausea (2%) and vomiting (1%).
Lox -2% contraindications
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What is the most important information I should know about Lox -2%?
You should not receive this medication if you are allergic to Lox -2% or any other type of numbing medicine.
Before you receive Lox -2% injection, tell your doctor if you have liver or kidney disease, heart disease, coronary artery disease, circulation problems, or a history of malignant hyperthermia.
To treat irregular heart rhythms, your doctor may prescribe a LidoPen auto-injector. This is a prefilled automatic injection device to be used in an emergency. Keep the device with you at all times.
Your doctor will describe the signs and symptoms to watch for when deciding when it's time to use Lox -2% injection at home. Never use the LidoPen auto-injector without first calling your doctor.
With the LidoPen auto-injector you will also receive a CardioBeeper to transmit your heart rate and rhythm to your doctor over a telephone. Read all provided instructions and practice using the CardioBeeper.
Lox -2% can cause side effects that may impair your thinking or reactions. Unless absolutely necessary, do not drive after using this medication
Active ingredient matches for Lox -2%:
Unit description / dosage (Manufacturer) | Price, USD |
Lox -2% 21.3mg/mL INJ / 30ml | $ 0.29 |
List of Lox -2% substitutes (brand and generic names): | |
Lox Topical (India) | |
LOX TOPICAL topical soln 4 % x 30ml (Neon Labs) | $ 0.33 |
LTA 360 (United States) | |
LTA II (United States) | |
Luan (Georgia, Russian Federation) | |
Gel; Local; Lidocaine Hydrochloride 1% (Molteni) | |
Gel; Local; Lidocaine Hydrochloride 2.5% (Molteni) | |
Luan Chir. (Italy) | |
Lubogliss (Switzerland) | |
Lumbar Puncture Tray | |
Injectable; Injection; Lidocaine Hydrochloride 1% | |
Lumbar Puncture Tray Pediatric / Infant | |
Injectable; Injection; Lidocaine Hydrochloride 1% | |
Lurocaine (France, Luxembourg) | |
Liquid; Parenteral / Unspecified; Lidocaine Hydrochloride 20 mg / ml | |
Lygnonex (Philippines) | |
Lygnonex / vial 20 mg/1 mL x 50 mL (Medopharm) | |
Maricaine | |
Maxilene (Mexico) | |
Cream; Topical; Lidocaine 4% (Andromaco) | |
Lotion; Topical; Glycerol Oxyester; Silicon (Andromaco) | |
Shampoo; Topical; Glycerol Oxyester; Silicon (Andromaco) | |
MB-Cain (Pakistan) | |
Medcaine (Japan) | |
Medcaine 2% (Japan) | |
Mésocaïne (France) | |
Injectable; Injection; Lidocaine Hydrochloride 0.5% | |
Injectable; Injection; Lidocaine Hydrochloride 1% | |
Mesocaine (France) | |
Injectable; Injection; Lidocaine Hydrochloride 0.5% (Pharmy) | |
Injectable; Injection; Lidocaine Hydrochloride 1% (Pharmy) | |
Mésocaïne (France) | |
Injectable; Injection; Lidocaine Hydrochloride 0.5% | |
Injectable; Injection; Lidocaine Hydrochloride 1% | |
Min-I-Jet Lignocaine (Australia) | |
Min-I-Jet Lignocaine Hydrochloride (Australia) | |
Monocain (Turkey) | |
Mouth Gel (United Kingdom) | |
Mucosoothe (Australia, New Zealand) | |
Myelogram Tray | |
Injectable; Injection; Lidocaine Hydrochloride 1% | |
Nene Dent (Peru) | |
Nene-Dent (Colombia, Mexico, Peru) | |
Nenedol (Colombia) | |
Neo-Novutox (Germany) | |
Neo-Xylestesin Forte (Austria) | |
Nervocaine | |
Nervoderm (Australia) | |
Neurodol (Switzerland, Tunisia) | |
Neurodol Tissugel (Switzerland) | |
Patch; Topical; Lidocaine 700 mg (Ibsa) | |
Neurolid (Austria) | |
Neusthetic (Pakistan) | |
NIRCAINE | |
NIRCAINE INJECTION 1 vial / 30 ML injection each (Nirlife Healthcare) | $ 0.97 |
See 1761 substitutes for Lox -2% |
References
- DailyMed. "LIDOCAINE; TETRACAINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "lidocaine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "lidocaine". http://www.drugbank.ca/drugs/DB00281 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Lox -2% are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Lox -2%. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
1 consumer reported useful
Was the Lox -2% drug useful in terms of decreasing the symptom or the disease?According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users | % | ||
---|---|---|---|
Not useful | 1 | 100.0% |
Consumer reported price estimates
No survey data has been collected yetConsumer reported time for results
No survey data has been collected yet1 consumer reported age
Users | % | ||
---|---|---|---|
46-60 | 1 | 100.0% |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology