Nuhenz Uses

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Consists of alpha lipoic acid, benfotiamine, chromium polynicotinate, folic acid, mecobalamin, myo-inositol, pyridoxine hydrochloride

What is Alpha lipoic acid (Nuhenz)?

Alpha-lipoic acid is a naturally occurring fatty acid that can be found in many foods such as yeast, spinach, broccoli, potatoes, and organ meats such as liver or kidney.

Alpha-lipoic acid has been used as a nutritional supplement and antioxidant.

Not all uses for alpha-lipoic acid have been approved by the FDA. Alpha-lipoic acid should not be substituted for medications prescribed for you by your doctor.

Alpha-lipoic acid is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Alpha-lipoic acid may also be used for purposes not listed in this product guide.

Alpha lipoic acid (Nuhenz) indications

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is used for its antoxidant effects in the treatment of diabetic neuropathy. It has been tried in the treatment of liver dysfunction and in subacute necrotising encephalopathy. Beneficial results have been claimed in amanitin poisoning after ingestion of the mushroom Amanita phalloides, but such use is controversial

Uses of Alpha lipoic acid (Nuhenz) in details

Alpha lipoic acid (Nuhenz) (ALA) is used to enhance effects of primary antidiabetic therapy (adjuvant therapy) in patients with diabetes as it lowers blood glucose by binding to insulin (a hormone that controls blood sugar level in the body) receptor in the body which leads to increase glucose utilization. Also, due to its antioxidant activity, ALA is used to treat nerve damage due to uncontrolled blood sugar level that causes pain, tingling, or numbness over hands and feet (diabetic neuropathy). ALA is used as an antioxidant as an adjuvant treatment of HIV, cancer, liver ailments, and various other conditions.

Alpha lipoic acid (Nuhenz) dosage

Usual Adult Dose for Dietary Supplement

Alpha-lipoic acid 300 mg oral capsule:

1 capsule once or twice daily.

Alpha-lipoic acid 50 mg oral tablet:

1 tablet orally per day with a meal.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

What other drugs will affect Alpha lipoic acid (Nuhenz)?

Do not take alpha-lipoic acid without medical advice if you are using any of the following medications:

This list is not complete and other drugs may interact with alpha-lipoic acid. Tell your healthcare provider about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your healthcare provider.

Alpha lipoic acid (Nuhenz) side effects

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What are the possible side effects of Alpha lipoic acid (Nuhenz)?

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Nausea, Abdominal pain, Allergic reaction, Diarrhoea, Vertigo, Vomiting

What is the most important information I should know about Alpha lipoic acid (Nuhenz)?

Not all uses for alpha-lipoic acid have been approved by the FDA. Alpha-lipoic acid should not be substituted for medications prescribed for you by your doctor.

Alpha-lipoic acid is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Talk with a doctor, pharmacist, herbalist, or other healthcare provider before using alpha-lipoic acid if you have kidney or liver disease, diabetes, low blood sugar (hypoglycemia), or a thyroid disorder.

Use alpha-lipoic acid as directed on the label, or as your healthcare provider has prescribed. Do not use this product in larger amounts or for longer than recommended.

Taking alpha-lipoic acid may lower your blood sugar. Tell your doctor, pharmacist, herbalist, or other healthcare provider if you have symptoms such as hunger, weakness, nausea, irritability, dizziness, headache, blurred vision, confusion, sweating, fast heart rate, or fainting.

Less serious side effects are more likely to occur, and you may have none at all.

Benfotiamine (Nuhenz) indications

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Pernicious anaemia, peripheral neuritis especially diabetic and alcoholic polyneuritis, trigeminal neuritis, vomiting of pregnancy, vitamin B complex deficiency, anorexia, agranulocytosis, radiation sickness, coeliac and idiopathic, steatorrhoea which are usually accompanied by malabsorption of vitamin B 12 and during administration of broad-spectrum antibiotics.

Uses of Benfotiamine (Nuhenz) in details

Beri Beri, Wenicke-korsakoff syndrome. diabetic neuropathy.

Benfotiamine (Nuhenz) description

Benfotiamine (Nuhenz) (rINN, or S-benzoylthiamine O-monophoshate) is a synthetic S-acyl derivative of thiamine (vitamine B1). After absorption, Benfotiamine (Nuhenz) can be dephosphorylated by cells bearing an ecto-alkaline phosphatase to the lipid-soluble S-benzoylthiamine. Benfotiamine (Nuhenz) should not be confused with allithiamine, a naturally occurring thiamine disulfide derivative with a distinct pharmacological profile.

Benfotiamine (Nuhenz) dosage

Oral

Alcoholic neuropathy; Diabetic neuropathy

Adult: 100 mg 4 times daily.

Benfotiamine (Nuhenz) interactions

none known

Benfotiamine (Nuhenz) side effects

anaphylactic reactions rarely, severe cases can cause death, urine yellow colouration,peripheral neuropathy in case of prolonged useage, arrythmias,

Benfotiamine (Nuhenz) contraindications

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do not use in the treatment of leber disease or tobaco intoxication.

What is Folic acid (Nuhenz)?

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Folic acid (Nuhenz) (vitamin B 9) is necessary for strong blood.

Lack of Folic acid (Nuhenz) may lead to anemia (weak blood). Your health care professional may treat this by prescribing Folic acid (Nuhenz) for you.

Some conditions may increase your need for Folic acid (Nuhenz). These include:

In addition, infants smaller than normal, breast-fed infants, or those receiving unfortified formulas (such as evaporated milk or goat's milk) may need additional Folic acid (Nuhenz).

Increased need for Folic acid (Nuhenz) should be determined by your health care professional.

Some studies have found that Folic acid (Nuhenz) taken by women before they become pregnant and during early pregnancy may reduce the chances of certain birth defects (neural tube defects).

Claims that Folic acid (Nuhenz) and other B vitamins are effective for preventing mental problems have not been proven. Many of these treatments involve large and expensive amounts of vitamins.

Injectable Folic acid (Nuhenz) is given by or under the direction of your health care professional. Another form of Folic acid (Nuhenz) is available without a prescription.

Folic acid (Nuhenz) indications

Folic acid (Nuhenz) is used in the treatment and prevention of the folate deficiency state. It does not correct folate deficiency due to dihydrofolate reductase inhibitors. Folic acid (Nuhenz) is also used in women of child-bearing potential and pregnant women to protect against neural tube defects in their offspring. It is also used for the treatment of folate-deficient megaloblastic anaemia, chronic haemolytic states such as thalassaemia major or sickle-cell anaemia.

How should I use Folic acid (Nuhenz)?

Use Folic acid (Nuhenz) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Folic acid (Nuhenz).

Uses of Folic acid (Nuhenz) in details

Folic acid (Nuhenz) is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.

Folic acid (Nuhenz) supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of Folic acid (Nuhenz) either through their diet or supplements to prevent infant spinal cord birth defects.

How to use Folic acid (Nuhenz)

Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.

Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician. See also Notes section.

If your condition persists or worsens, or if you think you may have a serious medical problem, get medical help right away.

Folic acid (Nuhenz) description

A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid (Nuhenz) is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]

Folic acid (Nuhenz) dosage

Folic acid (Nuhenz) Dosage

Applies to the following strength(s): 1 mg; 0.4 mg; 5 mg/mL; 0.8 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Megaloblastic Anemia

1 mg orally, intramuscularly, subcutaneously or IV once a day. May continue until clinical symptoms of folate deficiency and the hematological profile have normalized.

Usual Adult Dose for Folic acid (Nuhenz) Deficiency

400 to 800 mcg orally, intramuscularly, subcutaneously or IV once a day.

Women of childbearing age, pregnant, and lactating women: 800 mcg orally, intramuscularly, subcutaneously or IV once a day.

Usual Pediatric Dose for Folic acid (Nuhenz) Deficiency

Infant:

0.1 mg orally, intramuscularly, subcutaneously or IV once a day.

Child:

Less than 4 years: up to 0.3 mg orally, intramuscularly, subcutaneously or IV once a day.

4 years or older: 0.4 mg orally, intramuscularly, subcutaneously or IV once a day.

Usual Pediatric Dose for Vitamin/Mineral Supplementation

Recommended daily allowance (RDA):

Premature neonates: 50 mcg/day (15 mcg/kg/day).

Full-term neonates and infants 1 to 6 months: 25 to 35 mcg/day.

Children:

1 to 3 years: 150 mcg/day.

4 to 8 years: 200 mcg/day.

9 to 13 years: 300 mcg/day.

14 years and older: 400 mcg/day.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Rarely, a dosage of 2 mg/day may be required, particularly in patients with malabsorption, alcoholism, chronic hemolysis, chronic exfoliative skin disease or who are on concomitant anticonvulsant therapy.

Dialysis

Folic acid (Nuhenz) is removed by both hemodialysis and peritoneal dialysis. The amount removed varies with type equipment used.

Because folate may accumulate in patients with end-stage renal disease, side effects may be more likely in this patient who is undergoing dialysis. Once this patient's body stores of folate are replete, three times a week dosing may be just as beneficial as once daily dosing but should portend a lower risk of side effects.

Other Comments

The recommended daily allowance of Folic acid (Nuhenz) for adult males and females ranges from 150 to 200 and 150 to 180 mcg/day, respectively.

There is a potential danger in administering Folic acid (Nuhenz) to patients with undiagnosed anemia, since Folic acid (Nuhenz) may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress.

Severe megaloblastic anemia may require therapy for 4 to 5 weeks. Once stabilized, if dietary intake is inadequate, maintenance therapy can be started.

More about Folic acid (Nuhenz)

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Folic acid (Nuhenz) interactions

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What other drugs will affect Folic acid (Nuhenz)?

Medications that interfere with your bodys ability to use folate may also increase the need for this vitamin. Medications can interfere with folate utilization, including: anticonvulsant medications (such as phenytoin, and primidone) metformin (sometimes prescribed to control blood sugar in type 2 diabetes) sulfasalazine (used to control inflammation associated with Crohns disease and ulcerative colitis) triamterene (a diuretic) Methotrexate There has been concern about the interaction between vitamin B12 and Folic acid (Nuhenz). Folic acid (Nuhenz) supplements can correct the anemia associated with vitamin B12 deficiency. Unfortunately, Folic acid (Nuhenz) will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental Folic acid (Nuhenz) should not exceed 1000 micrograms (g, sometimes mcg) per day to prevent Folic acid (Nuhenz) from masking symptoms of vitamin B12 deficiency. It is important for older adults to be aware of the relationship between Folic acid (Nuhenz) and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains Folic acid (Nuhenz).

Folic acid (Nuhenz) side effects

See also:
What are the possible side effects of Folic acid (Nuhenz)?

Allergic sensitization has been reported following both oral and parenteral administration of Folic acid (Nuhenz).

Folic acid (Nuhenz) is relatively nontoxic in man. Rare instances of allergic responses to Folic acid (Nuhenz) preparations have been reported and have included erythema, skin rash, itching, general malaise, and respiratory difficulty due to bronchospasm. One patient experienced symptoms suggesting anaphylaxis following injection of the drug. Gastrointestinal side effects, including anorexia, nausea, abdominal distention, flatulence, and a bitter or bad taste, have been reported in patients receiving 15 mg Folic acid (Nuhenz) daily for 1 month. Other side effects reported in patients receiving 15 mg daily include altered sleep patterns, difficulty in concentrating, irritability, overactivity, excitement, mental depression, confusion, and impaired judgment. Decreased vitamin B12 serum levels may occur in patients receiving prolonged Folic acid (Nuhenz) therapy.

In an uncontrolled study, orally administered Folic acid (Nuhenz) was reported to increase the incidence of seizures in some epileptic patients receiving phenobarbital, primidone, or diphenylhydantoin. Another investigator reported decreased diphenylhydantoin serum levels in folate-deficient patients receiving diphenylhydantoin who were treated with 5 mg or 15 mg of Folic acid (Nuhenz) daily.

CALL YOUR DOCTOR FOR MEDICAL ADVICE ABOUT SIDE EFFECTS. YOU MAY REPORT SIDE EFFECTS TO THE FDA AT 1-800-FDA-1088 OR LEADING PHARMA, LLC AT 844-740-7500.

Folic acid (Nuhenz) contraindications

See also:
What is the most important information I should know about Folic acid (Nuhenz)?

Because it may mask the hematologic abnormalities while neurological damage progresses, Folic acid (Nuhenz) should not be used in the therapy of patients with vitamin B12 deficiency of any cause, unless there is associated folate deficiency. The Folic acid (Nuhenz) content of one tablet a day however, is unlikely to mask pernicious anemia should this condition be present. Also, pregnancy during pernicious anemia is very rare.

Mecobalamin (Nuhenz) indications

Pernicious anemia, both uncomplicated and accompanied by nervous system involvement.

Dietary deficiency of Vitamin B12, occurring in strict vegetarians and in their breast-fed infants. (Isolated vitamin B12 deficiency is very rare).

Malabsorption of vitamin B12, resulting from structural or functional damage to the stomach, where intrinsic factor is secreted or to the ileum, where intrinsic factor facilitates vitamin B12 absorption. These conditions include tropical sprue, and nontropical sprue (idiopathic steatorrhea, gluten-induced enteropathy). Folate deficiency in these patients is usually more severe than vitamin B12 deficiency.

Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy). Total gastrectomy always produces vitamin B12 deficiency.

Structural lesions leading to vitamin B12 deficiency include regional ileitis, ileal resections, malignancies, etc.

Competition for Vitamin B12 by intestinal parasites or bacteria.

The fish tapeworm (Diphyilobothrium latum) absorbs huge quantities of vitamin B12 and infested patients often have associated gastric atrophy. The blind-loop syndrome may produce deficiency of Vitamin B12 or folate.

Inadequate utilization of vitamin B12. This may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia.

For the Schilling Test.

Mecobalamin (Nuhenz) description

Mecobalamin (Nuhenz)/Mecobalamin (Nuhenz)-1500 also contains the following inactive ingredients: Lactose, maize starch, microcrystalline cellulose, povidone (K-30), purified talc, anhydrous colloidal silica, hypromellose, macrogol, titanium dioxide, isopropyl alcohol, dicholoromethane, red iron oxide and yellow iron oxide.

Mecobalamin (Nuhenz) dosage

Mecobalamin (Nuhenz): The daily dose is 1 tab 3 times daily.

Mecobalamin (Nuhenz)-1500: The daily dose is 1 tab once daily. The dosage should be adjusted according to age of patient and severity of symptoms.

Mecobalamin (Nuhenz) interactions

Antibiotics: The use of antibiotics may alter the intestinal microflora and may decrease the possible contribution of mecobalamin by certain inhabitants of the microflora (eg, Lactobacillus spp) to the body's requirement for the vitamin. This may particularly be a problem for vegetarians. Garlic, onions, leeks, bananas, asparagus and artichokes, among other vegetables and fruits, contain inulins which promote the growth of certain colonic bacteria including Lactobacillus spp.

Cholestyramine: Cholestyramine may decrease the enterohepatic reabsorption of mecobalamin.

Colchicine: Colchicine may cause decreased absorption of mecobalamin.

Colestipol: Colestipol may decrease the enterohepatic reabsorption of mecobalamin.

H2-Blockers (Cimetidine, Famotidine, Nizatidine, Ranitidine): Chronic use of H2-blockers may result to decreased absorption of mecobalamin. They are unlikely to affect the absorption of supplemental B12.

Metformin: Metformin may decrease the absorption of mecobalamin. This possible effect may be reversed with oral calcium supplementation.

Nitrous Oxide: Inhalation of the anesthetic agent nitrous oxide (not to be confused with nitric oxide) can produce a functional deficiency. Nitrous oxide forms a complex with cobalt in mecobalamin, the cofactor for methionine synthase, resulting in inactivation of the enzyme.

Para-Amino Salicylic Acid: Chronic use of the anti-tuberculosis drug may decrease the absorption of mecobalamin.

Potassium Chloride: It has been reported that potassium chloride may decrease the absorption of mecobalamin.

Proton Pump Inhibitors (Lansoprazole, Omeprazole, Pantoprazole, Rabeprazole): Chronic use of proton pump inhibitors may result in decreased absorption, naturally found in food sources.

Mecobalamin (Nuhenz) side effects

water weight gain, edema, increase in BUN, and dilutional hyponatremia. Asterixis was reported to have worsened in one patient during infusion of this medicine.

Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia.

Symptoms may result from an excess or deficit of one or more of the ions present in the solution; therefore, frequent monitoring of electrolyte levels is essential.

Phosphorus deficiency may lead to impaired tissue oxygenation and acute hemolytic anemia. Relative to calcium, excessive phosphorus intake can precipitate hypocalcemia with cramps, tetany and muscular hyperexcitability.

If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.

Mecobalamin (Nuhenz) contraindications

Hypersensitivity to mecobalamin or other vit B12-containing, cobalamin products or cobalt.

What is Pyridoxine hydrochloride (Nuhenz)?

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Pyridoxine hydrochloride (Nuhenz) (vitamin B 6) is necessary for normal breakdown of proteins, carbohydrates, and fats.

Some conditions may increase your need for Pyridoxine hydrochloride (Nuhenz). These include:

In addition, infants receiving unfortified formulas such as evaporated milk may need additional Pyridoxine hydrochloride (Nuhenz).

Increased need for Pyridoxine hydrochloride (Nuhenz) should be determined by your health care professional.

Lack of Pyridoxine hydrochloride (Nuhenz) may lead to anemia (weak blood), nerve damage, seizures, skin problems, and sores in the mouth. Your doctor may treat these problems by prescribing Pyridoxine hydrochloride (Nuhenz) for you.

Claims that Pyridoxine hydrochloride (Nuhenz) is effective for treatment of acne and other skin problems, alcohol intoxication, asthma, hemorrhoids, kidney stones, mental problems, migraine headaches, morning sickness, and menstrual problems, or to stimulate appetite or milk production have not been proven.

Injectable Pyridoxine hydrochloride (Nuhenz) is given by or under the supervision of a health care professional. Other forms of Pyridoxine hydrochloride (Nuhenz) are available without a prescription.

Pyridoxine hydrochloride (Nuhenz) indications

* Sideroblastic anaemia

* Treatment and prophylaxis of vitamin B6 deficiency states

How should I use Pyridoxine hydrochloride (Nuhenz)?

Use Pyridoxine hydrochloride (Nuhenz) (vitamin b6) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Pyridoxine hydrochloride (Nuhenz) (vitamin b6).

Uses of Pyridoxine hydrochloride (Nuhenz) in details

Use: Labeled Indications

Pyridoxine hydrochloride (Nuhenz) deficiency: Treatment and prevention of Pyridoxine hydrochloride (Nuhenz) (vitamin B) deficiency.

Off Label Uses

Ethylene glycol poisoning

The American Academy of Clinical Toxicology guidelines recognize the lack of human clinical data for this use and consider Pyridoxine hydrochloride (Nuhenz) as an adjunctive cofactor therapy in ethylene glycol poisoning without a formal or evidence-based recommendation, especially in patients who may have vitamin deficiencies (eg, patients with alcoholism). Additional data may be necessary to further define the role of Pyridoxine hydrochloride (Nuhenz) in this condition.

Peripheral neuropathy associated with isoniazid therapy for Mycobacterium tuberculosis (prevention)

Based on the Department of Health and Human Services (DHHS) Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, Pyridoxine hydrochloride (Nuhenz) is effective and recommended in the prevention of peripheral neuropathy associated with isoniazid therapy for Mycobacterium tuberculosis.

Pyridoxine hydrochloride (Nuhenz) description

Pyridoxine hydrochloride (Nuhenz) is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Pyridoxal 5-phosphate is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although Pyridoxine hydrochloride (Nuhenz) and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading. [PubChem]

Pyridoxine hydrochloride (Nuhenz) dosage

Pyridoxine hydrochloride (Nuhenz) Dosage

Applies to the following strength(s): 25 mg; 50 mg; 100 mg; 100 mg/mL; (as pyridoxal 5'-phosphate); pyridoxal 5'-phosphate 50 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Drug Induced Vitamin/Mineral Deficiency

Drug Induced Neuritis:

Cycloserine: 100 to 300 mg/day orally in divided doses.

Isoniazid or penicillamine: 100 to 200 mg/day orally for 3 weeks or 25 to 100 mg/day for prophylaxis.

Oral contraceptives: 25 to 30 mg/day orally.

Acute Intoxication:

Hydralazine: 25 mg/kg. One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.

Isoniazid: 1 to 4 grams IV as a first dose, then 1 g IM every 30 minutes until the total required dose has been administered (given with other anticonvulsants as needed). The total dose administered should equal the amount of isoniazid ingested.

Mushroom ingestion (genus Gyromitra): 25 mg/kg IV infused over 15 to 30 minutes. Repeat as needed to a maximum total daily dose of 15 to 20 g.

Usual Adult Dose for Dietary Supplement

Pyridoxine hydrochloride (Nuhenz) Deficiency:

10 to 25 mg/day orally, IM, or IV for 3 weeks followed by 2 to 5 mg/day from a multivitamin product.

Usual Adult Dose for Anemia

Sideroblastic, hereditary: 200 to 600 mg orally daily. If adequate response obtained, dose may be decreased to 30 to 50 mg orally daily.

If therapeutic response is not obtained after 1 to 2 months of Pyridoxine hydrochloride (Nuhenz) therapy, a different therapy should be considered.

Usual Adult Dose for Nausea/Vomiting

Nausea and vomiting of Pregnancy:

25 mg orally every 8 hours.

Usual Pediatric Dose for Drug Induced Vitamin/Mineral Deficiency

Drug Induced Neuritis (cycloserine, isoniazid, hydralazine, penicillamine) :

Treatment: 10 to 50 mg/day.

Prophylaxis: 1 to 2 mg/kg/day

Acute Intoxication:

Hydralazine: 25 mg/kg: One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.

Isoniazid: Acute ingestion of known amount: Initial: A total dose of Pyridoxine hydrochloride (Nuhenz) equal to the amount of isoniazid ingested (maximum dose: 70 mg/kg, up to 5 g); administer at a rate of 0.5 to 1 g/minute until seizures stop or the maximum initial dose has been administered; may repeat every 5 to 10 minutes as needed to control persistent seizure activity and/or CNS toxicity. If seizures stop prior to the administration of the calculated initial dose, infuse the remaining Pyridoxine hydrochloride (Nuhenz) over 4 to 6 hours. Acute ingestion of unknown amount: Initial: 70 mg/kg (maximum dose: 5 g); administer at a rate of 0.5 to 1 g/minute; may repeat every 5 to 10 minutes as needed to control persistent seizure activity and/or CNS toxicity.

Mushroom ingestion (genus Gyromitra): 25 mg/kg IV. Repeat as needed up to a maximum total dose of 15 to 20 g.

Usual Pediatric Dose for Dietary Supplement

Pyridoxine hydrochloride (Nuhenz) Deficiency:

5 to 25 mg/day orally, IM, or IV for 3 weeks followed by 1.5 to 2.5 mg/day from a multivitamin product.

Usual Pediatric Dose for Seizures

Pyridoxine hydrochloride (Nuhenz)-dependent seizures:

10 to 100 mg PO, IM, or IV initially, followed by 2 to 100 mg orally daily.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Drug dependence has been reported in patients withdrawn from the drug at doses of 200 mg per day.

Pyridoxine hydrochloride (Nuhenz) should not be administered intravenously to patients with heart disease.

Sensory neuropathy with axonal degeneration has been reported following a single large dose of Pyridoxine hydrochloride (Nuhenz) (10 g) administered intravenously. It may rarely occur following chronic administration of lower doses.

Dialysis

Data not available

Other Comments

Administer parenteral Pyridoxine hydrochloride (Nuhenz) by slow IV push.

When administering large parenteral doses, the patients heart rate, respiratory rate and blood pressure should be monitored closely.

Oral Pyridoxine hydrochloride (Nuhenz) may be given with or without food.

Urinary excretion of 4-pyridoxic acid <0.1 mg/24 hours is suggestive of a deficiency.

Vitamin B6 (Pyridoxine hydrochloride (Nuhenz)) is found in meat, liver, whole-grain breads and cereals, soybeans, vegetables, eggs, peanuts, walnuts, and corn.

Average Adequate Intake (AI) in Adults:

>=19 to 50 years: 1.3 mg/day

>=51 years:

Men: 1.7 mg/day

Women: 1.5 mg/day

Recommended Daily Allowance (RDA) in Pediatrics:

1 to 3 years: 0.5 mg/day

4 to 8 years: 0.6 mg/day

Average Adequate Intake (AI) in Pediatrics:

0 to 6 months: 0.1 mg/day

7 to 12 months: 0.3 mg/day

9 to 13 years: 1 mg/day

Males:

>=14 years: 1.3 mg/day

Female:

>=14 years: 1.2 mg/day

More about Pyridoxine hydrochloride (Nuhenz)

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Pyridoxine hydrochloride (Nuhenz) interactions

See also:
What other drugs will affect Pyridoxine hydrochloride (Nuhenz)?

Cycloserine, isoniazid, hydralazine, oral contraceptives, penicillamine

Increased need for Pyridoxine hydrochloride (Nuhenz).

Levodopa

Decreased effect of levodopa. (Interaction does not occur with levodopa/carbidopa in combination with Pyridoxine hydrochloride (Nuhenz).)

Phenytoin

Phenytoin serum levels may be decreased.

Incompatibility

Incompatible with alkaline solutions, iron salts and oxidizing agents (parenteral).

Laboratory Test Interactions

May result in false-positive urobilinogen in the spot test using Ehrlich reagent.

Pyridoxine hydrochloride (Nuhenz) side effects

See also:
What are the possible side effects of Pyridoxine hydrochloride (Nuhenz)?

CNS

Neuropathy; unstable gait; drowsiness; somnolence.

EENT

Perioral numbness.

Miscellaneous

Numbness of feet; decreased sensation to touch, temperature or vibration; paresthesia; low serum Pyridoxine hydrochloride (Nuhenz) levels; burning/stinging at IM injection site; photoallergic reaction; ataxia.

Pyridoxine hydrochloride (Nuhenz) contraindications

See also:
What is the most important information I should know about Pyridoxine hydrochloride (Nuhenz)?

Contraindications for Vitamin B6 (Pyridoxine hydrochloride (Nuhenz))

Vitamin B6 is contraindicated in those hypersensitive to any component of a vitamin B6-containing product.

Active ingredient matches for Nuhenz:

Alpha lipoic acid/benfotiamine/chromium polynicotinate/folic acid/mecobalamin/myo-inositol/pyridoxine hydrochloride in India.


Unit description / dosage (Manufacturer)Price, USD
NUHENZ film-coated tab 10's (La Renon)$ 2.23

List of Nuhenz substitutes (brand and generic names):

alpha lipoic acid/benfotiamine/chromium polynicotinate/folic acid/mecobalamin/myo-inositol/pyridoxine hydrochloride (India)

References

  1. DailyMed. "ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PHYTONADIONE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN 5'-PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "ASCORBIC ACID; BIOTIN; CHOLECALCIFEROL; CYANOCOBALAMIN; DEXPANTHENOL; FOLIC ACID; NIACINAMIDE; PYRIDOXINE; RIBOFLAVIN; THIAMINE; TOCOPHEROL ACETATE; VITAMIN A; VITAMIN K: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. PubChem. "folic acid". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Nuhenz are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Nuhenz. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

4 consumers reported useful

Was the Nuhenz drug useful in terms of decreasing the symptom or the disease?
According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users%
Useful3
75.0%
Not useful1
25.0%


6 consumers reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by ndrugs.com website users about whether the Nuhenz drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Users%
Expensive6
100.0%


33 consumers reported time for results

To what extent do I have to use Nuhenz before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes > 3 month and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Nuhenz. To get the time effectiveness of using Nuhenz drug by other patients, please click here.
Users%
> 3 month11
33.3%
3 month6
18.2%
1 month5
15.2%
2 weeks4
12.1%
1 week2
6.1%
5 days2
6.1%
1 day2
6.1%
2 days1
3.0%


70 consumers reported age

Users%
> 6026
37.1%
46-6019
27.1%
30-4518
25.7%
16-297
10.0%


Consumer reviews


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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