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Renerve Plus Uses |
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Pernicious anemia, both uncomplicated and accompanied by nervous system involvement.
Dietary deficiency of Vitamin B12, occurring in strict vegetarians and in their breast-fed infants. (Isolated vitamin B12 deficiency is very rare).
Malabsorption of vitamin B12, resulting from structural or functional damage to the stomach, where intrinsic factor is secreted or to the ileum, where intrinsic factor facilitates vitamin B12 absorption. These conditions include tropical sprue, and nontropical sprue (idiopathic steatorrhea, gluten-induced enteropathy). Folate deficiency in these patients is usually more severe than vitamin B12 deficiency.
Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy). Total gastrectomy always produces vitamin B12 deficiency.
Structural lesions leading to vitamin B12 deficiency include regional ileitis, ileal resections, malignancies, etc.
Competition for Vitamin B12 by intestinal parasites or bacteria.
The fish tapeworm (Diphyilobothrium latum) absorbs huge quantities of vitamin B12 and infested patients often have associated gastric atrophy. The blind-loop syndrome may produce deficiency of Vitamin B12 or folate.
Inadequate utilization of vitamin B12. This may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia.
For the Schilling Test.
Renerve Plus/Renerve Plus-1500 also contains the following inactive ingredients: Lactose, maize starch, microcrystalline cellulose, povidone (K-30), purified talc, anhydrous colloidal silica, hypromellose, macrogol, titanium dioxide, isopropyl alcohol, dicholoromethane, red iron oxide and yellow iron oxide.
Renerve Plus: The daily dose is 1 tab 3 times daily.
Renerve Plus-1500: The daily dose is 1 tab once daily. The dosage should be adjusted according to age of patient and severity of symptoms.
Antibiotics: The use of antibiotics may alter the intestinal microflora and may decrease the possible contribution of Renerve Plus by certain inhabitants of the microflora (eg, Lactobacillus spp) to the body's requirement for the vitamin. This may particularly be a problem for vegetarians. Garlic, onions, leeks, bananas, asparagus and artichokes, among other vegetables and fruits, contain inulins which promote the growth of certain colonic bacteria including Lactobacillus spp. Cholestyramine:
Colchicine: Colchicine may cause decreased absorption of Renerve Plus. Colestipol:
H2-Blockers (Cimetidine, Famotidine, Nizatidine, Ranitidine): Chronic use of H2-blockers may result to decreased absorption of Renerve Plus. They are unlikely to affect the absorption of supplemental B12.
Metformin: Metformin may decrease the absorption of Renerve Plus. This possible effect may be reversed with oral calcium supplementation.
Nitrous Oxide: Inhalation of the anesthetic agent nitrous oxide (not to be confused with nitric oxide) can produce a functional deficiency. Nitrous oxide forms a complex with cobalt in Renerve Plus, the cofactor for methionine synthase, resulting in inactivation of the enzyme.
Para-Amino Salicylic Acid: Chronic use of the anti-tuberculosis drug may decrease the absorption of Renerve Plus.
Potassium Chloride: It has been reported that potassium chloride may decrease the absorption of Renerve Plus.
Proton Pump Inhibitors (Lansoprazole, Omeprazole, Pantoprazole, Rabeprazole): Chronic use of proton pump inhibitors may result in decreased absorption, naturally found in food sources.
water weight gain, edema, increase in BUN, and dilutional hyponatremia. Asterixis was reported to have worsened in one patient during infusion of this medicine.
Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia.
Symptoms may result from an excess or deficit of one or more of the ions present in the solution; therefore, frequent monitoring of electrolyte levels is essential.
Phosphorus deficiency may lead to impaired tissue oxygenation and acute hemolytic anemia. Relative to calcium, excessive phosphorus intake can precipitate hypocalcemia with cramps, tetany and muscular hyperexcitability.
If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.
Hypersensitivity to Renerve Plus or other vit B12-containing, cobalamin products or cobalt.
Mecobalamin in India.
Nicotinamide/pyridoxine hydrochloride in India.
Unit description / dosage (Manufacturer) | Price, USD |
Renerve Plus Mecobalamin 1000 mcg/2 mL, Pyridoxine hydrochloride 100mg/2 mL, Thiaminehydrochloride 100 mg/2 mL, Niacinamide 100 mg/2 mL, D-panthenol 50 mg/2 mL. INJ / 2ml | $ 0.90 |
2ml | $ 0.90 |
RENERVE PLUS inj 2ml (Strides) | $ 0.99 |
List of Renerve Plus substitutes (brand and generic names): | |
Renerve Plus Cap (India) | |
Renerve Plus Cap Mecobalamin 1500 mcg, Alphalipoic acid 100 mg, Folic acid5 mg, Inositol 100 mg, Chromium polynicotinate 200mcg, Selenium dioxide 163.6mcg, Vitamin E acetate 25 mg, Thiamine hydrochloride 10 mg, Calcium pantothenate 10 mg, Pyridoxine 1.5 mg, v (Strides) | $ 1.55 |
RENURON-PLUS (India) | |
10's | $ 0.96 |
Reticolan (Japan) | |
Rincobal (Indonesia) | |
Roumis (Japan) | |
Rouvit (India) | |
Rouvit 1500 mcg INJ / 2ml (Rouzel) | |
1500 mcg x 2ml (Rouzel) | |
ROUVIT inj 1500 mcg x 2ml (Rouzel) | |
Rouvit Plus (India) | |
Rouvit Plus Mecobalamin 1000 mcg, Pyridoxine hydrochloride 100mg, niacinamide 100 mg. INJ / 2ml (Rouzel) | |
2ml (Rouzel) | |
ROUVIT PLUS inj 2ml (Rouzel) | |
Rudimin-Alpha (India) | |
Rudimin-Alpha Alpha lipoic acid 200 mg, mecobalamin 750 mcg, folicacid 1.5 mg, pyridoxinehydrochloride 3 mg. CAP / 10 (Shield) | $ 1.11 |
RUDIMIN-ALPHA cap 10's (Shield) | $ 1.11 |
Safyvit (India) | |
Safyvit Mecobalamin 1000 mcg, VitaminB1 100 mg, Vitamin B6 100 mg, D-panthenol 50 mg, nicotinamide. VIAL / 1 (Sanify) | $ 0.60 |
1's (Sanify) | $ 0.60 |
SAFYVIT inj 2ml (Sanify) | $ 0.60 |
Safyvit M | |
Safyvit M 1500 mcg Tablet (Syntonic (Sanify Healthcare Pvt Ltd)) | $ 0.08 |
Safyvit Syr (India) | |
Safyvit Syr Mecobalamin 500 mcg, Folicacid 1500 mcg. SYR / 100ml (Sanify) | $ 0.47 |
100ml (Sanify) | $ 0.47 |
SAFYVIT SYR syr 100ml (Sanify) | $ 0.47 |
Safyvit-M (India) | |
Safyvit-M 1500 mcg TAB / 10 (Sanify (Syntonic)) | $ 0.84 |
1500 mcg x 10's (Sanify (Syntonic)) | $ 0.84 |
SAFYVIT-M tab 1500 mcg x 10's (Sanify (Syntonic)) | $ 0.84 |
Salcob (India) | |
Salcob 1500 mcg AMP / 1 (Salvus) | |
1500 mcg x 1's (Salvus) | |
SALCOB inj 1500 mcg x 2ml (Salvus) | |
Salcob Plus (India) | |
Salcob Plus Mecobalamin 1000 mcg, Pyridoxine 100 mg, Niacinamide100 mg. VIAL / 1 (Salvus) | |
1's (Salvus) | |
SALCOB PLUS inj 1's (Salvus) | |
Salcob-G (India) | |
Salcob-G Gabapentin 300 mg, Mecobalamin500 mcg. CAP / 10 (Salvus) | |
10's (Salvus) | |
SALCOB-G cap 10's (Salvus) | |
Salcob-OD (India) | |
Salcob-OD Mecobalamin 1500 mcg, Alphalipoic acid 100 mg, Pyridoxinehydrochloride 3 mg. S-GEL / 10 (Salvus) | |
10's (Salvus) | |
SALCOB-OD softgel 10's (Salvus) | |
Salute INJ (India) | |
Salute INJ 500 mcg AMP / 1ml (Vensat) | $ 0.22 |
500 mcg x 1ml (Vensat) | $ 0.22 |
SALUTE INJ inj 500 mcg x 1ml (Vensat) | $ 0.22 |
Salute MD | |
Salute MD 1000 mcg Injection (Vensat Bio) | $ 0.30 |
Salute-MD INJ (India) | |
Salute-MD INJ Mecobalamin 1 mg, Vitamins. AMP / 2ml (Vensat) | $ 0.59 |
2ml (Vensat) | $ 0.59 |
SALUTE-MD INJ inj 2ml (Vensat) | $ 0.59 |
See 2613 substitutes for Renerve Plus |
Users | % | ||
---|---|---|---|
Useful | 2 | 100.0% |
Users | % | ||
---|---|---|---|
Expensive | 2 | 66.7% | |
Not expensive | 1 | 33.3% |
Users | % | ||
---|---|---|---|
5 days | 1 | 20.0% | |
1 day | 1 | 20.0% | |
1 week | 1 | 20.0% | |
3 month | 1 | 20.0% | |
2 days | 1 | 20.0% |
Users | % | ||
---|---|---|---|
> 60 | 9 | 36.0% | |
46-60 | 7 | 28.0% | |
30-45 | 7 | 28.0% | |
6-15 | 1 | 4.0% | |
1-5 | 1 | 4.0% |
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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