What is Voperan 10?
Voperan 10 is used to treat the symptoms of a certain type of stomach problem called gastroparesis in patients with diabetes. It works by increasing the movements or contractions of the stomach and intestines. It relieves symptoms such as nausea, vomiting, heartburn, a feeling of fullness after meals, and loss of appetite. Voperan 10 is also used to treat heartburn for patients with gastroesophageal reflux disease (GERD). GERD is esophageal irritation from the backward flow of gastric acid into the esophagus.
Voperan 10 is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Voperan 10 is used in certain patients with the following medical conditions:
- Failure of the stomach to empty its contents.
- Nausea and vomiting caused by other medicines.
- Persistent hiccups.
- Prevention of aspirating fluid into the lungs during surgery.
- Vascular headaches.
Voperan 10 indications
Voperan 10 increases muscle contractions in the upper digestive tract. This speeds up the rate at which the stomach empties into the intestines.
Voperan 10 is used short-term to treat heartburn caused by gastroesophageal reflux in people who have used other medications without relief of symptoms.
Voperan 10 is also used to treat slow gastric emptying in people with diabetes (also called diabetic gastroparesis), which can cause nausea, vomiting, heartburn, loss of appetite, and a feeling of fullness after meals.
How should I use Voperan 10?
Use Voperan 10 as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Voperan 10 comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Voperan 10 refilled.
- Take Voperan 10 by mouth 30 minutes before meals and at bedtime without food or water unless directed otherwise by your doctor.
- Do not remove the tablet from the blister pack until you are ready to take Voperan 10. Make sure that your hands are dry when you open the blister pack. If the tablet breaks or crumbles while handling, discard and remove a new tablet. Place the tablet on your tongue. The tablet dissolves quickly and can be swallowed with saliva. Take the tablet immediately after opening the blister pack. Do not store the removed tablet for future use.
- It may take several days to weeks for Voperan 10 to work. Do not stop taking Voperan 10 without checking with your doctor.
- If you miss a dose of Voperan 10, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Voperan 10.
Uses of Voperan 10 in details
How to use Voperan 10 injection
Voperan 10 description
Each ampoule of injection contains anhydrous Voperan 10 (as Voperan 10) 10 mg in 2 mL and sodium chloride in water for injections. When necessary, pH is adjusted with sodium hydroxide and/or hydrochloric acid.
Voperan 10 is 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxybenzamide HCl monohydrate. It has a molecular weight of 354.3 and its molecular formula is C14H22ClN3O2·HCl·H2O.
Voperan 10 hydrochloride occurs as a white or almost white, crystalline powder or crystals, very soluble in water, freely soluble in alcohol, sparingly soluble in methylene chloride, practically insoluble in ether.
Voperan 10 dosage
Usual Adult Voperan 10 Dose for Nausea/Vomiting:
Postoperative nausea and vomiting:
Parenteral: 10 to 20 mg IM at or near the end of surgery
Usual Adult Voperan 10 Dose for Gastroesophageal Reflux Disease:
Oral: 10 to 15 mg up to 4 times a day 30 minutes before meals and at bedtime, depending upon symptoms being treated and clinical response. Therapy should not exceed 12 weeks.
Usual Adult Voperan 10 Dose for Small Intestine Intubation:
If the tube has not passed the pylorus with conventional methods in 10 minutes, a single (undiluted) dose may be administered IV slowly over 1 to 2 minutes:
Adults and pediatric patients greater than or equal to 14 years: 10 mg IV as a single dose administered over 1 to 2 minutes.
Usual Adult Voperan 10 Dose for Radiographic Exam:
Adults and pediatric patients greater than or equal to 14 years: 10 mg IV as a single dose administered over 1 to 2 minutes to facilitate gastric emptying where delayed gastric emptying interferes with radiological examination of the stomach and/or small intestine.
Usual Adult Voperan 10 Dose for Gastroparesis:
During the earliest manifestations of diabetic gastric stasis, oral administration may be initiated. If severe symptoms are present, therapy should begin with IM or IV administration for up to 10 days until symptoms subside at which time the patient can be switched to oral therapy. Since diabetic gastric stasis is often recurrent, therapy should be reinstituted at the earliest manifestation.
Parenteral: 10 mg 4 times daily, IV (slowly over a 1 to 2 minute period) or IM for up to 10 days.
Oral: 10 mg 4 times daily, 30 minutes before meals and at bedtime, for 2 to 8 weeks depending on clinical response.
Usual Adult Voperan 10 Dose for Nausea/Vomiting -- Chemotherapy Induced:
IV infusion: 1 to 2 mg/kg/dose (depending on the emetogenic potential of the agent) IV (infused over a period of not less than 15 minutes) 30 minutes before administration of chemotherapy. The dose may be repeated twice at 2 hour intervals following the initial dose. If vomiting is still not suppressed, the same dose may be repeated 3 more times at 3 hour intervals.
For doses higher than 10 mg, the injection should be diluted in 50 mL of a parenteral solution. Normal saline is the preferred diluent.
If acute dystonic reactions occur, 50 mg of diphenhydramine hydrochloride may be injected IM.
Usual Adult Voperan 10 Dose for Migraine:
Use for treatment of migraine headaches is not an FDA approved indication; however, Voperan 10 has shown efficacy in studies at a dose of 10 to 20 mg IV once (used in combination with analgesics or ergot derivatives).
Usual Pediatric Voperan 10 Dose for Gastroesophageal Reflux Disease:
Voperan 10 is not approved by the FDA for gastroesophageal reflux disease in pediatric patients; however, the following doses have been studied:
Oral, IM, IV:
Infants and Children: 0.4 to 0.8 mg/kg/day in 4 divided doses
Usual Pediatric Voperan 10 Dose for Small Intestine Intubation:
Voperan 10 IV is approved by the FDA for pediatric use to facilitate small bowel intubation by causing gastric emptying where delayed gastric emptying interferes with radiological examination of the stomach and/or small intestine.
If the tube has not passed the pylorus with conventional methods in 10 minutes, a single (undiluted) dose may be administered IV slowly over 1 to 2 minutes:
Less than 6 years: 0.1 mg/kg IV as a single dose
6 to 14 years: 2.5 to 5 mg IV as a single dose
Children greater than 14 years: 10 mg as a single dose
Usual Pediatric Voperan 10 Dose for Nausea/Vomiting -- Chemotherapy Induced:
Voperan 10 is not approved by the FDA for chemotherapy induced nausea and vomiting in pediatric patients; however, the following doses have been studied:
IV:
1 to 2 mg/kg/dose IV every 30 minutes before chemotherapy and every 2 to 4 hours
Usual Pediatric Voperan 10 Dose for Nausea/Vomiting -- Postoperative:
Voperan 10 is not approved by the FDA for postoperative nausea and vomiting in pediatric patients; however, the following doses have been studied:
IV:
Children less than or equal to 14 years: 0.1 to 0.2 mg/kg/dose (maximum dose: 10 mg/dose); repeat every 6 to 8 hours as needed
Children greater than 14 years and Adults: 10 mg; repeat every 6 to 8 hours as needed
Voperan 10 interactions
See also:
What other drugs will affect Voperan 10?
Before taking Voperan 10, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by Voperan 10.
Tell your doctor about all other medications you use, especially:
acetaminophen (Tylenol);
cyclosporine (Gengraf, Neoral, Sandimmune);
digoxin (digitalis, Lanoxin);
glycopyrrolate (Robinul);
levodopa (Larodopa, Atamet, Parcopa, Sinemet);
mepenzolate (Cantil);
tetracycline (Brodspec, Panmycin, Robitet, Sumycin, Tetracap, and others);
atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);
bladder or urinary medications such as darifenacin (Enablex), tolterodine (Detrol), or solifenacin (Vesicare);
bronchodilators such as ipratroprium (Atrovent) or tiotropium (Spiriva);
irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin), or propantheline (Pro-Banthine);
an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate); or
medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (Clozaril, FazaClo), haloperidol (Haldol), olanzapine (Zyprexa, Symbyax), prochlorperazine (Compazine), risperidone (Risperdal), thiothixene (Navane), and others.
Voperan 10 side effects
See also:
What are the possible side effects of Voperan 10?
Get emergency medical help if you have any of these signs of an allergic reaction to Voperan 10: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Voperan 10 and call your doctor at once if you have any of these serious side effects:
tremors, or restless muscle movements in your eyes, tongue, jaw, or neck;
mask-like appearance of the face;
very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;
depressed mood, thoughts of suicide or hurting yourself;
hallucinations, anxiety, agitation, jittery feeling, trouble staying still;
swelling, fluid retention;
jaundice (yellowing of your skin or eyes); or
seizure (convulsions).
Less serious Voperan 10 side effects may include:
feeling restless, drowsy, tired, or dizzy;
headache, sleep problems (insomnia);
nausea, vomiting, diarrhea;
breast tenderness or swelling;
changes in your menstrual periods; or
urinating more than usual.
Voperan 10 contraindications
See also:
What is the most important information I should know about Voperan 10?
You should not take this medication if you are allergic to Voperan 10, or if you have bleeding or blockage in your stomach or intestines, epilepsy or other seizure disorder, or an adrenal gland tumor (pheochromocytoma).
Active ingredient matches for Voperan 10:
List of Voperan 10 substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Barkabromide | |
| Barkabromide 20 | |
| Barkabromide 5 | |
| Briface-OPC (Vietnam) | |
| Briface-OPC 10 mg x 2 Blister x 20 Tablet | |
| Cerucal 10 | |
| Clopramed 2.6 | |
| Demetic® | |
| DHA Metoclopramide (Vietnam) | |
| DHA Metoclopramide 10 mg x 1000 Tablet | |
| Dospertine 5 | |
| Emeliv (Singapore) | |
| Emeliv 10 mg x 1000's | $ 43.00 |
| Gingsuwel (Taiwan) | |
| Gingsuwel 5 mg | |
| Imperan 10 | |
| Medioran 20 | |
| Metamid 10 | |
| Metoperan 10 | |
| Metoperan 2.6 | |
| Metopramide 10 | |
| Metopramide 5 | |
| Metoran (Vietnam) | |
| Metoran 10 mg/2 mL x 10 tube x 2 mL | |
| Nausin (Thailand) | |
| Nausin 10 mg x 1000's | |
| Octamide Pfs | |
| Pasperan 2.6 | |
| Pasperan 5 | |
| Pasperan Adult | |
| Pasperan Child | |
| Pladic® | |
| Plazilin® | |
| Praminal (Indonesia) | |
| R-J Tab/Syrup (Thailand) | |
| R-J Tab/Syrup 10 mg x 1, 000's | |
| R-J Tab/Syrup 5 mg/5 mL x 30 mL | |
| R-J Tab/Syrup 5 mg/5 mL x 1 gal | |
| Syntomide (Singapore) | |
| Syntomide 10 mg x 1's | |
| Topram (Indonesia) | |
| Vincomid (Vietnam) | |
| Vincomid 10 mg/2 mL x 12 tube x 2 ml | |
| Vomaine (Philippines) | |
| Vomaine 5 mg/1 mL x 2 mL x 10's | |
| Weiperan (Taiwan) | |
| Weiperan 10 mg x 1000's | |
| YSPPulin (Vietnam) | |
| YSPPulin 10 mg x 10 Blister x 1o Tablet | |
| YSPPulin 10 mg x 1 Bottle 1000 Tablet | |
| Zumatrol (Indonesia) | |
References
- PubChem. "metoclopramide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "metoclopramide". http://www.drugbank.ca/drugs/DB01233 (accessed September 17, 2018).
- MeSH. "Antiemetics". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Voperan 10 are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Voperan 10. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
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Information checked by Dr. Sachin Kumar, MD Pharmacology
