Deslonorm Uses

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What is Deslonorm?

Deslonorm is an antihistamine that reduces the effects of the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Deslonorm is used to treat the symptoms of allergies, such as sneezing, watery eyes, and runny nose. It is also used to treat skin hives and itching in people with chronic skin reactions.

Deslonorm may also be used for purposes not listed in this medication guide.

Deslonorm indications

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1.1 Seasonal Allergic Rhinitis

Deslonorm Tablets are indicated for the relief of the nasal and non-nasal symptoms of seasonal allergic rhinitis in patients 12 years of age and older.

1.2 Perennial Allergic Rhinitis

Deslonorm Tablets are indicated for the relief of the nasal and non-nasal symptoms of perennial allergic rhinitis in patients 12 years of age and older.

1.3 Chronic Idiopathic Urticaria

Deslonorm Tablets are indicated for the symptomatic relief of pruritus, reduction in the number of hives, and size of hives, in patients with chronic idiopathic urticaria 12 years of age and older.

How should I use Deslonorm?

Use Deslonorm orally disintegrating tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Deslonorm orally disintegrating tablets.

Uses of Deslonorm in details

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Use: Labeled Indications

Allergic rhinitis: Relief of nasal and non-nasal symptoms of seasonal (SAR) and perennial (PAR) allergic rhinitis

Urticaria: Symptomatic relief of pruritus, reduction in number of hives, and reduction in size of hives associated with chronic idiopathic urticaria (CIU)

Off Label Uses

NSAID-associated urticaria (prophylaxis)

Data from a retrospective study with a limited number of patients suggest that Deslonorm may be beneficial for prophylactic therapy in patients with NSAID-associated urticaria prior to receiving a strong COX-1 inhibitor. Additional trials may be needed to further define the role of Deslonorm in this setting.

Deslonorm description

Deslonorm Tab: Each tablet contains 5.0 mg of Deslonorm.

Deslonorm Syr: Each mL of Deslonorm syrup contains 500 mcg of Deslonorm.

Excipients/Inactive Ingredients: Deslonorm Tab: Dibasic calcium phosphate dihydrate, microcrystalline cellulose, maize starch, talc, blue color film-coat material, clear film coat material, white wax and carnauba wax.

Deslonorm dosage

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Deslonorm Dosage

Generic name: Deslonorm 5mg

Dosage form: tablet, film coated; oral solution

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Although an orally disintegrating tablet formulation of Deslonorm may be available in the marketplace, Deslonorm® RediTabs® Tablets are no longer marketed.

Deslonorm Tablets,

Oral Solution, or RediTabs Tablets may be taken without regard to meals. Place Deslonorm (Deslonorm) RediTabs Tablets on the tongue and allow to disintegrate before swallowing. Tablet disintegration occurs rapidly. Administer with or without water. Take tablet immediately after opening the blister.

The age-appropriate dose of Deslonorm

Oral Solution should be administered with a commercially available measuring dropper or syringe that is calibrated to deliver 2 mL and 2.5 mL (½ teaspoon).

Adults and Adolescents 12 Years of Age and Over

The recommended dose of Deslonorm Tablets or Deslonorm Tablets is one 5-mg tablet once daily. The recommended dose of Deslonorm

Oral Solution is 2 teaspoonfuls (5 mg in 10 mL) once daily.

Children 6 to 11 Years of Age

The recommended dose of Deslonorm

Oral Solution is 1 teaspoonful (2.5 mg in 5 mL) once daily. The recommended dose of Deslonorm Tablets is one 2.5-mg tablet once daily.

Children 12 Months to 5 Years of Age

The recommended dose of Deslonorm

Oral Solution is ½ teaspoonful (1.25 mg in 2.5 mL) once daily.

Children 6 to 11 Months of Age

The recommended dose of Deslonorm

Oral Solution is 2 mL (1 mg) once daily.

Adults with Hepatic or Renal Impairment

In adult patients with liver or renal impairment, a starting dose of one 5-mg tablet every other day is recommended based on pharmacokinetic data. Dosing recommendation for children with liver or renal impairment cannot be made due to lack of data.

More about Deslonorm (Deslonorm)

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Professional resources

Other formulations

Related treatment guides

Deslonorm interactions

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What other drugs will affect Deslonorm?

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Inhibitors Of Cytochrome P450 3A4

In controlled clinical studies co-administration of Deslonorm with ketoconazole, erythromycin, or azithromycin resulted in increased plasma concentrations of Deslonorm and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of Deslonorm.

Fluoxetine

In controlled clinical studies co-administration of Deslonorm with fluoxetine, a selective serotonin reuptake inhibitor (SSRI), resulted in increased plasma concentrations of Deslonorm and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of Deslonorm.

Cimetidine

In controlled clinical studies co-administration of Deslonorm with cimetidine, a histamine H2-receptor antagonist, resulted in increased plasma concentrations of Deslonorm and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of Deslonorm.

Drug Abuse And Dependence

There is no information to indicate that abuse or dependency occurs with Deslonorm Tablets.

Deslonorm side effects

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What are the possible side effects of Deslonorm?

In clinical trials in a range of indications including allergic rhinitis and chronic idiopathic urticaria, at the recommended dose of 5 mg daily, undesirable effects with Deslonorm tablets were reported in 3 % of patients in excess of those treated with placebo. The most frequent adverse events reported in excess of placebo were fatigue (1.2 %), dry mouth (0.8 %), and headache (0.6 %).

Very rare cases of hypersensitivity reactions (including anaphylaxis and rash) tachycardia, palpitations, psychomotor hyperactivity, seizures, elevations of liver enzymes, hepatitis, and increased bilirubin have been reported during the marketing of Deslonorm.

Deslonorm Syr: In clinical trials in a paediatric population, Deslonorm Syrup was administered to a total of 246 children aged 6 months through 11 years. The overall incidence of adverse events in children 2 through 11 years of age was similar for Deslonorm Syrup and the placebo groups. In infants and toddlers aged 6 to 23 months, the most frequent adverse events reported in excess of placebo were diarrhea (3.7%), fever (2.3%) and insomnia (2.3%).

Deslonorm contraindications

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What is the most important information I should know about Deslonorm?

You should not take this medication if you are allergic to Deslonorm or to loratadine (Claritin).

Before taking Deslonorm, tell your doctor if you are allergic to any drugs, or if you have liver or kidney disease.

Do not give this medication to a child younger than 2 years old without the advice of a doctor.

Deslonorm disintegrating tablets (Deslonorm) may contain phenylalanine. Talk to your doctor before using this form of Deslonorm if you have phenylketonuria (PKU).

Active ingredient matches for Deslonorm:

Desloratadine in Georgia.


List of Deslonorm substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
DESLOR Capsule/ Tablet / 5mg / 10 units (Solarase (Sun Pharmaceutical Industries Ltd.))$ 0.61
Deslor 5mg TAB / 10 (Solarase (Sun Pharmaceutical Industries Ltd.))$ 0.66
5 mg x 10's (Solarase (Sun Pharmaceutical Industries Ltd.))$ 0.66
Deslor 5 mg x 100's (Solarase (Sun Pharmaceutical Industries Ltd.))
Deslor 5 mg Tablet (Solarase (Sun Pharmaceutical Industries Ltd.))$ 0.07
DESLOR 5 MG TABLET 1 strip / 10 tablets each (Solarase (Sun Pharmaceutical Industries Ltd.))$ 0.88
DESLOR 5 MG TABLET MD 1 strip / 10 tablet mds each (Solarase (Sun Pharmaceutical Industries Ltd.))$ 0.73
DESLOR tab 5 mg x 10's (Solarase (Sun Pharmaceutical Industries Ltd.))$ 0.71
Deslor 5mg Tablet (Solarase (Sun Pharmaceutical Industries Ltd.))$ 0.09
Deslor 5mg Tablet MD (Solarase (Sun Pharmaceutical Industries Ltd.))$ 0.07
Deslora 5 mg x 3 Blister x 10 Tablet (Stada)
Deslora FC tab 5 mg 5's (Stada)
DESLORANID tab 5 mg x 10's (Nidus)$ 0.45

References

  1. DailyMed. "DESLORATADINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "Desloratadine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "Desloratadine". http://www.drugbank.ca/drugs/DB00967 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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