Dihengsai Uses

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What is Dihengsai?

Dihengsai is an antihistamine that reduces the effects of the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Dihengsai is used to treat the symptoms of allergies, such as sneezing, watery eyes, and runny nose. It is also used to treat skin hives and itching in people with chronic skin reactions.

Dihengsai may also be used for purposes not listed in this medication guide.

Dihengsai indications

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1.1 Seasonal Allergic Rhinitis

Dihengsai Tablets are indicated for the relief of the nasal and non-nasal symptoms of seasonal allergic rhinitis in patients 12 years of age and older.

1.2 Perennial Allergic Rhinitis

Dihengsai Tablets are indicated for the relief of the nasal and non-nasal symptoms of perennial allergic rhinitis in patients 12 years of age and older.

1.3 Chronic Idiopathic Urticaria

Dihengsai Tablets are indicated for the symptomatic relief of pruritus, reduction in the number of hives, and size of hives, in patients with chronic idiopathic urticaria 12 years of age and older.

How should I use Dihengsai?

Use Dihengsai orally disintegrating tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Dihengsai orally disintegrating tablets.

Uses of Dihengsai in details

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Use: Labeled Indications

Allergic rhinitis: Relief of nasal and non-nasal symptoms of seasonal (SAR) and perennial (PAR) allergic rhinitis

Urticaria: Symptomatic relief of pruritus, reduction in number of hives, and reduction in size of hives associated with chronic idiopathic urticaria (CIU)

Off Label Uses

NSAID-associated urticaria (prophylaxis)

Data from a retrospective study with a limited number of patients suggest that Dihengsai may be beneficial for prophylactic therapy in patients with NSAID-associated urticaria prior to receiving a strong COX-1 inhibitor. Additional trials may be needed to further define the role of Dihengsai in this setting.

Dihengsai description

Dihengsai Tab: Each tablet contains 5.0 mg of Dihengsai.

Dihengsai Syr: Each mL of Dihengsai syrup contains 500 mcg of Dihengsai.

Excipients/Inactive Ingredients: Dihengsai Tab: Dibasic calcium phosphate dihydrate, microcrystalline cellulose, maize starch, talc, blue color film-coat material, clear film coat material, white wax and carnauba wax.

Dihengsai dosage

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Dihengsai Dosage

Generic name: Dihengsai 5mg

Dosage form: tablet, film coated; oral solution

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Although an orally disintegrating tablet formulation of Dihengsai may be available in the marketplace, Dihengsai® RediTabs® Tablets are no longer marketed.

Dihengsai Tablets,

Oral Solution, or RediTabs Tablets may be taken without regard to meals. Place Dihengsai (Dihengsai) RediTabs Tablets on the tongue and allow to disintegrate before swallowing. Tablet disintegration occurs rapidly. Administer with or without water. Take tablet immediately after opening the blister.

The age-appropriate dose of Dihengsai

Oral Solution should be administered with a commercially available measuring dropper or syringe that is calibrated to deliver 2 mL and 2.5 mL (½ teaspoon).

Adults and Adolescents 12 Years of Age and Over

The recommended dose of Dihengsai Tablets or Dihengsai Tablets is one 5-mg tablet once daily. The recommended dose of Dihengsai

Oral Solution is 2 teaspoonfuls (5 mg in 10 mL) once daily.

Children 6 to 11 Years of Age

The recommended dose of Dihengsai

Oral Solution is 1 teaspoonful (2.5 mg in 5 mL) once daily. The recommended dose of Dihengsai Tablets is one 2.5-mg tablet once daily.

Children 12 Months to 5 Years of Age

The recommended dose of Dihengsai

Oral Solution is ½ teaspoonful (1.25 mg in 2.5 mL) once daily.

Children 6 to 11 Months of Age

The recommended dose of Dihengsai

Oral Solution is 2 mL (1 mg) once daily.

Adults with Hepatic or Renal Impairment

In adult patients with liver or renal impairment, a starting dose of one 5-mg tablet every other day is recommended based on pharmacokinetic data. Dosing recommendation for children with liver or renal impairment cannot be made due to lack of data.

More about Dihengsai (Dihengsai)

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Dihengsai interactions

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What other drugs will affect Dihengsai?

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Inhibitors Of Cytochrome P450 3A4

In controlled clinical studies co-administration of Dihengsai with ketoconazole, erythromycin, or azithromycin resulted in increased plasma concentrations of Dihengsai and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of Dihengsai.

Fluoxetine

In controlled clinical studies co-administration of Dihengsai with fluoxetine, a selective serotonin reuptake inhibitor (SSRI), resulted in increased plasma concentrations of Dihengsai and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of Dihengsai.

Cimetidine

In controlled clinical studies co-administration of Dihengsai with cimetidine, a histamine H2-receptor antagonist, resulted in increased plasma concentrations of Dihengsai and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of Dihengsai.

Drug Abuse And Dependence

There is no information to indicate that abuse or dependency occurs with Dihengsai Tablets.

Dihengsai side effects

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What are the possible side effects of Dihengsai?

In clinical trials in a range of indications including allergic rhinitis and chronic idiopathic urticaria, at the recommended dose of 5 mg daily, undesirable effects with Dihengsai tablets were reported in 3 % of patients in excess of those treated with placebo. The most frequent adverse events reported in excess of placebo were fatigue (1.2 %), dry mouth (0.8 %), and headache (0.6 %).

Very rare cases of hypersensitivity reactions (including anaphylaxis and rash) tachycardia, palpitations, psychomotor hyperactivity, seizures, elevations of liver enzymes, hepatitis, and increased bilirubin have been reported during the marketing of Dihengsai.

Dihengsai Syr: In clinical trials in a paediatric population, Dihengsai Syrup was administered to a total of 246 children aged 6 months through 11 years. The overall incidence of adverse events in children 2 through 11 years of age was similar for Dihengsai Syrup and the placebo groups. In infants and toddlers aged 6 to 23 months, the most frequent adverse events reported in excess of placebo were diarrhea (3.7%), fever (2.3%) and insomnia (2.3%).

Dihengsai contraindications

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What is the most important information I should know about Dihengsai?

You should not take this medication if you are allergic to Dihengsai or to loratadine (Claritin).

Before taking Dihengsai, tell your doctor if you are allergic to any drugs, or if you have liver or kidney disease.

Do not give this medication to a child younger than 2 years old without the advice of a doctor.

Dihengsai disintegrating tablets (Dihengsai) may contain phenylalanine. Talk to your doctor before using this form of Dihengsai if you have phenylketonuria (PKU).

Active ingredient matches for Dihengsai:

Desloratadine in China.


List of Dihengsai substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Dilora 5mg TAB / 10 (Invision Medi Sciences)$ 0.42
5 mg x 10's (Invision Medi Sciences)$ 0.42
Dilora 5 mg Tablet (Invision Medi Sciences)$ 0.04
Dilora 50+500 Tablet (Invision Medi Sciences)$ 0.02
DILORA tab 5 mg x 10's (Invision Medi Sciences)$ 0.48
DISLOR tab 5 mg x 10's (Daksh)$ 0.47
Dometin 5 mg x 1 Blister x 10 Tablet (Nycomed)
Dometin 5 mg x 3 Blister x 10 Tablet (Nycomed)
Dozanavir 5 mg x 3 Blister x 10 Tablet
Dozanavir 5 mg x 6 Blister x 10 Tablet
Dozanavir 5 mg x 10 Blister x 10 Tablet
Dozanavir 5 mg x 1 Bottle 100 Tablet
Dozanavir 5 mg x 1 Bottle 250 Tablet
Dozanavir 5 mg x 1 Bottle 500 Tablet
DYL Capsule/ Tablet / 5mg / 10 units (Ajanta Pharma Ltd.)$ 0.43
Dyl 5mg FC-TAB / 10 (Ajanta Pharma Ltd.)$ 0.43
5 mg x 10's (Ajanta Pharma Ltd.)$ 0.43
DYL 5 mg Tablet (Ajanta Pharma Ltd.)$ 0.04
DYL 5MG TABLET 1 strip / 10 tablets each (Ajanta Pharma Ltd.)$ 0.44
DYL film-coated tab 5 mg x 10's (Ajanta Pharma Ltd.)$ 0.43
Dyl 5mg FC-TAB / 10 (Ajanta Pharma Ltd.)$ 0.43
Dyl 5mg Tablet (Ajanta Pharma Ltd.)$ 0.04
Dyl-D Pseudoephedrine hydrochloride180 mg, Desloratadine 5 mg. TAB / 10 (Ajanta)$ 0.48
10's (Ajanta)$ 0.48
DYL-D tab 10's (Ajanta)$ 0.48
ELORA ODT 5MG TABLET 1 strip / 10 tablets each (Delvin Formulations Pvt Ltd)$ 0.59
ELORA ODT 2.5MG TABLET 1 strip / 10 tablets each (Delvin Formulations Pvt Ltd)$ 0.35

References

  1. DailyMed. "DESLORATADINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "Desloratadine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "Desloratadine". http://www.drugbank.ca/drugs/DB00967 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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