Gabaciz M indications
Pernicious anemia, both uncomplicated and accompanied by nervous system involvement.
Dietary deficiency of Vitamin B12, occurring in strict vegetarians and in their breast-fed infants. (Isolated vitamin B12 deficiency is very rare).
Malabsorption of vitamin B12, resulting from structural or functional damage to the stomach, where intrinsic factor is secreted or to the ileum, where intrinsic factor facilitates vitamin B12 absorption. These conditions include tropical sprue, and nontropical sprue (idiopathic steatorrhea, gluten-induced enteropathy). Folate deficiency in these patients is usually more severe than vitamin B12 deficiency.
Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy). Total gastrectomy always produces vitamin B12 deficiency.
Structural lesions leading to vitamin B12 deficiency include regional ileitis, ileal resections, malignancies, etc.
Competition for Vitamin B12 by intestinal parasites or bacteria.
The fish tapeworm (Diphyilobothrium latum) absorbs huge quantities of vitamin B12 and infested patients often have associated gastric atrophy. The blind-loop syndrome may produce deficiency of Vitamin B12 or folate.
Inadequate utilization of vitamin B12. This may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia.
For the Schilling Test.
Gabaciz M description
Gabaciz M also contains the following inactive ingredients: Lactose, maize starch, microcrystalline cellulose, povidone (K-30), purified talc, anhydrous colloidal silica, hypromellose, macrogol, titanium dioxide, isopropyl alcohol, dicholoromethane, red iron oxide and yellow iron oxide.
Gabaciz M dosage
Gabaciz M-500: The daily dose is 1 tab 3 times daily.
Gabaciz M-1500: The daily dose is 1 tab once daily. The dosage should be adjusted according to age of patient and severity of symptoms.
Gabaciz M interactions
Antibiotics: The use of antibiotics may alter the intestinal microflora and may decrease the possible contribution of Gabaciz M by certain inhabitants of the microflora (eg, Lactobacillus spp) to the body's requirement for the vitamin. This may particularly be a problem for vegetarians. Garlic, onions, leeks, bananas, asparagus and artichokes, among other vegetables and fruits, contain inulins which promote the growth of certain colonic bacteria including Lactobacillus spp. Cholestyramine:
Colchicine: Colchicine may cause decreased absorption of Gabaciz M. Colestipol:
H2-Blockers (Cimetidine, Famotidine, Nizatidine, Ranitidine): Chronic use of H2-blockers may result to decreased absorption of Gabaciz M. They are unlikely to affect the absorption of supplemental B12.
Metformin: Metformin may decrease the absorption of Gabaciz M. This possible effect may be reversed with oral calcium supplementation.
Nitrous Oxide: Inhalation of the anesthetic agent nitrous oxide (not to be confused with nitric oxide) can produce a functional deficiency. Nitrous oxide forms a complex with cobalt in Gabaciz M, the cofactor for methionine synthase, resulting in inactivation of the enzyme.
Para-Amino Salicylic Acid: Chronic use of the anti-tuberculosis drug may decrease the absorption of Gabaciz M.
Potassium Chloride: It has been reported that potassium chloride may decrease the absorption of Gabaciz M.
Proton Pump Inhibitors (Lansoprazole, Omeprazole, Pantoprazole, Rabeprazole): Chronic use of proton pump inhibitors may result in decreased absorption, naturally found in food sources.
Gabaciz M side effects
water weight gain, edema, increase in BUN, and dilutional hyponatremia. Asterixis was reported to have worsened in one patient during infusion of this medicine.
Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia.
Symptoms may result from an excess or deficit of one or more of the ions present in the solution; therefore, frequent monitoring of electrolyte levels is essential.
Phosphorus deficiency may lead to impaired tissue oxygenation and acute hemolytic anemia. Relative to calcium, excessive phosphorus intake can precipitate hypocalcemia with cramps, tetany and muscular hyperexcitability.
If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.
Gabaciz M contraindications
Hypersensitivity to Gabaciz M or other vit B12-containing, cobalamin products or cobalt.
Active ingredient matches for Gabaciz M:
| Unit description / dosage (Manufacturer) | Price, USD |
| Gabaciz M 100 mg+500 mcg Tablet | $ 0.12 |
List of Gabaciz M substitutes (brand and generic names): | |
| Gababit-MN (India) | |
| GABABIT-MN tab 10's (Cubit) | |
| Gabacord M | |
| Gabacord M 300 mg+500 mcg Tablet (Accord Pharmaceuticals) | $ 0.13 |
| Gabalex-MN (India) | |
| Gabalex-MN Methylcobalamin 1500 mcg, Gabapentin 300 mg. TAB / 10 (Lexus) | |
| 10's (Lexus) | |
| GABALEX-MN tab 10's (Lexus) | |
| Gabaquin | |
| Gabaquin 300 mg+500 mcg Tablet (Mak Pharmaceuticals) | $ 0.12 |
| Gabastar M | |
| Gabastar M 300 mg+500 mcg Tablet (Lupin Laboratories Ltd.) | $ 0.15 |
| Gabatop (India) | |
| Gabatop Mecobalamin 750 mcg, Pregabalin 75 mg. CAP / 100 (CureMax (Solitaire Pharmacia Pvt Ltd)) | $ 11.93 |
| Gabatop Mecobalamin 750 mg, Pregabalin150 mg. CAP / 100 (CureMax (Solitaire Pharmacia Pvt Ltd)) | $ 21.08 |
| 100's (CureMax (Solitaire Pharmacia Pvt Ltd)) | $ 21.08 |
| Gabatop 150 mg+750 mcg Capsule (CureMax (Solitaire Pharmacia Pvt Ltd)) | $ 0.21 |
| Gabatop 75 mg+750 mcg Capsule (CureMax (Solitaire Pharmacia Pvt Ltd)) | $ 0.12 |
| GABATOP cap 10's (CureMax (Solitaire Pharmacia Pvt Ltd)) | $ 2.11 |
| Gabion M | |
| Gabion M 300 mg+500 mcg Tablet (Zenon Healthcare) | $ 0.12 |
| Gabsoft M | |
| Gabsoft M 300 mg+500 mcg Capsule (Elnova Pharma) | $ 0.14 |
| Gabufast | |
| Gabufast 300 mg+500 mcg Tablet (Medicamen Biotech Ltd.) | $ 0.13 |
| Game (India) | |
| Game Gabapentin 300 mg, Mecobalamin300 mcg. TAB / 10 (Dyota Numandis) | $ 1.30 |
| 10's (Dyota Numandis) | $ 1.30 |
| Game 300 mg+500 mcg Tablet (Dyota Numandis) | $ 0.13 |
| GAME tab 10's (Dyota Numandis) | $ 1.30 |
| Game Tablet (Dyota Numandis) | $ 0.13 |
| GB 29 | |
| GB 29 75 mg+750 mcg Capsule (Xmex (Corona Remedies Pvt Ltd)) | $ 0.10 |
| GB 29 CAPSULE 1 strip / 10 capsules each (Xmex (Corona Remedies Pvt Ltd)) | $ 1.12 |
| GB 29 Capsule (Xmex (Corona Remedies Pvt Ltd)) | $ 0.12 |
| Genacob (Vietnam) | |
| Genacob 0.5 mg x 3 Blister x 10 Tablet | |
| Geocobalamin (Philippines) | |
| Geocobalamin 500 mcg x 20's | |
| Geocobalamin / amp 500 mcg/1 mL x 1 mL x 10's | |
| Geofcobal (Vietnam) | |
| Geofcobal 0.5 mg/1 mL x 10 tube x 1 mL | |
| Gic-M (India) | |
| Gic-M Methylcobalamin 500 mcg, Gabapentin 300 mg. FC-TAB / 100 (Vensat) | $ 14.46 |
| 100's (Vensat) | $ 14.46 |
| GIC-M film-coated tab 10's (Vensat) | $ 1.45 |
| Gl-Max INJ (India) | |
| Gl-Max INJ Mecobalamin 1000 mcg, pyridoxine hydrochloride 100mg, D-panthenol 50 mg, nicotinamide 100 mg. INJ / 2mlx5 (Green Lab) | $ 1.51 |
| GL-MAX INJ inj 2ml (Green Lab) | $ 0.30 |
| Gl-Pg (India) | |
| Gl-Pg Pregabalin 75 mg, mecobalamin750 mcg. CAP / 10 (Green Lab) | $ 1.20 |
| GL-PG cap 10's (Green Lab) | $ 1.20 |
| Glomec (India) | |
| Glomec 500 mg x 1mL AMP / 1ml (Glories) | |
| 500 mg x 1 mL x 1ml (Glories) | |
| GLOMEC inj 500 mg x 1 mL x 1ml (Glories) | |
| Glomec Plus (India) | |
| Glomec Plus Vitamin B1 100 mg, Vitamin B6100 mg, Nicotinamide 100 mg, D-panthenol 50 mg, mecobalamin100 mg. AMP / 2ml (Glories) | |
| 2ml (Glories) | |
| GLOMEC PLUS inj 2ml (Glories) | |
| Golvaska (Vietnam) | |
| Golvaska 500 mcg x 10 Blister x 10 Tablet | |
See 2615 substitutes for Gabaciz M | |
Reviews
The results of a survey conducted on ndrugs.com for Gabaciz M are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Gabaciz M. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
