Consists of dextromethorphan HBr, loratadine, Paracetamol
What is Dextromethorphan HBr (Hapacol CF)?
Dextromethorphan HBr (Hapacol CF) is a cough suppressant. It affects the signals in the brain that trigger cough reflex.
Dextromethorphan HBr (Hapacol CF) is used to treat a cough.
Dextromethorphan HBr (Hapacol CF) will not treat a cough that is caused by smoking, asthma, or emphysema.
Dextromethorphan HBr (Hapacol CF) may also be used for purposes not listed in this medication guide.
Dextromethorphan HBr (Hapacol CF) indications
used to treat symptoms caused by the common cold, flu, allergies, hay fever, or other breathing illnesses (e.g., sinusitis, bronchitis). Dextromethorphan HBr (Hapacol CF) is a cough suppressant that affects a certain part of the brain (cough center), reducing the urge to cough. Decongestants help relieve stuffy nose symptoms. Antihistamines relieve watery eyes, itchy eyes/nose/throat, runny nose, and sneezing.
How should I use Dextromethorphan HBr (Hapacol CF)?
Use Dextromethorphan HBr (Hapacol CF) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Dextromethorphan HBr (Hapacol CF) by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Do not remove the strip from the pouch until you are ready to take Dextromethorphan HBr (Hapacol CF). Be sure that your hands are dry when you touch the strip.
- Remove the strip from the pouch and place it onto the tongue. The strip dissolves quickly and can be swallowed with saliva. It may be taken with or without water.
- Use the strip right away after you open the pouch. Do not store it for future use.
- If you miss a dose of Dextromethorphan HBr (Hapacol CF) and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Dextromethorphan HBr (Hapacol CF).
Uses of Dextromethorphan HBr (Hapacol CF) in details
This medication is used for temporary relief of coughs without phlegm that are caused by certain infections of the air passages (e.g., sinusitis, common cold). This product should not usually be used for an ongoing cough from smoking or long-term breathing problems (e.g., chronic bronchitis, emphysema) unless directed by your doctor. This product contains Dextromethorphan HBr (Hapacol CF). It is a cough suppressant that works by decreasing the feeling of needing to cough.
Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Ask your doctor or pharmacist for more details about using your product safely.
These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients. Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).
How to use Dextromethorphan HBr (Hapacol CF)
Take this medication by mouth, usually every 4 to 12 hours as needed or as directed by your doctor. If stomach upset occurs, take with food or milk. Use a medication-measuring device to measure your dose of liquid medication. Do not use a household spoon because you may not get the correct dose. If you are taking a suspension, shake the product well before measuring out your dose.
Dosage is based on the product you are taking and your age, medical condition, and response to treatment. If you are using this medication for self-treatment (without a prescription from your doctor), follow the specific dosing instructions on the packaging to find the correct dose for your age.
If your doctor directs you to take this medication daily, take it regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.
Improper use of this medication (abuse) may result in serious harm (e.g., brain damage, seizure, death). Do not increase your dose, take it more frequently, or use it for a longer time than prescribed. Properly stop the medication when so directed.
Tell your doctor if your symptoms persist or worsen after more than 1 week or if you also have fever, chills, headache, or rash. These may be signs of a more serious condition.
Dextromethorphan HBr (Hapacol CF) description
The d-isomer of the codeine analog of levorphanol. Dextromethorphan HBr (Hapacol CF) shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.
Dextromethorphan HBr (Hapacol CF) dosage
For adults and children over 12 years Dextromethorphan HBr (Hapacol CF) prescribed on 15 mg 4 times / day, children aged 6 years - 7.5 mg 4 times / day.
Dextromethorphan HBr (Hapacol CF) interactions
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What other drugs will affect Dextromethorphan HBr (Hapacol CF)?
MAO inhibitors (including furazolidone, procarbazine, selegiline) when administered simultaneous with Dextromethorphan HBr (Hapacol CF) may cause adrenergic crisis, collapse, coma, dizziness, agitation, increased blood pressure, hyperpyrexia, intracranial hemorrhage, lethargy, nausea, cramps, tremor. In combination with tricyclic antidepressants (amitriptyline, etc.) Dextromethorphan HBr (Hapacol CF) may appeal serotonin syndrome and possible subsequent death. Amiodarone, fluoxetine, quinidine, inhibiting system cytochrome P450, may increase the drug concentration in the blood. Tobacco smoke can lead to increased secretion of glands in the background of inhibition of cough reflex. Some inhibitors of CYP450 (such as quinidine) increase and extended effects of this medicine.
Dextromethorphan HBr (Hapacol CF) side effects
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What are the possible side effects of Dextromethorphan HBr (Hapacol CF)?
Slight drowsiness/dizziness, nausea, or vomiting may occur. Rarely, some people may experience severe drowsiness/dizziness with normal doses. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Dextromethorphan HBr (Hapacol CF) contraindications
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What is the most important information I should know about Dextromethorphan HBr (Hapacol CF)?
Respiratory depression, obstructive airway disease, asthma. Acute alcoholism, convulsive disorders, head injuries, comatose patients, raised intracranial pressure. Pregnancy (prolonged use or high doses at term).
What is Loratadine (Hapacol CF)?
Loratadine (Hapacol CF) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Loratadine (Hapacol CF) is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms.
Loratadine (Hapacol CF) is also used to treat skin hives and itching in people with chronic skin reactions.
Loratadine (Hapacol CF) may also be used for purposes not listed in this medication guide.
Loratadine (Hapacol CF) indications
Treatment of seasonal allergic rhinitis, perennial rhinitis, urticaria, allergic dermatologic disorders, angioedema and conjunctivitis. Loratadine (Hapacol CF) is generally considered to be ineffective in asthma.
Acute anaphylaxis should be treated with adrenaline; Loratadine (Hapacol CF) and corticosteroids are given to prevent relapse.
Loratadine (Hapacol CF) is also used to control the pruritus associated with skin disorders eg, atopic eczema.
How should I use Loratadine (Hapacol CF)?
Use Loratadine (Hapacol CF) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Loratadine (Hapacol CF) by mouth with or without food.
- Be sure that your hands are completely dry before you handle Loratadine (Hapacol CF). Use the tablet right away after you remove it from the tablet blister.
- To open the tablet blister, peel back the foil, then gently remove the tablet. Place the tablet on the tongue. The tablet will dissolve quickly. You may take Loratadine (Hapacol CF) with or without water.
- If you miss a dose of Loratadine (Hapacol CF), take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Loratadine (Hapacol CF).
Uses of Loratadine (Hapacol CF) in details
This medication is an antihistamine that treats symptoms such as itching, runny nose, watery eyes, and sneezing from "hay fever" and other allergies. It is also used to relieve itching from hives.
Loratadine (Hapacol CF) does not prevent hives or prevent/treat a serious allergic reaction (e.g., anaphylaxis). Therefore, if your doctor has prescribed epinephrine to treat allergic reactions, always carry your epinephrine injector with you. Do not use Loratadine (Hapacol CF) in place of your epinephrine.
If you are self-treating with this medication, it is important to read the manufacturer's package instructions carefully so you know when to consult your doctor or pharmacist.
Do not use this medication in children younger than 6 years unless directed by the doctor. If you are using the chewable tablets, do not use in children younger than 2 years unless directed by your doctor.
How to use Loratadine (Hapacol CF)
If you are using the over-the-counter product to self-treat, read all the directions on the product package before taking this medication. If your doctor has prescribed this medication, follow your doctor's directions and the instructions on your prescription label. If you have any questions, consult your doctor or pharmacist.
Take this medication by mouth with or without food, usually once a day or as directed by your doctor or the product package. If you are using the chewable tablets, chew each tablet well and swallow. Dosage is based on your age, condition, and response to treatment. Do not increase your dose or take this drug more often than directed. Do not take more of this medication than recommended for your age.
Tell your doctor if your allergy symptoms do not improve after 3 days of treatment or if your hives last more than 6 weeks. Seek immediate medical attention if your condition worsens or you think you have a serious medical problem (e.g., very serious allergic reaction/anaphylaxis).
Loratadine (Hapacol CF) description
Loratadine (Hapacol CF) competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. Loratadine (Hapacol CF)'s anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsible for its antiemetic effects, although the exact mechanism is unknown. It also is used commonly to treat drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease.
Loratadine (Hapacol CF) dosage
Loratadine (Hapacol CF) Dosage
Applies to the following strength(s): 10 mg; 5 mg/5 mL; 5 mg
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
- Allergic Rhinitis
- Urticaria
Usual Pediatric Dose for:
- Allergic Rhinitis
- Urticaria
Additional dosage information:
- Renal Dose Adjustments
- Liver Dose Adjustments
- Dialysis
Usual Adult Dose for Allergic Rhinitis
10 mg orally once a day
Usual Adult Dose for Urticaria
10 mg orally once a day
Usual Pediatric Dose for Allergic Rhinitis
2 to 5 years: 5 mg orally once a day (syrup)
6 years or older: 10 mg orally once a day (tablets, capsule, and disintegrating tablets)
Usual Pediatric Dose for Urticaria
2 to 5 years: 5 mg orally once a day (syrup)
6 years or older: 10 mg orally once a day (tablets, capsule, and disintegrating tablets)
Renal Dose Adjustments
CrCl less than 30 mL/min: administer dosage every other day initially
Liver Dose Adjustments
Liver failure: administer dosage every other day initially
Dialysis
Loratadine (Hapacol CF) is not significantly removed by hemodialysis, thus supplementary dosing is not required following hemodialysis.
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Related treatment guides
- Allergic Rhinitis
- Urticaria
Loratadine (Hapacol CF) interactions
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What other drugs will affect Loratadine (Hapacol CF)?
Loratadine (Hapacol CF) (10 mg once daily) has been coadministered with therapeutic doses of erythromycin, cimetidine, and ketoconazole in controlled clinical pharmacology studies in adult volunteers. Although increased plasma concentrations (AUC 0-24 hrs) of Loratadine (Hapacol CF) and/or descarboethoxyloratadine were observed following coadministration of Loratadine (Hapacol CF) with each of these drugs in normal volunteers (n = 24 in each study), there were no clinically relevant changes in the safety profile of Loratadine (Hapacol CF), as assessed by electrocardiographic parameters, clinical laboratory tests, vital signs, and adverse events. There were no significant effects on QTc intervals, and no reports of sedation or syncope. No effects on plasma concentrations of cimetidine or ketoconazole were observed. Plasma concentrations (AUC 0-24 hrs) of erythromycin decreased 15% with coadministration of Loratadine (Hapacol CF) relative to that observed with erythromycin alone. The clinical relevance of this difference is unknown. These above findings are summarized in TABLE 1.
| TABLE 1 Effects on Plasma Concentrations (AUC 0-24 hrs) of Loratadine (Hapacol CF) and Descarboethoxyloratadine After 10 Days of Coadministration (Loratadine (Hapacol CF) 10 mg) in Normal Volunteers | ||
| Loratadine (Hapacol CF) | Descarboethoxyloratadine | |
|---|---|---|
| Erythromycin (500 mg q8h) | + 40% | +46% |
| Cimetidine (300 mg qid) | +103% | + 6% |
| Ketoconazole (200 mg q12h) | +307% | +73% |
Loratadine (Hapacol CF) side effects
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What are the possible side effects of Loratadine (Hapacol CF)?
Applies to Loratadine (Hapacol CF): oral fixed-combination tablets, oral orally disintegrating tablets, oral solution, oral tablets
Side effects include:
Children 2–5 years of age receiving oral solution: Diarrhea, epistaxis, pharyngitis, flu-like symptoms, fatigue, stomatitis, tooth disorder, earache, viral infection, rash.
Children 6–12 years of age receiving oral solution: Nervousness, wheezing, fatigue, hyperkinesia, abdominal pain, conjunctivitis, dysphonia, upper respiratory tract infection.
Adults and children ≥12 years of age receiving conventional or orally disintegrating tablets: Headache, somnolence, fatigue, dry mouth.
Fixed combination Loratadine (Hapacol CF) (the active ingredient contained in Loratadine (Hapacol CF) Reditab) pseudoephedrine sulfate preparations: Insomnia, dry mouth, headache, somnolence, nervousness, dizziness, fatigue.
Loratadine (Hapacol CF) contraindications
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What is the most important information I should know about Loratadine (Hapacol CF)?
Do NOT use Loratadine (Hapacol CF) if:
you are allergic to any ingredient in Loratadine (Hapacol CF)
Contact your doctor or health care provider right away if any of these apply to you.
What is Paracetamol (Hapacol CF)?
Paracetamol (Hapacol CF) (acetaminophen) is a pain reliever and a fever reducer. The exact mechanism of Paracetamol (Hapacol CF) of is not known.
Paracetamol (Hapacol CF) is used to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers. It relieves pain in mild arthritis but has no effect on the underlying inflammation and swelling of the joint.
Paracetamol (Hapacol CF) may also be used for other purposes not listed in this medication guide.
Paracetamol (Hapacol CF) indications
For systemic use of Paracetamol (Hapacol CF) Sante Naturelle: prevention and treatment of hypo- and avitaminosis of vitamin C; providing increased need for vitamin C during growth, pregnancy, lactation, with heavy loads, fatigue and during recovery after prolonged severe illness; in winter with an increased risk of infectious diseases.
For intravaginal use: chronic or recurrent vaginitis (bacterial vaginosis, nonspecific vaginitis) caused by the anaerobic flora (due to changes in pH of the vagina) in order to normalize disturbed vaginal microflora.
How should I use Paracetamol (Hapacol CF)?
Use Paracetamol (Hapacol CF) exactly as directed on the label, or as prescribed by your doctor.
Do not use more of this medication than is recommended. An overdose of Paracetamol (Hapacol CF) can cause serious harm. The maximum amount for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. Using more Paracetamol (Hapacol CF) could cause damage to your liver. If you drink more than three alcoholic beverages per day, talk to your doctor before taking Paracetamol (Hapacol CF) and never use more than 2 grams (2000 mg) per day. If you are treating a child, use a pediatric form of Paracetamol (Hapacol CF). Carefully follow the dosing directions on the medicine label. Do not give the medication to a child younger than 2 years old without the advice of a doctor.
Measure the liquid form of Paracetamol (Hapacol CF) with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. You may need to shake the liquid before each use. Follow the directions on the medicine label.
The Paracetamol (Hapacol CF) chewable tablet must be chewed thoroughly before you swallow it.
Make sure your hands are dry when handling the Paracetamol (Hapacol CF) disintegrating tablet. Place the tablet on your tongue. It will begin to dissolve right away. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.
To use the Paracetamol (Hapacol CF) effervescent granules, dissolve one packet of the granules in at least 4 ounces of water. Stir this mixture and drink all of it right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.
Do not take a Paracetamol (Hapacol CF) rectal suppository by mouth. It is for use only in your rectum. Wash your hands before and after inserting the suppository.
Try to empty your bowel and bladder just before using the Paracetamol (Hapacol CF) suppository. Remove the outer wrapper from the suppository before inserting it. Avoid handling the suppository too long or it will melt in your hands.
For best results from the suppository, lie down and insert the suppository pointed tip first into the rectum. Hold in the suppository for a few minutes. It will melt quickly once inserted and you should feel little or no discomfort while holding it in. Avoid using the bathroom just after inserting the suppository.
Stop using Paracetamol (Hapacol CF) and call your doctor if:
-
you still have a fever after 3 days of use;
-
you still have pain after 7 days of use (or 5 days if treating a child);
-
you have a skin rash, ongoing headache, or any redness or swelling; or
-
if your symptoms get worse, or if you have any new symptoms.
Urine glucose tests may produce false results while you are taking Paracetamol (Hapacol CF). Talk to your doctor if you are diabetic and you notice changes in your glucose levels during treatment.
Store Paracetamol (Hapacol CF) at room temperature away from heat and moisture. The rectal suppositories can be stored at room temperature or in the refrigerator.
Uses of Paracetamol (Hapacol CF) in details
This drug is used to treat mild to moderate pain (from headaches, menstrual periods, toothaches, backaches, osteoarthritis, or cold/flu aches and pains) and to reduce fever.
How to use Paracetamol (Hapacol CF)
Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.
There are many brands and forms of acetaminophen available. Read the dosing instructions carefully for each product because the amount of acetaminophen may be different between products. Do not take more acetaminophen than recommended.
If you are giving acetaminophen to a child, be sure you use a product that is meant for children. Use your child's weight to find the right dose on the product package. If you don't know your child's weight, you can use their age.
For suspensions, shake the medication well before each dose. Some liquids do not need to be shaken before use. Follow all directions on the product package. Measure the liquid medication with the provided dose-measuring spoon/dropper/syringe to make sure you have the correct dose. Do not use a household spoon.
For rapidly-dissolving tablets, chew or allow to dissolve on the tongue, then swallow with or without water. For chewable tablets, chew thoroughly before swallowing.
Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.
For effervescent tablets, dissolve the dose in the recommended amount of water, then drink.
Pain medications work best if they are used as the first signs of pain occur. If you wait until the symptoms have worsened, the medication may not work as well.
Do not take this medication for fever for more than 3 days unless directed by your doctor. For adults, do not take this product for pain for more than 10 days (5 days in children) unless directed by your doctor. If the child has a sore throat (especially with high fever, headache, or nausea/vomiting), consult the doctor promptly.
Tell your doctor if your condition persists or worsens or if you develop new symptoms. If you think you may have a serious medical problem, get medical help right away.
Paracetamol (Hapacol CF) description
Paracetamol (Hapacol CF) is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. Paracetamol (Hapacol CF) exists as small alkaline deliquescent crystals with a saline tasteacinol was introduced to medicine as a solvent for uric acid. When taken into the body the drug is partly oxidized and partly eliminated unchanged. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successfulacinol was first introduced as an anthelmintic in 1953. A large number of piperazine compounds have anthelmintic Paracetamol (Hapacol CF). Their mode of Paracetamol (Hapacol CF) is generally by paralysing parasites, which allows the host body to easily remove or expel the invading organism.
Paracetamol (Hapacol CF) dosage
Usual Adult Paracetamol (Hapacol CF) Dose for Fever:
General Dosing Guidelines: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours orally or rectally.
Paracetamol (Hapacol CF) 500mg tablets: Two 500 mg tablets orally every 4 to 6 hours
Usual Adult Paracetamol (Hapacol CF) Dose for Pain:
General Dosing Guidelines: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours orally or rectally.
Paracetamol (Hapacol CF) 500mg tablets: Two 500 mg tablets orally every 4 to 6 hours
Usual Pediatric Dose for Fever:
Oral or Rectal:
<=1 month: 10 to 15 mg/kg/dose every 6 to 8 hours as needed.
>1 month to 12 years: 10 to 15 mg/kg/dose every 4 to 6 hours as needed (Maximum: 5 doses in 24 hours)
Fever: 4 months to 9 years: Initial Dose: 30 mg/kg (Reported by one study (n=121) to be more effective in reducing fever than a 15 mg/kg maintenance dose with no difference regarding clinical tolerance.)
>=12 years: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours.
Usual Pediatric Dose for Pain:
Oral or Rectal:
<=1 month: 10 to 15 mg/kg/dose every 6 to 8 hours as needed.
>1 month to 12 years: 10 to 15 mg/kg/dose every 4 to 6 hours as needed (Maximum: 5 doses in 24 hours)
Fever: 4 months to 9 years: Initial Dose: 30 mg/kg (Reported by one study (n=121) to be more effective in reducing fever than a 15 mg/kg maintenance dose with no difference regarding clinical tolerance.)
>=12 years: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours.
Paracetamol (Hapacol CF) interactions
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What other drugs will affect Paracetamol (Hapacol CF)?
With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic Paracetamol (Hapacol CF) of Paracetamol (Hapacol CF).
With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.
With the simultaneous use of anticholinergics may decrease absorption of Paracetamol (Hapacol CF).
With the simultaneous use of oral contraceptives accelerated excretion of Paracetamol (Hapacol CF) from the body and may reduce its analgesic Paracetamol (Hapacol CF).
With the simultaneous use with urological means reduced their effectiveness.
With the simultaneous use of activated charcoal reduced bioavailability of Paracetamol (Hapacol CF).
When Axcel Paracetamol (Hapacol CF) applied simultaneously with diazepam may decrease excretion of diazepam.
There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Paracetamol (Hapacol CF). A case of severe toxic liver injury.
Described cases of toxic effects of Paracetamol (Hapacol CF), while the use of isoniazid.
When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Paracetamol (Hapacol CF), which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Paracetamol (Hapacol CF) and phenobarbital.
In applying cholestyramine a period of less than 1 h after administration of Paracetamol (Hapacol CF) may decrease of its absorption.
At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.
With the simultaneous use of metoclopramide may increase absorption of Paracetamol (Hapacol CF) and its increased concentration in blood plasma.
When applied simultaneously with probenecid may decrease clearance of Paracetamol (Hapacol CF), with rifampicin, sulfinpyrazone - may increase clearance of Paracetamol (Hapacol CF) due to increasing its metabolism in the liver.
At simultaneous application of Axcel Paracetamol (Hapacol CF) with ethinylestradiol increases absorption of Paracetamol (Hapacol CF) from the gut.
Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).
Paracetamol (Hapacol CF) side effects
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What are the possible side effects of Paracetamol (Hapacol CF)?
Effects due to the presence of acetylsalicylic acid.
Accidents awareness with respiratory or skin reactions (angioedema, urticaria, asthma, anaphylactic shock);
Cross hypersensitivity reactions with NSAIDs and with tartrazine;
At low doses recommended for the use of Paracetamol (Hapacol CF), side effects of aspirin are generally limited to some irritation of the gastro-intestinal tract.
At higher doses, side effects include gastrointestinal mucosal erosions, gastric ulcer or duodenal ulcer, occult blood loss, melena.
Acetylsalicylic acid may also increase the tendency to bleeding and bleeding time (the lengthening of bleeding continues 4-6 days after stopping the drug).
It may also worsen renal function including cases of pre-existing condition (the long-term use can cause chronic kidney disease).
The signs of salicylic overdose described under.
Effects due to the presence of Paracetamol (Hapacol CF).
At the doses and duration of recommended treatment, side effects are usually negligible, but the prolonged use of Paracetamol (Hapacol CF) in therapeutic doses large (2-4 g per day, or 10-20 tablets Paracetamol (Hapacol CF)) may cause the appearance chronic hepatitis. This justifies the recommendations of caution especially in patients with liver disease prior.
Very rarely, it can produce thrombocytopenia.
The acute liver toxicity in overdose massive (doses greater than 8 g of Paracetamol (Hapacol CF)) is described in paragraph overdose.
Paracetamol (Hapacol CF) contraindications
See also:
What is the most important information I should know about Paracetamol (Hapacol CF)?
Paracetamol (Hapacol CF) should not be used in patients who have previously exhibited hypersensitivity to aspirin and/or nonsteroidal antiinflammatory agents. Paracetamol (Hapacol CF) should not be given to patients with a recent history of gastrointestinal bleeding or in patients with bleeding disorders (e.g., hemophilia).
Active ingredient matches for Hapacol CF:
Dextromethorphan HBr/loratadine/Paracetamol in Vietnam.
| Unit description / dosage (Manufacturer) | Price, USD |
| Hapacol CF 10 Blister x 5 Tablet | |
List of Hapacol CF substitutes (brand and generic names): | |
| Biviflu (Vietnam) | |
| Biviflu 6 Blister x 10 Tablet | |
| Cadicold (Vietnam) | |
| Cadicold 25 Blister x 4 Tablet | |
| dextromethorphan HBr/loratadine/Paracetamol (Vietnam) | |
| Doltuxil (Vietnam) | |
| Doltuxil 10 Blister x 10 Tablet | |
| Doltuxil 1 Bottle 100 Tablet | |
| Ravonol (Vietnam) | |
| Ravonol 25 Blister x 4 Tablet | |
| Ravonol 10 Blister x 10 Tablet | |
| Rhetanol Day (Vietnam) | |
| Rhetanol Day 25 Blister x 4 Tablet | |
| Rhumex (Vietnam) | |
| Rhumex 2 Blister x 5 Tablet | |
| Rhumex 5 Blister x 5 Tablet | |
| Rhumex 10 Blister x 5 Tablet | |
| Roblotidin (Vietnam) | |
| Roblotidin 3 Blister x 10 Tablet | |
| Rumenadol (Vietnam) | |
| Rumenadol 10 Blister x 4 Tablet | |
| Savi Day (Vietnam) | |
| Savi Day 25 Blister xeГ№ x 4 Tablet | |
| Savi Day 10 Blister x 10 Tablet | |
References
- DailyMed. "DEXTROMETHORPHAN HYDROBROMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "LORATADINE; PSEUDOEPHEDRINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "dextromethorphan". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Hapacol CF are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Hapacol CF. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
1 consumer reported useful
Was the Hapacol CF drug useful in terms of decreasing the symptom or the disease?According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
| Users | % | ||
|---|---|---|---|
| Not useful | 1 | 100.0% | |
1 consumer reported price estimates
Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?The below mentioned numbers have been reported by ndrugs.com website users about whether the Hapacol CF drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
| Users | % | ||
|---|---|---|---|
| Expensive | 1 | 100.0% | |
2 consumers reported time for results
To what extent do I have to use Hapacol CF before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 1 week and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Hapacol CF. To get the time effectiveness of using Hapacol CF drug by other patients, please click here.
| Users | % | ||
|---|---|---|---|
| 1 week | 1 | 50.0% | |
| 2 days | 1 | 50.0% | |
4 consumers reported age
| Users | % | ||
|---|---|---|---|
| 6-15 | 1 | 25.0% | |
| 16-29 | 1 | 25.0% | |
| 30-45 | 1 | 25.0% | |
| 46-60 | 1 | 25.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
