Levolin Uses

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What is Levolin?

Albuterol is used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases. This medicine is also used to prevent wheezing caused by exercise (exercise-induced bronchospasm).

Albuterol belongs to the family of medicines known as adrenergic bronchodilators. Adrenergic bronchodilators are medicines that are breathed in through the mouth to open up the bronchial tubes (air passages) in the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.

This medicine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, albuterol is used in certain patients with the following medical condition:

Levolin indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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As a bronchodilator in the treatment of bronchospasm associated with bronchial asthma, emphysema and chronic bronchitis and other conditions associated with reversible airways obstruction. Levolin also decreases uterine contractility and arrests premature labor.

Uses of Levolin in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Levolin is used to prevent reversible airways obstruction occurring during asthma, infections of airway passages (bronchitis), lung disorder in which the flow of air to the lungs is blocked (emphysema), and other lung diseases.

Levolin description

Each 200 mcg/dose powder for inhalation solution contains Salbutamol sulphate equivalent to Levolin 200 mcg per metered dose. The dose, which the patient gets through the mouthpiece of the device is Levolin 180 mcg.

It contains lactose monohydrate (milk protein) as excipient.

The Levolin multiple dose powder inhaler contains 200 doses of finely powdered Levolin sulphate mixed in a small quantity of lactose. The amount of drug received by the patient (180 mcg/dose) corresponds to that from Levolin inhalation aerosol. The dose to be inhaled is released from the container by pressing the device between the thumb and forefinger. This is followed by inhalation through the device. As a result, Levolin particles are transferred to their target, the lungs. Use of the Levolin does not require coordination of actuation of the dose and inhalation.

Levolin dosage

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Tablet: Adults: Usual Dose: 4 mg or 10 mL (2 tsp) of syrup. If adequate bronchodilation is not obtained, each single dose may be gradually increased to as much as 8 mg or 20 mL (4 tsp) of syrup.

To be taken every 6 or 8 hrs.

In some patients known to be unusually sensitive to β-adrenergic stimulant drugs who obtain adequate relief with 5 mL of syrup, it is advisable to initiate treatment with 5 mL (1 tsp) of syrup 3 or 4 times a day.

Children >12 years: 2-4 mg or 5-10 mL (1-2 tsp) of syrup; 6-12 years: 2 mg or 5 mL (1 tsp) of syrup; 2-6 years: 1-2 mg or 2.5-5 mL (½-1 tsp) of syrup.

Nebulizing Solution: Adults and Adolescents: Usual Dose: The usual initial dose of Levolin by wet inhalation is 2.5-5 mg. Treatment may be repeated up to 4 times daily. In adults, higher dosing up to 40 mg/day can be given under strict medical supervision in hospital for the treatment of severe airway obstruction.

Children up to 12 years: Dosage has not been established. Note: As there may be adverse effects associated with excessive dosing, the dosage or frequency of administration should only be increased on medical advice.

Administration: Levolin 1 mg/mL nebulizing solution for inhalation is given undiluted using a nebulizer, under the direction of a physician. However, if prolonged administration is desired (>10 min), the solution can be diluted with 0.9% sodium chloride solution.

Direction for Dilution/Prolonged Inhalation: Pipette 2.5-5 mL (equivalent to 2.5-5 mg Levolin, as sulfate) of Levolin nebulizing solution from the bottle by using a calibrated medicine dropper provided in the pack. Drop the solution into an electric nebulizer and dilute it with 2-4 mL normal saline solution and start inhalation. Any unused solution in the chamber of the nebulizer must be discarded. Repeat the same procedure every 8 hrs in a 24-hr period.

Levolin interactions

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The concomitant use of Levolin (albuterol sulfate syrup) and other oral sympathomimetic agents is not recommended since such combined use may lead to deleterious cardiovascular effects. This recommendation does not preclude the judicious use of an aerosol bronchodilator of the adrenergic stimulant type in patients receiving Levolin (albuterol sulfate syrup). Such concomitant use, however, should be individualized and not given on a routine basis. If regular coadministration is required, then alternative therapy should be considered.

Beta-Blockers

Beta-adrenergic receptor blocking agents not only block the pulmonary effect of beta-agonists, such as Levolin (albuterol sulfate syrup), but may produce severe bronchospasm in asthmatic patients. Therefore, patients with asthma should not normally be treated with beta-blockers. However, under certain circumstances, eg, as prophylaxis after myocardial infarction, there may be no acceptable alternatives to the use of beta-adrenergic blocking agents in patients with asthma. In this setting, cardioselective beta-blockers could be considered, although they should be administered with caution.

Diuretics

The ECG changes and/or hypokalemia that may result from the administration of nonpotassium-sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. Although the clinical significance of these effects is not known, caution is advised in the coadministration of beta-agonists with nonpotassium-sparing diuretics.

Digoxin

Mean decreases of 16% to 22% in serum digoxin levels were demonstrated after single dose intravenous and oral administration of albuterol, respectively, to normal volunteers who had received digoxin for 10 days. The clinical significance of these findings for patients with obstructive airway disease who are receiving albuterol and digoxin on a chronic basis is unclear. Nevertheless, it would be prudent to carefully evaluate the serum digoxin levels in patients who are currently receiving digoxin and albuterol.

Monoamine Oxidase Inhibitors or Tricyclic Antidepressants

Albuterol should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents, because the action of albuterol on the vascular system may be potentiated.

Levolin side effects

See also:
What are the possible side effects of Levolin?

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The adverse reactions to albuterol are similar in nature to those of other sympathomimetic agents. In clinical trials, the most frequent adverse reactions to Levolin (albuterol sulfate syrup) in adults and older children were:

Percent Incidence of Adverse Reactions in Adults and Children (6-12 Years of Age)

Adverse Event

Percent Incidence

Central Nervous System

Tremor

10

Nervousness

9

Shakiness

9

Headache

4

Dizziness

3

Excitement

2

Hyperactivity

2

Sleeplessness

1

Disturbed sleep

<1

Irritable behavior

<1

Dilated pupils

<1

Weakness

1

Cardiovascular

Tachycardia

1

Palpitations

<1

Sweating

<1

Chest Pain

<1

Ear, Nose, and Throat

Epistaxis

1

Gastrointestinal

Increased appetite

3

Epigastric pain

<1

Stomachache

<1

Musculoskeletal

Muscle spasm

<1

Respiratory

Cough

<1

In clinical trials, the following adverse reactions to Levolin (albuterol sulfate syrup) were noted more frequently in young children 2 to 6 years of age than in adults and older children:

Percent Incidence of Adverse Reactions Noted More Frequently in Children 2 to 6 Years of Age Than in Older Children and Adults

Adverse Event

Percent Incidence

Central Nervous System

Excitement

20

Nervousness

15

Hypokinesia

4

Sleeplessness

2

Emotional lability

1

Fatigue

1

Cardiovascular

Tachycardia

2

Pallor

1

Gastrointestinal

Gastrointestinal symptoms

2

Loss of appetite

1

Ophthalmologic

Conjunctivitis

1

Cases of urticaria, angioedema, rash, bronchospasm, oropharyngeal edema, and arrhythmias (including atrial fibrillation, supraventricular tachycardia, and extrasystoles) have been reported after the use of Levolin (albuterol sulfate syrup).

In addition, albuterol, like other sympathomimetic agents, can cause adverse reactions such as angina, central nervous system stimulation, drying or irritation of the oropharynx, hypertension, nausea, unusual taste, vertigo, and vomiting.

The reactions are generally transient in nature, and it is usually not necessary to discontinue treatment with Levolin (albuterol sulfate syrup). In selected cases, however, dosage may be reduced temporarily; after the reaction has subsided, dosage should be increased in small increments to the optimal dosage.

Levolin contraindications

Hyperthyroidism and cardiac disease. Levolin may interact with monoamine oxidase inhibitors and should not be given to patients receiving such treatment or within 14 days after stopping treatment.

Use in pregnancy & lactation: Safety in pregnancy and lactating women has not been established.

Levolin is not indicated for the prevention of premature labor associated with toxemia of pregnancy or ante partum hemorrhage, nor should it be used for threatened abortion during the 1st and 2nd trimesters of pregnancy.

Active ingredient matches for Levolin:

Salbutamol in India.

Levalbuterol Hcl

Levosalbutamol hydrochloride in India.

Levosalbutamol in India.


Unit description / dosage (Manufacturer)Price, USD
LEVOLIN Capsule/ Tablet / 2mg / 10 units (Cipla)$ 0.13
LEVOLIN Capsule/ Tablet / 1mg / 10 units (Cipla)$ 0.08
Levolin Respiratory Capsule / 0.31mg / 2.5ml units (Cipla)$ 0.05
Levolin Levosalbutamol sulphate 1mg TAB / 10$ 0.08
Levolin Levosalbutamol sulphate 2mg TAB / 10$ 0.12
Levolin Levosalbutamol sulphate1mg/5ml SYR / 100ml$ 0.27
Levolin Levosalbutamol sulphate 100mcg R-CAP / 30$ 0.33
1 mg x 10's$ 0.04
2 mg x 10's$ 0.12
100 mcg x 30's$ 0.33
1 mg x 5 mL x 100ml$ 0.26
LEVOLIN 0.31 MG RESPULES 1 strip / 5 respuless each (Cipla Ltd)$ 0.27
LEVOLIN 0.63 MG RESPULES 1 strip / 10 respuless each (Cipla Ltd)$ 0.64
LEVOLIN 0.63 MG RESPULES 1 strip / 5 respuless each (Cipla Ltd)$ 0.32
LEVOLIN 1 MG SYRUP 1 bottle / 100 ML syrup each (Cipla Ltd)$ 0.26
LEVOLIN 1 MG TABLET 1 strip / 10 tablets each (Cipla Ltd)$ 0.08
LEVOLIN 1.25 MG RESPULES 1 strip / 10 respuless each (Cipla Ltd)$ 0.90
LEVOLIN 1.25 MG RESPULES 1 strip / 5 respuless each (Cipla Ltd)$ 0.45
LEVOLIN 100 MCG ROTACAP 1 packet / 30 rotacaps each (Cipla Ltd)$ 0.36
LEVOLIN 2 MG TABLET 1 strip / 10 tablets each (Cipla Ltd)$ 0.12
LEVOLIN 50 MCG INHALER 1 packet / 200 MDI inhaler each (Cipla Ltd)$ 2.10
LEVOLIN 0.31 MG RESPULES 2.5ML 1 strip / 5 respuless each (Cipla Ltd)$ 0.27
LEVOLIN 0.63 MG RESPULES 2.5ML 1 strip / 10 respuless each (Cipla Ltd)$ 0.64
LEVOLIN 0.63 MG RESPULES 2.5ML 1 strip / 5 respuless each (Cipla Ltd)$ 0.32
LEVOLIN 1.25 MG RESPULES 2.5ML 1 strip / 10 respuless each (Cipla Ltd)$ 0.90
LEVOLIN 1.25 MG RESPULES 2.5ML 1 strip / 5 respuless each (Cipla Ltd)$ 0.45
LEVOLIN tab 1 mg x 10's (Cipla)$ 0.08
LEVOLIN tab 2 mg x 10's (Cipla)$ 0.12
LEVOLIN rotacap 100 mcg x 30's (Cipla)$ 0.33
LEVOLIN syr 1 mg x 5 mL x 100ml (Cipla)$ 0.26
Levolin 0.31mg Respules (Cipla Ltd)$ 0.05
Levolin 0.63mg Respules (Cipla Ltd)$ 0.06
Levolin 1.25mg Respules (Cipla Ltd)$ 0.09
Levolin 100mcg Rotacap (Cipla Ltd)$ 0.01
Levolin 1mg Syrup (Cipla Ltd)$ 0.26
Levolin 1mg Tablet (Cipla Ltd)$ 0.01
Levolin 2mg Tablet (Cipla Ltd)$ 0.01
Levolin 50mcg Inhaler (Cipla Ltd)$ 2.30

List of Levolin substitutes (brand and generic names):

LEVOLIN AUTOHALER autohaler 50 mcg x 1 puff x 200md (Cipla)$ 8.73
LEVOLIN AUTOHALER autohaler 50 mcg x 1 puff x 300md (Cipla)$ 10.32
LEVOLIN INHALER Inhaler / 50mcg per dose / 200 doses units (Cipla)$ 1.35
50 mcg x 200md (Cipla)$ 1.56
Levolin Inhaler Levosalbutamol sulphate 50mcg MDI / 200md (Cipla)$ 1.56
LEVOLIN INHALER MDI 50 mcg x 1 puff x 200md (Cipla)$ 1.28
Levolin Inhaler Levosalbutamol sulphate 50mcg MDI / 200md (Cipla)$ 1.56
LEVOLIN Liquid Liquid / 1mg per 5ml / 100ml units (Cipla)$ 0.26
Levolin Repules 0.31mg RESP / 2.5ml * 5$ 0.31
Levolin Repules 0.63mg RESP / 2.5ml$ 0.06
Levolin Repules 1.25mg RESP / 2.5ml$ 0.08
LEVOLIN RESPULES Respiratory Capsule / 1.25mg / 2.5ml units (Cipla)$ 0.08
LEVOLIN RESPULES Respiratory Capsule / 0.63mg / 2.5ml units (Cipla)$ 0.06
0.31 mg x 1's (Cipla)$ 0.05
0.63 mg x 1's (Cipla)$ 0.06
1.25 mg x 1's (Cipla)$ 0.09
Levolin Respules .31mg RESPULE / 1 (Cipla)$ 0.05
Levolin Respules 0.63mg RESPULE / 1 (Cipla)$ 0.06
Levolin Respules 1.25mg RESPULE / 1 (Cipla)$ 0.09
LEVOLIN RESPULES respules 0.31 mg x 2.5ml (Cipla)$ 0.05
LEVOLIN RESPULES respules 0.63 mg x 2.5ml (Cipla)$ 0.06
LEVOLIN RESPULES respules 1.25 mg x 2.5ml (Cipla)$ 0.09
Levolin Respules .31mg RESPULE / 1 (Cipla)$ 0.05
Levolin Respules 0.63mg RESPULE / 1 (Cipla)$ 0.06
Levolin Respules 1.25mg RESPULE / 1 (Cipla)$ 0.09
LEVOLIN ROTACAPS Respiratory Capsule / 100mcg per dose / 30 units (Cipla)$ 0.32
LEVOSTAR TABLET 1 strip / 10 tablets each (Pacific Drugs & Chemicals)$ 1.30
Medolin 2 mg x 100 x 10's (Medochemie)
Medolin 4 mg x 100 x 10's (Medochemie)
Medolin 2 mg x 100 Tablet (Medochemie)
Medolin 2 mg x 500 Tablet (Medochemie)
Medolin 2 mg x 1000 Tablet (Medochemie)
Medolin 4 mg x 10 Blister x 10 Tablet (Medochemie)
Medolin 4 mg x 1 Bottle 500 Tablet (Medochemie)
Medolin 4 mg x 1 Bottle 1000 Tablet (Medochemie)

References

  1. DailyMed. "ALBUTEROL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "Salbutamol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. PubChem. "Levalbuterol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Levolin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Levolin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


Consumer reported price estimates

No survey data has been collected yet


1 consumer reported time for results

To what extent do I have to use Levolin before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 1 week and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Levolin. To get the time effectiveness of using Levolin drug by other patients, please click here.
Users%
1 week1
100.0%


17 consumers reported age

Users%
1-57
41.2%
6-154
23.5%
< 13
17.6%
> 602
11.8%
30-451
5.9%


Consumer reviews


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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