• Moxifloxacin HEC Pharm indications
• Uses of Moxifloxacin HEC Pharm in details
• Moxifloxacin HEC Pharm description
• Moxifloxacin HEC Pharm dosage
• Moxifloxacin HEC Pharm interactions
• Moxifloxacin HEC Pharm side effects
• Moxifloxacin HEC Pharm contraindications

What is Moxifloxacin HEC Pharm?

Moxifloxacin HEC Pharm injection is used to treat bacterial infections in many different parts of the body.

Moxifloxacin HEC Pharm belongs to the class of medicines known as quinolone antibiotics. It works by killing bacteria or preventing their growth. However, Moxifloxacin HEC Pharm will not work for colds, flu, or other virus infections.

Moxifloxacin HEC Pharm is to be given only by or under the direct supervision of your doctor.

Moxifloxacin HEC Pharm indications

Community Acquired Pneumonia

Moxifloxacin HEC Pharm is indicated in adult patients for the treatment of Community Acquired Pneumonia caused by susceptible isolates of Streptococcus pneumoniae (including multi-drug resistant Streptococcus pneumoniae [MDRSP]), Haemophilus influenzae, Moraxella catarrhalis, methicillin-susceptible Staphylococcus aureus, Klebsiella pneumoniae, Mycoplasma pneumoniae, or Chlamydophila pneumonia .

MDRSP isolates are isolates resistant to two or more of the following antibacterial drugs: penicillin (minimum inhibitory concentrations [MIC] ≥ 2 mcg/mL), 2nd generation cephalosporins (for example, cefuroxime), macrolides, tetracyclines, and trimethoprim/sulfamethoxazole.

Uncomplicated Skin And Skin Structure Infections

Moxifloxacin HEC Pharm is indicated in adult patients for the treatment of Uncomplicated Skin and Skin Structure Infections caused by susceptible isolates of methicillin-susceptible Staphylococcus aureus or Streptococcus pyogenes.

Complicated Skin And Skin Structure Infections

Moxifloxacin HEC Pharm is indicated in adult patients for the treatment of Complicated Skin and Skin Structure Infections caused by susceptible isolates of methicillin-susceptible Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, or Enterobacter cloacae.

Complicated Intra-Abdominal Infections

Moxifloxacin HEC Pharm is indicated in adult patients for the treatment of Complicated Intra-Abdominal Infections including polymicrobial infections such as abscess caused by susceptible isolates of Escherichia coli, Bacteroides fragilis, Streptococcus anginosus, Streptococcus constellatus, Enterococcus faecalis, Proteus mirabilis, Clostridium perfringens, Bacteroides thetaiotaomicron, or Peptostreptococcus species.

Plague

Moxifloxacin HEC Pharm is indicated in adult patients for the treatment of plague, including pneumonic and septicemic plague, due to susceptible isolates of Yersinia pestis and prophylaxis of plague in adult patients. Efficacy studies of Moxifloxacin HEC Pharm could not be conducted in humans with plague for feasibility reasons. Therefore this indication is based on an efficacy study conducted in animals only.

Acute Bacterial Sinusitis

Moxifloxacin HEC Pharm is indicated in adult patients (18 years of age and older) for the treatment of acute bacterial sinusitis (ABS) caused by susceptible isolates of Streptococcus pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis.

Because fluoroquinolones, including Moxifloxacin HEC Pharm, have been associated with serious adverse reactions and for some patients ABS is self-limiting, reserve Moxifloxacin HEC Pharm for treatment of ABS in patients who have no alternative treatment options.

Acute Bacterial Exacerbation Of Chronic Bronchitis

Moxifloxacin HEC Pharm is indicated in adult patients for the treatment of Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB) caused by susceptible isolates of Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, methicillin-susceptible Staphylococcus aureus, or Moraxella catarrhalis.

Because fluoroquinolones, including Moxifloxacin HEC Pharm, have been associated with serious adverse reactions and for some patients ABECB is self-limiting, reserve Moxifloxacin HEC Pharm for treatment of ABECB in patients who have no alternative treatment options.

Usage

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Moxifloxacin HEC Pharm and other antibacterial drugs, Moxifloxacin HEC Pharm should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

How should I use Moxifloxacin HEC Pharm?

Use Moxifloxacin HEC Pharm tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Moxifloxacin HEC Pharm tablets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Moxifloxacin HEC Pharm tablets refilled.
• Take Moxifloxacin HEC Pharm tablets by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Drink plenty of liquids while taking Moxifloxacin HEC Pharm tablets.
• Do not take a product that has magnesium, aluminum, calcium, zinc, iron, or sucralfate in it within 8 hours before or 4 hours after you take Moxifloxacin HEC Pharm tablets. Examples of these products include antacids, multivitamins, chewable/buffered didanosine, didanosine suspension, and quinapril. Check with your doctor or pharmacist if you have a question about whether you should separate Moxifloxacin HEC Pharm tablets from a certain food or product.
• Take Moxifloxacin HEC Pharm tablets on a regular schedule to get the most benefit from it.
• To clear up your infection completely, take Moxifloxacin HEC Pharm tablets for the full course of treatment. Keep taking it even if you feel better in a few days.
• If you miss a dose of Moxifloxacin HEC Pharm tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take more than 1 dose in the same day.

Ask your health care provider any questions you may have about how to use Moxifloxacin HEC Pharm tablets.

Uses of Moxifloxacin HEC Pharm in details

Use: Labeled Indications

Treatment of mild to moderate community-acquired pneumonia, including multidrug-resistant Streptococcus pneumoniae (MDRSP); acute bacterial exacerbation of chronic bronchitis; acute bacterial rhinosinusitis; complicated and uncomplicated skin and skin structure infections; complicated intra-abdominal infections; prophylaxis and treatment of plague, including pneumonic and septicemic plague, due to Yersinia pestis.

Limitations of use: Because fluoroquinolones have been associated with disabling and potentially irreversible serious adverse reactions (eg, tendinitis and tendon rupture, peripheral neuropathy, CNS effects), reserve Moxifloxacin HEC Pharm for use in patients who have no alternative treatment options for acute exacerbation of chronic bronchitis or acute sinusitis.

Off Label Uses

Anthrax

Based on the Centers for Disease Control and Prevention (CDC) Expert Panel Meetings on Prevention and Treatment of Anthrax in Adults, Moxifloxacin HEC Pharm is as an effective and recommended agent for the treatment of cutaneous anthrax and an alternative agent for postexposure prophylaxis and treatment of systemic anthrax (with or without possible/confirmed meningitis).

Bite wounds (animal/human)

Based on the Infectious Diseases Society of America (IDSA) guidelines for the diagnosis and management of skin and soft tissue infections (SSTI), Moxifloxacin HEC Pharm is an effective and recommended alternative option for treatment of bite wounds, particularly in patients with a human bite wound who are hypersensitive to beta-lactams.

Diabetic foot infections

Based on the Infectious Diseases Society of America (IDSA) guidelines for diagnosis and treatment of diabetic foot infections, Moxifloxacin HEC Pharm is an effective and recommended treatment option for moderate to severe diabetic foot infections.

Meningitis, bacterial

Based on the Infectious Diseases Society of America (IDSA) guidelines for the management of bacterial meningitis and health care-associated ventriculitis and meningitis, Moxifloxacin HEC Pharm is an effective and recommended alternative agent for the treatment of meningitis caused by penicillin- and cephalosporin-resistant Streptococcus pneumoniae.

Mycoplasma genitalium

Noncontrolled trials support the use of Moxifloxacin HEC Pharm as alternative treatment in patients with persistent detection of Mycoplasma genitalium who have not responded to or are intolerant of azithromycin. Additional data may be necessary to further define the role of Moxifloxacin HEC Pharm in this condition.

Pelvic inflammatory disease

Based on the Centers for Disease Control and Prevention (CDC) sexually transmitted diseases treatment guidelines, Moxifloxacin HEC Pharm may be considered as alternative treatment in patients allergic to cephalosporins with pelvic inflammatory disease. The CDC recommends use as an alternative therapy only if standard parenteral cephalosporin therapy is not feasible and community prevalence of quinolone-resistant gonococcal organisms is low. Culture sensitivity must be confirmed.

Surgical prophylaxis

Based on the American Society of Health-System Pharmacists (ASHP), the Infectious Diseases Society of America (IDSA), the Surgical Infection Society (SIS), and the Society of Healthcare Epidemiology of America (SHEA) guidelines for antimicrobial prophylaxis in surgery, Moxifloxacin HEC Pharm (systemic) may be administered (in combination with either clindamycin or vancomycin) as an alternative regimen in patients with beta-lactam allergy.

Tuberculosis (second-line therapy)

Based on the American Thoracic Society, Centers for Disease Control and Prevention (CDC), and Infectious Diseases Society of America (IDSA) Treatment of Tuberculosis guidelines, Moxifloxacin HEC Pharm (systemic) given for second-line therapy of tuberculosis is effective and recommended in the management of this condition.

Moxifloxacin HEC Pharm description

Each tablet contains Moxifloxacin HCl 436.8 mg equivalent to Moxifloxacin HEC Pharm 400 mg. It also contains croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, hypromellose, macrogol 4000, titanium dioxide (E171) and ferric oxide (E172) as inactive constituents.

Each 250 mL solution for infusion contain Moxifloxacin HEC Pharm HCl 436.8 mg equivalent to Moxifloxacin HEC Pharm 400 mg. It also contains sodium chloride, 1N hydrochloric acid, 2N sodium hydroxide and water for injection. The solution for infusion (250 mL) contains sodium 34 mmol.

Moxifloxacin HEC Pharm dosage

Moxifloxacin HEC Pharm Dosage

Generic name: Moxifloxacin HEC Pharm HYDROCHLORIDE 5mg in 1mL

Dosage form: ophthalmic solution

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Instill one drop in the affected eye 3 times a day for 7 days.

More about Moxifloxacin HEC Pharm (Moxifloxacin HEC Pharm ophthalmic)

• Side Effects
• During Pregnancy or Breastfeeding
• Dosage Information
• Support Group
• Pricing & Coupons
• En Espanol
• 12 Reviews - Add your own review/rating
• Generic Availability

Consumer resources

• Moxifloxacin HEC Pharm
• Moxifloxacin HEC Pharm drops
• Moxifloxacin HEC Pharm (Advanced Reading)

• Other brands: Moxeza

Professional resources

• Moxifloxacin HEC Pharm eent (AHFS Monograph)
• Moxifloxacin HEC Pharm (FDA)

Related treatment guides

• Conjunctivitis, Bacterial

• Ophthalmic Surgery

Moxifloxacin HEC Pharm interactions

See also:
What other drugs will affect Moxifloxacin HEC Pharm?

Tablet: For the following substances, absence of a clinically relevant interaction with Moxifloxacin HEC Pharm was proven: Atenolol, ranitidine, calcium supplements, theophylline, oral contraceptives, glibenclamide, itraconazole, digoxin, morphine, probenecid. No dose adjustment is necessary for these drugs.

Antacids, Minerals and Multivitamins: Concomitant ingestion of Moxifloxacin HEC Pharm with antacids, minerals and multivitamins may result in impaired absorption of Moxifloxacin HEC Pharm after oral administration due to formation of chelate complexes with the multivalent cations contained in these preparations. This may lead to plasma concentrations considerably lower than desired. Hence, antacids, antiretroviral drugs (eg, didanosine) and other preparations containing magnesium or aluminium, sucralfate and agents containing iron or zinc should be administered at least 4 hours before or 2 hours after ingestion of an oral Moxifloxacin HEC Pharm dose.

Ranitidine: The concomitant administration with ranitidine did not change the absorption characteristics of Moxifloxacin HEC Pharm. Absorption parameters (C_max, t_max, AUC) were comparable, indicating absence of an influence of gastric pH on Moxifloxacin HEC Pharm uptake from the gastrointestinal tract.

Calcium Supplements: When given with high dose calcium supplements, only a slightly reduced rate of absorption was observed, while extent of absorption remained unaffected. The effect of high-dose calcium supplements on the absorption of Moxifloxacin HEC Pharm is considered as clinically not relevant.

Theophylline: In accordance with in vitro data, no influence of Moxifloxacin HEC Pharm on theophylline pharmacokinetics (and vice versa) at steady state was detected in humans, indicating that Moxifloxacin HEC Pharm does not interfere with the 1A2 subtypes of the CYP450 enzymes.

Warfarin: No interaction during concomitant treatment with warfarin on pharmacokinetics, prothrombin time and other coagulation parameters has been observed.

Changes in International Normalized Ratio (INR): Cases of increased anticoagulant activity have been reported in patients receiving anticoagulants concurrently with antibiotics, including Moxifloxacin HEC Pharm. The infectious disease (and its accompanying inflammatory process), age and general status of the patient are risk factors. Although an interaction between Moxifloxacin HEC Pharm and warfarin was not demonstrated in clinical trials, INR monitoring should be performed and, if necessary, the oral anticoagulant dosage should be adjusted as appropriate.

Oral Contraceptives:

No interaction has occured following concomitant oral administration of Moxifloxacin HEC Pharm with oral contraceptives.

Antidiabetics: No clinically relevant interaction was seen between glibenclamide and Moxifloxacin HEC Pharm.

Itraconazole: Exposure (AUC) to itraconazole was only marginally altered under concomitant Moxifloxacin HEC Pharm treatment. Pharmacokinetics of Moxifloxacin HEC Pharm were not significantly altered by itraconazole. No dose adjustment is necessary for itraconazole when given with Moxifloxacin HEC Pharm and vice versa.

Digoxin: The pharmacokinetics of digoxin are not significantly influenced by Moxifloxacin HEC Pharm (and vice versa). After repeated dosing in healthy volunteers, Moxifloxacin HEC Pharm increased C_max of digoxin by approximately 30% at steady state without affecting AUC or trough levels.

Morphine:

Parenteral administration of morphine with Moxifloxacin HEC Pharm did not reduce the oral bioavailability of Moxifloxacin HEC Pharm and only slighlty decreased C_max (17 %).

Atenolol: The pharmacokinetics of atenolol are not significantly altered by Moxifloxacin HEC Pharm. Following single dose administration in healthy subjects, AUC was marginally increased (by approximately 4%) and peak concentrations were decreased by 10%.

Probenecid: No significant effect on apparent total body clearance and renal clearance of Moxifloxacin HEC Pharm was found in a clinical study investigating the impact of probenecid on renal excretion.

Charcoal: Concomitant dosing of charcoal and oral Moxifloxacin HEC Pharm 400 mg reduced the systemic availability of the drug by >80% by preventing absorption in vivo. The application of activated charcoal in the early absorption phase prevents further increase of systemic exposure in cases of overdose.

After IV drug administration, carbo medicinalis only slightly reduces systemic exposure (approximately 20%).

Food and Dairy Products: Absorption of Moxifloxacin HEC Pharm was not altered by food intake (including dairy products). Moxifloxacin HEC Pharm can be taken independent from food intake.

Infusion: No interaction during concomitant treatment with warfarin, itraconazole, theophylline, digoxin and oral contraceptives.

Moxifloxacin HEC Pharm side effects

See also:
What are the possible side effects of Moxifloxacin HEC Pharm?

Applies to Moxifloxacin HEC Pharm ophthalmic: ophthalmic solution

As well as its needed effects, Moxifloxacin HEC Pharm ophthalmic (the active ingredient contained in Moxifloxacin HEC Pharm) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking Moxifloxacin HEC Pharm ophthalmic, check with your doctor immediately:

Incidence not known:

• Fainting or loss of consciousness
• fast or irregular breathing
• itching
• skin rash
• swelling of the eyes or eyelids
• tightness in the chest or wheezing
• trouble with breathing

Minor Side Effects

Some Moxifloxacin HEC Pharm ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:

• Burning, dry, or itching eyes
• change in vision
• decreased vision
• dry eye
• excessive tearing
• eye discharge
• itching of the eye
• pain in the eye
• red, sore eyes
• redness of the eye
• swelling of the eye, eyelid, or inner lining of the eyelid
• tearing

Less common:

• Body aches or pain
• congestion
• cough or hoarseness
• decreased hearing
• dryness or soreness of the throat
• fever or chills
• general body discomfort
• lower back or side pain
• painful or difficult urination
• rash
• rubbing or pulling of the ears (in children)
• runny nose
• sore throat
• tender, swollen glands in the neck
• trouble with swallowing
• voice changes
• vomiting and diarrhea (in infants)

Moxifloxacin HEC Pharm contraindications

See also:
What is the most important information I should know about Moxifloxacin HEC Pharm?

You should not use this medication if you have a history of myasthenia gravis, or if you are allergic to Moxifloxacin HEC Pharm or similar antibiotics such as ciprofloxacin (Cipro), gemifloxacin (Factive), levofloxacin (Levaquin), ofloxacin (Floxin), norfloxacin (Noroxin), and others.

Before taking Moxifloxacin HEC Pharm, tell your doctor if you have a heart rhythm disorder, kidney or liver disease, joint problems, a history of seizures, low levels of potassium in your blood (hypokalemia), muscle weakness or trouble breathing, a personal or family history of Long QT syndrome, or if you have ever had an allergic reaction to an antibiotic.

Avoid taking antacids, vitamin or mineral supplements, sucralfate (Carafate), or didanosine (Videx) powder or chewable tablets within 8 hours before or 4 hours after you take Moxifloxacin HEC Pharm. These other medicines can make Moxifloxacin HEC Pharm much less effective when taken at the same time.

Taking Moxifloxacin HEC Pharm can make your skin more sensitive to sunlight. Avoid exposure to sunlight, sun lamps, or tanning beds.

Moxifloxacin HEC Pharm may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. These effects may be more likely to occur if you are over 60, if you take steroid medication, or if you have had a kidney, heart, or lung transplant. Stop taking Moxifloxacin HEC Pharm and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions.

Do not share this medication with another person (especially a child), even if they have the same symptoms you do.

Active ingredient matches for Moxifloxacin HEC Pharm:

Moxifloxacin in Germany.

List of Moxifloxacin HEC Pharm substitutes (brand and generic names)	Sort by popularity
Unit description / dosage (Manufacturer)	Price, USD
Moxifloxacin-Ratiopharm 400mg (Hungary, Luxembourg)
Moxifloxacina Aurobindo (Portugal)
Moxifloxacina La Santé (Colombia, Costa Rica, Ecuador, Panama)
Moxifloxacina Lafedar (Argentina)
Moxifloxacina MK (Colombia)
Moxifloxacina Rompharm (Romania)
Moxifloxacina Sandoz (Italy, Romania)
Moxifloxacina Teva (Italy)
Moxifloxacina Vesalius (Colombia)
Moxifloxacine Double-E Pharma (Netherlands)
Moxifloxacine EG (Belgium, France)
Moxifloxacine EG 400mg (Luxembourg)
Moxifloxacine Fresenius Kabi (Netherlands)
Moxifloxacine Krka (France)
Moxifloxacine Mylan (Belgium)
Moxifloxacine PCH (Netherlands)
Moxifloxacine Pharmathen (Netherlands)
Moxifloxacine Sandoz (France, Netherlands)
Moxifloxacine Teva (Belgium, Netherlands)
Moxifloxacine VIOSER (Netherlands)
Moxifloxacino Actavis (Spain)
Moxifloxacino Apotex (Spain)
Moxifloxacino Aurobindo (Spain)
Moxifloxacino Bayfarma (Spain)
Moxifloxacino Cinfa (Spain)
Moxifloxacino G.E.S. (Spain)
Moxifloxacino Hetero (Spain)
Moxifloxacino Kabi (Spain)
Moxifloxacino Kern Pharma (Spain)
Moxifloxacino Krka (Spain)
Moxifloxacino MK (Colombia)
Moxifloxacino Mylan (Spain)
Moxifloxacino Pharmathen (Spain)
Moxifloxacino Qualigen (Spain)
Moxifloxacino Ratiopharm (Spain)
Moxifloxacino Sandoz (Spain)
Moxifloxacino Stada (Spain)
Moxifloxacino Tevagen (Spain)
Moxifloxacino Zentiva (Spain)
Moxifloxan (Bulgaria)
See 879 substitutes for Moxifloxacin HEC Pharm

References

1. PubChem. "moxifloxacin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
2. DrugBank. "moxifloxacin". http://www.drugbank.ca/drugs/DB00218 (accessed September 17, 2018).
3. MeSH. "Anti-Bacterial Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Moxifloxacin HEC Pharm are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Moxifloxacin HEC Pharm. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology