Nicip COLD & FLU Uses
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Consists of Caffeine, Cetirizine, Nimesulide, Paracetamol, Phenylephrine

What is Caffeine (Nicip COLD & FLU)?

Caffeine (Nicip COLD & FLU) is a central nervous system stimulant. It works by stimulating the brain. Caffeine (Nicip COLD & FLU) is found naturally in foods and beverages such as coffee, tea, colas, energy and chocolate. Botanical sources of Caffeine (Nicip COLD & FLU) include kola nuts, guarana, and yerba mate. Caffeine (Nicip COLD & FLU) is also available in prescription and non-prescription medications.

Caffeine (Nicip COLD & FLU) is used to restore mental alertness or wakefulness during fatigue or drowsiness. Caffeine (Nicip COLD & FLU) is also found in some headache and migraine medications, in certain dietary supplements used for weight loss, and in many popular energy drinks.

Caffeine (Nicip COLD & FLU) (Caffeine (Nicip COLD & FLU)) is available by prescription only. It is used for short-term treatment of neonatal apnea (breathing problems).

Caffeine (Nicip COLD & FLU) may also be used for other conditions as determined by your health care provider.

Caffeine (Nicip COLD & FLU) indications

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Caffeine (Nicip COLD & FLU) and Sodium Benzoate Injection has been used in conjunction with supportive measure to treat respiratory depression associated with overdosage with CNS depressant drugs (e.g., narcotic analgesics, alcohol). However, because of questionable benefit and transient action, most authorities believe Caffeine (Nicip COLD & FLU) and other analeptics should not be used in these conditions and recommend other supportive therapy.

How should I use Caffeine (Nicip COLD & FLU)?

Use Caffeine (Nicip COLD & FLU) as directed by your health care provider. If the medication is OTC, check the label on the bottle for the exact dosing instructions. If you have any questions about the use of an OTC medication, ask your pharmacist.

Ask your health care provider any questions you may have about how to use Caffeine (Nicip COLD & FLU).

Uses of Caffeine (Nicip COLD & FLU) in details

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Use: Labeled Indications

Caffeine (Nicip COLD & FLU): Treatment of idiopathic apnea of prematurity

Caffeine (Nicip COLD & FLU) and sodium benzoate: See Off-Label uses.

Caffeine (Nicip COLD & FLU) [OTC labeling]: Restore mental alertness or wakefulness when experiencing fatigue

Off Label Uses

Augmentation of seizure induction during electroconvulsive therapy (Caffeine (Nicip COLD & FLU) and sodium benzoate)

Data from a randomized, double blind study as well as a few unblinded studies support the use of Caffeine (Nicip COLD & FLU)/sodium benzoate in the treatment of augmentation of seizure induction during electroconvulsive therapy (ECT).

Caffeine (Nicip COLD & FLU) description

A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine (Nicip COLD & FLU)'s most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes smooth muscle, stimulates cardiac muscle, stimulates diuresis, and appears to be useful in the treatment of some types of headache. Several cellular actions of Caffeine (Nicip COLD & FLU) have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide phosphodiesterases, antagonism of adenosine receptors, and modulation of intracellular calcium handling. [PubChem]

Caffeine (Nicip COLD & FLU) dosage

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Usual Adult Dose for Drowsiness:

100 to 200 mg orally not more often than every 3 to 4 hours.

For occasional use only.

Not intended for use as a substitute for sleep.

Limit the use of Caffeine (Nicip COLD & FLU) containing medications, foods, or beverages while taking this product because too much Caffeine (Nicip COLD & FLU) may cause nervousness, irritability, sleeplessness, and occasionally, rapid heartbeat.

Usual Pediatric Dose for Drowsiness:

>= 12 years: 100 to 200 mg not more often than every 3 to 4 hours.

For occasional use only.

Not intended for use as a substitute for sleep.

Limit the use of Caffeine (Nicip COLD & FLU) containing medications, foods, or beverages while taking this product because too much Caffeine (Nicip COLD & FLU) may cause nervousness, irritability, sleeplessness, and occasionally, rapid heartbeat.

Usual Pediatric Dose for Apnea of Prematurity:

For short term treatment of apnea of prematurity in infants between 28 and <33 weeks gestational age.

Prior to initiation of Caffeine (Nicip COLD & FLU), baseline serum levels of Caffeine (Nicip COLD & FLU) should be measured in infants previously treated with theophylline, since preterm infants metabolize theophylline to Caffeine (Nicip COLD & FLU). Likewise, baseline serum levels of Caffeine (Nicip COLD & FLU) should be measured in infants born to mothers who consumed Caffeine (Nicip COLD & FLU) prior to delivery, since Caffeine (Nicip COLD & FLU) readily crosses the placenta.

Loading Dose: 20 mg/kg Caffeine (Nicip COLD & FLU) intravenous (over 30 minutes) once

Maintenance Dose: 5 mg/kg Caffeine (Nicip COLD & FLU) intravenous (over 10 minutes) or orally every 24 hours.

Note: The dose of Caffeine (Nicip COLD & FLU) base is one-half the dose when expressed as Caffeine (Nicip COLD & FLU) (e.g., 20 mg of Caffeine (Nicip COLD & FLU) is equivalent to 10 mg of Caffeine (Nicip COLD & FLU) base).

Serum concentrations of Caffeine (Nicip COLD & FLU) may need to be monitored periodically throughout treatment to avoid toxicity. Serious toxicity has been associated with serum levels greater than 50 mg/L.

Apnea of prematurity is a diagnosis of exclusion. Other causes of apnea (e.g., central nervous system disorders, primary lung disease, anemia, sepsis, metabolic disturbances, cardiovascular abnormalities, or obstructive apnea) should be ruled out or properly treated prior to initiation of Caffeine (Nicip COLD & FLU).

Caffeine (Nicip COLD & FLU) should be used with caution in infants with seizure disorders or cardiovascular disease.

The duration of treatment of apnea of prematurity in the placebo-controlled trial was limited to 10 to 12 days. The safety and efficacy of Caffeine (Nicip COLD & FLU) for longer periods of treatment have not been established.

Caffeine (Nicip COLD & FLU) interactions

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What other drugs will affect Caffeine (Nicip COLD & FLU)?

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Acebrophylline: May enhance the stimulatory effect of CNS Stimulants. Avoid combination

Adenosine: Caffeine (Nicip COLD & FLU) and Caffeine (Nicip COLD & FLU) Containing Products may diminish the therapeutic effect of Adenosine. Management: Monitor for decreased effect of adenosine if patient is receiving Caffeine (Nicip COLD & FLU). Discontinue Caffeine (Nicip COLD & FLU) in advance of scheduled diagnostic use of adenosine whenever possible. Consider therapy modification

Amifampridine: Agents With Seizure Threshold Lowering Potential may enhance the neuroexcitatory and/or seizure-potentiating effect of Amifampridine. Monitor therapy

AtoMOXetine: May enhance the hypertensive effect of Sympathomimetics. AtoMOXetine may enhance the tachycardic effect of Sympathomimetics. Monitor therapy

Broccoli: May decrease the serum concentration of CYP1A2 Substrates (High risk with Inducers). Monitor therapy

Bromperidol: Caffeine (Nicip COLD & FLU) and Caffeine (Nicip COLD & FLU) Containing Products may decrease the absorption of Bromperidol. Monitor therapy

BuPROPion: May enhance the neuroexcitatory and/or seizure-potentiating effect of Agents With Seizure Threshold Lowering Potential. Monitor therapy

Cannabinoid-Containing Products: May enhance the tachycardic effect of Sympathomimetics. Exceptions: Cannabidiol. Monitor therapy

Cannabis: May decrease the serum concentration of CYP1A2 Substrates (High risk with Inducers). Monitor therapy

CloZAPine: CYP1A2 Inhibitors (Weak) may increase the serum concentration of CloZAPine. Management: Drugs listed as exceptions to this monograph are discussed in further detail in separate drug interaction monographs. Monitor therapy

Cocaine (Topical): May enhance the hypertensive effect of Sympathomimetics. Management: Consider alternatives to use of this combination when possible. Monitor closely for substantially increased blood pressure or heart rate and for any evidence of myocardial ischemia with concurrent use. Consider therapy modification

CYP1A2 Inducers (Moderate): May decrease the serum concentration of Caffeine (Nicip COLD & FLU) and Caffeine (Nicip COLD & FLU) Containing Products. Monitor therapy

CYP1A2 Inhibitors (Moderate): May increase the serum concentration of Caffeine (Nicip COLD & FLU) and Caffeine (Nicip COLD & FLU) Containing Products. Monitor therapy

CYP1A2 Inhibitors (Strong): May increase the serum concentration of Caffeine (Nicip COLD & FLU) and Caffeine (Nicip COLD & FLU) Containing Products. Monitor therapy

Doxofylline: Caffeine (Nicip COLD & FLU) and Caffeine (Nicip COLD & FLU) Containing Products may enhance the adverse/toxic effect of Doxofylline. Avoid combination

Esketamine: May enhance the hypertensive effect of CNS Stimulants. Monitor therapy

Formoterol: Caffeine (Nicip COLD & FLU) and Caffeine (Nicip COLD & FLU) Containing Products may enhance the adverse/toxic effect of Formoterol. Caffeine (Nicip COLD & FLU) and Caffeine (Nicip COLD & FLU) Containing Products may enhance the hypokalemic effect of Formoterol. Monitor therapy

Guanethidine: May enhance the arrhythmogenic effect of Sympathomimetics. Guanethidine may enhance the hypertensive effect of Sympathomimetics. Monitor therapy

Indacaterol: Caffeine (Nicip COLD & FLU) and Caffeine (Nicip COLD & FLU) Containing Products may enhance the adverse/toxic effect of Indacaterol. Caffeine (Nicip COLD & FLU) and Caffeine (Nicip COLD & FLU) Containing Products may enhance the hypokalemic effect of Indacaterol. Monitor therapy

Iohexol: Agents With Seizure Threshold Lowering Potential may enhance the adverse/toxic effect of Iohexol. Specifically, the risk for seizures may be increased. Management: Discontinue agents that may lower the seizure threshold 48 hours prior to intrathecal use of iohexol. Wait at least 24 hours after the procedure to resume such agents. In nonelective procedures, consider use of prophylactic anticonvulsants. Consider therapy modification

Iomeprol: Agents With Seizure Threshold Lowering Potential may enhance the adverse/toxic effect of Iomeprol. Specifically, the risk for seizures may be increased. Management: Discontinue agents that may lower the seizure threshold 48 hours prior to intrathecal use of iomeprol. Wait at least 24 hours after the procedure to resume such agents. In nonelective procedures, consider use of prophylactic anticonvulsants. Consider therapy modification

Iopamidol: Agents With Seizure Threshold Lowering Potential may enhance the adverse/toxic effect of Iopamidol. Specifically, the risk for seizures may be increased. Management: Discontinue agents that may lower the seizure threshold 48 hours prior to intrathecal use of iopamidol. Wait at least 24 hours after the procedure to resume such agents. In nonelective procedures, consider use of prophylactic anticonvulsants. Consider therapy modification

Linezolid: May enhance the hypertensive effect of Sympathomimetics. Management: Reduce initial doses of sympathomimetic agents, and closely monitor for enhanced pressor response, in patients receiving linezolid. Specific dose adjustment recommendations are not presently available. Consider therapy modification

Lithium: Caffeine (Nicip COLD & FLU) and Caffeine (Nicip COLD & FLU) Containing Products may decrease the serum concentration of Lithium. Monitor therapy

Norfloxacin: May increase the serum concentration of Caffeine (Nicip COLD & FLU) and Caffeine (Nicip COLD & FLU) Containing Products. Monitor therapy

Olodaterol: Caffeine (Nicip COLD & FLU) and Caffeine (Nicip COLD & FLU) Containing Products may enhance the adverse/toxic effect of Olodaterol. Caffeine (Nicip COLD & FLU) and Caffeine (Nicip COLD & FLU) Containing Products may enhance the hypokalemic effect of Olodaterol. Monitor therapy

Ozanimod: May enhance the hypertensive effect of Sympathomimetics. Management: Concomitant use of ozanimod with sympathomimetic agents is not recommended. If combined, monitor patients closely for the development of hypertension, including hypertensive crises. Consider therapy modification

Pipemidic Acid: May increase the serum concentration of Caffeine (Nicip COLD & FLU) and Caffeine (Nicip COLD & FLU) Containing Products. Monitor therapy

Regadenoson: Caffeine (Nicip COLD & FLU) and Caffeine (Nicip COLD & FLU) Containing Products may diminish the vasodilatory effect of Regadenoson. Management: Avoiding using Caffeine (Nicip COLD & FLU) or other methylxanthine containing products (e.g., theophylline) for at least 12 hours prior to the administration of regadenoson. Consider therapy modification

Solriamfetol: Sympathomimetics may enhance the hypertensive effect of Solriamfetol. Sympathomimetics may enhance the tachycardic effect of Solriamfetol. Monitor therapy

Solriamfetol: CNS Stimulants may enhance the hypertensive effect of Solriamfetol. CNS Stimulants may enhance the tachycardic effect of Solriamfetol. Monitor therapy

Stiripentol: May increase the serum concentration of Caffeine (Nicip COLD & FLU) and Caffeine (Nicip COLD & FLU) Containing Products. Avoid combination

Sympathomimetics: May enhance the adverse/toxic effect of other Sympathomimetics. Monitor therapy

Tedizolid: May enhance the hypertensive effect of Sympathomimetics. Tedizolid may enhance the tachycardic effect of Sympathomimetics. Monitor therapy

Theophylline Derivatives: CYP1A2 Inhibitors (Weak) may increase the serum concentration of Theophylline Derivatives. Exceptions: Dyphylline. Monitor therapy

TiZANidine: CYP1A2 Inhibitors (Weak) may increase the serum concentration of TiZANidine. Management: Avoid these combinations when possible. If combined use is necessary, initiate tizanidine at an adult dose of 2 mg and increase in 2 to 4 mg increments based on patient response. Monitor for increased effects of tizanidine, including adverse reactions. Consider therapy modification

Tobacco (Smoked): May decrease the serum concentration of Caffeine (Nicip COLD & FLU) and Caffeine (Nicip COLD & FLU) Containing Products. Monitor therapy

Caffeine (Nicip COLD & FLU) side effects

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What are the possible side effects of Caffeine (Nicip COLD & FLU)?

Cardiovascular

Tachycardia; extrasystoles; palpitations; other cardiac arrhythmias.

CNS

Insomnia; restlessness; excitement; nervousness; tinnitus; scintillating scotoma; muscular tremor; headache; lightheadedness.

Dermatologic

Urticaria; rash, dry skin, skin breakdown (Caffeine (Nicip COLD & FLU)).

EENT

Retinopathy of prematurity (Caffeine (Nicip COLD & FLU)).

GI

Vomiting; nausea; diarrhea; stomach pain; necrotizing enterocolitis, gastritis, GI hemorrhage (Caffeine (Nicip COLD & FLU)).

Genitourinary

Diuresis; kidney failure (Caffeine (Nicip COLD & FLU)).

Hematologic

Disseminated intravascular coagulation (Caffeine (Nicip COLD & FLU)).

Metabolic

Hyperglycemia; acidosis (Caffeine (Nicip COLD & FLU)).

Respiratory

Dyspnea, lung edema (Caffeine (Nicip COLD & FLU)).

Miscellaneous

Hypersensitivity (eg, dermatitis, rhinitis, bronchial asthma); feeding intolerance, sepsis, accidental injury, hemorrhage, cerebral hemorrhage (Caffeine (Nicip COLD & FLU)).

Caffeine (Nicip COLD & FLU) contraindications

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What is the most important information I should know about Caffeine (Nicip COLD & FLU)?

Caffeine (Nicip COLD & FLU) should not be given to a child who has had an allergic reaction to it in the past.

Before using Caffeine (Nicip COLD & FLU), tell the doctor if your child is allergic to any drugs, or has a seizure disorder, heart disease, kidney disease, liver disease, or high or low blood sugar.

Do not use the medication for longer than 12 days without the advice of your child's doctor.

Each bottle of Caffeine (Nicip COLD & FLU) is for one use only, even if your child does not use the entire bottle for a single dose. Throw away any medication left over in the bottle after measuring your child's dose.

Call your doctor if the child's breathing symptoms do not improve after using Caffeine (Nicip COLD & FLU).

To be sure Caffeine (Nicip COLD & FLU) is helping your child's condition, the child's blood will need to be tested on a regular basis. Do not miss any scheduled appointments.

What is Cetirizine (Nicip COLD & FLU)?

Cetirizine (Nicip COLD & FLU) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Cetirizine (Nicip COLD & FLU) is used to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose.

Cetirizine (Nicip COLD & FLU) is also used to treat itching and swelling caused by chronic urticaria (hives).

Cetirizine (Nicip COLD & FLU) may also be used for purposes not listed in this medication guide.

Cetirizine (Nicip COLD & FLU) indications

Perennial Allergic Rhinitis: Cetirizine (Nicip COLD & FLU) hydrochloride syrup is indicated for the relief of symptoms associated with perennial allergic rhinitis due to allergens such as dust mites, animal dander and molds in children 6 to 23 months of age. Symptoms treated effectively include sneezing, rhinorrhea, postnasal discharge, nasal pruritus, ocular pruritus, and tearing.

Chronic Urticaria: Cetirizine (Nicip COLD & FLU) hydrochloride syrup is indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in children 6 months to 5 years of age. It significantly reduces the occurrence, severity, and duration of hives and significantly reduces pruritus.

How should I use Cetirizine (Nicip COLD & FLU)?

Use Cetirizine (Nicip COLD & FLU) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Cetirizine (Nicip COLD & FLU).

Uses of Cetirizine (Nicip COLD & FLU) in details

Use: Labeled Indications

Oral:

Allergic rhinitis: Relief of symptoms associated with allergic rhinitis.

Urticaria, chronic spontaneous: Treatment of uncomplicated skin manifestations of chronic spontaneous urticaria.

Injection:

Urticaria, acute: Treatment of acute urticaria.

Off Label Uses

Anaphylaxis (adjunct to epinephrine for relief of cutaneous symptoms)

Based on joint guidelines from the American Academy of Allergy, Asthma & Immunology, American College of Allergy, Asthma & Immunology, and Joint Council of Allergy, Asthma and Immunology on the diagnosis and management of anaphylaxis and guidelines from the World Allergy Organization on anaphylaxis, Cetirizine (Nicip COLD & FLU) may be used as adjunctive treatment, although should not be used as monotherapy or as first-line therapy of anaphylaxis.

Angioedema, acute allergic or recurrent idiopathic

Clinical experience suggests the utility of second-generation H receptor antagonists (eg, Cetirizine (Nicip COLD & FLU)) for the treatment of acute allergic or recurrent idiopathic angioedema.

Cetirizine (Nicip COLD & FLU) description

Cetirizine (Nicip COLD & FLU) HCl is a piperazine derivative and a metabolite of hydroxyzine. It competes reversibly with histamine to block the histamine (H1) receptor sites. Cetirizine (Nicip COLD & FLU) HCl is considered a long-acting nonsedating antihistamine and has some mast-cell stabilizing activity.

Cetirizine (Nicip COLD & FLU) dosage

Cetirizine (Nicip COLD & FLU) Dosage

Applies to the following strength(s): 10 mg; 5 mg; 1 mg/mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Allergic Rhinitis

5 to 10 mg orally or chewed once a day

Usual Adult Dose for Urticaria

5 to 10 mg orally or chewed once a day

Usual Pediatric Dose for Allergic Rhinitis

6 months to 2 years: 2.5 mg orally once a day, 12 months and older may be increased to 2.5 mg orally twice a day.

2 to 5 years: 2.5 mg orally once a day, may be increased to 5 mg/day in 1 to 2 divided doses.

6 years or older: 5 to 10 mg orally or chewed once a day.

Usual Pediatric Dose for Urticaria

6 months to 2 years: 2.5 mg orally once a day, 12 months and older may be increased to 2.5 mg orally twice a day.

2 to 5 years: 2.5 mg orally once a day, may be increased to 5 mg/day in 1 to 2 divided doses.

6 years or older: 5 to 10 mg orally or chewed once a day.

Renal Dose Adjustments

CrCl less than 30 mL/min: 5 mg orally or chewed once a day.

Use of Cetirizine (Nicip COLD & FLU) is not recommended in children under 6 years of age with renal impairment due to the difficulty in reliably administering doses less than 2.5 mg (1/2 teaspoonful) and the lack of pharmacokinetic and safety information of Cetirizine (Nicip COLD & FLU) in such patients.

Liver Dose Adjustments

5 mg orally or chewed once a day

Use of Cetirizine (Nicip COLD & FLU) is not recommended in children under 6 years of age with hepatic impairment due to the difficulty in reliably administering doses less than 2.5 mg (1/2 teaspoonful) and the lack of pharmacokinetic and safety information of Cetirizine (Nicip COLD & FLU) in such patients.

Precautions

In clinical trials, the occurrence of somnolence has been reported. Due caution should therefore be exercised when driving a car or operating potential dangerous machinery. Concurrent use of alcohol or other CNS depressants should be avoided because additional reductions in alertness and additional impairment of CNS performance may occur.

Dialysis

Cetirizine (Nicip COLD & FLU) is not significantly removed by hemodialysis, thus supplementary dosing is not required following hemodialysis. The recommended dosage for patients on hemodialysis is 5 mg orally or chewed once a day.

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Cetirizine (Nicip COLD & FLU) interactions

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What other drugs will affect Cetirizine (Nicip COLD & FLU)?

Tablet: Concurrent use with alcohol may potentiate the CNS depressant effects of Cetirizine (Nicip COLD & FLU); maprotiline or tricyclic antidepressants may potentiate the anticholinergic effects of either these medications or Cetirizine (Nicip COLD & FLU).

Monoamine oxidase (MAO) inhibitors are not recommended because the use may prolong and intensify the anticholinergic and CNS depressant effects of Cetirizine (Nicip COLD & FLU).

Concurrent use with ototoxic medications may mask the symptoms of ototoxicity eg, tinnitus, dizziness or vertigo; photosensitizing medications may cause additive photosensitizing effects.

Syrup: No interaction is observed for Cetirizine (Nicip COLD & FLU) with pseudoephedrine, cimetidine, ketoconazole, erythromycin and azithromycin. Small decrease in Cetirizine (Nicip COLD & FLU) clearance is observed when theophylline (400 mg once daily) is taken with Cetirizine (Nicip COLD & FLU). However, disposition of theophylline was not altered by concomitant Cetirizine (Nicip COLD & FLU) administration. Concomitant administration of Cetirizine (Nicip COLD & FLU) and macrolides or ketoconazole has never resulted clinically relevant EGG changes. Extent of exposure to Cetirizine (Nicip COLD & FLU) was increased by 40% when ritonavir is taken with Cetirizine (Nicip COLD & FLU). Disposition of ritonavir was slightly altered further to concomitant Cetirizine (Nicip COLD & FLU) administration.

Cetirizine (Nicip COLD & FLU) side effects

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What are the possible side effects of Cetirizine (Nicip COLD & FLU)?

Pediatric studies were conducted with Cetirizine (Nicip COLD & FLU) hydrochloride. More than 1300 pediatric patients aged 6 to 11 years with more than 900 treated with Cetirizine (Nicip COLD & FLU) hydrochloride at doses of 1.25 to 10 mg per day were included in controlled and uncontrolled clinical trials conducted in the United States. The duration of treatment ranged from 2 to 12 weeks. Placebo-controlled trials up to 4 weeks duration included 168 pediatric patients aged 2 to 5 years who received Cetirizine (Nicip COLD & FLU), the majority of whom received single daily doses of 5 mg. A placebo-controlled trial 18 months in duration included 399 patients aged 12 to 24 months treated with Cetirizine (Nicip COLD & FLU) (0.25 mg/kg bid), and another placebo-controlled trial of 7 days duration included 42 patients aged 6 to 11 months who were treated with Cetirizine (Nicip COLD & FLU) (0.25 mg/kg bid).

The majority of adverse reactions reported in pediatric patients aged 2 to 11 years with Cetirizine (Nicip COLD & FLU) hydrochloride were mild or moderate. In placebo-controlled trials, the incidence of discontinuations due to adverse reactions in pediatric patients receiving up to 10 mg of Cetirizine (Nicip COLD & FLU) hydrochloride was uncommon (0.4% on Cetirizine (Nicip COLD & FLU) hydrochloride vs. 1.0% on placebo).

Table 1 lists adverse experiences which were reported for Cetirizine (Nicip COLD & FLU) hydrochloride 5 and 10 mg in pediatric patients aged 6 to 11 years in placebo-controlled clinical trials in the United States and were more common with Cetirizine (Nicip COLD & FLU) hydrochloride than placebo. Of these, abdominal pain was considered treatment-related and somnolence appeared to be dose-related, 1.3% in placebo, 1.9% at 5 mg and 4.2% at 10 mg. The adverse experiences reported in pediatric patients aged 2 to 5 years in placebo-controlled trials were qualitatively similar in nature and generally similar in frequency to those reported in trials with children aged 6 to 11 years.

In the placebo-controlled trials of pediatric patients 6 to 24 months of age, the incidences of adverse experiences, were similar in the Cetirizine (Nicip COLD & FLU) and placebo treatment groups in each study. Somnolence occurred with essentially the same frequency in patients who received Cetirizine (Nicip COLD & FLU) hydrochloride and patients who received placebo. In a study of 1 week duration in children 6 to 11 months of age, patients who received Cetirizine (Nicip COLD & FLU) exhibited greater irritability/fussiness than patients on placebo. In a study of 18 months duration in patients 12 months and older, insomnia occurred more frequently in patients who received Cetirizine (Nicip COLD & FLU) compared to patients who received placebo (9.0% v. 5.3%). In those patients who received 5 mg or more per day of Cetirizine (Nicip COLD & FLU) as compared to patients who received placebo, fatigue (3.6% v. 1.3%) and malaise (3.6% v. 1.8%) occurred more frequently.

Table 1.

Adverse Experiences Reported in Pediatric Patients Aged 6 to 11 Years in Placebo-Controlled United States Cetirizine (Nicip COLD & FLU) Hydrochloride Trials (5 or 10 mg Dose) Which Occurred at a Frequency of ≥2% in Either the 5-mg or the 10-mg Cetirizine (Nicip COLD & FLU) Hydrochloride Group, and More Frequently Than in the Placebo Group

Adverse Experiences Placebo

(N=309)

 Cetirizine (Nicip COLD & FLU) Hydrochloride
5 mg

(N=161)

 10 mg

(N=215)

Headache 12.3% 11.0% 14.0%
Pharyngitis 2.9% 6.2% 2.8%
Abdominal pain 1.9% 4.4% 5.6%
Coughing 3.9% 4.4% 2.8%
Somnolence 1.3% 1.9% 4.2%
Diarrhea 1.3% 3.1% 1.9%
Epistaxis 2.9% 3.7% 1.9%
Bronchospasm 1.9% 3.1% 1.9%
Nausea 1.9% 1.9% 2.8%
Vomiting 1.0% 2.5% 2.3%

The following events were observed infrequently (less than 2%), in either 3982 adults and children 12 years and older or in 659 pediatric patients aged 6 to 11 years who received Cetirizine (Nicip COLD & FLU) hydrochloride in U.S. trials, including an open adult study of six months duration. A causal relationship of these infrequent events with Cetirizine (Nicip COLD & FLU) hydrochloride administration has not been established.

Autonomic Nervous System: anorexia, flushing, increased salivation, urinary retention.

Cardiovascular: cardiac failure, hypertension, palpitation, tachycardia.

Central and Peripheral Nervous Systems: abnormal coordination, ataxia, confusion, dysphonia, hyperesthesia, hyperkinesia, hypertonia, hypoesthesia, leg cramps, migraine,

myelitis, paralysis, paresthesia, ptosis, syncope, tremor, twitching, vertigo, visual field defect.

Gastrointestinal: abnormal hepatic function, aggravated tooth caries, constipation, dyspepsia, eructation, flatulence, gastritis, hemorrhoids, increased appetite, melena, rectal hemorrhage, stomatitis including ulcerative stomatitis, tongue discoloration, tongue edema.

Genitourinary: cystitis, dysuria, hematuria, micturition frequency, polyuria, urinary incontinence, urinary tract infection.

Hearing and Vestibular: deafness, earache, ototoxicity, tinnitus.

Metabolic/Nutritional: dehydration, diabetes mellitus, thirst.

Musculoskeletal: arthralgia, arthritis, arthrosis, muscle weakness, myalgia.

Psychiatric: abnormal thinking, agitation, amnesia, anxiety, decreased libido, depersonalization, depression, emotional lability, euphoria, impaired concentration, insomnia, nervousness, paroniria, sleep disorder.

Respiratory System: bronchitis, dyspnea, hyperventilation, increased sputum, pneumonia, respiratory disorder, rhinitis, sinusitis, upper respiratory tract infection.

Reproductive: dysmenorrhea, female breast pain, intermenstrual bleeding, leukorrhea, menorrhagia, vaginitis.

Reticuloendothelial: lymphadenopathy.

Skin: acne, alopecia, angioedema, bullous eruption, dermatitis, dry skin, eczema, erythematous rash, furunculosis, hyperkeratosis, hypertrichosis, increased sweating, maculopapular rash, photosensitivity reaction, photosensitivity toxic reaction, pruritus, purpura, rash, seborrhea, skin disorder, skin nodule, urticaria.

Special Senses: parosmia, taste loss, taste perversion.

Vision: blindness, conjunctivitis, eye pain, glaucoma, loss of accommodation, ocular hemorrhage, xerophthalmia.

Body as a Whole: accidental injury, asthenia, back pain, chest pain, enlarged abdomen, face edema, fever, generalized edema, hot flashes, increased weight, leg edema, malaise, nasal polyp, pain, pallor, periorbital edema, peripheral edema, rigors.

Occasional instances of transient, reversible hepatic transaminase elevations have occurred during Cetirizine (Nicip COLD & FLU) therapy. Hepatitis with significant transaminase elevation and elevated bilirubin in association with the use of Cetirizine (Nicip COLD & FLU) hydrochloride has been reported.

Post-Marketing Experience

In the post-marketing experience period, the following additional rare, but potentially severe adverse events have been reported: aggressive reaction, anaphylaxis, cholestasis, convulsions, glomerulonephritis, hallucinations, hemolytic anemia, hepatitis, orofacial dyskinesia, severe hypotension, stillbirth, suicidal ideation, suicide and thrombocytopenia.

Cetirizine (Nicip COLD & FLU) contraindications

See also:
What is the most important information I should know about Cetirizine (Nicip COLD & FLU)?

Tablet: Cetirizine (Nicip COLD & FLU) should not be used except under special circumstances for patients with hepatic and renal function impairment.

The risk-benefit should be considered when medical problems eg, bladder neck obstruction, prostatic hypertrophy, urinary retention and glaucoma exists.

Syrup: Hypersensitivity to Cetirizine (Nicip COLD & FLU) dihydrochloride, hydroxyzine, any piperazine derivatives or to any of the excipients of Cetirizine (Nicip COLD & FLU). Patients with severe renal impairment CrCl <10 mL/min. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take Cetirizine (Nicip COLD & FLU).

Nimesulide (Nicip COLD & FLU) indications

Tablet/Suspension: Adults: Treatment of a variety of painful inflammatory conditions including those associated with osteoarthritis, postoperative trauma, sports injuries, ear, nose and throat disorders, dental surgery, bursitis/tendinitis, thrombophlebitis, pharyngitis and gynaecological disorders.

Children: Suspension: Fever and inflammatory symptoms associated with upper respiratory tract infections (viral or bacterial origin) and in reducing pain of various origin in children eg, postoperative pain, pain due to musculoskeletal injury, pain due to minor soft tissue injury, etc.

Gel: For local application in the treatment of acute and chronic musculoskeletal disorders characterized by pain and inflammation including non-articular rheumatic disorders and soft-tissue injuries. These conditions include backache, tendonitis, tenosynovitis, sprains and strains.

Uses of Nimesulide (Nicip COLD & FLU) in details

Nimesulide (Nicip COLD & FLU) is used to treat acute pain, osteoarthritis (pain and swelling of joints due to degeneration) and pain during periods.

Nimesulide (Nicip COLD & FLU) description

Nimesulide (Nicip COLD & FLU) is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. Due to concerns about the risk of hepatotoxicity, Nimesulide (Nicip COLD & FLU) has been withdrawn from market in many countries.

Nimesulide (Nicip COLD & FLU) dosage

Tablet/Suspension: Adults: Usual

Oral Dose: 100-mg tab twice daily.

Children: 1.5 mg/kg body weight, twice or thrice daily.

Gel: For external use only. Adults: Apply approximately 3 cm or 1¼ inches of Nimesulide (Nicip COLD & FLU) gel lightly in a thin layer to the affected site and surrounding areas 3-4 times/day, or as directed by the physician. Clean and dry the affected areas thoroughly before treating with the gel. Patients should be advised to avoid occlusive dressing. Hands should be washed before and after using this medicine.

Nimesulide (Nicip COLD & FLU) interactions

Clinically important interactions involving interference with drug metabolism have not been described with Nimesulide (Nicip COLD & FLU).

Gel: No clinically significant interactions involving interference with drug metabolism have been reported with topical application of Nimesulide (Nicip COLD & FLU).

Nimesulide (Nicip COLD & FLU) side effects

Nimesulide (Nicip COLD & FLU): Adverse effects possibly related to local treatment have been infrequently reported. In clinical trials, the majority of adverse effects are local reactions at the application site eg, mild or moderate local irritation, erythema, rash, desquamation, pruritus. Staining of clothing has been noted.

The frequency of adverse events listed as follows is defined using the following convention: Very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000); very rare (<1/10,000), not known (cannot be estimated from the available data).

Skin and Subcutaneous Tissue Disorders: Uncommon: Pruritus, erythema. Not Known: Desquamation, pruritus, rash, mild or moderate local irritation.

When Nimesulide (Nicip COLD & FLU) is applied topically, the possibility of occurrence of systemic adverse effects is less in comparison to oral administration. However, when Nimesulide (Nicip COLD & FLU) is applied long-term and in high doses, the occurrence of systemic adverse effects should not be neglected.

Sulidin Thermo: Adverse effects possibly related to local treatment have been infrequently reported. In clinical studies, the majority of adverse effects are local reactions at the application area eg, mild or moderate local irritation, erythema, rash, desquamation, pruritus.

The frequency classification of adverse effects are listed as following: Very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000), not known (cannot be estimated from the available data).

İmmune System Disorders: Very Rare: Allergic reactions (anaphylactic shock may be seen in severe events).

Nervous System Disorders: Uncommon: Dyschezia, hypoesthesia. Very Rare: Nervousness, restlessness, euphoria, confusion, tinnitus, somnolence, blurred or double vision, chill, tremor, loss of consciousness.

Eye Disorders: Uncommon: Eye irritation.

Vascular Disorders: Uncommon: Hypertension.

Respiratory, Thoracic or Mediastinal Disorders: Uncommon: Cough, throat irritation, dyspnea, labored breathing and asthma exacerbation.

Gastrointestinal Disorders: Uncommon: Nausea.

Musculoskeletal Disorders, Connective Tissue and Bone Disorders: Uncommon: Pain in extremities, muscle spasms.

General Disorders and Administration Site Conditions: Very Common: Pain in the administration area, erythema. Common: Pruritus in the administration area, papule, vesicle, edema, swelling, dryness. Uncommon: Urticaria in the administration area, paresthesia, dermatitis, hyperesthesia, inflammation, irritation, cyanosis, peripheral edema.

When Nimesulide (Nicip COLD & FLU) and capsaicin is applied topically, the possibility of occurrence systemic adverse effects is less in comparison to oral administration of Nimesulide (Nicip COLD & FLU) and capsaicin. However, when Sulidin Thermo is applied long-term and in high doses, the occurrence of systemic adverse effects should not be neglected.

Nimesulide (Nicip COLD & FLU) contraindications

Nimesulide (Nicip COLD & FLU): Hypersensitivity to Nimesulide (Nicip COLD & FLU) or any of the excipients of Nimesulide (Nicip COLD & FLU). It should not be administered to patients in whom aspirin or other NSAIDs induced the symptoms of asthma, bronchospasm, rhinitis, angioedema, nasal polyps or urticaria by prostaglandin synthesis inhibition. It should not be used on injured or abraded skin or in the presence of local infection. It should not be used simultaneously with other topical products.

Use in Children: It should not be used in children <12 years.

Sulidin Thermo: Hypersensitivity to Nimesulide (Nicip COLD & FLU), capsaicin or any of the excipients of Sulidin Thermo. In patients with hypersensitivity to aspirin and other NSAIDs that induce symptoms of asthma, rhinitis, angioedema, urticaria or nasal polyposis. In injured, damaged and sensitive skin, pruritic conditions eg, eczema and prurigo or open wounds.

Use in Pregnancy: Pregnancy Category C.

Sulidin Thermo is not recommended for use during pregnancy. Especially, it should not be used in 3rd trimester because of the risk of premature ductal constriction and uterine atony.

Use in Children: Dosage recommendations and indications for use in children have not been established. Thus, it should not be used in children.

What is Paracetamol (Nicip COLD & FLU)?

Paracetamol (Nicip COLD & FLU) (acetaminophen) is a pain reliever and a fever reducer. The exact mechanism of Paracetamol (Nicip COLD & FLU) of is not known.

Paracetamol (Nicip COLD & FLU) is used to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers. It relieves pain in mild arthritis but has no effect on the underlying inflammation and swelling of the joint.

Paracetamol (Nicip COLD & FLU) may also be used for other purposes not listed in this medication guide.

Paracetamol (Nicip COLD & FLU) indications

For systemic use of Paracetamol (Nicip COLD & FLU) Sante Naturelle: prevention and treatment of hypo- and avitaminosis of vitamin C; providing increased need for vitamin C during growth, pregnancy, lactation, with heavy loads, fatigue and during recovery after prolonged severe illness; in winter with an increased risk of infectious diseases.

For intravaginal use: chronic or recurrent vaginitis (bacterial vaginosis, nonspecific vaginitis) caused by the anaerobic flora (due to changes in pH of the vagina) in order to normalize disturbed vaginal microflora.

How should I use Paracetamol (Nicip COLD & FLU)?

Use Paracetamol (Nicip COLD & FLU) exactly as directed on the label, or as prescribed by your doctor.

Do not use more of this medication than is recommended. An overdose of Paracetamol (Nicip COLD & FLU) can cause serious harm. The maximum amount for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. Using more Paracetamol (Nicip COLD & FLU) could cause damage to your liver. If you drink more than three alcoholic beverages per day, talk to your doctor before taking Paracetamol (Nicip COLD & FLU) and never use more than 2 grams (2000 mg) per day. If you are treating a child, use a pediatric form of Paracetamol (Nicip COLD & FLU). Carefully follow the dosing directions on the medicine label. Do not give the medication to a child younger than 2 years old without the advice of a doctor.

Measure the liquid form of Paracetamol (Nicip COLD & FLU) with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. You may need to shake the liquid before each use. Follow the directions on the medicine label.

The Paracetamol (Nicip COLD & FLU) chewable tablet must be chewed thoroughly before you swallow it.

Make sure your hands are dry when handling the Paracetamol (Nicip COLD & FLU) disintegrating tablet. Place the tablet on your tongue. It will begin to dissolve right away. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.

To use the Paracetamol (Nicip COLD & FLU) effervescent granules, dissolve one packet of the granules in at least 4 ounces of water. Stir this mixture and drink all of it right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.

Do not take a Paracetamol (Nicip COLD & FLU) rectal suppository by mouth. It is for use only in your rectum. Wash your hands before and after inserting the suppository.

Try to empty your bowel and bladder just before using the Paracetamol (Nicip COLD & FLU) suppository. Remove the outer wrapper from the suppository before inserting it. Avoid handling the suppository too long or it will melt in your hands.

For best results from the suppository, lie down and insert the suppository pointed tip first into the rectum. Hold in the suppository for a few minutes. It will melt quickly once inserted and you should feel little or no discomfort while holding it in. Avoid using the bathroom just after inserting the suppository.

Stop using Paracetamol (Nicip COLD & FLU) and call your doctor if:

Urine glucose tests may produce false results while you are taking Paracetamol (Nicip COLD & FLU). Talk to your doctor if you are diabetic and you notice changes in your glucose levels during treatment.

Store Paracetamol (Nicip COLD & FLU) at room temperature away from heat and moisture. The rectal suppositories can be stored at room temperature or in the refrigerator.

Uses of Paracetamol (Nicip COLD & FLU) in details

This drug is used to treat mild to moderate pain (from headaches, menstrual periods, toothaches, backaches, osteoarthritis, or cold/flu aches and pains) and to reduce fever.

How to use Paracetamol (Nicip COLD & FLU)

Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

There are many brands and forms of acetaminophen available. Read the dosing instructions carefully for each product because the amount of acetaminophen may be different between products. Do not take more acetaminophen than recommended.

If you are giving acetaminophen to a child, be sure you use a product that is meant for children. Use your child's weight to find the right dose on the product package. If you don't know your child's weight, you can use their age.

For suspensions, shake the medication well before each dose. Some liquids do not need to be shaken before use. Follow all directions on the product package. Measure the liquid medication with the provided dose-measuring spoon/dropper/syringe to make sure you have the correct dose. Do not use a household spoon.

For rapidly-dissolving tablets, chew or allow to dissolve on the tongue, then swallow with or without water. For chewable tablets, chew thoroughly before swallowing.

Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

For effervescent tablets, dissolve the dose in the recommended amount of water, then drink.

Pain medications work best if they are used as the first signs of pain occur. If you wait until the symptoms have worsened, the medication may not work as well.

Do not take this medication for fever for more than 3 days unless directed by your doctor. For adults, do not take this product for pain for more than 10 days (5 days in children) unless directed by your doctor. If the child has a sore throat (especially with high fever, headache, or nausea/vomiting), consult the doctor promptly.

Tell your doctor if your condition persists or worsens or if you develop new symptoms. If you think you may have a serious medical problem, get medical help right away.

Paracetamol (Nicip COLD & FLU) description

Paracetamol (Nicip COLD & FLU) is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. Paracetamol (Nicip COLD & FLU) exists as small alkaline deliquescent crystals with a saline tasteacinol was introduced to medicine as a solvent for uric acid. When taken into the body the drug is partly oxidized and partly eliminated unchanged. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successfulacinol was first introduced as an anthelmintic in 1953. A large number of piperazine compounds have anthelmintic Paracetamol (Nicip COLD & FLU). Their mode of Paracetamol (Nicip COLD & FLU) is generally by paralysing parasites, which allows the host body to easily remove or expel the invading organism.

Paracetamol (Nicip COLD & FLU) dosage

Usual Adult Paracetamol (Nicip COLD & FLU) Dose for Fever:

General Dosing Guidelines: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours orally or rectally.

Paracetamol (Nicip COLD & FLU) 500mg tablets: Two 500 mg tablets orally every 4 to 6 hours

Usual Adult Paracetamol (Nicip COLD & FLU) Dose for Pain:

General Dosing Guidelines: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours orally or rectally.

Paracetamol (Nicip COLD & FLU) 500mg tablets: Two 500 mg tablets orally every 4 to 6 hours

Usual Pediatric Dose for Fever:

Oral or Rectal:

<=1 month: 10 to 15 mg/kg/dose every 6 to 8 hours as needed.

>1 month to 12 years: 10 to 15 mg/kg/dose every 4 to 6 hours as needed (Maximum: 5 doses in 24 hours)

Fever: 4 months to 9 years: Initial Dose: 30 mg/kg (Reported by one study (n=121) to be more effective in reducing fever than a 15 mg/kg maintenance dose with no difference regarding clinical tolerance.)

>=12 years: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours.

Usual Pediatric Dose for Pain:

Oral or Rectal:

<=1 month: 10 to 15 mg/kg/dose every 6 to 8 hours as needed.

>1 month to 12 years: 10 to 15 mg/kg/dose every 4 to 6 hours as needed (Maximum: 5 doses in 24 hours)

Fever: 4 months to 9 years: Initial Dose: 30 mg/kg (Reported by one study (n=121) to be more effective in reducing fever than a 15 mg/kg maintenance dose with no difference regarding clinical tolerance.)

>=12 years: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours.

Paracetamol (Nicip COLD & FLU) interactions

See also:
What other drugs will affect Paracetamol (Nicip COLD & FLU)?

With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic Paracetamol (Nicip COLD & FLU) of Paracetamol (Nicip COLD & FLU).

With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.

With the simultaneous use of anticholinergics may decrease absorption of Paracetamol (Nicip COLD & FLU).

With the simultaneous use of oral contraceptives accelerated excretion of Paracetamol (Nicip COLD & FLU) from the body and may reduce its analgesic Paracetamol (Nicip COLD & FLU).

With the simultaneous use with urological means reduced their effectiveness.

With the simultaneous use of activated charcoal reduced bioavailability of Paracetamol (Nicip COLD & FLU).

When Paracetamol (Nicip COLD & FLU) applied simultaneously with diazepam may decrease excretion of diazepam.

There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Paracetamol (Nicip COLD & FLU). A case of severe toxic liver injury.

Described cases of toxic effects of Paracetamol (Nicip COLD & FLU), while the use of isoniazid.

When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Paracetamol (Nicip COLD & FLU), which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Paracetamol (Nicip COLD & FLU) and phenobarbital.

In applying cholestyramine a period of less than 1 h after administration of Paracetamol (Nicip COLD & FLU) may decrease of its absorption.

At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.

With the simultaneous use of metoclopramide may increase absorption of Paracetamol (Nicip COLD & FLU) and its increased concentration in blood plasma.

When applied simultaneously with probenecid may decrease clearance of Paracetamol (Nicip COLD & FLU), with rifampicin, sulfinpyrazone - may increase clearance of Paracetamol (Nicip COLD & FLU) due to increasing its metabolism in the liver.

At simultaneous application of Paracetamol (Nicip COLD & FLU) with ethinylestradiol increases absorption of Paracetamol (Nicip COLD & FLU) from the gut.

Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of Paracetamol (Nicip COLD & FLU) increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).

Paracetamol (Nicip COLD & FLU) side effects

See also:
What are the possible side effects of Paracetamol (Nicip COLD & FLU)?

Effects due to the presence of acetylsalicylic acid.

Accidents awareness with respiratory or skin reactions (angioedema, urticaria, asthma, anaphylactic shock);

Cross hypersensitivity reactions with NSAIDs and with tartrazine;

At low doses recommended for the use of Paracetamol (Nicip COLD & FLU), side effects of aspirin are generally limited to some irritation of the gastro-intestinal tract.

At higher doses, side effects include gastrointestinal mucosal erosions, gastric ulcer or duodenal ulcer, occult blood loss, melena.

Acetylsalicylic acid may also increase the tendency to bleeding and bleeding time (the lengthening of bleeding continues 4-6 days after stopping the drug).

It may also worsen renal function including cases of pre-existing condition (the long-term use can cause chronic kidney disease).

The signs of salicylic overdose described under.

Effects due to the presence of Paracetamol (Nicip COLD & FLU).

At the doses and duration of recommended treatment, side effects are usually negligible, but the prolonged use of Paracetamol (Nicip COLD & FLU) in therapeutic doses large (2-4 g per day, or 10-20 tablets Paracetamol (Nicip COLD & FLU)) may cause the appearance chronic hepatitis. This justifies the recommendations of caution especially in patients with liver disease prior.

Very rarely, it can produce thrombocytopenia.

The acute liver toxicity in overdose massive (doses greater than 8 g of Paracetamol (Nicip COLD & FLU)) is described in paragraph overdose.

Paracetamol (Nicip COLD & FLU) contraindications

See also:
What is the most important information I should know about Paracetamol (Nicip COLD & FLU)?

Paracetamol (Nicip COLD & FLU) should not be used in patients who have previously exhibited hypersensitivity to aspirin and/or nonsteroidal antiinflammatory agents. Paracetamol (Nicip COLD & FLU) should not be given to patients with a recent history of gastrointestinal bleeding or in patients with bleeding disorders (e.g., hemophilia).

What is Phenylephrine (Nicip COLD & FLU)?

Phenylephrine (Nicip COLD & FLU) (Phenylephrine (Nicip COLD & FLU)) is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Phenylephrine (Nicip COLD & FLU) is used to treat nasal and sinus congestion, or congestion of the tubes that drain fluid from your inner ears, called the eustachian (yoo-STAY-shun) tubes.

Phenylephrine (Nicip COLD & FLU) may also be used for purposes not listed in this medication guide.

Phenylephrine (Nicip COLD & FLU) indications

Phenylephrine (Nicip COLD & FLU) is used for the temporary relief of stuffy nose, sinus, and ear symptoms caused by the common cold, flu, allergies, or other breathing illnesses (e.g., sinusitis, bronchitis). This medication works by decreasing swelling in the nose and ears, thereby lessening discomfort and making it easier to breathe.

Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.

How should I use Phenylephrine (Nicip COLD & FLU)?

Use Phenylephrine (Nicip COLD & FLU) drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Phenylephrine (Nicip COLD & FLU) drops.

Uses of Phenylephrine (Nicip COLD & FLU) in details

Use: Labeled Indications

Hypotension/shock: Treatment of hypotension, vascular failure in shock. Note: Not recommended for routine use in the treatment of septic shock; use should be limited until more evidence demonstrating positive clinical outcomes becomes available (Rhodes 2017).

Guideline recommendations:

Cardiogenic shock: The 2017 American Heart Association (AHA) scientific statement for the Contemporary Management of Cardiogenic Shock recommends Phenylephrine (Nicip COLD & FLU), if needed, be considered for initial vasoactive management of cardiogenic shock due to aortic stenosis, mitral stenosis, or dynamic left ventricular outflow tract (LVOT) obstruction (AHA [van Diepen 2017]).

Hypotension during anesthesia: As a vasoconstrictor in regional analgesia

Nasal congestion: As a decongestant [OTC]

Off Label Uses

Hypotension in patients with obstructive hypertrophic cardiomyopathy

Phenylephrine (Nicip COLD & FLU) is a pure alpha1 agonist that will increase systemic vascular resistance without increasing heart rate or contractility. This is advantageous in patients with obstructive hypertrophic cardiomyopathy and hypotension since increases in both heart rate and contractility may cause the obstruction to worsen, leading to a decrease in cardiac output. Other vasopressors like dopamine, epinephrine, and norepinephrine may increase contractility and/or heart rate. Additional trials may be necessary to further define the role of Phenylephrine (Nicip COLD & FLU) in this condition.

Based on the American Urological Association guidelines for the management of priapism, due to the low risk of cardiovascular side effects intracavernous injection of Phenylephrine (Nicip COLD & FLU) is recommended for ischemic priapism that persists following aspiration/irrigation.

Phenylephrine (Nicip COLD & FLU) description

Phenylephrine (Nicip COLD & FLU) is a sympathomimetic amine that acts predominantly on α-adrenergic receptors. It is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs.

Phenylephrine (Nicip COLD & FLU) dosage

Phenylephrine (Nicip COLD & FLU) Dosage

Generic name: Phenylephrine (Nicip COLD & FLU) HYDROCHLORIDE 10mg in 1mL

Dosage form: injection

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

General Dosage and Administration Instructions

Phenylephrine (Nicip COLD & FLU) (Phenylephrine (Nicip COLD & FLU) hydrochloride) Injection, 10 mg/mL must be diluted before administration as an intravenous bolus or continuous intravenous infusion to achieve the desired concentration:

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. Do not use if the solution is colored or cloudy, or if it contains particulate matter. The diluted solution should not be held for more than 4 hours at room temperature or for more than 24 hours under refrigerated conditions. Discard any unused portion.

During Phenylephrine (Nicip COLD & FLU) administration:

Dosing for Treatment of Hypotension during Anesthesia

The following are the recommended dosages for the treatment of hypotension during anesthesia.

Prepare a 100 mcg/mL Solution for Bolus

Intravenous Administration

For bolus intravenous administration, prepare a solution containing a final concentration of 100 mcg/mL of Phenylephrine (Nicip COLD & FLU):

Prepare a Solution for Continuous

Intravenous Administration

For continuous intravenous infusion, prepare a solution containing a final concentration of 20 mcg/mL of Phenylephrine (Nicip COLD & FLU) in 5% Dextrose Injection, USP or 0.9% Sodium Chloride Injection, USP:

Directions for Dispensing from Pharmacy Bulk Vial

The Pharmacy Bulk Vial is intended for dispensing of single doses to multiple patients in a pharmacy admixture program and is restricted to the preparation of admixtures for infusion. Each closure shall be penetrated only one time with a suitable sterile transfer device or dispensing set that allows measured dispensing of the contents. The Pharmacy Bulk Vial is to be used only in a suitable work area such as a laminar flow hood (or an equivalent clean air compounding area). Dispensing from a pharmacy bulk vial should be completed within 4 hours after the vial is penetrated.

More about Phenylephrine (Nicip COLD & FLU) (Phenylephrine (Nicip COLD & FLU))

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Phenylephrine (Nicip COLD & FLU) interactions

See also:
What other drugs will affect Phenylephrine (Nicip COLD & FLU)?

Acetaminophen: May increase the serum concentration of Phenylephrine (Nicip COLD & FLU) (Systemic). Monitor therapy

Alpha1-Blockers: May diminish the vasoconstricting effect of Alpha1-Agonists. Similarly, Alpha1-Agonists may antagonize Alpha1-Blocker vasodilation. Monitor therapy

AtoMOXetine: May enhance the hypertensive effect of Sympathomimetics. AtoMOXetine may enhance the tachycardic effect of Sympathomimetics. Monitor therapy

Benzylpenicilloyl Polylysine: Alpha1-Agonists may diminish the diagnostic effect of Benzylpenicilloyl Polylysine. Management: Consider use of a histamine skin test as a positive control to assess a patient's ability to mount a wheal and flare response. Consider therapy modification

Cannabinoid-Containing Products: May enhance the tachycardic effect of Sympathomimetics. Exceptions: Cannabidiol. Monitor therapy

Chloroprocaine: May enhance the hypertensive effect of Phenylephrine (Nicip COLD & FLU) (Systemic). Monitor therapy

CloZAPine: May diminish the therapeutic effect of Phenylephrine (Nicip COLD & FLU) (Systemic). Monitor therapy

Cocaine (Topical): May enhance the hypertensive effect of Sympathomimetics. Management: Consider alternatives to use of this combination when possible. Monitor closely for substantially increased blood pressure or heart rate and for any evidence of myocardial ischemia with concurrent use. Consider therapy modification

Doxofylline: Sympathomimetics may enhance the adverse/toxic effect of Doxofylline. Monitor therapy

Ergot Derivatives: May enhance the hypertensive effect of Alpha1-Agonists. Ergot Derivatives may enhance the vasoconstricting effect of Alpha1-Agonists. Exceptions: Ergoloid Mesylates; Nicergoline. Avoid combination

FentaNYL: Alpha1-Agonists may decrease the serum concentration of FentaNYL. Specifically, fentanyl nasal spray serum concentrations may decrease and onset of effect may be delayed. Monitor therapy

Guanethidine: May enhance the arrhythmogenic effect of Sympathomimetics. Guanethidine may enhance the hypertensive effect of Sympathomimetics. Monitor therapy

Hyaluronidase: May enhance the vasoconstricting effect of Phenylephrine (Nicip COLD & FLU) (Systemic). Management: Avoid the use of hyaluronidase to enhance dispersion or absorption of Phenylephrine (Nicip COLD & FLU). Use of hyaluronidase for other purposes in patients receiving Phenylephrine (Nicip COLD & FLU) may be considered as clinically indicated. Avoid combination

Iobenguane Radiopharmaceutical Products: Alpha1-Agonists may diminish the therapeutic effect of Iobenguane Radiopharmaceutical Products. Management: Discontinue all drugs that may inhibit or interfere with catecholamine transport or uptake for at least 5 biological half-lives before iobenguane administration. Do not administer these drugs until at least 7 days after each iobenguane dose. Avoid combination

Ioflupane I 123: Phenylephrine (Nicip COLD & FLU) (Systemic) may diminish the diagnostic effect of Ioflupane I 123. Monitor therapy

Linezolid: May enhance the hypertensive effect of Sympathomimetics. Management: Reduce initial doses of sympathomimetic agents, and closely monitor for enhanced pressor response, in patients receiving linezolid. Specific dose adjustment recommendations are not presently available. Consider therapy modification

Monoamine Oxidase Inhibitors: May enhance the hypertensive effect of Alpha1-Agonists. While linezolid is expected to interact via this mechanism, management recommendations differ from other monoamine oxidase inhibitors. Refer to linezolid specific monographs for details. Exceptions: Linezolid. Avoid combination

Ozanimod: May enhance the hypertensive effect of Sympathomimetics. Management: Concomitant use of ozanimod with sympathomimetic agents is not recommended. If combined, monitor patients closely for the development of hypertension, including hypertensive crises. Consider therapy modification

Propacetamol: May increase the serum concentration of Phenylephrine (Nicip COLD & FLU) (Systemic). Management: Monitor patients closely for increased side effects of Phenylephrine (Nicip COLD & FLU) if propacetamol is used concomitantly. Patients with underlying blood pressure issues or arrhythmias may need closer monitoring and may warrant consideration of alternative therapies. Monitor therapy

Solriamfetol: Sympathomimetics may enhance the hypertensive effect of Solriamfetol. Sympathomimetics may enhance the tachycardic effect of Solriamfetol. Monitor therapy

Sympathomimetics: May enhance the adverse/toxic effect of other Sympathomimetics. Monitor therapy

Tedizolid: May enhance the hypertensive effect of Sympathomimetics. Tedizolid may enhance the tachycardic effect of Sympathomimetics. Monitor therapy

Tricyclic Antidepressants: May enhance the therapeutic effect of Alpha1-Agonists. Tricyclic Antidepressants may diminish the therapeutic effect of Alpha1-Agonists. Monitor therapy

Phenylephrine (Nicip COLD & FLU) side effects

See also:
What are the possible side effects of Phenylephrine (Nicip COLD & FLU)?

Applies to Phenylephrine (Nicip COLD & FLU): intravenous solution

As well as its needed effects, Phenylephrine (Nicip COLD & FLU) (the active ingredient contained in Phenylephrine (Nicip COLD & FLU)) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking Phenylephrine (Nicip COLD & FLU), check with your doctor or nurse immediately:

Incidence not known:

If any of the following symptoms of overdose occur while taking Phenylephrine (Nicip COLD & FLU), get emergency help immediately:

Symptoms of overdose:

Minor Side Effects

Some Phenylephrine (Nicip COLD & FLU) side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known:

Phenylephrine (Nicip COLD & FLU) contraindications

See also:
What is the most important information I should know about Phenylephrine (Nicip COLD & FLU)?

Minims Phenylephrine (Nicip COLD & FLU) hydrochloride should not be used in patients with severe hypertension, ventricular tachycardia, or in patients who are hypersensitive to it or to any of the components.

Active ingredient matches for Nicip COLD & FLU:

Caffeine/Cetirizine/Nimesulide/Paracetamol/Phenylephrine


List of Nicip COLD & FLU substitutes (brand and generic names)

Sort by popularity
Unit description / dosage (Manufacturer)Price, USD
Caffeine/Cetirizine/Nimesulide/Paracetamol/Phenylephrine
COLDTER PLUS (India)
COLDTER PLUS tab 10's (Altar)$ 0.59
DAVIS-COLD PLUS (India)
DAVIS-COLD PLUS tab 10's (DML)$ 0.54
MAXTRA COLD
MEGACET FORTE (India)
MEGACET FORTE tab 10's (Systemic)
NEEMACT-PLUS (India)
NEEMACT-PLUS tab 10's (Fitwel)
Neemact-Plus Tablet (Fitwel)$ 0.07
NICSUL PLUS (India)
NICSUL PLUS tab 10's (Bionics)
NILE COLD (India)
NILE COLD tab 10's (Intra Labs)$ 0.66
NIMOWIC-COLD (India)
NIMOWIC-COLD tab 10's (Jaiwik)$ 0.55
NIMUCET COLD N FLU NF (India)
NIMUCET COLD N FLU NF tab 10's (Intas)$ 0.67
NIMUPAN COLD FLU
NIMZEN FORTE (India)
NIMZEN FORTE tab 10's (Allenge)$ 0.51
NP FLU (India)
NP FLU tab 10's (Profic)
ORSUS PLUS (India)
ORSUS PLUS tab 10's (Aprique)
P-COLD PLUS (India)
P-COLD PLUS tab 10's (Pax Healthcare)$ 0.54
SKYRYL PLUS
ZIPCOLD-NP (India)
ZIPCOLD-NP tab 10's (Lifekyor)$ 0.48

References

  1. DailyMed. "CETIRIZINE HYDROCHLORIDE; PSEUDOEPHEDRINE HYDROCHLORIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "CAFFEINE; ERGOTAMINE TARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. PubChem. "phenylephrine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Nicip COLD & FLU are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Nicip COLD & FLU. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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