Roxonin indications
Roxonin has anti-inflammatory and analgesic effects on the following diseases and symptoms: Chronic articular rheumatism, osteoarthritis, lumbago, periarthritis of the shoulder and shoulder-arm-neck syndrome.
Roxonin relieves pain and inflammation after operation, trauma and tooth extraction.
Roxonin description
Roxonin (INN) is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. It is marketed in Brazil, Mexico and Japan by Sankyo as its sodium salt, Roxonin sodium, under the trade name Loxonin, Argentina as Oxeno and in India as Loxomac. It is available in these countries for oral administration, and a transdermal preparation was approved for sale in Japan on January 2006.
Roxonin dosage
For general use, 60 mg of Roxonin sodium (as anhydrous) is orally administered to adults 3 times a day.
For a single administration, 60-120 mg is orally given.
The dosages should be adjusted according to age and symptoms.
Roxonin interactions
Coumarin-Type Anticoagulants: Several short-term controlled studies failed to wshow that ibuprofen significantly affected prothrombin times or a variety of other clotting factors when administered to individuals on coumarin-type anticoagulants. However, because bleeding has been reported when ibuprofen and other nonsteroidal anti-inflammatory agents have been administered to patients on coumarin-type anticoagulants, the physician should be cautious when administering ibuprofen to patients on anticoagulants.
Aspirin: Animal studies wshow that aspirin given with nonsteroidal anti-inflammatory agents, including ibuprofen, yields a net decrease in anti-inflammatory activity with lowered blood levels of the non-aspirin drug. Single dose bioavailability studies in normal volunteers have failed to wshow an effect of aspirin on ibuprofen blood levels. Correlative clinical studies have not been performed.
Methotrexate: Roxonin, as well as other nonsteroidal anti-inflammatory drugs, probably reduces the tubular secretion of methotrexate based on in vitro studies in rabbit kidney slices. This may indicate that ibuprofen could enhance the toxicity of methotrexate. Caution should be used if ibuprofen is administered concomitantly with methotrexate.
H-2 Antagonists: In studies with human volunteers, co-administration of cimetidine or ranitidine with ibuprofen had no substantive effect on ibuprofen serum concentrations.
Furosemide: Clinical studies, as well as random observations, have shown that ibuprofen can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with ibuprofen, the patient should be observed closely for signs of renal failure, as well as to assure diuretic efficacy.
Lithium: Roxonin produced an elevation of plasma lithium levels and a reduction in renal lithium clearance in a study of eleven normal volunteers. The mean minimum lithium concentration increased 15% and the renal clearance of lithium was decreased by 19% during this period of concomitant drug administration.
This effect has been attributed to inhibition of renal prostaglandin synthesis by ibuprofen. Thus, when ibuprofen and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity. (Read circulars for lithium preparation before use of such concurrent therapy).
Roxonin side effects
Adverse GI effects, anorexia, vomiting, diarrhoea, constipation. Anaemia, leucopenia, thrombocytopenia.
Roxonin contraindications
Roxonin tablets or ibuprofen childrens suspension should not be used in patients who have previously exhibited hypersensitivity to the drug, or in individuals with the syndrome of nasal polyps, angioedema, and bronchospastic reactivity to aspirin or other nonsteroidal anti-inflammatory agents. Anaphylactoid reactions have occurred in such patients.
Active ingredient matches for Roxonin:
Loxoprofen in Oman.
References
- PubChem. "Loxoprofen". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Loxoprofen". http://www.drugbank.ca/drugs/DB09212 (accessed September 17, 2018).
- MeSH. "Anti-Inflammatory Agents, Non-Steroidal". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Roxonin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Roxonin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
2 consumers reported useful
Was the Roxonin drug useful in terms of decreasing the symptom or the disease?According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
| Users | % | ||
|---|---|---|---|
| Useful | 1 | 50.0% | |
| Not useful | 1 | 50.0% | |
3 consumers reported price estimates
Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?The below mentioned numbers have been reported by ndrugs.com website users about whether the Roxonin drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
| Users | % | ||
|---|---|---|---|
| Not expensive | 3 | 100.0% | |
18 consumers reported time for results
To what extent do I have to use Roxonin before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 5 days and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Roxonin. To get the time effectiveness of using Roxonin drug by other patients, please click here.
| Users | % | ||
|---|---|---|---|
| 5 days | 5 | 27.8% | |
| 3 days | 3 | 16.7% | |
| 1 week | 3 | 16.7% | |
| 2 weeks | 2 | 11.1% | |
| 1 day | 2 | 11.1% | |
| 1 month | 2 | 11.1% | |
| 2 days | 1 | 5.6% | |
43 consumers reported age
| Users | % | ||
|---|---|---|---|
| 30-45 | 16 | 37.2% | |
| 46-60 | 10 | 23.3% | |
| 16-29 | 8 | 18.6% | |
| > 60 | 6 | 14.0% | |
| 6-15 | 3 | 7.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
