Amocol Uses

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Amocol indications

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For use Max Pidek Pharmaceuticals as monotherapy and in combination with clavulanic acid: an infectious-inflammatory diseases caused by susceptible microorganisms, including bronchitis, pneumonia, tonsillitis, pyelonephritis, urethritis, infections of the gastrointestinal tract, gynecological infections, infections of the skin and soft tissue, listeria, leptospirosis, gonorrhea.

For use Max Pidek Pharmaceuticals in combination with metronidazole: chronic gastritis in acute, peptic ulcer and duodenal ulcer in acute, associated with Helicobacter Pylori.

Uses of Amocol in details

Amocol is used to treat certain diseases of the respiratory tract and to relieve cough associated with thickened mucous.

Amocol description

Each retard capsule contains Ambroxol hydrochloride 75 mg.

Each tablet contains Ambroxol hydrochloride 30 mg.

Each 5 mL of syrup contains Ambroxol hydrochloride 15 or 30 mg.

Each mL of syrup (infant drops) contains Ambroxol hydrochloride 6 mg.

Amocol hydrochloride is trans-4-[(2-amino-3,5-dibromo-benzyl)amino] cyclohexanol hydrochloride.

It also contains the following excipients: Retard Capsules: Crospovidone collidon CL, carnauba wax, stearyl alcohol, magnesium stearate.

Tablets: Lactose, maize starch, colloidal silica, magnesium stearate.

Syrup: Purified water, sorbitol liquid, glycerol 85%, woodberry aroma (15 mg only), strawberry aroma (30 mg only), hydroxyethylcellulose, benzoic acid, acesulfame potassium, vanilla aroma.

Infant Drops: Hydroxyethylcellulose, sorbitol solution, glycerol 85%, sodium saccharin, pharma flavors, menthol, benzoic acid, propylene glycol.

Amocol dosage

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Sustained-Release Capsule: Adults and Children >12 years: 1 cap once daily after meal with plenty of liquid (sufficient supply of liquid supports the expectorant effect of Amocol).

Amocol SR capsule is not suitable for children <12 years.

Tablet: Adults and Children >12 years: 1 tab thrice daily for the first 2-3 days and then 1 tab twice daily or ½ tab thrice daily. Children 6-12 years: ½ tab 2-3 times a day.

Syrup: Adults and Children >12 years: 10 mL thrice daily during the first 2-3 days, them 10 mL twice daily or 5 mL thrice daily. Children 6-12 years: 5 mL 2-3 times a day; 2-5 years: 2.5 mL 3 times a day; <2 years: 2.5 mL 2 times a day.

DS Syrup: Adults and Children >12 years: 5 mL thrice daily for 2-3 days then 5 mL twice daily for 2.5 mL thrice daily. Children 6-12 years: 2.5 mL 2-3 times a day.

Infant Drops: Children 13-24 months: 1.25 mL twice a day; 7-12 months: 1 mL twice a day; ≤6 months: 0.5 mL twice a day.

Amocol interactions

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Amoxicillin may decrease the effectiveness of contraceptives for oral administration.

With the simultaneous use of Max Pidek Pharmaceuticals with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) appears synergies; with bacteriostatic antibiotic (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulphonamide) - antagonism.

Amoxicillin increases the effects of indirect anticoagulants inhibiting intestinal microflora, reduces the synthesis of vitamin K and prothrombin index.

Amoxicillin reduces the effect of drugs, in the process of metabolism that produce PABA.

Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs decrease the tubular secretion of amoxicillin, which can be accompanied by an increase in its concentration in blood plasma.

Antacids, glucosamine, laxatives, aminoglycosides, slow down and reduce, and ascorbic acid increases the absorption of amoxicillin.

With the combined use of amoxicillin and clavulanic acid pharmacokinetics of both components unchanged.

Amocol side effects

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Allergic reactions: urticaria, erythema, edema Quincke, rhinitis, conjunctivitis, rarely - fever, joint pain, eosinophilia, in rare cases - anaphylactic shock.

Side effects associated with chemotherapy effect: possible development of super-infection (particularly in patients with chronic diseases or low resistance of the organism).

With prolonged use at high doses: dizziness, ataxia, confusion, depression, peripheral neuropathy, seizures.

Mostly when Max Pidek Pharmaceuticals used in combination with metronidazole: nausea, vomiting, anorexia, diarrhea, constipation, epigastric pain, glossitis, stomatitis; rarely - hepatitis, pseudomembranous colitis, allergic reactions (urticaria, angioedema), interstitial nephritis, a violation of hematopoiesis.

Mostly when Max Pidek Pharmaceuticals used in combination with clavulanic acid: cholestatic jaundice, hepatitis, rarely - erythema multiforme, toxic epidermal necrolysis, exfoliative dermatitis.

Amocol contraindications

Hypersensitivity to Amocol hydrochloride or to any other excipients of Amocol.

In case of rare hereditary conditions that may be incompatible with an excipient of Amocol, the use of Amocol is contraindicated.



Active ingredient matches for Amocol:

Ambroxol in Mexico.

Ambroxol Hcl


List of Amocol substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Ampromed 30 mg x 1, 000's (Millimed)
Amriz Ambroxol hydrochloride, Terbutaline sulphate, Guaiphenesin, Menthol. SYR / 100ml (Ritz Pharma)$ 0.51
Amriz Ambroxol hydrochloride, Terbutaline sulphate, Guaiphenesin, Menthol. SYR / 60ml (Ritz Pharma)$ 0.34
100ml (Ritz Pharma)$ 0.51
60ml (Ritz Pharma)$ 0.34
AMRIZ syr 100ml (Ritz Pharma)$ 0.51
AMRIZ syr 60ml (Ritz Pharma)$ 0.34
Amrolite 2S Ambroxol30mg, Guaiphenesin50mg, Salbutamol2mg/5ml SYR / 100ml$ 0.45
Amrolite 2S Ambroxol 30mg, Guaiphenesin 50mg, Salbutamol 2mg/5ml SYR / 100ml$ 0.45
Amrolite-2S Ambroxol 30mg, Guaiphenesin 50mg, Salbutamol 2mg/5ml Amrolite-2S SYR / 100ml$ 0.45
Amrox-GT Ambroxol hydrochloride 7.5 mg, terbutaline sulphate 0.25 mg, guaiphenesin 12.5 mg. O-DPS / 15ml (Systemic)
AMROX-GT oral drops 15ml (Systemic)
Amsol 30 mg x 1000's
Amsol 30 mg x 100 x 10's
Amsol-SR 75mg TAB / 10 (Kopran (Kresp))$ 0.42
75 mg x 10's (Kopran (Kresp))$ 0.42
AMSOL-SR tab 75 mg x 10's (Kopran (Kresp))$ 0.42
Amsolvon 30 mg x 1000's
Amsolvon 75 mg x 1000's
Amsolyn 30 mg x 1 Bottle 100 Tablet
Amsovan 3 mg/1 mL x 1 mL
Amsovan 3 mg/1 mL x 60 mL
Amsovan 3 mg/1 mL x 120 mL
Amtuss 30 mg x 50 x 10's (Unison)
Amtuss 30 mg/5 mL x 60 mL x 50's (Unison)
Amtuss tab 30 mg 50 x 10's (Unison)
Amtuss syr 30 mg/5 mL 60 mL x 1's (Unison)
Amtuss Syrup 30 mg/5 mL x 60 mL
Amucap 30 mg x 10 Blister x 10 Tablet
Amxol 30 mg x 10 x 10's (Biolab)$ 53.00
Amxol 30 mg x 500's (Biolab)
Amxol 30 mg/5 mL x 60 mL (Biolab)
Amxol 3 mg/1 mL x 60 mL (Biolab)
Amxol 3 mg/1 mL x 100 mL (Biolab)
Amxol 3 mg/1 mL x 120 mL (Biolab)
Amxol 30 mg/5 mL x 1 L (Biolab)
Amxol 30 mg x 10 x 10's (Biolab)
Amxol 30 mg/5 mL x 1000 mL x 1's (Biolab)
Amxol syr 30 mg/5 mL 60 mL x 1's (Biolab)

References

  1. PubChem. "ambroxol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "ambroxol". http://www.drugbank.ca/drugs/DB06742 (accessed September 17, 2018).
  3. MeSH. "Expectorants". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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