Avimet SUSP Uses

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What is Avimet SUSP?

Avimet SUSP is used to treat bacterial infections in different areas of the body. The extended-release tablets are used to treat women with vaginal infections (bacterial vaginosis).

Avimet SUSP belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, Avimet SUSP will not work for colds, flu, or other virus infections.

Avimet SUSP is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Avimet SUSP is used in certain patients with the following medical conditions:

Avimet SUSP indications

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Symptomatic Trichomoniasis. Avimet SUSP Capsules USP 375 mg are indicated for the treatment of T. vaginalis infection in females and males when the presence of the trichomonad has been confirmed by appropriate laboratory procedures (wet smears and/or cultures).

Asymptomatic Trichomoniasis. Avimet SUSP Capsules USP 375 mg are indicated in the treatment of asymptomatic T. vaginalis infection in females when the organism is associated with endocervicitis, cervicitis, or cervical erosion. Since there is evidence that presence of the trichomonad can interfere with accurate assessment of abnormal cytological smears, additional smears should be performed after eradication of the parasite.

Treatment of Asymptomatic Sexual Partners. T. vaginalis infection is a venereal disease. Therefore, asymptomatic sexual partners of treated patients should be treated simultaneously if the organism has been found to be present, in order to prevent reinfection of the partner. The decision as to whether to treat an asymptomatic male partner who has a negative culture or one for whom no culture has been attempted is an individual one. In making this decision, it should be noted that there is evidence that a woman may become reinfected if her sexual partner is not treated. Also, since there can be considerable difficulty in isolating the organism from the asymptomatic male carrier, negative smears and cultures cannot be relied upon in this regard. In any event, the sexual partner should be treated with Avimet SUSP in cases of reinfection.

Amebiasis. Avimet SUSP Capsules USP 375 mg are indicated in the treatment of acute intestinal amebiasis (amebic dysentery) and amebic liver abscess.

In amebic liver abscess, Avimet SUSP Capsules USP 375 mg therapy does not obviate the need for aspiration or drainage of pus.

Anaerobic Bacterial Infections. Avimet SUSP Capsules USP 375 mg are indicated in the treatment of serious infections caused by susceptible anaerobic bacteria. Indicated surgical procedures should be performed in conjunction with Avimet SUSP therapy. In a mixed aerobic and anaerobic infection, antimicrobials appropriate for the treatment of the aerobic infection should be used in addition to Avimet SUSP Capsules USP 375 mg.

INTRA-ABDOMINAL INFECTIONS, including peritonitis, intra-abdominal abscess, and liver abscess, caused by Bacteroides species including the B. fragilis group (B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus), Clostridium species, Eubacterium species, Peptococcus species, or Peptostreptococcus species.

SKIN AND SKIN STRUCTURE INFECTIONS caused by Bacteroides species including the B. fragilis group, Clostridium species, Peptococcus species, Peptostreptococcus species, or Fusobacterium species.

GYNECOLOGIC INFECTIONS, including endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection, caused by Bacteroides species including the B. fragilis group, Clostridium species, Peptococcus species, Peptostreptococcus species, or Fusobacterium species.

BACTERIAL SEPTICEMIA caused by Bacteroides species including the B. fragilis group or Clostridium species.

BONE AND JOINT INFECTIONS (as adjunctive therapy) caused by Bacteroides species including the B. fragilis group.

CENTRAL NERVOUS SYSTEM (CNS) INFECTIONS, including meningitis and brain abscess, caused by Bacteroides species including the B. fragilis group.

LOWER RESPIRATORY TRACT INFECTIONS, including pneumonia, empyema, and lung abscess, caused by Bacteroides species including the B. fragilis group.

ENDOCARDITIS caused by Bacteroides species including the B. fragilis group.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Avimet SUSP Capsules USP 375 mg and other antibacterial drugs, Avimet SUSP Capsules USP 375 mg should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

How should I use Avimet SUSP?

Use Avimet SUSP cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Avimet SUSP cream.

Uses of Avimet SUSP in details

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Avimet SUSP is an antibiotic that is used to treat a wide variety of infections. It works by stopping the growth of certain bacteria and parasites.

This antibiotic treats only certain bacterial and parasitic infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.

Avimet SUSP may also be used with other medications to treat certain stomach/intestinal ulcers caused by a bacteria (H. pylori).

How to use Avimet SUSP

Take this medication by mouth as directed by your doctor. To prevent stomach upset, take this medication with food or a full glass of water or milk. The dosage is based on your medical condition and response to treatment.

Antibiotics work best when the amount of medicine in your body is kept at a constant level. Take this drug at evenly spaced intervals.

Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.

Tell your doctor if your condition lasts or gets worse.

Avimet SUSP description

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Each 100 mL contains metronidazole USP 500 mg, sodium chloride USP 0.72% w/v, water for injection USP as needed.

Avimet SUSP injection, USP is a parenteral dosage form of the synthetic antibacterial agent 1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole. The empirical formula is C6H9N3O3 and the molecular weight is 171.15.

Avimet SUSP injection, USP in 100 mL is a sterile, nonpyrogenic, iso-osmotic, buffered solution of 500 mg Avimet SUSP, USP, 790 mg sodium chloride, USP, 47.6 mg dried dibasic sodium phosphate, USP and 22.9 mg anhydrous citric acid, USP. Avimet SUSP injection, USP has an osmolarity of 310 mOsmol/L (calc) and a pH of 5.5 (4.5 to 7).

Avimet SUSP dosage

Avimet SUSP ER Dosage

Generic name: Avimet SUSP 750mg

Dosage form: tablet, film coated, extended release

See also:

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Bacterial Vaginosis

750 mg once daily by mouth for seven consecutive days.

Avimet SUSP ER 750 mg tablets should be taken under fasting conditions, at least one hour before or two hours after meals. The optimum extended-release characteristics of Avimet SUSP ER 750 mg are obtained when the drug is taken under fasting conditions.

Avimet SUSP ER tablets should not be split, chewed, or crushed.

Dosage Adjustments

Patients Undergoing Hemodialysis

Hemodialysis removes significant amounts of Avimet SUSP and its metabolites from systemic circulation. The clearance of Avimet SUSP will depend on the type of dialysis membrane used, the duration of the dialysis session, and other factors. If the administration of Avimet SUSP cannot be separated from a hemodialysis session, supplementation of Avimet SUSP dosage following the hemodialysis session should be considered, depending on the patient's clinical situation.

More about Avimet SUSP ER (Avimet SUSP)

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Other formulations

Related treatment guides

Avimet SUSP interactions

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What other drugs will affect Avimet SUSP?

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Simultaneous administration of Zol with:

  • antacids that contain aluminum hydroxide, with kolestiraminom slightly decreases absorption of Avimet SUSP from the gastrointestinal tract;
  • Avimet SUSP potentiates the effect of indirect anticoagulants;
  • disulfiram may develop acute psychosis and impaired consciousness;
  • lansoprazole possible glossitis, stomatitis and / or the appearance of dark color language; with lithium carbonate - may increase the concentration of lithium in blood plasma and the development of symptoms of intoxication with prednisone - increased excretion of Avimet SUSP from the body by accelerating its metabolism in the liver under the influence of prednisone. It is possible a decrease the effectiveness of Zol.
  • rifampicin increased the clearance of Avimet SUSP from the body, with phenytoin - it is perhaps a slight increase in the concentration of phenytoin in blood plasma, described the case of toxic action;
  • phenobarbital significantly increased excretion of Avimet SUSP from the body, apparently due to acceleration of its metabolism in the liver under the influence of phenobarbital. It is possible a decrease the effectiveness of Zol;
  • fluorouracil enhanced the toxic effect but not the effectiveness of fluorouracil;
  • cimetidine may inhibit the metabolism of Avimet SUSP in the liver that can lead to slow its elimination and increase the concentration in blood plasma. It can not be excluded the increase in the concentration of carbamazepine in plasma and increased risk of toxicity with concomitant use of Zol. There was described a case of acute dystonia after a single dose of chloroquine in patients treated with Avimet SUSP.

    Avimet SUSP side effects

    See also:
    What are the possible side effects of Avimet SUSP?

    In a controlled clinical trial, safety data from 141 patients who used Avimet SUSP Lotion

    Topical Lotion (n=71), or the lotion vehicle (n=70), twice daily and experienced a local cutaneous adverse event which may or may not have been related to the treatments include: local allergic reaction, Avimet SUSP

    Topical Lotion 2 (3%), lotion vehicle 0; contact dermatitis, Avimet SUSP Lotion

    Topical Lotion 2 (3%), lotion vehicle 1 (1%); pruritus, Avimet SUSP Lotion

    Topical Lotion 1 (1%), lotion vehicle 0; skin discomfort (burning and stinging), Avimet SUSP Lotion

    Topical Lotion 1 (1%), lotion vehicle 2 (3%); erythema, Avimet SUSP Lotion

    Topical Lotion 4 (6%), lotion vehicle 0; dry skin, Avimet SUSP Lotion

    Topical Lotion 0, lotion vehicle 1 (1%); and worsening of rosacea, Avimet SUSP Lotion

    Topical Lotion 1 (1%), lotion vehicle 7 (10%).

    The following additional adverse experiences have been reported with the topical use of Avimet SUSP: skin irritation, transient redness, metallic taste, tingling or numbness of extremities, and nausea.

    Avimet SUSP contraindications

    See also:
    What is the most important information I should know about Avimet SUSP?

    Hypersensitivity

    Avimet SUSP Capsules 375 mg are contraindicated in patients with a prior history of hypersensitivity to Avimet SUSP or other nitroimidazole derivatives.

    In patients with trichomoniasis, Avimet SUSP Capsules 375 mg are contraindicated during the first trimester of pregnancy.

    Psychotic Reaction with Disulfiram

    Use of oral Avimet SUSP is associated with psychotic reactions in alcoholic patients who were using disulfiram concurrently. Do not administer Avimet SUSP to patients who have taken disulfiram within the last two weeks.

    Interaction with Alcohol

    Use of oral Avimet SUSP is associated with a disulfiram-like reaction to alcohol, including abdominal cramps, nausea, vomiting, headaches, and flushing. Discontinue consumption of alcohol or products containing propylene glycol during and for at least three days after therapy with Avimet SUSP.

    Active ingredient matches for Avimet SUSP:

    Metronidazole in India.


    Unit description / dosage (Manufacturer)Price, USD
    100 mg x 30ml$ 0.19
    Avimet Susp 100mg SUSP / 30ml$ 0.19
    AVIMET SUSP oral susp 100 mg x 30ml (Moraceae)$ 0.19
    Avimet Susp 100mg SUSP / 30ml$ 0.19

    List of Avimet SUSP substitutes (brand and generic names):

    Avimet 500mg TAB / 10 (Avinash)$ 0.11
    Axcel Metronidazole 200 mg x 1's
    B Braun Metronidazole 500 mg/100 mL x 1's (B Braun)
    Bacimex / IV 500 mg x 100 mL (Alter)
    BALGYL 400MG TABLET 1 strip / 10 tablets each (Micro Labs Ltd)$ 1.68
    BALGYL GEL Cream/ Gel/ Ointment / 0.01 / 30gm units (Bal Pharma)$ 0.33
    30g (Bal Pharma)$ 0.33
    Balgyl Gel 30g GEL (Bal Pharma)$ 0.33
    BALGYL GEL topical gel 10 mg x 1 g x 30g (Bal Pharma)$ 0.33
    Balgyl Gel 30g GEL (Bal Pharma)$ 0.33
    Balvidine M Skin 30 ml Lotion (Bal Pharma Limited)$ 0.31
    Balvidine M Skin 15 gm Ointment (Bal Pharma Limited)$ 0.31
    Bendiar 1000+500+7.5 Tablet (Ben Pharmaceuticals)$ 0.09
    Betadix 300+200 Tablet (Agron Remedies Pvt Ltd)$ 0.03
    Betadix 30 ml Syrup (Agron Remedies Pvt Ltd)$ 0.02
    Tablet; Oral; Metronidazole
    Tablets; Oral; Metronidazole
    Biatron 500 500 mg x 5 x 10's$ 8.46
    Boie Metronidazole 500 mg x 100's$ 8.89
    C Dial 30 ml Suspension (Corona Laboratories)$ 0.05

    References

    1. DailyMed. "BISMUTH SUBCITRATE POTASSIUM; METRONIDAZOLE; TETRACYCLINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
    2. PubChem. "metronidazole". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
    3. DrugBank. "metronidazole". http://www.drugbank.ca/drugs/DB00916 (accessed September 17, 2018).

    Reviews

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    Information checked by Dr. Sachin Kumar, MD Pharmacology

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