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• Axcel Metronidazole indications
• Uses of Axcel Metronidazole in details
• Axcel Metronidazole description
• Axcel Metronidazole dosage
• Axcel Metronidazole interactions
• Axcel Metronidazole side effects
• Axcel Metronidazole contraindications

What is Axcel Metronidazole?

Axcel Metronidazole is used to treat bacterial infections in different areas of the body. The extended-release tablets are used to treat women with vaginal infections (bacterial vaginosis).

Axcel Metronidazole belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, Axcel Metronidazole will not work for colds, flu, or other virus infections.

Axcel Metronidazole is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Axcel Metronidazole is used in certain patients with the following medical conditions:

• Clostridium difficile diarrhea or colitis (antibiotic-associated colitis).
• Crohn's disease (inflammatory bowel disease).
• Gastritis or stomach ulcers due to Helicobacter pylori.
• Giardiasis (parasite infection in the intestines).

Axcel Metronidazole indications

Symptomatic Trichomoniasis. Axcel Metronidazole Capsules USP 375 mg are indicated for the treatment of T. vaginalis infection in females and males when the presence of the trichomonad has been confirmed by appropriate laboratory procedures (wet smears and/or cultures).

Asymptomatic Trichomoniasis. Axcel Metronidazole Capsules USP 375 mg are indicated in the treatment of asymptomatic T. vaginalis infection in females when the organism is associated with endocervicitis, cervicitis, or cervical erosion. Since there is evidence that presence of the trichomonad can interfere with accurate assessment of abnormal cytological smears, additional smears should be performed after eradication of the parasite.

Treatment of Asymptomatic Sexual Partners. T. vaginalis infection is a venereal disease. Therefore, asymptomatic sexual partners of treated patients should be treated simultaneously if the organism has been found to be present, in order to prevent reinfection of the partner. The decision as to whether to treat an asymptomatic male partner who has a negative culture or one for whom no culture has been attempted is an individual one. In making this decision, it should be noted that there is evidence that a woman may become reinfected if her sexual partner is not treated. Also, since there can be considerable difficulty in isolating the organism from the asymptomatic male carrier, negative smears and cultures cannot be relied upon in this regard. In any event, the sexual partner should be treated with Axcel Metronidazole in cases of reinfection.

Amebiasis. Axcel Metronidazole Capsules USP 375 mg are indicated in the treatment of acute intestinal amebiasis (amebic dysentery) and amebic liver abscess.

In amebic liver abscess, Axcel Metronidazole Capsules USP 375 mg therapy does not obviate the need for aspiration or drainage of pus.

Anaerobic Bacterial Infections. Axcel Metronidazole Capsules USP 375 mg are indicated in the treatment of serious infections caused by susceptible anaerobic bacteria. Indicated surgical procedures should be performed in conjunction with Axcel Metronidazole therapy. In a mixed aerobic and anaerobic infection, antimicrobials appropriate for the treatment of the aerobic infection should be used in addition to Axcel Metronidazole Capsules USP 375 mg.

INTRA-ABDOMINAL INFECTIONS, including peritonitis, intra-abdominal abscess, and liver abscess, caused by Bacteroides species including the B. fragilis group (B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus), Clostridium species, Eubacterium species, Peptococcus species, or Peptostreptococcus species.

SKIN AND SKIN STRUCTURE INFECTIONS caused by Bacteroides species including the B. fragilis group, Clostridium species, Peptococcus species, Peptostreptococcus species, or Fusobacterium species.

GYNECOLOGIC INFECTIONS, including endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection, caused by Bacteroides species including the B. fragilis group, Clostridium species, Peptococcus species, Peptostreptococcus species, or Fusobacterium species.

BACTERIAL SEPTICEMIA caused by Bacteroides species including the B. fragilis group or Clostridium species.

BONE AND JOINT INFECTIONS (as adjunctive therapy) caused by Bacteroides species including the B. fragilis group.

CENTRAL NERVOUS SYSTEM (CNS) INFECTIONS, including meningitis and brain abscess, caused by Bacteroides species including the B. fragilis group.

LOWER RESPIRATORY TRACT INFECTIONS, including pneumonia, empyema, and lung abscess, caused by Bacteroides species including the B. fragilis group.

ENDOCARDITIS caused by Bacteroides species including the B. fragilis group.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Axcel Metronidazole Capsules USP 375 mg and other antibacterial drugs, Axcel Metronidazole Capsules USP 375 mg should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

How should I use Axcel Metronidazole?

Use Axcel Metronidazole cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Wash and completely dry the affected area. Be sure the area is completely dry before applying Axcel Metronidazole cream.
• Apply a thin layer of Axcel Metronidazole cream to the affected area. Gently rub the medicine in until it is evenly distributed.
• Wash your hands immediately after using Axcel Metronidazole cream.
• You may apply cosmetics after you use Axcel Metronidazole cream. If you are using the lotion, wait 5 minutes after you use Axcel Metronidazole cream before you apply cosmetics so that the lotion has time to dry.
• Use Axcel Metronidazole cream on a regular schedule to get the most benefit from it. Using it at the same time(s) each day will help you remember to use it.
• Continue to use Axcel Metronidazole cream even if your condition improves, unless a doctor tells you otherwise. Do not miss any doses.
• If you miss a dose of Axcel Metronidazole cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Axcel Metronidazole cream.

Uses of Axcel Metronidazole in details

Axcel Metronidazole is an antibiotic that is used to treat a wide variety of infections. It works by stopping the growth of certain bacteria and parasites.

This antibiotic treats only certain bacterial and parasitic infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.

Axcel Metronidazole may also be used with other medications to treat certain stomach/intestinal ulcers caused by a bacteria (H. pylori).

How to use Axcel Metronidazole

Take this medication by mouth as directed by your doctor. To prevent stomach upset, take this medication with food or a full glass of water or milk. The dosage is based on your medical condition and response to treatment.

Antibiotics work best when the amount of medicine in your body is kept at a constant level. Take this drug at evenly spaced intervals.

Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.

Tell your doctor if your condition lasts or gets worse.

Axcel Metronidazole description

Each 100 mL contains Metronidazole USP 500 mg, sodium chloride USP 0.72% w/v, water for injection USP as needed.

Axcel Metronidazole injection, USP is a parenteral dosage form of the synthetic antibacterial agent 1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole. The empirical formula is C₆H₉N₃O₃ and the molecular weight is 171.15.

Axcel Metronidazole injection, USP in 100 mL is a sterile, nonpyrogenic, iso-osmotic, buffered solution of 500 mg Axcel Metronidazole, USP, 790 mg sodium chloride, USP, 47.6 mg dried dibasic sodium phosphate, USP and 22.9 mg anhydrous citric acid, USP. Axcel Metronidazole injection, USP has an osmolarity of 310 mOsmol/L (calc) and a pH of 5.5 (4.5 to 7).

Axcel Metronidazole dosage

Axcel Metronidazole ER Dosage

Generic name: Axcel Metronidazole 750mg

Dosage form: tablet, film coated, extended release

See also:

• Axcel Metronidazole tablet, film coated
• Axcel Metronidazole 375 Capsules capsule
• Axcel Metronidazole Injection injection, solution

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Bacterial Vaginosis

750 mg once daily by mouth for seven consecutive days.

Axcel Metronidazole ER 750 mg tablets should be taken under fasting conditions, at least one hour before or two hours after meals. The optimum extended-release characteristics of Axcel Metronidazole ER 750 mg are obtained when the drug is taken under fasting conditions.

Axcel Metronidazole ER tablets should not be split, chewed, or crushed.

Dosage Adjustments

Patients Undergoing Hemodialysis

Hemodialysis removes significant amounts of Axcel Metronidazole and its metabolites from systemic circulation. The clearance of Axcel Metronidazole will depend on the type of dialysis membrane used, the duration of the dialysis session, and other factors. If the administration of Axcel Metronidazole cannot be separated from a hemodialysis session, supplementation of Axcel Metronidazole dosage following the hemodialysis session should be considered, depending on the patient's clinical situation.

More about Axcel Metronidazole ER (Axcel Metronidazole)

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Consumer resources

• Axcel Metronidazole ER extended-release tablets
• Axcel Metronidazole ER
• Axcel Metronidazole ER (Advanced Reading)

• Other brands: Metro

Professional resources

• Axcel Metronidazole ER (FDA)
• Axcel Metronidazole Hydrochloride (AHFS Monograph)

Other formulations

• Axcel Metronidazole
• Axcel Metronidazole IV
• Axcel Metronidazole 375

Related treatment guides

• Bacterial Vaginitis
• Balantidium coli
• Dientamoeba fragilis
• Nongonococcal Urethritis
• STD Prophylaxis

Axcel Metronidazole interactions

See also:
What other drugs will affect Axcel Metronidazole?

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