Dramenex Uses

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What is Dramenex?

Dramenex is an antihistamine that reduces the effects of natural chemical histamine in the body.

Dramenex is used to treat or prevent nausea, vomiting, and dizziness associated with motion sickness.

Dramenex may also be used for purposes not listed in this medication guide.

Dramenex indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Dramenex Injection, USP is indicated for the prevention and treatment of nausea, vomiting, or vertigo of motion sickness.

How should I use Dramenex?

Use Dramenex chewable tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Dramenex chewable tablets may be taken with or without food.
  • Chew thoroughly before swallowing.
  • Use Dramenex chewable tablets exactly as directed on the package, unless instructed differently by your doctor. If you are taking Dramenex chewable tablets without a prescription, follow any warnings and precautions on the label.
  • Take the first dose at least 30 minutes before activity or travel.
  • If you miss a dose of Dramenex chewable tablets and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Dramenex chewable tablets.

Uses of Dramenex in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Dramenex is an antihistamine used to prevent and treat nausea, vomiting and dizziness caused by motion sickness when medication cannot be given by mouth.

Dramenex injection should not be used in newborns because of an increased risk of side effects.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

Dramenex is also used to treat symptoms of other motion and balance problems such as feelings of dizziness/spinning (vertigo) and inner ear problems (e.g., Meniere's disease). It may also be used to treat nausea and vomiting due to surgery, radiation sickness, side effects of drug treatment, and other causes.

How to use Dramenex injection

This medication is injected into a vein (IV), or it can be injected into a muscle by a health care professional, as directed by your doctor. Your dosage is based on your medical condition and response to therapy.

Tell your doctor if your condition persists or worsens.

Dramenex description

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An alkaloid from Solanaceae, especially Datura metel L. and Scopola carniolica. Dramenex and its quaternary derivatives act as antimuscarinics like atropine, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in urinary incontinence, in motion sickness, as an antispasmodic, and as a mydriatic and cycloplegic.

Dramenex dosage

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Solution, Injection:

Generic: 50 mg/mL (1 mL)

Tablet,

Oral:

Dramamine: 50 mg

Driminate: 50 mg

Driminate: 50 mg [scored]

GoodSense Motion Sickness: 50 mg [scored]

Motion Sickness: 50 mg [DSC]

Generic: 50 mg [DSC]

Tablet Chewable,

Oral:

Dramamine: 50 mg [contains aspartame, fd&c yellow #6 aluminum lake]

Dosing: Adult

US labeling: Motion sickness, nausea/vomiting, or vertigo:

Oral: 50 to 100 mg every 4 to 6 hours (maximum: 400 mg/day)

IM, IV: 50 mg every 4 hours; maximum: 100 mg every 4 hours

Canadian labeling: Nausea/vomiting or vertigo:

Motion sickness:

Oral: 50 to 100 mg every 4 hours as necessary (maximum: 400 mg/day); Long acting formulation: 100 mg every 8 to 12 hours (maximum: 300 mg/day)

Rectal: 50 to 100 mg every 6 to 8 hours as necessary

Postoperative nausea/vomiting:

Oral: 50 to 100 mg prior to procedure then 50 to 100 mg post-procedure; repeat as necessary (maximum: 400 mg/day)

IM, IV: 50 mg prior to treatment then 50 mg post-procedure; repeat as necessary (maximum: 400 mg/day)

Radiation sickness:

IM, IV: 50 to 100 mg 30 to 60 minutes prior to treatment; 50 mg 1.5 and 3 hours after treatment. Repeat dose as necessary (maximum: 400 mg/day)

Rectal: 50 to 100 mg 30 to 60 minutes prior to treatment; repeat as necessary (maximum: 400 mg/day)

Nausea and vomiting of pregnancy (off-label use) (Arsenault 2002):

Oral, rectal: 50 to 100 mg every 4 to 6 hours; maximum dose: 200 mg/day (when taking four doxylamine/pyridoxine tablets per day) or 400 mg/day

IV: 50 mg every 4 to 6 hours

Dosing: Geriatric

Avoid use (Beers Criteria [AGS 2019]).

Dosing: Pediatric

Motion sickness, nausea/vomiting, or vertigo, prophylaxis:

Oral products:

Fixed dose: Administer initial dose 30 to 60 minutes before travel/activity

Children ≥2 to <6 years:

Oral: 12.5 to 25 mg every 6 to 8 hours; maximum daily dose: 75 mg/24 hours

Children ≥6 years to <12 years:

Oral: 25 to 50 mg every 6 to 8 hours; maximum daily dose: 150 mg/24 hours

Children ≥12 years and Adolescents:

Oral: 50 to 100 mg every 4 to 6 hours; maximum daily dose: 400 mg/24 hours

Weight-based dosing: Children 2 to 12 years:

Oral: Limited data available: 1 to 1.5 mg/kg/dose every 6 hours; maximum dose: 25 mg/dose. First dose should be administered 60 minutes prior to travel (CDC 2017).

Parenteral products: IM:

Weight-based dosing: Infants, Children, and Adolescents: IM: 1.25 mg/kg/dose 4 times daily; maximum daily dose: 300 mg/day

BSA-based dosing: Infants, Children, and Adolescents: IM: 37.5 mg/m/dose 4 times daily; maximum daily dose: 300 mg/day

Canadian labeling: Rectal suppository [Canadian product]:

Children 2 to ≤5 years: Rectal: 12.5 mg to 25 mg once; if more doses needed, contact health care provider

Children 6 to 7 years: Rectal: 12.5 to 25 mg every 8 to 12 hours as needed

Children 8 to 11 years: Rectal: 25 to 50 mg every 8 to 12 hours as needed

Children ≥12 years and Adolescents: Rectal: 50 mg every 8 to 12 hours as needed

Postoperative nausea and vomiting (PONV): Limited data available:

Prevention: Infants, Children, and Adolescents: IV: 0.5 mg/kg/dose; maximum dose: 25 mg/dose (Gan 2014)

Treatment:

Weight-directed: Infants, Children, and Adolescents: IV: 0.5 mg/kg/dose; maximum dose: 25 mg/dose; for treatment of PONV, use only if prophylaxis fails and Dramenex is from a different pharmacologic class than prophylactic drug (Gan 2014)

Fixed dose (Gravol prescribing information [Canada] 2016):

Children 6 to 7 years: IM, IV: 15 to 25 mg two or three times daily

Children 8 to 12 years: IM, IV: 25 to 50 mg two or three times daily

Children ≥12 years and Adolescents: IM, IV: 50 mg two or three times daily

Dramenex interactions

See also:
What other drugs will affect Dramenex?

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The absorption of oral medications may be decreased during the concurrent use of scopolamine because of decreased gastric motility and delayed gastric emptying.

Dramenex should be used with care in patients taking other drugs that are capable of causing CNS effects such as sedatives, tranquilizers, or alcohol. Special attention should be paid to potential interactions with drugs having anticholinergic properties; e.g., other belladonna alkaloids, antihistamines (including meclizine), tricyclic antidepressants, and muscle relaxants.

Laboratory Test Interactions

Dramenex will interfere with the gastric secretion test.

Dramenex side effects

See also:
What are the possible side effects of Dramenex?

Applies to Dramenex: oral solution, oral tablets, parenteral injection

Side effects include:

Drowsiness, headache, blurred vision, tinnitus, dryness of the mouth and respiratory passages, incoordination, palpitation, dizziness, hypotension.

Paradoxical CNS stimulation in pediatric patients and occasionally in adults.

With IM injection: Pain at the injection site.

Because Dramenex (the active ingredient contained in Dramenex) contains diphenhydramine, the possibility of other diphenhydramine-related adverse effects should also be considered.

Dramenex contraindications

See also:
What is the most important information I should know about Dramenex?

Hypersensitivity to Dramenex or any component of the formulation; neonates (injection contains benzyl alcohol)

Canadian labeling: Hypersensitivity to Dramenex, its components (diphenhydramine or 8-chlorotheophylline) or any component of the formulation; concurrent use of or use within 14 days following therapy with a monoamine oxidase inhibitor; narrow angle glaucoma; chronic pulmonary disease; prostatic hypertrophy; patients <2 years of age

Active ingredient matches for Dramenex:

Dimenhydrinate in Egypt.


List of Dramenex substitutes (brand and generic names)

Sort by popularity
Unit description / dosage (Manufacturer)Price, USD
Tablet; Oral; Dimenhydrinate 50 mg (Jadran)
DRAMINATE Capsule/ Tablet / 50mg / 10 units (RPG Life Sciences Ltd)$ 0.20
Draminate 50mg TAB / 10 (RPG Life Sciences Ltd)$ 0.23
50 mg x 10's (RPG Life Sciences Ltd)$ 0.23
Draminate 30 ml Syrup (RPG Life Sciences Ltd)$ 0.02
Draminate 50 mg Tablet (RPG Life Sciences Ltd)$ 0.02
DRAMINATE 50 MG TABLET 1 strip / 10 tablets each (RPG Life Sciences Ltd)$ 0.31
DRAMINATE tab 50 mg x 10's (RPG Life Sciences Ltd)$ 0.23
Draminate 50mg Tablet (RPG Life Sciences Ltd)$ 0.03
Capsule; Oral; Dimenhydrinate 50 mg
Dramnate 30 ml Syrup (RPG Life Sciences Ltd)$ 0.02
Dramnate 50 mg Tablet (RPG Life Sciences Ltd)$ 0.02
Dramnate Inj 50 mg Injection (RPG Life Sciences Ltd)$ 0.04
Driminate 50 mg x 10's x 10 (Ysp)
Driminate tablet 50 mg/1 (Ysp)
Suppositories; Rectal; Dimenhydrinate (Montavit)
Emes 50 mg x 100's$ 5.33
Furammine 50 mg
Garcol 50 mg x 1, 000's (Christo)

Reviews

The results of a survey conducted on ndrugs.com for Dramenex are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Dramenex. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


Consumer reported price estimates

No survey data has been collected yet


2 consumers reported time for results

To what extent do I have to use Dramenex before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Dramenex. To get the time effectiveness of using Dramenex drug by other patients, please click here.
Users%
1 day2
100.0%


9 consumers reported age

Users%
16-293
33.3%
30-453
33.3%
1-51
11.1%
> 601
11.1%
46-601
11.1%


Consumer reviews


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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