What is Dramenex?
Dramenex is an antihistamine that reduces the effects of natural chemical histamine in the body.
Dramenex is used to treat or prevent nausea, vomiting, and dizziness associated with motion sickness.
Dramenex may also be used for purposes not listed in this medication guide.
Dramenex indications
Dramenex Injection, USP is indicated for the prevention and treatment of nausea, vomiting, or vertigo of motion sickness.
How should I use Dramenex?
Use Dramenex chewable tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Dramenex chewable tablets may be taken with or without food.
- Chew thoroughly before swallowing.
- Use Dramenex chewable tablets exactly as directed on the package, unless instructed differently by your doctor. If you are taking Dramenex chewable tablets without a prescription, follow any warnings and precautions on the label.
- Take the first dose at least 30 minutes before activity or travel.
- If you miss a dose of Dramenex chewable tablets and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Dramenex chewable tablets.
Uses of Dramenex in details
Dramenex is an antihistamine used to prevent and treat nausea, vomiting and dizziness caused by motion sickness when medication cannot be given by mouth.
Dramenex injection should not be used in newborns because of an increased risk of side effects.
OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.
Dramenex is also used to treat symptoms of other motion and balance problems such as feelings of dizziness/spinning (vertigo) and inner ear problems (e.g., Meniere's disease). It may also be used to treat nausea and vomiting due to surgery, radiation sickness, side effects of drug treatment, and other causes.
How to use Dramenex injection
This medication is injected into a vein (IV), or it can be injected into a muscle by a health care professional, as directed by your doctor. Your dosage is based on your medical condition and response to therapy.
Tell your doctor if your condition persists or worsens.
Dramenex description
An alkaloid from Solanaceae, especially Datura metel L. and Scopola carniolica. Dramenex and its quaternary derivatives act as antimuscarinics like atropine, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in urinary incontinence, in motion sickness, as an antispasmodic, and as a mydriatic and cycloplegic.
Dramenex dosage
Dramenex Dosage
Applies to the following strength(s): 50 mg/mL; 50 mg; 12.5 mg/5 mL; 12.5 mg/4 mL
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
- Motion Sickness
Usual Pediatric Dose for:
- Motion Sickness
Additional dosage information:
- Renal Dose Adjustments
- Liver Dose Adjustments
- Precautions
- Dialysis
- Other Comments
Usual Adult Dose for Motion Sickness
-IM: 50 mg every 4 hours injected intramuscularly as needed; Maximum Dose: 100 mg every 4 hours
-IV: 50 mg every 4 hours injected intravenously over a period of 2 minutes; Maximum Dose: 100 mg every 4 hours
-Oral: 50 to 100 mg orally every 4 to 6 hours; Maximum Dose: 400 mg in 24 hours
Comments:
-For IV administration: Each mL (50 mg) must be diluted in 10 mL of 0.9% sodium chloride injection.
-The first dose should be taken one-half to one hour before starting activity.
-The injectable form is indicated when the oral form is impractical.
Use: Prevention and treatment of nausea, vomiting, dizziness, or vertigo associated with motion sickness.
Usual Pediatric Dose for Motion Sickness
IM: 1.25 mg/kg OR 37.5 mg/m2 injected intramuscularly 4 times a day; Maximum Dose: 300 mg/day
Oral:
-Age 2 to 5: 12.5 to 25 mg orally every 6 to 8 hours; Maximum Dose: 75 mg in 24 hours
-Age 6 to 11: 25 to 50 mg orally every 6 to 8 hours; Maximum Dose: 150 mg in 24 hours
-Age 12 and older: 50 to 100 mg orally every 4 to 6 hours; Maximum Dose: 400 mg in 24 hours
Comments:
-The first dose should be taken one-half to one hour before starting activity.
-The injectable form is indicated when the oral form is impractical.
Use: Prevention and treatment of nausea, vomiting, dizziness, or vertigo associated with motion sickness.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
Do not use in patients younger than 2 years unless directed by a doctor.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration Advice:
-The solution form should not be injected intra-arterially.
Storage Requirements:
-This drug should be protected from moisture and stored at 20 to 25 degrees Celsius (68 to 77 Fahrenheit).
General:
-Overdosage: Convulsions, coma, respiratory depression, and drowsiness may occur with overdosage. There is no specific antidote; the manufacturer product information should be consulted for drugs that may be used to treat overdosage effects.
-In mice, the oral LD50 is 203 mg/kg and the intraperitoneal LD50 is 149 mg/kg; the LD50 in rats is 1,320 mg/kg.
-There is no human data indicating this drug is a carcinogen or mutagen.
Patient Advice:
-Avoid alcoholic drinks, sedatives, and tranquilizers while taking this drug.
-This drug may cause side effects such as drowsiness and dizziness that can affect your ability to perform certain activities; avoid driving and potentially hazardous activities such as operating machinery until you know how this drug affects you.
-If overdosage occurs, get immediate medical help or contact a Poison Control Center right away.
More about Dramenex
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Espanol
- 36 Reviews - Add your own review/rating
Consumer resources
- Dramenex
- Dramenex chewable tablets
- Dramenex tablets
- Other brands: Dramamine, Dramenex, Driminate, Travel-Eze
Professional resources
- Dramenex (AHFS Monograph)
- More (2) »
Related treatment guides
- Insomnia
- Motion Sickness
- Nausea/Vomiting
Dramenex interactions
See also:
What other drugs will affect Dramenex?
The absorption of oral medications may be decreased during the concurrent use of scopolamine because of decreased gastric motility and delayed gastric emptying.
Dramenex should be used with care in patients taking other drugs that are capable of causing CNS effects such as sedatives, tranquilizers, or alcohol. Special attention should be paid to potential interactions with drugs having anticholinergic properties; e.g., other belladonna alkaloids, antihistamines (including meclizine), tricyclic antidepressants, and muscle relaxants.
Laboratory Test Interactions
Dramenex will interfere with the gastric secretion test.
Dramenex side effects
See also:
What are the possible side effects of Dramenex?
Applies to Dramenex: oral solution, oral tablets, parenteral injection
Side effects include:
Drowsiness, headache, blurred vision, tinnitus, dryness of the mouth and respiratory passages, incoordination, palpitation, dizziness, hypotension.
Paradoxical CNS stimulation in pediatric patients and occasionally in adults.
With IM injection: Pain at the injection site.
Because Dramenex (the active ingredient contained in Dramenex) contains diphenhydramine, the possibility of other diphenhydramine-related adverse effects should also be considered.
Dramenex contraindications
See also:
What is the most important information I should know about Dramenex?
Hypersensitivity to Dramenex or any component of the formulation; neonates (injection contains benzyl alcohol)
Canadian labeling: Hypersensitivity to Dramenex, its components (diphenhydramine or 8-chlorotheophylline) or any component of the formulation; concurrent use of or use within 14 days following therapy with a monoamine oxidase inhibitor; narrow angle glaucoma; chronic pulmonary disease; prostatic hypertrophy; patients <2 years of age
Active ingredient matches for Dramenex:
Dimenhydrinate in Egypt.
List of Dramenex substitutes (brand and generic names) | Sort by popularity |
Unit description / dosage (Manufacturer) | Price, USD |
Dramavol (El Salvador, Guatemala, Honduras, Nicaragua, Panama) | |
Dramilin (United States) | |
Dramin (Brazil) | |
Dramina (Bosnia & Herzegowina, Croatia (Hrvatska), Georgia, Russian Federation, Serbia, Slovenia) | |
Tablet; Oral; Dimenhydrinate 50 mg (Jadran) | |
Draminal (Portugal) | |
Draminate (India) | |
DRAMINATE Capsule/ Tablet / 50mg / 10 units (RPG Life Sciences Ltd) | $ 0.15 |
Draminate 50mg TAB / 10 (RPG Life Sciences Ltd) | $ 0.18 |
50 mg x 10's (RPG Life Sciences Ltd) | $ 0.18 |
Draminate 30 ml Syrup (RPG Life Sciences Ltd) | $ 0.02 |
Draminate 50 mg Tablet (RPG Life Sciences Ltd) | $ 0.02 |
DRAMINATE 50 MG TABLET 1 strip / 10 tablets each (RPG Life Sciences Ltd) | $ 0.24 |
DRAMINATE tab 50 mg x 10's (RPG Life Sciences Ltd) | $ 0.18 |
Draminate 50mg Tablet (RPG Life Sciences Ltd) | $ 0.02 |
Draminex (Dominican Republic) | |
Dramit-GB (Mexico) | |
Capsule; Oral; Dimenhydrinate 50 mg | |
Dramnate (India) | |
Dramnate 30 ml Syrup (RPG Life Sciences Ltd) | $ 0.01 |
Dramnate 50 mg Tablet (RPG Life Sciences Ltd) | $ 0.01 |
Dramnate Inj | |
Dramnate Inj 50 mg Injection (RPG Life Sciences Ltd) | $ 0.03 |
Dramoject | |
Dramyl | |
Dravom (Greece) | |
Drimen (Greece) | |
Driminate | |
Driminate 50 mg x 10's x 10 (Ysp) | |
Driminate tablet 50 mg/1 (Ysp) | |
Dritol (Peru) | |
Dromyl | |
Dymenate | |
Dymin (Pakistan) | |
Eldodram | |
Emebrid (Brazil) | |
Emedyl (Austria) | |
Suppositories; Rectal; Dimenhydrinate (Montavit) | |
Emedyl Kinder (Austria) | |
Emegrav (Peru) | |
Emes (Philippines) | |
Emes 50 mg x 100's | $ 5.33 |
Enjomin (Portugal) | |
Epha-Retard (Germany) | |
Furammine (Taiwan) | |
Furammine 50 mg | |
Garcol (Hong Kong) | |
Garcol 50 mg x 1, 000's (Christo) | |
GIB Dimenhydrinat (Germany) | |
Gomivol D (Peru) | |
GoodSense Motion Sickness | |
Graflomed (Peru) | |
See 501 substitutes for Dramenex |
Reviews
The results of a survey conducted on ndrugs.com for Dramenex are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Dramenex. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yet2 consumers reported time for results
To what extent do I have to use Dramenex before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Dramenex. To get the time effectiveness of using Dramenex drug by other patients, please click here.
Users | % | ||
---|---|---|---|
1 day | 2 | 100.0% |
9 consumers reported age
Users | % | ||
---|---|---|---|
16-29 | 4 | 44.4% | |
30-45 | 4 | 44.4% | |
> 60 | 1 | 11.1% |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology