Levofloxacin Uses

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How do you administer this medicine?

What is Levofloxacin?

Treating corneal ulcers caused by bacteria sensitive to Levofloxacin. It may also be used for other conditions as determined by your doctor.

Levofloxacin is a fluoroquinolone eye drop. It works by blocking bacteria from reproducing in the eye.

Levofloxacin indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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To reduce the development of drug-resistant bacteria and maintain the effectiveness of Levofloxacin and other antibacterial drugs, Levofloxacin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Levofloxacin

Oral Solution is indicated for the treatment of adults (≥18 years of age) with mild, moderate, and severe infections caused by susceptible isolates of the designated microorganisms in the conditions listed in this section.

Culture and susceptibility testing

Appropriate culture and susceptibility tests should be performed before treatment in order to isolate and identify organisms causing the infection and to determine their susceptibility to levofloxacin. Therapy with Levofloxacin may be initiated before results of these tests are known; once results become available, appropriate therapy should be selected.

As with other drugs in this class, some isolates of Pseudomonas aeruginosa may develop resistance fairly rapidly during treatment with Levofloxacin. Culture and susceptibility testing performed periodically during therapy will provide information about the continued susceptibility of the pathogens to the antimicrobial agent and also the possible emergence of bacterial resistance.

Nosocomial Pneumonia

Levofloxacin is indicated for the treatment of nosocomial pneumonia due to methicillin-susceptible Staphylococcus aureus, Pseudomonas aeruginosa, Serratia marcescens, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, or Streptococcus pneumoniae. Adjunctive therapy should be used as clinically indicated. Where Pseudomonas aeruginosa is a documented or presumptive pathogen, combination therapy with an anti-pseudomonal ß-lactam is recommended.

Community-Acquired Pneumonia: 7–14 day Treatment Regimen

Levofloxacin is indicated for the treatment of community-acquired pneumonia due to methicillin-susceptible Staphylococcus aureus, Streptococcus pneumoniae (including multi-drug-resistant Streptococcus pneumoniae [MDRSP]), Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Chlamydophila pneumoniae, Legionella pneumophila, or Mycoplasma pneumoniae.

MDRSP isolates are isolates resistant to two or more of the following antibacterials: penicillin (MIC ≥2 mcg/mL), 2nd generation cephalosporins, e.g., cefuroxime, macrolides, tetracyclines and trimethoprim/sulfamethoxazole.

Community-Acquired Pneumonia: 5-day Treatment Regimen

Levofloxacin is indicated for the treatment of community-acquired pneumonia due to Streptococcus pneumoniae (excluding multi-drug-resistant isolates [MDRSP]), Haemophilus influenzae, Haemophilus parainfluenzae, Mycoplasma pneumoniae, or Chlamydophila pneumoniae.

Acute Bacterial Sinusitis: 5-day and 10–14 day Treatment Regimens

Levofloxacin is indicated for the treatment of acute bacterial sinusitis due to Streptococcus pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis.

Acute Bacterial Exacerbation of Chronic Bronchitis

Levofloxacin is indicated for the treatment of acute bacterial exacerbation of chronic bronchitis due to methicillin-susceptible Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, or Moraxella catarrhalis.

Complicated Skin and Skin Structure Infections

Levofloxacin is indicated for the treatment of complicated skin and skin structure infections due to methicillin-susceptible Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes, or Proteus mirabilis.

Uncomplicated Skin and Skin Structure Infections

Levofloxacin is indicated for the treatment of uncomplicated skin and skin structure infections (mild to moderate) including abscesses, cellulitis, furuncles, impetigo, pyoderma, wound infections, due to methicillin-susceptible Staphylococcus aureus, or Streptococcus pyogenes.

Chronic Bacterial Prostatitis

Levofloxacin is indicated for the treatment of chronic bacterial prostatitis due to Escherichiacoli, Enterococcus faecalis, or methicillin-susceptible Staphylococcus epidermidis.

Complicated Urinary Tract Infections: 5-day Treatment Regime

Levofloxacin is indicated for the treatment of complicated urinary tract infections due to Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis.

Complicated Urinary Tract Infections: 10-day Treatment Regimen

Levofloxacin is indicated for the treatment of complicated urinary tract infections (mild to moderate) due to Enterococcus faecalis, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, or Pseudomonas aeruginosa.

Acute Pyelonephritis: 5 or 10-day Treatment Regimen

Levofloxacin is indicated for the treatment of acute pyelonephritis caused by Escherichia coli, including cases with concurrent bacteremia.

Uncomplicated Urinary Tract Infections

Levofloxacin is indicated for the treatment of uncomplicated urinary tract infections (mild to moderate) due to Escherichia coli, Klebsiella pneumoniae, or Staphylococcus saprophyticus.

Inhalational Anthrax (Post-Exposure)

Levofloxacin is indicated for inhalational anthrax (post-exposure) to reduce the incidence or progression of disease following exposure to aerosolized Bacillus anthracis. The effectiveness of Levofloxacin is based on plasma concentrations achieved in humans, a surrogate endpoint reasonably likely to predict clinical benefit. Levofloxacin has not been tested in humans for the post-exposure prevention of inhalation anthrax. The safety of Levofloxacin in adults for durations of therapy beyond 28 days or in pediatric patients for durations of therapy beyond 14 days has not been studied. Prolonged Levofloxacin therapy should only be used when the benefit outweighs the risk.

Plague

Levofloxacin is indicated for treatment of plague, including pneumonic and septicemic plague, due to Yersinia pestis (Y. pestis) and prophylaxis for plague in adults and pediatric patients, 6 months of age and older. Efficacy studies of Levofloxacin could not be conducted in humans with plague for ethical and feasibility reasons. Therefore, approval of this indication was based on an efficacy study conducted in animals.

How should I use Levofloxacin?

Use Levofloxacin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Levofloxacin is only for the eye. Do not get it in your nose or mouth.
  • To use Levofloxacin in the eye, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eye for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
  • To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.
  • Do not wear contact lenses while you are using Levofloxacin. Take care of your contact lenses as directed by the manufacturer. Check with your doctor before you use them.
  • Levofloxacin works best if it is used at the same time each day.
  • To clear up your infection completely, use Levofloxacin for the full course of treatment. Keep using it even if you feel better in a few days.
  • Do not miss any doses of Levofloxacin. If you miss a dose of Levofloxacin, use it as soon as you remember. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Levofloxacin.

Uses of Levofloxacin in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Levofloxacin is used to treat bacterial infections of the respiratory tract, urinary tract, ear, tooth and prostate gland. It is also used to treat skin and soft tissue infections, anthrax and plague.

Levofloxacin description

infoPharmacology is a crucial part of medicine wherein various medications are used to advance the well-being of an individual. Some drugs cure the infection or a disease; few prevent the occurrence of a symptom or a disease, and few are used in long-term treatment of the disease. Drugs are obtained from the plants as well as they can be synthesized organically. The drugs are used in various combinations or a single drug by the pharmaceutical industry during its preparation. The half-life of each medicine is different, and the dosage of the drug depends on the half-life of the drug.

Each tablet contains levofloxacin 250 mg as active ingredient corresponding to levofloxacin hemihydrate 256.23 mg.

Cravit IV also contains the following inactive ingredients: Sodium chloride; sodium hydroxide; hydrochloric acid (qs: pH 4.8) and water for injection for a volume of 100 mL (Na+ concentration: 154 mmol/L).

Levofloxacin is a synthetic broad-spectrum antibacterial agent for oral and IV administration. Chemically, levofloxacin, a chiral fluorinated carboxyquinolone, is the pure (-)-(S)-enantiomer of the racemic drug substance ofloxacin. Levofloxacin is (-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4 benzoxazine-6-carboxylic acid hemihydrate.

Its empirical formula is C18H20FN3O4·½H2O and its molecular weight is 370.38.

Levofloxacin is a light yellowish-white to yellow-white crystal or crystalline powder. The molecule exists as a zwitterion at the pH conditions in the small intestine. The data demonstrate that from pH 0.6-5.8, the solubility of levofloxacin is essentially constant (approximately 100 mg/mL). Levofloxacin is considered soluble to freely soluble in this pH range, as defined by USP nomenclature. Above pH 5.8, the solubility increases rapidly to its maximum at pH 6.7 (272 mg/mL) and is considered freely soluble in this range. Above pH 6.7, the solubility decreases and reaches a minimum value (about 50 mg/mL) at a pH of approximately 6.9. Levofloxacin has the potential to form stable coordination compounds with many metal ions. This in vitro chelation potential has the following formation order: A1+3 > Cu+2 > Zn+2 > Mg+2 > Ca+2.


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Active ingredient matches for Levofloxacin:

Levofloxacin


Unit description / dosage (Manufacturer)Price, USD
Tablet; Oral; Levofloxacin 250 mg
Tablet; Oral; Levofloxacin 500 mg
Tablet; Oral; Levofloxacin 750 mg
Tablet, Film-Coated; Oral; Levofloxacin Hemihydrate 250 mg
Tablet, Film-Coated; Oral; Levofloxacin Hemihydrate 500 mg
Injectable; Injection; Levofloxacin 25 mg / ml
Solution; Ophthalmic; Levofloxacin 0.5%
Injectable; Injection; Levofloxacin 5 mg / ml
Iquix 1.5% Solution 5ml Bottle$ 81.68
Levofloxacin hemihydr 100% powder$ 42.69
Levaquin 750 mg tablet$ 28.06
Levaquin 750 mg leva-pak tablet$ 27.51
Levaquin 500 mg tablet$ 16.57
Iquix 1.5% eye drops$ 15.71
Levaquin 250 mg tablet$ 13.71
Quixin 0.5% eye drops$ 12.21
Quixin 0.5% Solution$ 11.40
Levaquin i.v. 25 mg/ml vial$ 1.94
Levaquin 500 mg/100 ml d5w$ 0.44
Levofloxacin 500 mg
Tablets; Oral; Levofloxacin 250 mg
Tablets; Oral; Levofloxacin 500 mg
Tablets; Oral; Levofloxacin 750 mg
Tablets, Film-Coated; Oral; Levofloxacin Hemihydrate 250 mg
Tablets, Film-Coated; Oral; Levofloxacin Hemihydrate 500 mg
Solution; Oral; Levofloxacin 25 mg / ml
Levofloxacin tablet 250 mg (Cobalt Pharmaceuticals Company (Canada))
Levofloxacin tablet 500 mg (Pro Doc Limitee (Canada))
Levofloxacin tablet 750 mg (Cobalt Pharmaceuticals Company (Canada))
Levofloxacin tablet, film coated 250 mg/1 (REMEDYREPACK INC. (US))
Levofloxacin tablet, film coated 500 mg/1 (Zydus Pharmaceuticals (USA, US) Inc.)
Levofloxacin tablet 500 mg/1 (Wockhardt Limited (US))
Levofloxacin injection, solution 5 mg/mL (Sandoz Inc (US))
Levofloxacin tablet 250 mg/1 (Aidarex Pharmaceuticals LLC (US))
Levofloxacin tablet 750 mg/1 (Wockhardt USA LLC. (US))
Levofloxacin tablet, film coated 750 mg/1 (Major Pharmaceuticals (US))
Levofloxacin solution/ drops 5 mg/mL (PACK Pharmaceuticals, LLC (US))
Levofloxacin injection, solution 750 mg/150mL (Auro Medics Pharma Llc (US))
Levofloxacin injection, solution 500 mg/100mL (West Ward Pharmaceuticals Corp (US))
Levofloxacin injection, solution, concentrate 500 mg/20mL (Auro Medics Pharma Llc (US))
Levofloxacin injection 5 mg/mL (Fresenius Kabi USA, LLC (US))
Levofloxacin solution 25 mg/mL (Department Of State Health Services, Pharmacy Branch (US))
Levofloxacin injection, solution 250 mg/50mL (West Ward Pharmaceuticals Corp (US))
Levofloxacin solution 5 mg/mL (Akorn Inc. (US))
Levofloxacin injection, solution, concentrate 750 mg/30mL (Auro Medics Pharma Llc (US))
Levofloxacin injection, solution 25 mg/mL (Claris Lifesciences Inc. (US))
Levofloxacin injection 25 mg/mL (Heritage Pharmaceuticals Inc. (US))

List of Levofloxacin substitutes (brand and generic names):

References

  1. DailyMed. "LEVOFLOXACIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailymed/se... (accessed September 18, 2017).
  2. Wikipedia. "levofloxacin anhydrous: Link to the compound information in Wikipedia.". https://en.wikipedia.org/wiki/Levofloxac... (accessed September 18, 2017).
  3. PubChem. "LEVOFLOXACIN". https://pubchem.ncbi.nlm.nih.gov/compoun... (accessed September 18, 2017).
  4. FDA Orange Book. "Patent:6806256: The publication, Approved Drug Products with Therapeutic Equivalence Evaluations (the List, commonly known as the Orange Book), identifies drug products approved on the basis of safety and effectiveness by the Food and Drug Administration (FDA) under the Federal Food, Drug, and Cosmetic Act (the Act).". https://www.fda.gov/Drugs/InformationOnD... (accessed September 18, 2017).

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