• Pyr-A-Pam II indications
• Pyr-A-Pam II description
• Pyr-A-Pam II dosage
• Pyr-A-Pam II interactions
• Pyr-A-Pam II side effects
• Pyr-A-Pam II contraindications

What is Pyr-A-Pam II?

Pyr-A-Pam II belongs to the family of medicines called anthelmintics. Anthelmintics are used in the treatment of worm infections.

Pyr-A-Pam II is used to treat pinworms (enterobiasis; oxyuriasis).

Pyr-A-Pam II may also be used for other worm infections as determined by your doctor.

Pyr-A-Pam II works by paralyzing the worms. They are then passed in the stool.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, Pyr-A-Pam II is used in certain patients with the following medical condition:

• Common roundworm infection
• Hookworm infection
• More than one worm infection at a time

For patients taking Pyr-A-Pam II for hookworm infection :

• Anemia (iron-poor blood) may occur in patients with hookworm infections. Therefore, your doctor may want you to take iron supplements to help clear up the anemia. If so, it is important to take iron every day while you are being treated for hookworms. Do not miss any doses. Your doctor may also want you to keep taking iron supplements for up to 6 months after you stop taking Pyr-A-Pam II. If you have any questions about this, check with your doctor.

Pyr-A-Pam II indications

Oral

Single or mixed infections due to susceptible worms

Adult: 10 mg/kg as a single dose.

Child: 10 mg/kg as a single dose.

Oral

Ascariasis

Adult: 5 mg/kg as a single dose. Max: 1 g/dose. For mass treatment programmes: 2.5 mg/kg as a single dose given 3-4 times a yr.

Oral

Necatoriasis

Adult: 10 mg/kg daily for 3-4 days or 20 mg/kg daily for 2 days.

Oral

Enterobiasis

Adult: 10 mg/kg repeated once after 2-4 wk. Max dose: 1 g/dose.

Oral

Trichinosis

Adult: 10 mg/kg daily for 5 days.

How should I use Pyr-A-Pam II?

Use Pyr-A-Pam II as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Pyr-A-Pam II may be taken on an empty stomach or with food, milk, or juice.
• Shake well before using a dose of Pyr-A-Pam II.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• Wear tight underwear both day and night while taking Pyr-A-Pam II.
• Pyr-A-Pam II is usually prescribed as a single dose.
• Only one dose of Pyr-A-Pam II is required. If you forget to take Pyr-A-Pam II, take it as soon as you remember.

Ask your health care provider any questions you may have about how to use Pyr-A-Pam II.

Pyr-A-Pam II description

Pyr-A-Pam II is an antinematodal thiophene

Pyr-A-Pam II dosage

Pyr-A-Pam II Dosage

Applies to the following strength(s): 144 mg/mL; 180 mg; 50 mg/mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

• Enterobiasis
• Pinworm Infection (Enterobius vermicularis)
• Hookworm Infection (Necator or Ancylostoma)
• Ascariasis
• Trichostrongylosis
• Moniliformis Infection

Usual Pediatric Dose for:

• Enterobiasis
• Pinworm Infection (Enterobius vermicularis)
• Hookworm Infection (Necator or Ancylostoma)
• Ascariasis
• Trichostrongylosis
• Moniliformis Infection

Additional dosage information:

• Renal Dose Adjustments
• Liver Dose Adjustments
• Dose Adjustments
• Precautions
• Dialysis
• Other Comments

Usual Adult Dose for Enterobiasis

11 mg/kg base (maximum 1 g) orally once. Repeat dose in 2 weeks.

Usual Adult Dose for Pinworm Infection (Enterobius vermicularis)

11 mg/kg base (maximum 1 g) orally once. Repeat dose in 2 weeks.

Usual Adult Dose for Hookworm Infection (Necator or Ancylostoma)

11 mg/kg base (maximum 1 g) orally daily for 3 days.

Usual Adult Dose for Ascariasis

11 mg/kg base (maximum 1 g) orally once.

Usual Adult Dose for Trichostrongylosis

11 mg/kg base (maximum 1 g) orally once.

Usual Adult Dose for Moniliformis Infection

11 mg/kg base (maximum 1 g) orally once. Repeat dose twice at 2 weeks intervals.

Usual Pediatric Dose for Enterobiasis

>=2 years: 11 mg/kg base (maximum 1 g) once. Repeat dose in 2 weeks.

Usual Pediatric Dose for Pinworm Infection (Enterobius vermicularis)

>=2 years: 11 mg/kg base (maximum 1 g) once. Repeat dose in 2 weeks.

Usual Pediatric Dose for Hookworm Infection (Necator or Ancylostoma)

>=2 years: 11 mg/kg base (maximum 1 g) orally daily for 3 days.

Usual Pediatric Dose for Ascariasis

>=2 years: 11 mg/kg base (maximum 1 g) orally once.

Usual Pediatric Dose for Trichostrongylosis

>=2 years: 11 mg/kg base (maximum 1 g) orally once.

Usual Pediatric Dose for Moniliformis Infection

>=2 years: 11 mg/kg base (maximum 1 g) orally once. Repeat dose twice at 2 weeks intervals.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Pyr-A-Pam II is contraindicated in patients with hepatic disease.

Dose Adjustments

In the treatment of ascariasis, Pyr-A-Pam II may be used only if it has been determined that the worm load will not worsen obstruction.

Precautions

Pyr-A-Pam II is contraindicated in patients with hepatic disease.

When one individual in a household has pinworms, the entire household should be treated unless otherwise advised. Pinworm infections are easily transmitted to others in the same household.

Pyr-A-Pam II should be used with caution in patients with severe malnutrition or anemia. Supportive therapy is recommended for anemic, dehydrated, or malnourished patients prior to administration of the drug.

Other medications are known to antagonize the anthelmintic effect of Pyr-A-Pam II. Patients should be advised to consult with their physician before initiating any drug therapy while receiving Pyr-A-Pam II.

Dialysis

Data not available

Other Comments

The dose should be taken as a single oral dose. It may be taken alone or with milk or fruit juice.

Pyr-A-Pam II pamoate 2.9 g is approximately equivalent to 1 g of Pyr-A-Pam II (base).

More about Pyr-A-Pam II

• Side Effects
• During Pregnancy or Breastfeeding
• Dosage Information
• Drug Interactions
• Support Group
• En Espanol
• 4 Reviews - Add your own review/rating

Consumer resources

• Pyr-A-Pam II chewable tablets
• Pyr-A-Pam II pamoate
• Pyr-A-Pam II pamoate suspension
• Pyr-A-Pam II
• Pyr-A-Pam II (Advanced Reading)

• Other brands: Pin-X, Pinworm Medicine, Reese's Pinworm Medicine, Pinworm Caplets, More (2) »

Professional resources

• Pyr-A-Pam II Pamoate (AHFS Monograph)

Related treatment guides

• Pinworm Infection (Enterobius vermicularis)
• Hookworm Infection (Necator or Ancylostoma)
• Ascariasis
• Enterobiasis
• Moniliformis Infection
• More (1) »

Pyr-A-Pam II interactions

See also:
What other drugs will affect Pyr-A-Pam II?

• Dexamethasone

Steady-state trough concentrations of albendazole sulfoxide were about 56% higher when 8 mg dexamethasone was coadministered with each dose of albendazole (15 mg/kg/day) in 8 neurocysticercosis patients.

• Praziquantel

• Cimetidine

Albendazole sulfoxide concentrations in bile and cystic fluid were increased (about 2-fold) in hydatid cyst patients treated with cimetidine (10 mg/kg/day) (n = 7) compared with albendazole (20 mg/kg/day) alone (n = 12). Albendazole sulfoxide plasma concentrations were unchanged 4 hours after dosing.

• Theophylline

The pharmacokinetics of theophylline (aminophylline 5.8 mg/kg infused over 20 minutes) were unchanged following a single oral dose of albendazole (400 mg) in 6 healthy subjects.

Pyr-A-Pam II side effects

See also:
What are the possible side effects of Pyr-A-Pam II?

Applies to Pyr-A-Pam II: oral suspension, oral tablet, oral tablet chewable

In addition to its needed effects, some unwanted effects may be caused by Pyr-A-Pam II (the active ingredient contained in Pyr-A-Pam II). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking Pyr-A-Pam II, check with your doctor or nurse as soon as possible:

Rare

• Skin rash

Minor Side Effects

Some of the side effects that can occur with Pyr-A-Pam II may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:

• Abdominal or stomach cramps or pain
• diarrhea
• dizziness
• drowsiness
• headache
• irritability
• loss of appetite
• nausea or vomiting
• trouble in sleeping

Pyr-A-Pam II contraindications

See also:
What is the most important information I should know about Pyr-A-Pam II?

This medicine is contraindicated in patients with known hypersensitivity to the benzimidazole class of compounds or any components of this medicine.

Active ingredient matches for Pyr-A-Pam II:

Pyrantel

Unit description / dosage (Manufacturer)	Price, USD
Tablet; Oral; Pyrantel Pamoate 125 mg
List of Pyr-A-Pam II substitutes (brand and generic names):
Pyr-A-Pam
Tablet; Oral; Pyrantel Pamoate 35 mg
Pyran
Tablet; Oral; Pyrantel Pamoate 35 mg
Tablet; Oral; Pyrantel Pamoate 125 mg
Pyrantel (Austria, Finland, France, Germany, Israel, Luxembourg, New Zealand, Norway, Poland, South Africa, Sweden, Switzerland, United Kingdom, United States)
Suspension; Oral; Pyrantel Pamoate 250 mg / 5 ml
Tablet; Oral; Pyrantel Pamoate 250 mg
Suspension; Oral; Pyrantel 250 mg / 5 ml
Tablet; Oral; Pyrantel 250 mg
Suspension; Oral; Pyrantel Embonate 250 mg / 5 ml
Pyrantel Chewable Tablets
Pyrantel Pamoate Farnam (United States)
Pyrantel Pamoato (Italy)
Pyrantel Paste (Germany)
Pyrantel Polpharma (Georgia, Latvia)
Pyrantel Sine (China)
Pyrantel Vetos-Farma dla kotow For cats (Poland)
Pyrantel Vetos-Farma dla psow For dogs (Poland)
Pyrantelum (Latvia, Poland)
Pyrantelum Medana (Latvia)
Pyrantelum Medana / / höông vò mô 250 mg/5 mL x 1 Bottle 15 mL in duïng cuï ñong coù chia vaïch
Pyrantelum Polpharma (Poland)
Pyrantesan (Poland)
Pyrantin (Sri Lanka, Tunisia)
Pyrantverm (Poland)
Pyrapam (Thailand)
Pyrapam 125 mg x 1, 000's (General Drugs House)
Pyrapam 50 mg/1 mL x 10 mL (General Drugs House)
Pyrapam oral susp 50 mg/mL 10 mL x 1's (General Drugs House)
Pyrapam tab 125 mg 1000's (General Drugs House)
Pyratape (Ireland, United Kingdom)
Pyraverm 250
Pyrequan
Pyteldon (Thailand)
Pyteldon 125 mg x 100's
Pyteldon 250 mg/5 mL x 10 mL x 12's
Q.T. Ban Tech (United States)
Quantrel (Colombia, Peru, Philippines)
Quantrel 10 mL (Johnson & Johnson)	$ 3.57
Quantrel oral susp 10 mL x 1's (Johnson & Johnson)	$ 3.57
Reese's Pinworm (United States)
Reese's Pinworm Medicine
Reese's Pinworm Medicine Suspension
RFD (United States)
Runcid (Germany)
Sepantel (Finland, France, Netherlands)
Strongid (Finland, France, Ireland, Italy, Netherlands, Portugal, Switzerland, United Kingdom, United States)
Strongid Banminth (United States)
See 286 substitutes for Pyr-A-Pam II

References

1. PubChem. "PYRANTEL". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
2. DrugBank. "Pyrantel". http://www.drugbank.ca/drugs/DB11156 (accessed September 17, 2018).
3. MeSH. "Antinematodal Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Pyr-A-Pam II are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Pyr-A-Pam II. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

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Information checked by Dr. Sachin Kumar, MD Pharmacology