What is Pleosan?
Pleosan belongs to the family of medicines called anthelmintics. Anthelmintics are used in the treatment of worm infections.
Pleosan is used to treat pinworms (enterobiasis; oxyuriasis).
Pleosan may also be used for other worm infections as determined by your doctor.
Pleosan works by paralyzing the worms. They are then passed in the stool.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, Pleosan is used in certain patients with the following medical condition:
- Common roundworm infection
- Hookworm infection
- More than one worm infection at a time
For patients taking Pleosan for hookworm infection :
- Anemia (iron-poor blood) may occur in patients with hookworm infections. Therefore, your doctor may want you to take iron supplements to help clear up the anemia. If so, it is important to take iron every day while you are being treated for hookworms. Do not miss any doses. Your doctor may also want you to keep taking iron supplements for up to 6 months after you stop taking Pleosan. If you have any questions about this, check with your doctor.
Pleosan indications
Oral
Single or mixed infections due to susceptible worms
Adult: 10 mg/kg as a single dose.
Child: 10 mg/kg as a single dose.
Oral
Ascariasis
Adult: 5 mg/kg as a single dose. Max: 1 g/dose. For mass treatment programmes: 2.5 mg/kg as a single dose given 3-4 times a yr.
Oral
Necatoriasis
Adult: 10 mg/kg daily for 3-4 days or 20 mg/kg daily for 2 days.
Oral
Enterobiasis
Adult: 10 mg/kg repeated once after 2-4 wk. Max dose: 1 g/dose.
Oral
Trichinosis
Adult: 10 mg/kg daily for 5 days.
How should I use Pleosan?
Use Pleosan as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Pleosan may be taken on an empty stomach or with food, milk, or juice.
- Shake well before using a dose of Pleosan.
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Wear tight underwear both day and night while taking Pleosan.
- Pleosan is usually prescribed as a single dose.
- Only one dose of Pleosan is required. If you forget to take Pleosan, take it as soon as you remember.
Ask your health care provider any questions you may have about how to use Pleosan.
Pleosan description
Pleosan is an antinematodal thiophene
Pleosan dosage
Pleosan Dosage
Applies to the following strength(s): 144 mg/mL; 180 mg; 50 mg/mL
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
- Enterobiasis
- Pinworm Infection (Enterobius vermicularis)
- Hookworm Infection (Necator or Ancylostoma)
- Ascariasis
- Trichostrongylosis
- Moniliformis Infection
Usual Pediatric Dose for:
- Enterobiasis
- Pinworm Infection (Enterobius vermicularis)
- Hookworm Infection (Necator or Ancylostoma)
- Ascariasis
- Trichostrongylosis
- Moniliformis Infection
Additional dosage information:
- Renal Dose Adjustments
- Liver Dose Adjustments
- Dose Adjustments
- Precautions
- Dialysis
- Other Comments
Usual Adult Dose for Enterobiasis
11 mg/kg base (maximum 1 g) orally once. Repeat dose in 2 weeks.
Usual Adult Dose for Pinworm Infection (Enterobius vermicularis)
11 mg/kg base (maximum 1 g) orally once. Repeat dose in 2 weeks.
Usual Adult Dose for Hookworm Infection (Necator or Ancylostoma)
11 mg/kg base (maximum 1 g) orally daily for 3 days.
Usual Adult Dose for Ascariasis
11 mg/kg base (maximum 1 g) orally once.
Usual Adult Dose for Trichostrongylosis
11 mg/kg base (maximum 1 g) orally once.
Usual Adult Dose for Moniliformis Infection
11 mg/kg base (maximum 1 g) orally once. Repeat dose twice at 2 weeks intervals.
Usual Pediatric Dose for Enterobiasis
>=2 years: 11 mg/kg base (maximum 1 g) once. Repeat dose in 2 weeks.
Usual Pediatric Dose for Pinworm Infection (Enterobius vermicularis)
>=2 years: 11 mg/kg base (maximum 1 g) once. Repeat dose in 2 weeks.
Usual Pediatric Dose for Hookworm Infection (Necator or Ancylostoma)
>=2 years: 11 mg/kg base (maximum 1 g) orally daily for 3 days.
Usual Pediatric Dose for Ascariasis
>=2 years: 11 mg/kg base (maximum 1 g) orally once.
Usual Pediatric Dose for Trichostrongylosis
>=2 years: 11 mg/kg base (maximum 1 g) orally once.
Usual Pediatric Dose for Moniliformis Infection
>=2 years: 11 mg/kg base (maximum 1 g) orally once. Repeat dose twice at 2 weeks intervals.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Pleosan is contraindicated in patients with hepatic disease.
Dose Adjustments
In the treatment of ascariasis, Pleosan may be used only if it has been determined that the worm load will not worsen obstruction.
Precautions
Pleosan is contraindicated in patients with hepatic disease.
When one individual in a household has pinworms, the entire household should be treated unless otherwise advised. Pinworm infections are easily transmitted to others in the same household.
Pleosan should be used with caution in patients with severe malnutrition or anemia. Supportive therapy is recommended for anemic, dehydrated, or malnourished patients prior to administration of the drug.
Other medications are known to antagonize the anthelmintic effect of Pleosan. Patients should be advised to consult with their physician before initiating any drug therapy while receiving Pleosan.
Dialysis
Data not available
Other Comments
The dose should be taken as a single oral dose. It may be taken alone or with milk or fruit juice.
Pleosan 2.9 g is approximately equivalent to 1 g of Pleosan (base).
More about Pleosan
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
- En Espanol
- 4 Reviews - Add your own review/rating
Consumer resources
- Pleosan chewable tablets
- Pleosan
- Pleosan suspension
- Pleosan
- Pleosan (Advanced Reading)
- Other brands: Pin-X, Pinworm Medicine, Reese's Pinworm Medicine, Pinworm Caplets, More (2) »
Professional resources
- Pleosan (AHFS Monograph)
Related treatment guides
- Pinworm Infection (Enterobius vermicularis)
- Hookworm Infection (Necator or Ancylostoma)
- Ascariasis
- Enterobiasis
- Moniliformis Infection
- More (1) »
Pleosan interactions
See also:
What other drugs will affect Pleosan?
• Dexamethasone
Steady-state trough concentrations of albendazole sulfoxide were about 56% higher when 8 mg dexamethasone was coadministered with each dose of albendazole (15 mg/kg/day) in 8 neurocysticercosis patients.
• Praziquantel
• Cimetidine
Albendazole sulfoxide concentrations in bile and cystic fluid were increased (about 2-fold) in hydatid cyst patients treated with cimetidine (10 mg/kg/day) (n = 7) compared with albendazole (20 mg/kg/day) alone (n = 12). Albendazole sulfoxide plasma concentrations were unchanged 4 hours after dosing.
• Theophylline
The pharmacokinetics of theophylline (aminophylline 5.8 mg/kg infused over 20 minutes) were unchanged following a single oral dose of albendazole (400 mg) in 6 healthy subjects.
Pleosan side effects
See also:
What are the possible side effects of Pleosan?
Applies to Pleosan: oral suspension, oral tablet, oral tablet chewable
In addition to its needed effects, some unwanted effects may be caused by Pleosan (the active ingredient contained in Pleosan). In the event that any of these side effects do occur, they may require medical attention.
Severity: Moderate
If any of the following side effects occur while taking Pleosan, check with your doctor or nurse as soon as possible:
Rare
- Skin rash
Minor Side Effects
Some of the side effects that can occur with Pleosan may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
Less common:
- Abdominal or stomach cramps or pain
- diarrhea
- dizziness
- drowsiness
- headache
- irritability
- loss of appetite
- nausea or vomiting
- trouble in sleeping
Pleosan contraindications
See also:
What is the most important information I should know about Pleosan?
This medicine is contraindicated in patients with known hypersensitivity to the benzimidazole class of compounds or any components of this medicine.
Active ingredient matches for Pleosan:
Pyrantel in Venezuela.
List of Pleosan substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Pirel (Colombia) | |
| Premelange 25 / 2 Porcs Medicamente Pro-Ban | |
| Drug Premix; Oral; Pyrantel Tartrate 8.48 g / kg | |
| Pro-Banminth | |
| Drug Premix; Oral; Pyrantel Tartrate 106 g / kg | |
| Pro-Banminth Swine Premix | |
| Drug Premix; Oral; Pyrantel Tartrate 106 g / kg | |
| Provid (Ireland, United Kingdom) | |
| PYMOLAR | |
| PYMOLAR Liquid / 250mg/5ml / 10ml units (Lark Laboratories) | $ 0.12 |
| PYMOLAR Capsule/ Tablet / 250mg / 3 units (Lark Laboratories) | $ 0.10 |
| PYMOLAR 250MG SUSPENSION 1 bottle / 10 ML suspension each (Lark Laboratories Ltd) | $ 0.13 |
| Pymolar 250mg Suspension (Lark Laboratories Ltd) | $ 0.13 |
| Pyr-A-Pam | |
| Tablet; Oral; Pyrantel Pamoate 35 mg | |
| Pyr-A-Pam II | |
| Tablet; Oral; Pyrantel Pamoate 125 mg | |
| Pyran | |
| Tablet; Oral; Pyrantel Pamoate 35 mg | |
| Tablet; Oral; Pyrantel Pamoate 125 mg | |
| Pyrantel (Austria, Finland, France, Germany, Israel, Luxembourg, New Zealand, Norway, Poland, South Africa, Sweden, Switzerland, United Kingdom, United States) | |
| Suspension; Oral; Pyrantel Pamoate 250 mg / 5 ml | |
| Tablet; Oral; Pyrantel Pamoate 250 mg | |
| Suspension; Oral; Pyrantel 250 mg / 5 ml | |
| Tablet; Oral; Pyrantel 250 mg | |
| Suspension; Oral; Pyrantel Embonate 250 mg / 5 ml | |
| Pyrantel 125 | |
| Pyrantel Chewable Tablets | |
| Pyrantel Indo Farma (Indonesia) | |
| Pyrantel Pamoate | |
| Pyrantel Pamoate Farnam (United States) | |
| Pyrantel Pamoate Suspension | |
| Pyrantel Pamoato (Italy) | |
| Pyrantel Paste (Germany) | |
| Pyrantel Pharimexco (Vietnam) | |
| Pyrantel Pharimexco 125 mg x 10 Blister x 10 Tablet | |
| Pyrantel Pharimexco 125 mg x 1 Bottle 100 Tablet | |
| Pyrantel Polpharma (Georgia, Latvia) | |
| Pyrantel Sine (China) | |
| Pyrantel Vetos-Farma dla kotow For cats (Poland) | |
| Pyrantel Vetos-Farma dla psow For dogs (Poland) | |
| Pyrantelum (Latvia, Poland) | |
| Pyrantelum Medana (Latvia) | |
| Pyrantelum Medana / / höông vò mô 250 mg/5 mL x 1 Bottle 15 mL in duïng cuï ñong coù chia vaïch | |
| Pyrantelum Polpharma (Poland) | |
| Pyrantesan (Poland) | |
| Pyrantin (Sri Lanka, Tunisia) | |
| Pyrantverm (Poland) | |
| Pyrapam (Thailand) | |
| Pyrapam 125 mg x 1, 000's (General Drugs House) | |
| Pyrapam 50 mg/1 mL x 10 mL (General Drugs House) | |
| Pyrapam oral susp 50 mg/mL 10 mL x 1's (General Drugs House) | |
| Pyrapam tab 125 mg 1000's (General Drugs House) | |
See 339 substitutes for Pleosan | |
References
- PubChem. "PYRANTEL". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Pyrantel". http://www.drugbank.ca/drugs/DB11156 (accessed September 17, 2018).
- MeSH. "Antinematodal Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Pleosan are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Pleosan. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
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Information checked by Dr. Sachin Kumar, MD Pharmacology
