• Pirantelis indications
• Pirantelis description
• Pirantelis dosage
• Pirantelis interactions
• Pirantelis side effects
• Pirantelis contraindications

What is Pirantelis?

Pirantelis belongs to the family of medicines called anthelmintics. Anthelmintics are used in the treatment of worm infections.

Pirantelis is used to treat pinworms (enterobiasis; oxyuriasis).

Pirantelis may also be used for other worm infections as determined by your doctor.

Pirantelis works by paralyzing the worms. They are then passed in the stool.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, Pirantelis is used in certain patients with the following medical condition:

• Common roundworm infection
• Hookworm infection
• More than one worm infection at a time

For patients taking Pirantelis for hookworm infection :

• Anemia (iron-poor blood) may occur in patients with hookworm infections. Therefore, your doctor may want you to take iron supplements to help clear up the anemia. If so, it is important to take iron every day while you are being treated for hookworms. Do not miss any doses. Your doctor may also want you to keep taking iron supplements for up to 6 months after you stop taking Pirantelis. If you have any questions about this, check with your doctor.

Pirantelis indications

Oral

Single or mixed infections due to susceptible worms

Adult: 10 mg/kg as a single dose.

Child: 10 mg/kg as a single dose.

Oral

Ascariasis

Adult: 5 mg/kg as a single dose. Max: 1 g/dose. For mass treatment programmes: 2.5 mg/kg as a single dose given 3-4 times a yr.

Oral

Necatoriasis

Adult: 10 mg/kg daily for 3-4 days or 20 mg/kg daily for 2 days.

Oral

Enterobiasis

Adult: 10 mg/kg repeated once after 2-4 wk. Max dose: 1 g/dose.

Oral

Trichinosis

Adult: 10 mg/kg daily for 5 days.

How should I use Pirantelis?

Use Pirantelis as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Pirantelis may be taken on an empty stomach or with food, milk, or juice.
• Shake well before using a dose of Pirantelis.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• Wear tight underwear both day and night while taking Pirantelis.
• Pirantelis is usually prescribed as a single dose.
• Only one dose of Pirantelis is required. If you forget to take Pirantelis, take it as soon as you remember.

Ask your health care provider any questions you may have about how to use Pirantelis.

Pirantelis description

Pirantelis is an antinematodal thiophene

Pirantelis dosage

Pirantelis Dosage

Applies to the following strength(s): 144 mg/mL; 180 mg; 50 mg/mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

• Enterobiasis
• Pinworm Infection (Enterobius vermicularis)
• Hookworm Infection (Necator or Ancylostoma)
• Ascariasis
• Trichostrongylosis
• Moniliformis Infection

Usual Pediatric Dose for:

• Enterobiasis
• Pinworm Infection (Enterobius vermicularis)
• Hookworm Infection (Necator or Ancylostoma)
• Ascariasis
• Trichostrongylosis
• Moniliformis Infection

Additional dosage information:

• Renal Dose Adjustments
• Liver Dose Adjustments
• Dose Adjustments
• Precautions
• Dialysis
• Other Comments

Usual Adult Dose for Enterobiasis

11 mg/kg base (maximum 1 g) orally once. Repeat dose in 2 weeks.

Usual Adult Dose for Pinworm Infection (Enterobius vermicularis)

11 mg/kg base (maximum 1 g) orally once. Repeat dose in 2 weeks.

Usual Adult Dose for Hookworm Infection (Necator or Ancylostoma)

11 mg/kg base (maximum 1 g) orally daily for 3 days.

Usual Adult Dose for Ascariasis

11 mg/kg base (maximum 1 g) orally once.

Usual Adult Dose for Trichostrongylosis

11 mg/kg base (maximum 1 g) orally once.

Usual Adult Dose for Moniliformis Infection

11 mg/kg base (maximum 1 g) orally once. Repeat dose twice at 2 weeks intervals.

Usual Pediatric Dose for Enterobiasis

>=2 years: 11 mg/kg base (maximum 1 g) once. Repeat dose in 2 weeks.

Usual Pediatric Dose for Pinworm Infection (Enterobius vermicularis)

>=2 years: 11 mg/kg base (maximum 1 g) once. Repeat dose in 2 weeks.

Usual Pediatric Dose for Hookworm Infection (Necator or Ancylostoma)

>=2 years: 11 mg/kg base (maximum 1 g) orally daily for 3 days.

Usual Pediatric Dose for Ascariasis

>=2 years: 11 mg/kg base (maximum 1 g) orally once.

Usual Pediatric Dose for Trichostrongylosis

>=2 years: 11 mg/kg base (maximum 1 g) orally once.

Usual Pediatric Dose for Moniliformis Infection

>=2 years: 11 mg/kg base (maximum 1 g) orally once. Repeat dose twice at 2 weeks intervals.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Pirantelis is contraindicated in patients with hepatic disease.

Dose Adjustments

In the treatment of ascariasis, Pirantelis may be used only if it has been determined that the worm load will not worsen obstruction.

Precautions

Pirantelis is contraindicated in patients with hepatic disease.

When one individual in a household has pinworms, the entire household should be treated unless otherwise advised. Pinworm infections are easily transmitted to others in the same household.

Pirantelis should be used with caution in patients with severe malnutrition or anemia. Supportive therapy is recommended for anemic, dehydrated, or malnourished patients prior to administration of the drug.

Other medications are known to antagonize the anthelmintic effect of Pirantelis. Patients should be advised to consult with their physician before initiating any drug therapy while receiving Pirantelis.

Dialysis

Data not available

Other Comments

The dose should be taken as a single oral dose. It may be taken alone or with milk or fruit juice.

Pirantelis pamoate 2.9 g is approximately equivalent to 1 g of Pirantelis (base).

More about Pirantelis

• Side Effects
• During Pregnancy or Breastfeeding
• Dosage Information
• Drug Interactions
• Support Group
• En Espanol
• 4 Reviews - Add your own review/rating

Consumer resources

• Pirantelis chewable tablets
• Pirantelis pamoate
• Pirantelis pamoate suspension
• Pirantelis
• Pirantelis (Advanced Reading)

• Other brands: Pin-X, Pinworm Medicine, Reese's Pinworm Medicine, Pinworm Caplets, More (2) »

Professional resources

• Pirantelis Pamoate (AHFS Monograph)

Related treatment guides

• Pinworm Infection (Enterobius vermicularis)
• Hookworm Infection (Necator or Ancylostoma)
• Ascariasis
• Enterobiasis
• Moniliformis Infection
• More (1) »

Pirantelis interactions

See also:
What other drugs will affect Pirantelis?

• Dexamethasone

Steady-state trough concentrations of albendazole sulfoxide were about 56% higher when 8 mg dexamethasone was coadministered with each dose of albendazole (15 mg/kg/day) in 8 neurocysticercosis patients.

• Praziquantel

• Cimetidine

Albendazole sulfoxide concentrations in bile and cystic fluid were increased (about 2-fold) in hydatid cyst patients treated with cimetidine (10 mg/kg/day) (n = 7) compared with albendazole (20 mg/kg/day) alone (n = 12). Albendazole sulfoxide plasma concentrations were unchanged 4 hours after dosing.

• Theophylline

The pharmacokinetics of theophylline (aminophylline 5.8 mg/kg infused over 20 minutes) were unchanged following a single oral dose of albendazole (400 mg) in 6 healthy subjects.

Pirantelis side effects

See also:
What are the possible side effects of Pirantelis?

Applies to Pirantelis: oral suspension, oral tablet, oral tablet chewable

In addition to its needed effects, some unwanted effects may be caused by Pirantelis (the active ingredient contained in Pirantelis). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking Pirantelis, check with your doctor or nurse as soon as possible:

Rare

• Skin rash

Minor Side Effects

Some of the side effects that can occur with Pirantelis may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:

• Abdominal or stomach cramps or pain
• diarrhea
• dizziness
• drowsiness
• headache
• irritability
• loss of appetite
• nausea or vomiting
• trouble in sleeping

Pirantelis contraindications

See also:
What is the most important information I should know about Pirantelis?

This medicine is contraindicated in patients with known hypersensitivity to the benzimidazole class of compounds or any components of this medicine.

Active ingredient matches for Pirantelis:

Pyrantel in Lithuania.

List of Pirantelis substitutes (brand and generic names)	Sort by popularity
Unit description / dosage (Manufacturer)	Price, USD
Pirantelina (Paraguay)
Pirantelis Medana (Lithuania)
Pirantrim (Mexico)
Piraska (Indonesia)
Pirel (Colombia)
Pleosan (Venezuela)
Premelange 25 / 2 Porcs Medicamente Pro-Ban
Drug Premix; Oral; Pyrantel Tartrate 8.48 g / kg
Pro-Banminth
Drug Premix; Oral; Pyrantel Tartrate 106 g / kg
Pro-Banminth Swine Premix
Drug Premix; Oral; Pyrantel Tartrate 106 g / kg
Provid (Ireland, United Kingdom)
Pyr-A-Pam
Tablet; Oral; Pyrantel Pamoate 35 mg
Pyr-A-Pam II
Tablet; Oral; Pyrantel Pamoate 125 mg
Pyran
Tablet; Oral; Pyrantel Pamoate 35 mg
Tablet; Oral; Pyrantel Pamoate 125 mg
Pyrantel (Austria, Finland, France, Germany, Israel, Luxembourg, New Zealand, Norway, Poland, South Africa, Sweden, Switzerland, United Kingdom, United States)
Suspension; Oral; Pyrantel Pamoate 250 mg / 5 ml
Tablet; Oral; Pyrantel Pamoate 250 mg
Suspension; Oral; Pyrantel 250 mg / 5 ml
Tablet; Oral; Pyrantel 250 mg
Suspension; Oral; Pyrantel Embonate 250 mg / 5 ml
Pyrantel Chewable Tablets
Pyrantel Pamoate Farnam (United States)
Pyrantel Pamoato (Italy)
Pyrantel Paste (Germany)
Pyrantel Polpharma (Georgia, Latvia)
Pyrantel Sine (China)
Pyrantel Vetos-Farma dla kotow For cats (Poland)
Pyrantel Vetos-Farma dla psow For dogs (Poland)
Pyrantelum (Latvia, Poland)
Pyrantelum Medana (Latvia)
Pyrantelum Medana / / höông vò mô 250 mg/5 mL x 1 Bottle 15 mL in duïng cuï ñong coù chia vaïch
Pyrantelum Polpharma (Poland)
Pyrantesan (Poland)
Pyrantin (Sri Lanka, Tunisia)
Pyrantverm (Poland)
Pyrapam (Thailand)
Pyrapam 125 mg x 1, 000's (General Drugs House)
Pyrapam 50 mg/1 mL x 10 mL (General Drugs House)
Pyrapam oral susp 50 mg/mL 10 mL x 1's (General Drugs House)
Pyrapam tab 125 mg 1000's (General Drugs House)
Pyratape (Ireland, United Kingdom)
Pyraverm 250
Pyrequan
Pyteldon (Thailand)
Pyteldon 125 mg x 100's
Pyteldon 250 mg/5 mL x 10 mL x 12's
See 286 substitutes for Pirantelis

References

1. PubChem. "PYRANTEL". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
2. DrugBank. "Pyrantel". http://www.drugbank.ca/drugs/DB11156 (accessed September 17, 2018).
3. MeSH. "Antinematodal Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Pirantelis are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Pirantelis. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

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Information checked by Dr. Sachin Kumar, MD Pharmacology